EKS-CAF-00374

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00374

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	411.7	1.3E-123	238	490	253

Status

Unreviewed

Ensembl Protein

ENSCAFP00000038181

UniProt Accession

F1PR52;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000004055	ENSCAFP00000038181	ENSCAFT00000043502
ENSCAFG00000004055	ENSCAFP00000006021	ENSCAFT00000006501

Organism

Canis familiaris

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MGGTCVRLCA HLRRWLPCAG REPEKPLVIA NPGARARPDA APTRGPQPGG GRYFVALFDY 60

RARTAEDLSF RAGERLQVLD ASLEGWWLAR RLDGRGEGRP QGYVPSNYLA EDRSLQAEPW 120

FFGAIKRTEA EKQLLYSGNQ TGAFLIRESE SQKGDFALSV LDERVVKHYR IRRMDEGEFF 180

LSQKRTFPTL NEFVSHYTKT SDGLCVQLGK PCLKIQVPVT FDLSYKTADQ WEIDRSSVQL 240

LKRLGSGQFG EVWEGLWNNT TSVAVKTLKP GSMDPNDFLR EAQIMKNLRH PKLIQLYAVC 300

TLEDPIYIIT ELMRHGSLQE YLQNDAGAKI HLNQQVDMAT QVACGMAYLE SQNYIHRDLA 360

ARNVLVGEHN IYKVADFGLA RVFKVDNEDI YESKHDIKLP VKWTAPEAIR TNKFSIKSDV 420

WSFGILLYEI ITYGKVPYSG LTGAQVIQML GQNYRLPQPP NCPSQFYNIM WECWDAEPKN 480

RPTFEALLWK FEDYFETDVS FSDYK 505

Nucleotide Sequence
(FASTA)

ATGGGCGGCA CCTGCGTGCG GCTGTGCGCG CACCTGCGGC GCTGGCTGCC CTGCGCGGGC 60

CGGGAGCCCG AGAAGCCGCT GGTGATCGCG AACCCGGGGG CCCGCGCCCG CCCCGACGCC 120

GCCCCGACGC GGGGTCCGCA GCCCGGCGGC GGCCGCTACT TCGTGGCGCT GTTCGACTAC 180

CGGGCGCGCA CGGCGGAGGA CCTGAGCTTC CGCGCGGGCG AGCGGCTGCA GGTGCTGGAC 240

GCGTCCCTGG AGGGCTGGTG GCTGGCCCGG CGGCTGGACG GGCGCGGCGA GGGGCGGCCG 300

CAGGGCTACG TGCCCTCCAA CTACCTGGCG GAGGACCGGA GCCTGCAGGC GGAGCCGTGG 360

TTCTTTGGCG CGATCAAGAG AACAGAAGCG GAAAAACAGC TGTTATATTC AGGAAATCAG 420

ACCGGTGCCT TTCTAATCAG AGAGAGTGAA AGCCAGAAAG GAGATTTCGC CCTTTCAGTT 480

TTAGACGAAA GGGTTGTGAA GCACTACAGA ATCAGAAGAA TGGACGAAGG GGAGTTTTTC 540

CTTAGCCAGA AAAGAACGTT TCCAACGCTG AATGAGTTTG TGAGCCACTA CACCAAGACA 600

AGCGACGGCC TGTGTGTCCA GCTGGGAAAG CCATGTTTAA AGATACAAGT GCCAGTGACT 660

TTTGATTTGT CGTATAAAAC CGCGGACCAG TGGGAGATAG ACCGCAGCTC CGTGCAGCTC 720

CTGAAGCGGT TGGGATCTGG CCAGTTTGGT GAAGTGTGGG AAGGCCTGTG GAACAACACC 780

ACTTCAGTAG CAGTAAAAAC ATTAAAACCA GGTTCAATGG ATCCAAATGA CTTCCTGAGG 840

GAGGCACAGA TAATGAAGAA CCTAAGACAT CCAAAGCTTA TCCAGCTTTA TGCTGTTTGC 900

ACTTTAGAAG ATCCAATTTA TATTATTACG GAGTTGATGA GACATGGAAG TCTGCAAGAA 960

TATCTCCAAA ATGACGCCGG AGCAAAGATC CACCTGAACC AGCAGGTAGA CATGGCCACA 1020

CAGGTTGCCT GCGGGATGGC TTATCTGGAG TCCCAGAACT ACATTCACAG GGACCTGGCT 1080

GCCAGGAATG TCCTGGTTGG GGAGCACAAT ATCTACAAAG TGGCAGATTT TGGACTGGCA 1140

AGAGTTTTTA AGGTAGATAA TGAAGACATC TATGAATCCA AACACGATAT AAAGCTGCCA 1200

GTGAAGTGGA CTGCGCCTGA AGCCATTCGT ACTAATAAAT TCAGCATTAA GTCCGATGTG 1260

TGGTCATTCG GAATCCTTCT TTATGAAATC ATTACTTATG GCAAAGTGCC TTACAGTGGC 1320

CTGACAGGTG CTCAGGTAAT CCAGATGTTG GGTCAAAACT ATAGACTCCC TCAACCTCCT 1380

AACTGTCCGT CCCAGTTCTA CAACATCATG TGGGAGTGCT GGGATGCAGA GCCGAAGAAC 1440

CGGCCCACAT TTGAGGCCCT GCTTTGGAAA TTTGAAGACT ATTTTGAAAC AGACGTTTCA 1500

TTTTCGGATT ACAAATAA 1518

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 238   VQLLKRLGSGQFGEVWEGLWNNTTSVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLY  297

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g k++l+++vd+a+qva Gmayle++n+ihr

Q: 298   AVCTLEDPIYIITELMRHGSLQEYLQNDAGAKIHLNQQVDMATQVACGMAYLESQNYIHR  357

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+++kf+ik

Q: 358   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHDIKLPVKWTAPEAIRTNKFSIK  417

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+GkvPy+G+t ++v++++ ++yrlp+p +cp+++y+++ ecw+++

Q: 418   SDVWSFGILLYEIITYGKVPYSGLTGAQVIQMLGQNYRLPQPPNCPSQFYNIMWECWDAE  477

         ************************************************************

S: 238   peerPtfetlqev  250

         p++rPtfe+l ++

Q: 478   PKNRPTFEALLWK  490

         *********9887

Domain Sequence
(FASTA)

VQLLKRLGSG QFGEVWEGLW NNTTSVAVKT LKPGSMDPND FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQNDAG AKIHLNQQVD MATQVACGMA YLESQNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHDI KLPVKWTAPE AIRTNKFSIK 180

SDVWSFGILL YEIITYGKVP YSGLTGAQVI QMLGQNYRLP QPPNCPSQFY NIMWECWDAE 240

PKNRPTFEAL LWK 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013