EKS-CAF-00442
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00442
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/DMPK461.97.7E-1396268263
StatusUnreviewed
Ensembl ProteinENSCAFP00000005284
UniProt AccessionF1PE53;
Protein Name
Protein Synonyms/Alias
Gene NameROCK2
Gene Synonyms/Alias ROCK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000003549ENSCAFP00000005284ENSCAFT00000005709
OrganismCanis familiaris
Functional Description
Protein Length1306
Protein Sequence
(FASTA)
MKAEDYDVVK VIGRGAFGEV QLVRHKASQK VYAMKLLSKF EMIKRSDSAF FWEERDIMAF 60
ANSPWVVQLF CAFQDDKYLY MVMEYMPGGD LVNLMSNYDV PEKWAKFYTA EVVLALDAIH 120
SMGLIHRDVK PDNMLLDKHG HLKLADFGTC MKMDETGMVH CDTAVGTPDY ISPEVLKSQG 180
GDGYYGRECD WWSVGVFLFE MLVGDTPFYA DSLVGTYSKI MDHKNSLCFP EDAEISKHAK 240
NLICAFLTDR EVRLGRNGVE EIKQHPFFKN DQWNWDNIRE TAAPVVPELS SDIDSSNFDD 300
IEDDKGDVET FPIPKAFVGN QLPFIGFTYY RENLLLSESS SCRENDSLQS RKNEESQEIQ 360
KKLYTLEEHL STEIQAKEEL EQKCKSVNTR LEKVAKELEE EITLRKNVES ALRQLEREKA 420
LLQHKNAEYQ RKADHEADKK RNLENDVNSL KDQLEDLKKR NQNSQISTEK VNQLQRQLDE 480
TNALLRTESD TTARLRKTQA ESSKQIQQLE SNNRDLQDKN CLLETAKLKL EKEFMNLQSV 540
LESERRDRTH GSEIINDLQG RISGLEEDLK NGKILLAKAE VEKRQLQERL TDLEKEKNNM 600
EIDMTYQLKV IQQSLEQEEA EHKATKARLA DKNKIYESIE EAKSEAMKEM EKKLSEERTL 660
KQKVENLLLE AEKRCSLFDC DLKQSQQKIN ELLKQKDVLN EDVRNLTLKI EQETQKRCLT 720
QNDLKMQTQQ VNTLKMSEKQ LKQENNHLME MKMSLEKQNA ELRKERQDAD GQMKELQDQL 780
EAEQYFSTLY KTQVRELKEE CEEKTKLCKE LQQKKQELQE ERDSLAAQLE ITLTKADSEQ 840
LARSIAEEQY SDLEKEKIMK ELEIKEMMAR HKQELTEKDA TIASLEETNR TLTSDVANLA 900
NEKEELNNKL KDAQEQLSRL KDEEISAAAI KAQFEKQLLT ERTLKTQAVN KLAEIMNRKE 960
PVKRGSDTDV RRKEKENRKL HMELKSEREK LTQQMIKYQK ELNEMQAQIA EESQIRIELQ 1020
MTLDSKDSDI EQLRSQLQAL HIGLDSSSIG SGPGDAEADD GFPESRLEGW LSLPLRNNTK 1080
KFGWTKKYVI VSSKKILFYD SEQDKEQSNP YMVLDIDKLF HVRPVTQTDV YRADAKDIPR 1140
IFQILYANEG ESKKEQEFPV EPVGEKSNYI CHKGHEFIPT LYHFPTNCEA CMKPLWHMFK 1200
PPPALECRRC HIKCHKDHMD KKEEIIAPCK VYCDISTAKN LLLLANSTEE QQKWVSRLVK 1260
KIPKKPPAPD PFARSSPRTS MKIQQNQSIR RPSRQLAPNK PRTFSI 1306
Nucleotide Sequence
(FASTA)
ATGAAGGCAG AAGACTATGA TGTTGTAAAA GTTATTGGAA GAGGTGCTTT TGGTGAGGTG 60
CAGCTGGTTC GTCATAAAGC ATCACAGAAG GTGTATGCTA TGAAGCTTCT TAGTAAGTTT 120
GAAATGATAA AAAGATCAGA TTCTGCTTTT TTCTGGGAAG AGAGAGATAT TATGGCCTTT 180
GCCAACAGTC CCTGGGTGGT TCAGCTCTTT TGTGCTTTTC AAGATGATAA GTATCTGTAC 240
