EKS-CAF-00177

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00177

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	470.4	2.1E-141	408	668	261

Status

Unreviewed

Ensembl Protein

ENSCAFP00000003817

UniProt Accession

F1PMX4;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCE

Gene Synonyms/Alias

PRKCE;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000002610	ENSCAFP00000003817	ENSCAFT00000004130

Organism

Canis familiaris

Functional Description

Protein Length

737

Protein Sequence
(FASTA)

MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT 60

NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE 120

PEGRVYVIID LSGSSGEAPK DNEERVFRER MRPRKRQGAV RRRVHQVNGH KFMATYLRQP 180

TYCSHCRDFI WGVIGKQGYQ CQVCTCVVHK RCHELIITKC AGLKKQETPD EVGSQRFSVN 240

MPHKFGIHNY KVPTFCDHCG SLLWGLLRQG LQCKVCKMNV HRRCETNVAP NCGVDARGIA 300

KVLADLGVTP DKITNSGQRR KKLIAGAESP QPTSGSSPSE EDRSKSAPTS PCDQEIKELE 360

NNIRKALSFD NRGEEHRAAA CGDGQLASPG ENGEVRQGQA KRLGLDEFTF IKVLGKGSFG 420

KVMLAELKGK DEVYAVKVLK KDVILQDDDV DCTMTEKRIL ALARKHPYLT QLYCCFQTKD 480

RLFFVMEYVN GGDLMFQIQR SRKFDEPRSR FYAAEVTSAL MFLHQHGVIY RDLKLDNILL 540

DAEGHCKLAD FGMCKEGILN GVTTTTFCGT PDYIAPEILQ ELEYGPSVDW WALGVLMYEM 600

MAGQPPFEAD NEDDLFESIL HDDVLYPVWL SKEAVSILKA FMTKNPHKRL GCVAAQNGED 660

AIKQHPFFKE IDWVLLEQKK IKPPFKPRIK TKRDVNNFDQ DFTREEPVLT LVDEAIVKQI 720

NQEEFKGFSY FGEDLMP 737

Nucleotide Sequence
(FASTA)

