EKS-CAF-00274

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00274

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	456.9	4.5E-137	85	413	329

Status

Unreviewed

Ensembl Protein

ENSCAFP00000006003

UniProt Accession

F1PR67;

Protein Name

Protein Synonyms/Alias

Gene Name

HIPK2

Gene Synonyms/Alias

HIPK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000004038	ENSCAFP00000006003	ENSCAFT00000006482

Organism

Canis familiaris

Functional Description

Protein Length

1135

Protein Sequence
(FASTA)

MRRSTVSLLD TYQKCGLKRK SEEIENTSSV QIIEEHPPMI QNNASGATVA TATTSTATSK 60

NSGSNSEGDY QLVQHEVLCS MTNTYEVLEF LGRGTFGQVV KCWKRGTNEI VAIKILKNHP 120

SYARQGQIEV SILARLSTES ADDYNFVRAY ECFQHKNHTC LVFEMLEQNL YDFLKQNKFS 180

PLPLKYIRPV LQQVATALMK LKSLGLIHAD LKPENIMLVD PSRQPYRVKV IDFGSASHVS 240

KAVCSTYLQS RYYRAPEIIL GLPFCEAIDM WSLGCVIAEL FLGWPLYPGA SEYDQIRYIS 300

QTQGLPAEYL LSAGTKTTRF FNRDTDSPYP LWRLKTPDDH EAETGIKSKE ARKYIFNCLD 360

DMAQVNMTTD LEGSDMLVEK ADRREFIDLL KKMLTIDADK RITPIETLNH PFVTMTHLLD 420

FPHSTHVKSC FQNMEICKRR VNMYDTVNQS KTPFITHVAP STSTNLTMTF NNQLNTVHNQ 480

APTSTSATIS LANPEVSILN YQSALYQPSA ASMAAVAQRS MPLQTGTAQI CARPDPFQQA 540

LIVCPPGFQG LQASPSKHAG YSVRMENAVP IVTQAPGAQP LQIQPGLLAQ QAWPSGTQQI 600

LLPPAWQQLT GVATHTSVQH ATVIPETMAG TQQLADWRNT HAHGSHYNPI MQQPALLTGH 660

VTLPAAQPLN VGVAHVMRQQ PTSTTSSRKS KQHQSSARNV STCEVSSSQA ISSPQRSKRV 720

KENTPPRCAL VHSSPACSSS VTCGWGDGAS STTRERQRQT IVIPDTPSPT VSVITISSDT 780

DEEEEQKHAP TSTVSKQRKN VISCVTVHDS PYSDSSSNTS PYSVQHRAGH HGNACDAKGS 840

LENHCTGNPR TIIVPPLKTQ ASEVLVECDS LVPVNASQHS SYKSKSSSNV TSTSGHSSGS 900

SSGAIAYRQQ RPGPHFQQQQ PLNLSQAQQH ITAERAGSHR RQQAYITPTM AQAPYSFPHN 960

SPSHGTVHPH LAAAAAAAHL PAQPHLYTYT APAALGSTGT VAHLVASQGS ARHTVQHTAY 1020

PASIVHQVPV SMGPRVLPSP TIHPSQYPAQ FAHQTYISAS PASTVYTGYP LSPAKDKGRC 1080

HLSETTGKWP VQREWGRKAF GGHVSQSPLR AMPARKIHLF LTWQRQMAAE PHHIS 1135

Nucleotide Sequence
(FASTA)

