EKS-CAF-00270

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00270

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	388.1	2.3E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSCAFP00000005783

UniProt Accession

E2RST5;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000003875	ENSCAFP00000005783	ENSCAFT00000006243
ENSCAFG00000003875	ENSCAFP00000041163	ENSCAFT00000047264

Organism

Canis familiaris

Functional Description

Protein Length

969

Protein Sequence
(FASTA)

MATCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DNNYVYLVLE MCHNGEMNRY LKNRMKPFSE NEARHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LKMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PAFLTREAKD 240

LIHQLLRRNP ADRLSLSSVL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAITASSST 300

SISGSLFDRR RLLIGQPLPN KVTVFPKNKN SSDFSSSGDG SSLYTQWGNQ EKETSNRGRG 360

RVIQDAEERP HSRYLRRAHS SDRSDTSNGQ SRAKTYTMER CHSAEMLSKP RRSGVDENEE 420

RYSPTNSDVN IFHFFKEKAS SSPGSFERPD NDQARSNHLC PGKTPFPFPD QTPQTEMVQQ 480

WFGNLQIKPH FRETTEHNSI GPNRDFQGHP DLQDTSRNAW TDTRVKKSPD ASDNVHSAKQ 540

LNTMKYMTAF QSKPEIIQQE SIYDSDPLSE QNKTRGMEPP YQKCTLRGIT SPLTAYRLKP 600

IRQKTKKAVV SILDSEEVCV ELLKEHTSQE YVKEVLQISS DGNMITIYYP NDGRGFPLAD 660

RPPPPTDNIS RYSFDNLPEK YWRKYQYASR FVHLVRSKSP KITYFTKYAK CILMENSPGA 720

DFEVWFYDGA KIHKTEDLIQ VIEKTGKSYT LKGESEINTL KGEIKLYMDH ADEGHRICLA 780

LESVISEEEK KSGSAPFFPI IVGRKPGNTS SPKALSPPTS VDPNYLMSDR ASLNKMIINS 840

AASPKPTPIF KSEMVTNEGC GFTAAASGTN IPSSSLKDCL PKSAQLLKSV FVKNVGWATQ 900

LTSGAVWVQF NDGSQLVVQA GVSSISYTSP NGQITRYGEN EKLPDYIKQK LQCLSSILLM 960

FSNPSPSFE 969

Nucleotide Sequence
(FASTA)

ATGGCGACCT GCATCGGGGA GAAGATCGAG GATTTTAAAG TTGGAAATCT GCTTGGTAAA 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CTGGTTTGGA AGTTGCAATC 120