ATGGTAGTGT TCAATGGCCT CCTTAAGATC AAAATCTGCG AGGCCGTGAG CTTGAAGCCC 60

ACAGCCTGGT CGCTGCGCCA TGCGGTGGGA CCCCGGCCGC AGACTTTCCT CCTCGACCCC 120

TACATCGCCC TCAACGTGGA CGACTCGCGC ATCGGCCAGA CGGCCACCAA GCAGAAGACC 180

AACAGCCCGG CCTGGCACGA CGAGTTCGTC ACCGATGTGT GCAACGGGCG CAAGATCGAG 240

CTGGCCGTCT TCCACGATGC CCCCATCGGC TACGACGACT TCGTGGCCAA CTGCACCATC 300

CAGTTCGAGG AGCTGCTGCA GAACGGGAGC CGGCACTTCG AGGACTGGAT TGATCTGGAG 360

CCAGAAGGAA GAGTGTATGT GATCATTGAT CTATCGGGGT CGTCGGGTGA AGCCCCTAAA 420

GACAATGAAG AGCGCGTGTT CAGGGAGCGC ATGCGGCCCA GGAAGCGGCA GGGGGCCGTC 480

AGGCGGAGGG TCCACCAGGT CAACGGCCAC AAGTTCATGG CCACCTACCT TCGGCAGCCC 540

ACCTACTGCT CCCACTGCAG AGACTTTATC TGGGGTGTCA TAGGAAAGCA GGGATACCAA 600

TGTCAAGTTT GCACTTGTGT GGTTCACAAG CGATGCCATG AGCTCATAAT TACGAAGTGT 660

GCTGGATTAA AGAAACAGGA AACTCCCGAT GAGGTGGGCT CCCAGCGGTT CAGCGTCAAC 720

ATGCCTCACA AGTTTGGTAT TCACAACTAC AAGGTCCCCA CCTTCTGCGA CCACTGTGGG 780

TCCTTGCTCT GGGGCCTCCT ACGGCAGGGT TTGCAGTGCA AAGTCTGCAA GATGAATGTT 840

CACCGGCGCT GTGAGACCAA CGTGGCCCCC AACTGTGGAG TGGATGCCAG AGGAATTGCC 900

AAGGTTTTGG CTGATCTAGG TGTCACTCCA GACAAAATCA CCAACAGCGG CCAGAGGAGG 960

AAAAAGCTCA TTGCCGGCGC CGAGTCCCCG CAGCCCACTT CTGGAAGCTC GCCATCTGAG 1020

GAAGATCGAT CCAAGTCAGC CCCCACCTCC CCTTGTGACC AGGAAATAAA AGAACTTGAA 1080

AACAACATCC GGAAGGCCTT GTCCTTTGAC AACCGAGGGG AGGAGCACAG GGCAGCAGCA 1140

TGCGGCGATG GCCAGCTGGC GAGCCCCGGC GAGAATGGCG AAGTGCGGCA GGGCCAGGCC 1200

AAGCGCCTGG GTCTGGATGA GTTCACCTTC ATCAAGGTGC TGGGCAAAGG CAGCTTTGGC 1260

AAGGTGATGT TGGCAGAGCT GAAAGGCAAA GATGAAGTAT ATGCTGTGAA GGTCTTAAAG 1320

AAGGATGTCA TCCTCCAGGA TGATGACGTA GACTGCACGA TGACAGAGAA GAGGATTTTG 1380

GCGCTGGCGC GGAAACACCC ATACCTAACC CAACTCTATT GCTGCTTTCA GACCAAGGAC 1440

CGCCTCTTTT TCGTCATGGA GTATGTAAAC GGTGGAGACC TCATGTTCCA GATTCAGCGC 1500

TCCCGAAAAT TCGATGAGCC TCGTTCCCGG TTCTATGCTG CAGAGGTTAC GTCAGCCCTC 1560

ATGTTCCTCC ACCAACATGG AGTCATCTAC AGGGATTTGA AACTGGACAA CATCCTTCTG 1620

GATGCAGAAG GTCACTGCAA GCTGGCCGAC TTCGGGATGT GCAAGGAAGG GATTCTGAAC 1680

GGTGTCACAA CCACCACCTT CTGTGGAACT CCTGACTACA TCGCACCTGA GATCCTGCAG 1740

GAGTTGGAGT ACGGCCCCTC GGTGGACTGG TGGGCCCTGG GGGTGCTGAT GTACGAGATG 1800

ATGGCCGGGC AGCCGCCCTT CGAGGCCGAC AATGAGGACG ACCTGTTCGA GTCCATCCTC 1860

CACGATGACG TGCTCTACCC CGTGTGGCTC AGCAAGGAGG CCGTCAGCAT CCTGAAAGCT 1920

TTCATGACCA AGAACCCCCA CAAGCGCCTG GGCTGTGTGG CAGCACAGAA CGGCGAGGAC 1980

GCCATCAAGC AGCACCCATT CTTCAAGGAG ATCGACTGGG TGCTCCTGGA GCAGAAGAAG 2040

ATCAAGCCGC CCTTCAAACC TCGAATTAAA ACCAAAAGAG ACGTCAATAA CTTTGACCAA 2100

GACTTTACCC GGGAAGAGCC AGTACTCACG CTTGTGGATG AAGCAATTGT GAAGCAGATC 2160

AACCAGGAGG AATTCAAAGG CTTCTCCTAC TTTGGTGAAG ACCTGATGCC CTAA 2214

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+++kvlGkGsfgkv+laelk++de+ya+kvlkkdv+lqdddv++t++ekr+lala+k+p

Q: 408   FTFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP  467

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         +l+ql++cfqt+drlffv+eyvnGGdlmf+iq++rk++e+r+rfyaae+++al+flh++g

Q: 468   YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHG  527

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         +iyrdlkldn+lldaeGh+kladfG+cke+il+g tt+tfcGtPdyiaPeil+e eyg s

Q: 528   VIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPS  587

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwalGvl+yem+agq+Pfe+++ed+lfesil+++vlyP++lskeav+ilk+++tk+p+

Q: 588   VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPH  647

         ************************************************************

S: 241   krlGv..keegeedikehaff  259

         krlG+  +++ge++ik+h+ff

Q: 648   KRLGCvaAQNGEDAIKQHPFF  668

         *****6449***********9

Domain Sequence
(FASTA)

FTFIKVLGKG SFGKVMLAEL KGKDEVYAVK VLKKDVILQD DDVDCTMTEK RILALARKHP 60

YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHQHG 120

VIYRDLKLDN ILLDAEGHCK LADFGMCKEG ILNGVTTTTF CGTPDYIAPE ILQELEYGPS 180

VDWWALGVLM YEMMAGQPPF EADNEDDLFE SILHDDVLYP VWLSKEAVSI LKAFMTKNPH 240

KRLGCVAAQN GEDAIKQHPF F 261

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013