EKS-CAF-00304

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00304

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	497.5	9.3E-150	683	940	258

Status

Unreviewed

Ensembl Protein

ENSCAFP00000005164

UniProt Accession

F1PF03;

Protein Name

Protein Synonyms/Alias

Gene Name

EGFR

Gene Synonyms/Alias

EGFR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000003465	ENSCAFP00000005164	ENSCAFT00000005575

Organism

Canis familiaris

Functional Description

Protein Length

1180

Protein Sequence
(FASTA)

VCQGTSNRLT QLGTFEDHFL SLQRMFNNCE VVLGNLEITY MQRNYDLSFL KTIQEVAGYV 60

LIALNTVEKI PLENLQIIRG NVLYENTHAL SVLSNYGSNK TGLQELPLRN LHEILQGAVR 120

FSNNPVLCNV ETIQWRDIVD NDFISNMSMD IQNQAGRCQK CDPSCPNGSC WGPGKENCQK 180

LTKIICAQQC SGRCRGRSPS DCCHNQCAAG CTGPRESDCL VCRKFRDEAT CKDTCPPLML 240

YNPTTYQMDV NPEGKYSFGA TCVKKCPRNY VVTDHGSCVR ACSSDSYEVE EDGVRKCKKC 300

EGPCRKVCNG IGIGEFKDTL SINATNIKHF KNCTSISGDL HILPVAFRGD SFTHTLPLDP 360

KELDILKTVK EITGFLLIQA WPENRTDLHA FENLEIIRGR TKQHGQFSLA VVGLNITSLG 420

LRSLKEISDG DVIISGNRKL CYANTINWKK LFGTSSQKTK IINNKDEKAC KAIGHVCHPL 480

CSSEGCWGPG PRDCVSCRNV SRGKECVEKC NILEGEPREF VENSECIQCH PECLPQAMNI 540

TCTGRGPDSC IKCAHYIDGP HCVKTCPAGI MGENNTLVWK FSDGSRMCHL CHPNCTYGCE 600

GPGLEGCAKP GPKIPSIATG IVGGLLLVVV VALGVGLFLR RRHIVRKRTL RRLLQERELV 660

EPLTPSGEAP NQALLRILKE TEFKKIKVLG SGAFGTVYKG LWIPEGEKVK IPVAIKELRE 720

ATSPKANKEI LDEAYVMASV DNPHVCRLLG ICLTSTVQLI TQLMPFGCLL DYVREHKDNI 780

GSQHLLNWCV QIAKGMNYLE DRRLVHRDLA ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY 840

HAEGGKVPIK WMALESILHR IYTHQSDVWS YGVTVWELMT FGSKPYDGIP ASEISTILEK 900

GERLPQPPIC TIDVYMIMVK CWMIDADSRP KFRELIIEFS KMARDPQRYL VIQGDERMHL 960

PSPTDSNFYR ALMDEEDMED VVDADEYLIP QQGFFHSPST SRTPLLSSLS ATSNSSNVAC 1020

IDRNGPQTCP LKEDSFLQRY SSDPTGTLTE DNIDDTFLPA PEYINQSVPK RPAGSVQNPV 1080

YHNQPLNPAP ARDPHYQNPH SNAVDNPEYL NTHPTCVNSV LDRPSLWTQE ANHQISLDNP 1140

DYQQDFFPKE AKSNGIFKGP AAENADYLRV APPSSEFIGA 1180

Nucleotide Sequence
(FASTA)