ATGCGTCGAA GCACTGTGAG CCTTCTTGAT ACCTACCAAA AATGTGGACT CAAGCGTAAG 60

AGTGAGGAGA TTGAGAACAC AAGCAGCGTG CAGATCATTG AAGAGCATCC ACCCATGATT 120

CAGAATAATG CAAGTGGGGC CACCGTAGCC ACTGCCACCA CATCGACTGC CACCTCCAAA 180

AACAGTGGCT CTAACAGCGA AGGTGATTAC CAGCTGGTTC AGCATGAGGT GCTGTGCTCC 240

ATGACCAACA CTTACGAAGT TTTAGAATTC CTGGGCCGAG GGACGTTTGG GCAAGTGGTC 300

AAGTGCTGGA AACGGGGCAC CAACGAAATC GTGGCCATCA AGATCCTGAA GAACCACCCG 360

TCATATGCCC GGCAAGGTCA GATCGAGGTG AGCATCCTGG CCCGCTTGAG CACGGAGAGC 420

GCCGACGACT ACAACTTTGT CCGCGCCTAT GAATGCTTCC AGCACAAGAA CCACACGTGC 480

TTGGTCTTTG AGATGTTGGA GCAGAACCTC TATGACTTTC TGAAGCAGAA CAAGTTTAGC 540

CCCTTGCCCC TCAAATACAT TCGCCCAGTC CTCCAGCAGG TAGCCACAGC CCTGATGAAA 600

CTGAAGAGCC TAGGTCTCAT CCATGCCGAC CTCAAACCAG AAAACATCAT GCTGGTAGAT 660

CCTTCCCGAC AGCCCTACAG AGTAAAGGTC ATCGACTTCG GTTCGGCCAG TCATGTGTCC 720

AAGGCTGTGT GTTCCACCTA CCTGCAGTCC AGATACTACA GGGCTCCTGA GATCATCCTT 780

GGTTTACCAT TTTGCGAGGC AATTGATATG TGGTCCCTGG GCTGTGTCAT TGCTGAGCTG 840

TTCCTGGGCT GGCCGCTCTA TCCAGGAGCT TCTGAGTACG ATCAGATTCG GTATATTTCA 900

CAAACACAGG GTTTGCCAGC TGAATATTTA TTAAGCGCAG GGACAAAGAC AACTAGGTTT 960

TTCAACCGTG ACACAGACTC ACCGTATCCC TTGTGGAGGC TGAAGACACC AGATGACCAT 1020

GAAGCAGAGA CAGGGATTAA GTCGAAAGAA GCAAGAAAGT ACATATTCAA CTGTTTAGAT 1080

GACATGGCCC AGGTGAACAT GACAACAGAT CTGGAAGGGA GTGACATGTT GGTGGAGAAG 1140

GCAGACCGGC GGGAGTTCAT CGACCTGTTA AAGAAGATGC TGACCATAGA TGCTGATAAG 1200

AGAATCACTC CCATCGAAAC CCTGAACCAC CCCTTTGTCA CCATGACACA CCTCCTCGAT 1260

TTTCCCCACA GTACACACGT CAAATCATGT TTCCAGAACA TGGAGATTTG CAAGCGTCGG 1320

GTGAATATGT ATGACACGGT GAACCAGAGC AAAACCCCTT TCATTACACA TGTGGCCCCC 1380

AGCACATCCA CCAACCTGAC CATGACCTTC AACAACCAGC TGAATACTGT CCACAACCAG 1440

GCTCCCACCT CCACCAGTGC CACTATTTCC TTAGCCAATC CCGAAGTCTC CATACTAAAC 1500

TACCAATCTG CACTCTACCA GCCTTCAGCG GCGTCCATGG CTGCAGTGGC TCAGCGGAGC 1560

ATGCCCCTGC AGACGGGAAC AGCCCAGATC TGTGCCCGGC CTGACCCCTT CCAGCAAGCT 1620

CTCATCGTGT GTCCGCCCGG CTTCCAAGGG TTGCAGGCCT CGCCCTCTAA GCACGCTGGC 1680

TATTCCGTGA GAATGGAGAA TGCGGTGCCC ATCGTCACTC AAGCCCCGGG AGCACAGCCT 1740

CTTCAGATCC AACCAGGTCT GCTTGCCCAG CAGGCCTGGC CAAGTGGGAC CCAGCAAATC 1800

CTGCTTCCCC CGGCATGGCA GCAGTTGACC GGAGTGGCCA CCCACACATC CGTGCAGCAC 1860

GCAACTGTGA TTCCCGAGAC CATGGCAGGC ACCCAGCAGT TGGCTGACTG GAGGAACACG 1920

CACGCTCACG GCAGCCATTA CAATCCCATC ATGCAGCAGC CCGCGCTGTT GACTGGTCAT 1980

GTGACCCTCC CCGCCGCCCA GCCCTTGAAT GTGGGCGTGG CCCACGTGAT GCGGCAGCAG 2040

CCAACCAGCA CCACCTCCTC CCGGAAGAGC AAGCAGCACC AGTCCTCTGC CAGAAACGTC 2100

TCCACCTGTG AGGTGTCCTC CTCACAGGCC ATCAGCTCCC CTCAGCGGTC CAAGCGCGTC 2160

AAGGAGAACA CGCCTCCCCG CTGCGCCCTG GTGCACAGCA GCCCGGCCTG CAGCTCCTCC 2220

GTCACGTGCG GGTGGGGCGA CGGGGCCTCC AGCACCACCA GGGAGCGGCA GCGGCAGACG 2280

ATTGTCATTC CTGACACCCC CAGCCCCACG GTCAGCGTCA TCACCATCAG CAGCGACACG 2340

GACGAGGAGG AGGAACAGAA GCATGCCCCC ACCAGCACTG TCTCCAAGCA GAGGAAAAAC 2400

GTCATCAGCT GTGTCACAGT CCACGACTCT CCGTACTCCG ACTCCTCCAG CAACACCAGC 2460

CCCTACTCCG TGCAGCACCG CGCTGGGCAC CACGGCAACG CCTGTGACGC CAAGGGGAGC 2520