ATGGTAATGG AGTACATGCC TGGTGGAGAT CTTGTAAACC TTATGAGTAA CTATGACGTG 300
CCTGAAAAAT GGGCCAAATT CTATACTGCT GAAGTTGTTC TTGCTCTGGA TGCCATACAC 360
TCCATGGGCT TAATTCACAG AGATGTAAAG CCTGACAACA TGCTCTTGGA TAAACATGGA 420
CATCTAAAGT TAGCAGATTT TGGCACATGT ATGAAGATGG ATGAAACAGG CATGGTGCAT 480
TGTGATACAG CAGTTGGAAC ACCTGATTAT ATTTCACCTG AGGTTCTCAA ATCACAAGGG 540
GGTGATGGTT ACTATGGGCG AGAATGTGAT TGGTGGTCGG TGGGTGTTTT CCTTTTTGAG 600
ATGCTGGTGG GGGATACTCC ATTTTATGCA GATTCACTTG TAGGAACTTA TAGCAAAATT 660
ATGGATCATA AAAACTCACT GTGTTTCCCT GAAGATGCAG AAATTTCTAA ACATGCGAAG 720
AATCTCATTT GCGCCTTCTT AACAGATAGG GAGGTACGAC TTGGGAGAAA TGGGGTAGAA 780
GAAATCAAAC AGCATCCTTT CTTTAAGAAT GATCAATGGA ATTGGGATAA CATAAGAGAG 840
ACGGCAGCTC CTGTAGTACC AGAACTCAGC AGTGACATAG ACAGCAGCAA TTTTGATGAC 900
ATCGAAGATG ATAAAGGAGA TGTAGAAACT TTTCCAATTC CTAAAGCTTT TGTGGGAAAT 960
CAGCTGCCTT TTATAGGATT TACCTACTAT AGAGAAAATC TGTTATTAAG TGAGTCTTCA 1020
TCTTGTAGAG AAAATGATTC ATTACAATCA AGGAAAAATG AAGAAAGTCA AGAGATTCAG 1080
AAAAAATTAT ATACATTAGA AGAACACCTC AGCACTGAGA TACAAGCCAA AGAAGAACTA 1140
GAGCAAAAGT GCAAATCTGT TAATACTCGA CTTGAAAAAG TAGCAAAGGA ATTAGAAGAA 1200
GAGATTACTT TAAGGAAAAA TGTGGAATCA GCATTAAGAC AATTAGAAAG AGAAAAGGCA 1260
CTTCTTCAGC ACAAAAATGC AGAATATCAG CGGAAAGCTG ATCACGAAGC AGACAAGAAG 1320
CGGAATTTGG AAAATGATGT TAACAGTTTA AAGGATCAAC TTGAAGATTT GAAAAAAAGA 1380
AATCAGAACT CTCAAATATC CACCGAGAAA GTGAATCAGC TCCAGAGACA ACTGGATGAA 1440
ACCAATGCTT TACTGAGAAC AGAATCTGAT ACTACGGCCC GGTTAAGAAA AACCCAGGCA 1500
GAAAGTTCAA AACAGATTCA GCAGCTGGAA TCTAACAATA GAGATCTCCA AGATAAAAAT 1560
TGCCTGCTAG AGACTGCCAA GTTAAAACTT GAAAAGGAAT TTATGAATCT TCAGTCAGTT 1620
CTAGAATCTG AAAGGAGGGA CCGAACCCAC GGATCCGAGA TAATTAATGA CTTACAAGGT 1680
AGAATATCTG GCCTAGAAGA AGACTTAAAG AATGGAAAAA TCTTATTAGC AAAAGCAGAG 1740
GTGGAGAAGA GACAACTGCA GGAGAGACTT ACTGATTTGG AAAAGGAAAA GAACAACATG 1800
GAAATAGATA TGACGTACCA ACTAAAAGTT ATACAGCAGA GCTTAGAACA AGAAGAAGCT 1860
GAGCATAAGG CCACAAAAGC ACGGCTGGCA GATAAAAATA AGATTTATGA GTCCATTGAA 1920
GAAGCAAAAT CAGAAGCCAT GAAAGAAATG GAGAAGAAGC TCTCAGAGGA AAGGACGTTA 1980
AAACAGAAGG TGGAGAATCT ATTGCTGGAA GCTGAGAAAA GATGCTCTTT ATTTGACTGT 2040
GACCTCAAGC AGTCACAGCA GAAAATAAAT GAACTCCTTA AACAGAAAGA TGTGCTAAAT 2100
GAGGATGTTA GAAACTTGAC ATTAAAAATA GAGCAGGAAA CTCAGAAGCG CTGCCTTACA 2160
CAAAATGACT TGAAGATGCA AACACAGCAA GTTAACACAC TAAAAATGTC AGAAAAACAG 2220