GTCTGCCAAG GCACGAGTAA CCGGCTCACC CAGTTGGGCA CTTTTGAAGA CCACTTTCTG 60

AGCCTTCAGA GGATGTTCAA TAACTGTGAG GTGGTCCTGG GGAATTTGGA AATTACCTAC 120

ATGCAAAGGA ATTATGACCT TTCCTTCTTA AAGACCATCC AGGAAGTTGC CGGGTATGTA 180

TTGATTGCCC TCAACACGGT GGAGAAGATT CCTTTGGAAA ACCTGCAGAT CATCCGAGGA 240

AATGTGCTCT ATGAAAACAC CCATGCCTTA TCCGTCCTCT CCAACTATGG CTCAAATAAA 300

ACTGGACTGC AGGAGCTTCC CCTGAGAAAC TTGCATGAAA TACTACAAGG CGCTGTGCGC 360

TTCAGCAATA ACCCTGTCCT CTGCAACGTG GAAACCATCC AGTGGCGGGA CATCGTTGAC 420

AACGATTTTA TAAGCAACAT GTCGATGGAC ATCCAGAACC AAGCGGGCAG GTGCCAAAAG 480

TGTGATCCAA GCTGTCCCAA TGGAAGTTGC TGGGGTCCGG GAAAGGAGAA TTGCCAGAAA 540

CTGACCAAAA TCATCTGTGC CCAGCAGTGT TCGGGGCGCT GCCGCGGCAG GTCCCCCAGC 600

GACTGCTGCC ACAACCAGTG TGCCGCCGGC TGCACGGGGC CCCGCGAGAG CGACTGCCTG 660

GTCTGCCGCA AGTTCCGGGA TGAAGCCACG TGCAAGGACA CCTGCCCGCC CCTCATGCTC 720

TACAACCCCA CCACCTACCA AATGGACGTC AACCCAGAGG GAAAATACAG CTTTGGTGCC 780

ACCTGCGTGA AGAAATGCCC CCGCAACTAC GTGGTGACAG ACCACGGTTC ATGTGTCCGC 840

GCCTGCAGCT CTGACAGCTA CGAGGTGGAG GAGGATGGTG TCCGCAAGTG TAAGAAGTGT 900

GAGGGGCCTT GTCGCAAAGT TTGTAATGGA ATAGGGATTG GAGAGTTCAA AGACACACTT 960

TCCATAAATG CTACAAACAT TAAACACTTC AAAAACTGCA CGTCGATCAG TGGAGACCTT 1020

CATATCTTGC CAGTCGCATT TAGAGGTGAC TCCTTCACGC ATACCCTACC TCTAGATCCG 1080

AAGGAGCTGG ATATCCTGAA AACTGTCAAG GAAATAACAG GGTTTTTGCT GATTCAGGCC 1140

TGGCCCGAAA ATAGGACTGA CCTCCATGCT TTCGAGAACC TAGAAATCAT ACGTGGAAGA 1200

ACAAAGCAAC ATGGCCAGTT TTCTCTGGCG GTCGTCGGCC TGAACATAAC GTCCTTGGGA 1260

TTACGCTCCC TCAAGGAGAT AAGCGATGGA GATGTGATCA TCTCTGGAAA CCGAAAATTG 1320

TGCTATGCAA ATACAATAAA CTGGAAGAAA CTCTTTGGGA CTTCAAGTCA GAAAACCAAA 1380

ATTATAAACA ACAAAGATGA AAAAGCCTGC AAGGCCATAG GCCACGTCTG CCATCCATTG 1440

TGCTCCTCAG AAGGCTGCTG GGGCCCAGGG CCGAGAGACT GCGTGTCCTG CCGAAACGTC 1500

AGCCGTGGCA AGGAATGTGT GGAAAAGTGC AACATTCTGG AGGGGGAGCC AAGGGAGTTT 1560

GTGGAGAATT CGGAGTGCAT ACAGTGCCAT CCGGAATGCC TGCCCCAGGC CATGAACATA 1620

ACCTGCACAG GACGGGGGCC GGACAGCTGC ATCAAGTGCG CCCACTACAT CGATGGCCCT 1680

CACTGCGTCA AGACCTGCCC GGCTGGCATC ATGGGAGAAA ACAACACCCT GGTCTGGAAG 1740

TTTTCGGATG GCAGCCGCAT GTGCCACCTG TGCCATCCAA ACTGCACCTA TGGCTGTGAG 1800

GGACCAGGTC TTGAAGGCTG TGCAAAACCT GGGCCCAAGA TCCCATCCAT TGCTACCGGG 1860

ATTGTCGGCG GCCTCCTCTT GGTGGTGGTG GTGGCCCTTG GAGTGGGCCT CTTTTTGCGC 1920

CGGCGCCACA TTGTCCGGAA GCGCACGCTT CGCAGACTGC TGCAAGAAAG AGAGCTTGTC 1980

GAGCCTCTTA CACCCAGCGG AGAAGCTCCC AACCAGGCTC TCTTGAGGAT CTTAAAGGAG 2040

ACGGAGTTCA AAAAGATCAA GGTGCTGGGC TCTGGAGCAT TCGGCACAGT GTACAAGGGA 2100

CTCTGGATCC CAGAAGGCGA GAAGGTTAAA ATTCCCGTGG CCATCAAGGA ATTGAGAGAA 2160

GCCACGTCTC CCAAAGCCAA CAAGGAAATT CTTGATGAAG CCTACGTGAT GGCCAGTGTG 2220