AAAATGATAG ATAAGAAAGC CATGTACAAA GCTGGAATGG TACAGAGAGT CCAAAATGAG 180

GTGAAAATAC ATTGCCAGTT GAAACATCCT TCTATCTTGG AGCTGTATAA CTATTTTGAA 240

GATAACAATT ATGTATATCT AGTATTAGAA ATGTGCCATA ATGGAGAAAT GAATAGATAT 300

CTAAAGAACA GAATGAAACC ATTCTCAGAA AACGAAGCTC GACACTTTAT GCACCAGATC 360

ATCACAGGAA TGTTGTATCT CCATTCTCAT GGTATATTAC ACCGGGATCT CACACTTTCT 420

AATCTCTTAC TTACACGTAA TATGAACATC AAGATTGCTG ATTTTGGGCT GGCAACTCAA 480

TTGAAAATGC CACATGAAAA GCACTATACG TTATGTGGAA CTCCTAATTA TATTTCACCA 540

GAAATTGCAA CTCGAAGTGC ACATGGACTT GAATCTGATG TTTGGTCCTT GGGCTGTATG 600

TTTTACACGT TGCTTATTGG GAGACCACCT TTTGACACTG ACACAGTCAA GAACACGTTA 660

AATAAAGTAG TATTGGCAGA TTATGAAATG CCAGCTTTTT TGACAAGAGA GGCCAAGGAC 720

CTTATTCACC AGTTACTTCG TAGAAATCCA GCAGATCGTT TAAGTCTGTC TTCAGTATTA 780

GACCATCCTT TTATGTCCCG AAATTCCTCA ACAAAAAGTA AAGATTTAGG GACTGTAGAA 840

GACTCAATTG ATAGTGGACA TGCCACAATT TCTACTGCAA TTACAGCTTC TTCCAGTACC 900

AGTATAAGTG GTAGTTTATT TGACAGAAGA AGACTCTTGA TTGGTCAACC ACTCCCAAAT 960

AAAGTGACTG TATTTCCAAA GAATAAAAAT TCAAGTGATT TTTCTTCTTC AGGAGATGGA 1020

AGCAGTCTTT ATACTCAGTG GGGAAATCAA GAAAAAGAAA CCAGCAATAG GGGAAGGGGA 1080

AGAGTGATCC AGGATGCAGA AGAAAGGCCA CATTCTAGAT ACCTTCGTAG AGCCCATTCC 1140

TCTGATAGAT CTGACACTTC TAATGGTCAG TCTCGAGCAA AAACATACAC AATGGAACGA 1200

TGTCACTCAG CAGAAATGCT TTCAAAGCCC AGAAGATCAG GAGTAGATGA AAATGAAGAA 1260

AGATATTCAC CTACAAACAG CGATGTCAAT ATTTTTCACT TCTTTAAAGA AAAGGCATCC 1320

AGTAGTCCTG GATCTTTTGA AAGACCTGAT AATGATCAAG CACGCTCCAA TCATCTTTGT 1380

CCAGGAAAAA CTCCTTTTCC ATTTCCAGAC CAGACACCTC AGACTGAAAT GGTGCAGCAG 1440

TGGTTTGGGA ATCTGCAAAT AAAGCCTCAT TTCAGAGAAA CTACTGAGCA CAATAGCATT 1500

GGCCCAAACA GAGATTTCCA AGGCCATCCA GATTTGCAGG ACACATCAAG AAATGCTTGG 1560

ACTGATACAC GAGTCAAAAA GAGCCCTGAT GCTTCTGATA ACGTACATTC TGCAAAACAG 1620

CTGAATACTA TGAAGTATAT GACTGCATTT CAAAGTAAAC CTGAAATAAT TCAACAAGAA 1680

TCTATTTATG ACTCTGATCC TCTTTCTGAA CAAAACAAGA CTAGGGGAAT GGAGCCACCA 1740

TATCAGAAAT GTACATTACG AGGCATTACA TCTCCTTTGA CTGCTTACAG GTTAAAACCA 1800

ATTAGACAGA AAACCAAAAA GGCTGTGGTT AGTATACTTG ATTCAGAGGA GGTCTGTGTG 1860

GAGCTTCTAA AGGAGCATAC ATCTCAAGAA TATGTGAAAG AAGTTCTTCA AATATCTAGT 1920

GATGGAAATA TGATCACTAT TTATTATCCG AATGATGGAA GAGGTTTTCC TCTTGCTGAT 1980

AGACCACCAC CCCCTACTGA CAACATTAGT AGGTACAGCT TTGACAATTT ACCAGAGAAG 2040

TACTGGCGAA AATATCAATA TGCTTCTAGA TTTGTACACC TTGTACGATC TAAATCACCC 2100

AAAATCACTT ATTTTACAAA ATATGCTAAA TGCATTTTGA TGGAGAATTC CCCTGGTGCT 2160

GATTTTGAGG TTTGGTTTTA TGATGGAGCA AAGATACACA AAACTGAAGA TTTAATTCAG 2220

GTGATTGAAA AGACTGGGAA ATCTTATACC TTAAAAGGTG AAAGTGAAAT CAATACCTTG 2280

AAAGGGGAAA TAAAATTGTA TATGGACCAT GCAGATGAGG GCCATCGTAT TTGCTTAGCA 2340

CTGGAATCCG TAATTTCAGA AGAGGAAAAG AAAAGTGGAA GTGCTCCCTT TTTCCCAATA 2400

ATTGTAGGAA GAAAACCTGG TAATACTAGT TCACCTAAGG CCTTATCACC TCCTACTTCT 2460

GTGGATCCAA ACTACCTGAT GAGTGACAGA GCATCTTTGA ATAAAATGAT CATAAATAGT 2520

GCTGCTTCTC CAAAACCAAC ACCAATATTT AAATCTGAAA TGGTTACAAA TGAAGGATGT 2580

GGCTTTACAG CTGCAGCTTC TGGAACAAAC ATTCCTTCTA GTAGTCTTAA AGATTGTCTT 2640

CCTAAATCAG CACAACTTTT GAAATCGGTT TTTGTGAAAA ATGTTGGTTG GGCTACACAG 2700

TTAACTAGTG GAGCTGTGTG GGTTCAGTTC AATGATGGGT CCCAGTTGGT CGTGCAGGCA 2760

GGAGTATCTT CTATCAGTTA TACATCACCA AATGGTCAAA TAACTAGGTA TGGAGAAAAT 2820

GAAAAATTAC CAGATTACAT CAAACAGAAA TTACAGTGTC TTTCTTCCAT CCTTTTGATG 2880

TTTTCTAATC CATCTCCTAG TTTTGAATGA 2910

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++

Q: 72    ILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRmKPFSENEARHFMHQIITGMLYLHSHG  131

         ********************************99**************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ l++eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPAFLTREAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED NNYVYLVLEM CHNGEMNRYL KNRMKPFSEN EARHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL KMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP AFLTREAKDL IHQLLRRNPA 240

DRLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication
GO:0060707	; P:trophoblast giant cell differentiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013