TTAAAACAAG AGAATAATCA TCTCATGGAA ATGAAAATGA GCTTGGAAAA GCAGAATGCT 2280
GAACTTCGGA AAGAACGTCA AGATGCAGAT GGGCAAATGA AAGAACTTCA GGATCAGCTT 2340
GAAGCGGAGC AGTATTTCTC AACCCTCTAT AAAACACAGG TGAGGGAACT TAAAGAAGAA 2400
TGTGAAGAAA AAACCAAACT TTGTAAAGAA TTACAGCAAA AGAAACAGGA ATTACAGGAA 2460
GAAAGGGATT CCTTGGCTGC TCAACTGGAG ATCACCTTGA CCAAAGCAGA TTCTGAGCAG 2520
CTGGCTCGTT CAATTGCTGA AGAGCAGTAT TCTGATTTGG AAAAAGAGAA AATTATGAAG 2580
GAGCTTGAGA TCAAAGAGAT GATGGCTAGA CACAAACAGG AACTCACTGA AAAAGATGCT 2640
ACAATTGCAT CTCTTGAAGA AACGAATAGA ACACTAACTA GTGATGTTGC CAATCTTGCA 2700
AATGAGAAAG AAGAATTAAA TAACAAATTG AAAGATGCAC AAGAACAGCT GTCACGGCTG 2760
AAGGATGAGG AGATCAGTGC AGCTGCTATT AAAGCACAGT TTGAGAAGCA GCTGCTCACA 2820
GAGAGAACAC TGAAAACTCA AGCTGTGAAT AAGTTGGCTG AGATCATGAA TCGAAAAGAA 2880
CCTGTCAAGC GTGGTAGTGA CACTGATGTG CGGAGAAAAG AGAAAGAAAA TCGGAAGCTA 2940
CATATGGAGC TTAAATCTGA ACGTGAAAAA CTGACCCAGC AGATGATCAA GTACCAGAAA 3000
GAACTGAATG AAATGCAGGC TCAAATAGCT GAAGAGAGCC AGATTCGAAT TGAACTGCAG 3060
ATGACACTGG ACAGTAAAGA TAGTGACATT GAGCAGCTGC GGTCACAGCT CCAGGCTTTG 3120
CATATTGGTC TGGATAGTTC CAGTATAGGC AGTGGACCGG GGGACGCTGA GGCAGATGAT 3180
GGGTTTCCAG AATCAAGACT AGAAGGATGG CTTTCATTGC CTTTACGAAA CAACACTAAG 3240
AAATTTGGAT GGACTAAAAA GTATGTGATT GTAAGCAGTA AGAAGATTCT TTTCTATGAC 3300
AGCGAACAAG ATAAAGAACA ATCTAATCCT TACATGGTTT TAGATATAGA CAAATTATTT 3360
CATGTCCGAC CAGTTACACA GACAGATGTA TATAGAGCAG ATGCTAAAGA TATTCCAAGG 3420
ATATTTCAGA TTCTGTACGC CAATGAAGGA GAAAGTAAGA AGGAACAAGA ATTTCCAGTG 3480
GAGCCAGTAG GAGAAAAATC AAATTATATT TGCCATAAAG GACATGAATT TATTCCTACT 3540
CTGTATCATT TCCCAACCAA CTGTGAGGCT TGTATGAAGC CATTGTGGCA TATGTTTAAA 3600
CCTCCTCCTG CTTTAGAATG CCGGCGCTGC CATATTAAAT GTCATAAAGA TCACATGGAC 3660
AAAAAGGAGG AGATTATAGC ACCTTGCAAG GTTTATTGTG ATATTTCGAC GGCAAAGAAT 3720
CTATTGTTGT TAGCAAATTC TACAGAAGAG CAGCAGAAGT GGGTTAGTCG GTTGGTGAAA 3780
AAGATTCCTA AAAAGCCTCC AGCTCCAGAC CCTTTTGCAC GGTCATCACC TAGAACTTCA 3840
ATGAAGATAC AACAAAACCA GTCTATTAGA CGGCCAAGTC GACAGCTTGC CCCAAACAAA 3900
CCAAGGACCT TCAGTATATG A 3921
Domain Profile
S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60
         ++++kviGrGafgev++vr+ka++kvyamk+l+k+e++kr++saff+eerd++++a+s+w
Q: 6     YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPW  65
         799*********************************************************
S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120