GACAATCCCC ACGTGTGCCG CCTCCTGGGC ATCTGCCTGA CGTCCACGGT GCAGCTCATC 2280

ACGCAGCTCA TGCCCTTTGG CTGCCTCCTG GACTATGTCC GCGAGCACAA GGACAACATC 2340

GGCTCCCAGC ACCTGCTCAA CTGGTGTGTG CAGATTGCAA AGGGCATGAA CTACCTGGAA 2400

GACCGGCGCT TGGTGCACCG CGACCTGGCG GCCAGGAACG TCCTGGTGAA GACCCCGCAG 2460

CACGTCAAGA TCACAGATTT TGGGCTGGCC AAACTGCTGG GTGCCGAGGA GAAAGAGTAC 2520

CACGCGGAAG GAGGCAAAGT GCCTATCAAG TGGATGGCTT TAGAATCGAT TTTACACCGA 2580

ATTTATACCC ACCAAAGCGA TGTGTGGAGC TACGGCGTCA CCGTGTGGGA GCTGATGACC 2640

TTCGGGTCCA AGCCTTACGA CGGTATCCCT GCAAGTGAGA TCTCCACCAT CCTGGAGAAG 2700

GGAGAGCGCC TCCCGCAGCC GCCCATATGC ACCATCGATG TCTACATGAT CATGGTCAAG 2760

TGCTGGATGA TAGATGCAGA CAGTCGCCCA AAATTCCGTG AGTTGATCAT CGAATTCTCC 2820

AAAATGGCCC GAGACCCGCA GCGCTACCTT GTCATCCAGG GAGATGAGAG GATGCATTTG 2880

CCAAGCCCTA CAGACTCCAA TTTTTACCGC GCCCTGATGG ACGAGGAGGA CATGGAGGAT 2940

GTTGTGGATG CTGACGAGTA CCTCATCCCC CAGCAGGGCT TCTTCCACAG CCCCTCCACT 3000

TCCCGGACCC CCCTCCTAAG TTCTCTGAGC GCCACCAGCA ACAGTTCCAA CGTGGCTTGC 3060

ATCGACCGAA ATGGGCCTCA GACCTGTCCC CTCAAAGAAG ACAGCTTCTT GCAGCGGTAC 3120

AGCTCAGACC CCACTGGCAC CTTGACGGAG GACAACATAG ATGACACTTT CCTCCCAGCA 3180

CCCGAATACA TAAACCAGTC TGTTCCCAAA AGGCCTGCGG GTTCTGTCCA GAATCCCGTC 3240

TATCACAATC AGCCTCTAAA TCCAGCTCCT GCCAGAGACC CTCACTACCA AAATCCCCAC 3300

AGCAACGCAG TGGACAACCC TGAGTATCTC AACACCCACC CCACCTGCGT CAACAGTGTC 3360

CTCGACAGGC CCAGCCTCTG GACCCAGGAG GCCAACCACC AAATCAGCCT GGACAACCCT 3420

GACTACCAGC AGGACTTCTT TCCCAAGGAA GCCAAGTCCA ATGGCATTTT TAAGGGCCCT 3480

GCAGCTGAAA ATGCAGACTA CCTGAGGGTA GCGCCACCAA GCAGTGAGTT TATTGGAGCG 3540

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+

Q: 683   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  742

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++

Q: 743   PHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQHLLNWCVQIAKGMNYLEDR  802

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y

Q: 803   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  862

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+ +lekGerl+qppictidvym++vkcw

Q: 863   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISTILEKGERLPQPPICTIDVYMIMVKCW  922

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkf+el+ efs

Q: 923   MIDADSRPKFRELIIEFS  940

         ****************96

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60

PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY VREHKDNIGS QHLLNWCVQI AKGMNYLEDR 120

RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180

THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISTILEKGE RLPQPPICTI DVYMIMVKCW 240

MIDADSRPKF RELIIEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013