CTGGAGAACC ACTGCACTGG GAACCCCCGA ACTATCATCG TGCCCCCCCT GAAAACCCAG 2580

GCCAGCGAAG TGCTGGTGGA ATGTGATAGC CTGGTGCCAG TCAACGCCAG TCAGCACTCG 2640

TCCTACAAGT CCAAGTCCTC CAGCAACGTG ACCTCCACCA GCGGTCACTC TTCAGGGAGC 2700

TCGTCCGGAG CCATCGCCTA CCGGCAGCAG CGGCCAGGAC CGCATTTCCA GCAGCAGCAG 2760

CCTCTCAATC TCAGCCAGGC TCAGCAGCAC ATCACCGCAG AGCGCGCCGG GAGCCACCGC 2820

CGGCAGCAGG CCTACATCAC TCCCACGATG GCTCAGGCCC CGTACTCCTT CCCGCACAAC 2880

AGCCCCAGCC ACGGCACTGT GCACCCCCAC CTGGCCGCCG CTGCTGCAGC AGCCCACCTC 2940

CCTGCCCAGC CCCACCTCTA CACCTACACG GCGCCCGCGG CCTTGGGCTC CACCGGCACC 3000

GTGGCCCACC TGGTGGCCTC CCAAGGCTCA GCGCGTCACA CCGTGCAGCA CACTGCCTAC 3060

CCGGCCAGCA TCGTCCACCA GGTCCCCGTG AGCATGGGCC CCCGGGTCCT GCCCTCACCC 3120

ACCATCCACC CGAGTCAGTA TCCAGCCCAG TTTGCCCACC AGACCTACAT CAGCGCCTCT 3180

CCAGCCTCCA CCGTCTACAC TGGATACCCA CTGAGCCCCG CCAAGGACAA GGGGAGGTGC 3240

CACCTCTCCG AGACCACGGG AAAATGGCCA GTCCAGAGAG AGTGGGGGAG AAAAGCCTTT 3300

GGAGGACATG TGAGCCAGAG CCCTCTCAGA GCCATGCCAG CCAGGAAAAT CCACCTGTTC 3360

CTGACTTGGC AGCGCCAGAT GGCAGCAGAG CCCCATCACA TCTCCTGA 3408

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++

Q: 85    YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ESADD  143

         9****************************************************9.999**

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         yn+vr++e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+

Q: 144   YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKS  203

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

         l++iHaDlKPeNi+lv+++r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+

Q: 204   LGLIHADLKPENIMLVDPSRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  263

         *********************999************************************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236

         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff

Q: 264   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  323

         **********************************************************88

S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286

          t++ +p ++lkt          ks++++k+++n+ +++++++++++ e +++l ek+d+

Q: 324   dTDSPYPLWRLKTPddheaetgiKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADR  383

         87889999999999********************************************99

S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315

         + f+dllk+ml++d++kRitp e+l+hpfv

Q: 384   ReFIDLLKKMLTIDADKRITPIETLNHPFV  413

         99***************************7

Domain Sequence
(FASTA)

YEVLEFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTESADDY 60

NFVRAYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPVLQQV ATALMKLKSL 120

GLIHADLKPE NIMLVDPSRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180

CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240

TDSPYPLWRL KTPDDHEAET GIKSKEARKY IFNCLDDMAQ VNMTTDLEGS DMLVEKADRR 300

EFIDLLKKML TIDADKRITP IETLNHPFV 329

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013