         +vql++afqd+kyly+vmey++GGdl++l+s+y+  +pe++a+fy+ae+vlald++h++g
Q: 66    VVQLFCAFQDDKYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMG  123
         **********************************..9***********************
S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180
         ++hrd+kpdn+lldk+Gh+kladfG+c+k++e+g+v++++avGtpdyispevlk+++ g+
Q: 124   LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQG-GD  182
         ********************************************************9.**
S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpedekvseeakdl  240
         g+yg+ecdwws+Gv+l+e+lvg+tpfya+slv tyski++hk+sl+fped+++s++ak+l
Q: 183   GYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNL  242
         ************************************************************
S: 241   ikklltsreerlgregiedlkkhpff  266
         i+++lt+re rlgr+g+e++k+hpff
Q: 243   ICAFLTDREVRLGRNGVEEIKQHPFF  268
         *************************9
Domain Sequence
(FASTA)
YDVVKVIGRG AFGEVQLVRH KASQKVYAMK LLSKFEMIKR SDSAFFWEER DIMAFANSPW 60
VVQLFCAFQD DKYLYMVMEY MPGGDLVNLM SNYDVPEKWA KFYTAEVVLA LDAIHSMGLI 120
HRDVKPDNML LDKHGHLKLA DFGTCMKMDE TGMVHCDTAV GTPDYISPEV LKSQGGDGYY 180
GRECDWWSVG VFLFEMLVGD TPFYADSLVG TYSKIMDHKN SLCFPEDAEI SKHAKNLICA 240
FLTDREVRLG RNGVEEIKQH PFF 263
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00414
EKS-ANC-00429
EKS-BOT-00443
EKS-CAJ-00447
EKS-CAP-00477
EKS-CII-00252
EKS-CIS-00203
EKS-DAR-00838
EKS-DRM-00209
EKS-EQC-00434
EKS-FEC-00423
EKS-GAG-00374
EKS-GAA-00538
EKS-LAC-00457
EKS-LOA-00452
EKS-MAM-00442
EKS-MEG-00367
EKS-MOD-00431
EKS-MUM-00475
EKS-MUP-00434
EKS-MYL-00435
EKS-NOL-00404
EKS-ORN-00562
EKS-ORA-00388
EKS-ORC-00415
EKS-OTG-00448
EKS-PAT-00418
EKS-PES-00393
EKS-PEM-00242
EKS-POA-00431
EKS-RAN-00456
EKS-SAH-00409
EKS-SUS-00392
EKS-TAG-00509
EKS-TAR-00553
EKS-TEN-00556
EKS-VIP-00080
EKS-XET-00594
EKS-XIM-00554
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000910; P:cytokinesis
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011072; HR1_rho-bd.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR020684; Rho-assoc_coiled-coil_kin.
IPR015008; Rho-bd.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF02185; HR1; 1.
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
PF08912; Rho_Binding; 1.
SMARTs
SM00109; C1; 1.
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
Created Date20-Feb-2013