EKS-CAF-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	314.5	6.4E-94	36	283	248

Status

Unreviewed

Ensembl Protein

ENSCAFP00000004663

UniProt Accession

E2R3R6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K7

Gene Synonyms/Alias

MAP3K7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000003123	ENSCAFP00000004663	ENSCAFT00000005028
ENSCAFG00000003123	ENSCAFP00000004664	ENSCAFT00000005029

Organism

Canis familiaris

Functional Description

Protein Length

579

Protein Sequence
(FASTA)

MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV 60

AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE 120

PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC 180

DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM 240

WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY 300

PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQVPA TNDTIKRLES KLLKNQAKQQ 360

SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTGNGQPRR RSIQDLTVTG 420

TEPGQVSSRS SSPSVRMITT SGPTSEKPTR SHPWTPDDST DTNGSDNSIP MAYLTLDHQL 480

QPLAPCPNSK ESMAVFEQHC KMAQEYMKVQ TEIALLLQRK QELVAELDQD EKDQQNTSRL 540

VQEHKKLLDE NKSLSTYYQQ CKKQLEVIRS QQQKRQGTS 579

Nucleotide Sequence
(FASTA)

ATGTCTACAG CCTCCGCCGC TTCCTCCTCT TCCTCGTCTT CGGCCGGTGA GATGATCGAA 60

GCCCCCTCCC AAGTCCTCAA CTTTGAAGAG ATCGATTACA AGGAGATCGA AGTGGAAGAG 120

GTTGTTGGAA GAGGAGCCTT TGGAGTAGTT TGCAAAGCTA AGTGGAGAGC AAAAGATGTT 180

GCTATTAAAC AAATAGAAAG TGAATCTGAG AGGAAAGCTT TTATTGTAGA GCTTCGACAG 240

TTATCCCGTG TGAACCATCC TAATATTGTA AAGCTATATG GAGCCTGCTT GAATCCAGTG 300

TGTCTTGTGA TGGAATATGC TGAAGGGGGC TCTTTATATA ATGTGCTGCA TGGTGCTGAA 360

CCATTGCCAT ATTATACTGC TGCCCATGCA ATGAGTTGGT GTTTACAGTG TTCCCAAGGA 420

GTGGCTTATC TTCACAGCAT GCAACCCAAA GCTCTAATTC ACAGGGACCT GAAACCACCA 480

AACTTACTGC TGGTTGCAGG GGGGACAGTT TTAAAAATCT GTGACTTTGG TACAGCCTGT 540

GACATTCAGA CACACATGAC CAATAACAAG GGGAGTGCTG CTTGGATGGC ACCTGAAGTT 600

TTTGAAGGTA GCAATTACAG TGAAAAATGT GATGTCTTCA GCTGGGGTAT TATCCTTTGG 660

GAAGTGATAA CACGTCGGAA ACCCTTTGAT GAGATTGGTG GCCCAGCTTT CCGTATCATG 720

TGGGCTGTTC ATAACGGTAC TCGACCACCA CTGATCAAAA ATTTACCTAA GCCCATTGAG 780

AGCCTGATGA CTCGTTGTTG GTCTAAAGAT CCTTCTCAGC GCCCTTCAAT GGAGGAAATT 840

GTGAAAATAA TGACTCACTT GATGCGGTAC TTTCCAGGAG CAGATGAACC ATTACAGTAT 900

CCTTGTCAGT ATTCAGATGA AGGACAGAGC AACTCTGCCA CCAGTACAGG CTCATTCATG 960

GACATCGCTT CTACAAATAC CAGTAATAAA AGTGACACTA ATATGGAGCA AGTTCCTGCC 1020

ACAAATGATA CTATTAAACG CTTAGAATCA AAATTGTTGA AAAACCAGGC AAAGCAACAG 1080

AGTGAATCGG GACGTTTAAG CTTGGGAGCT TCCCGTGGAA GCAGCGTGGA GAGCTTGCCC 1140

CCAACCTCCG AGGGCAAGAG GATGAGTGCT GACATGTCTG AAATAGAAGC CAGAATTGCT 1200

GCAACCACAG GCAACGGACA GCCAAGACGT AGATCCATCC AAGACTTGAC TGTTACTGGG 1260

ACAGAACCTG GTCAGGTAAG CAGTAGGTCA TCCAGTCCTA GCGTCAGAAT GATCACTACC 1320

TCAGGACCAA CCTCAGAAAA GCCAACTCGA AGTCATCCCT GGACTCCTGA TGATTCCACA 1380

GATACCAATG GATCAGATAA CTCTATCCCA ATGGCTTATC TTACACTGGA TCACCAACTA 1440

CAGCCTCTAG CACCGTGCCC AAACTCCAAA GAATCTATGG CAGTGTTTGA ACAGCATTGT 1500

AAAATGGCAC AAGAATATAT GAAAGTTCAA ACAGAAATTG CTTTGTTATT ACAGAGAAAG 1560

CAAGAACTAG TTGCAGAACT GGACCAGGAT GAAAAGGACC AGCAAAATAC ATCTCGTCTG 1620

GTACAGGAAC ATAAAAAGCT TTTAGATGAA AACAAAAGCC TTTCCACTTA CTACCAGCAA 1680

TGCAAGAAAC AACTAGAGGT CATCAGAAGT CAGCAGCAAA AACGACAAGG CACTTCATGA 1740

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniie  60

         ie+ee++g+gafg v+kakwr+k+va+K++++e+e+    +++  e+++ls+++hpni++

Q: 36    IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER----KAFIVELRQLSRVNHPNIVK  91

         5789****************************9888....********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhe.kskreidlevlvswalqiArGmaYLhseap  119

         l+G+cl++  ++lvmey+eggsL+nvlh+ +  + ++ ++++sw+lq+++G+aYLhs++p

Q: 92    LYGACLNP--VCLVMEYAEGGSLYNVLHGaEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP  149

         *******9..89*****************778899*************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         k++ihrdLk++n+Ll +  ++lkicdFGta++++ +++++++g++awmaPEv++ +++se

Q: 150   KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAPEVFEGSNYSE  208

         ********************************99.9************************

S: 180   ksDvwSygvvLWelltrevPykdlse..laiaykvalkglrlpipsscpeklkkLmkecw  237

         k+Dv+S+g++LWe++tr++P++++    ++i+++v ++g+r+p+++++p+++++Lm++cw

Q: 209   KCDVFSWGIILWEVITRRKPFDEIGGpaFRIMWAV-HNGTRPPLIKNLPKPIESLMTRCW  267

         **********************9987447889999.99**********************

S: 238   nedpekRpsfseivks  253

         ++dp++Rps++eivk+

Q: 268   SKDPSQRPSMEEIVKI  283

         *************986

Domain Sequence
(FASTA)

IEVEEVVGRG AFGVVCKAKW RAKDVAIKQI ESESERKAFI VELRQLSRVN HPNIVKLYGA 60

CLNPVCLVME YAEGGSLYNV LHGAEPLPYY TAAHAMSWCL QCSQGVAYLH SMQPKALIHR 120

DLKPPNLLLV AGGTVLKICD FGTACDIQTH MTNNKGSAAW MAPEVFEGSN YSEKCDVFSW 180

GIILWEVITR RKPFDEIGGP AFRIMWAVHN GTRPPLIKNL PKPIESLMTR CWSKDPSQRP 240

SMEEIVKI 248

Keyword

Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017421	; MAPKKK7.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013