EPS-CAF-00043

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAF-00043

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	618.2	2.7E-186	79	390	312

Status

Unreviewed

Ensembl Protein

ENSCAFP00000006422

UniProt Accession

F1PV61;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000004313	ENSCAFP00000006422	ENSCAFT00000006938

Organism

Canis familiaris

Functional Description

Protein Length

393

Protein Sequence
(FASTA)

MALGKFRAAL RDYETVVKVK PHDKDAKMKY QECNKIVKQK AFERAIAGDE HKRSVVDSLD 60

IESMTIEDEY SGPKLEDGKV TITFMKELMQ WYKDQKKLHR KCAYQILVQV KEALSKLSTL 120

VETTLKETEK ITVCGDTHGQ FYDLLNIFEL NGLPSETNPY IFNGDFVDRG SFSVEVILTL 180

FGFKLLYPDH FHLLRGNHET DNMNQIYGFE GEVKAKYTAQ MYELFSEVFE WLPLAQCING 240

KVLIMHGGLF SEDGVTLDDI RKIERNRQPP DSGPMCDLLW SDPQPQNGRS VSKRGVSCQF 300

GPDVTKAFLE ENHLDYIIRS HEVKAEGYEV AHGGRCVTVF SAPNYCDQMG NKASYIHLRG 360

SDLRPQFHQF TAVPHPDVKP MAYASTLLQL GMM 393

Nucleotide Sequence
(FASTA)

ATGGCACTGG GCAAGTTCCG GGCCGCCCTG CGTGACTATG AGACGGTGGT GAAGGTAAAG 60

CCCCACGACA AGGATGCCAA AATGAAGTAC CAGGAGTGCA ACAAAATCGT GAAGCAGAAA 120

GCCTTCGAGC GGGCCATTGC AGGCGATGAG CACAAGCGCT CCGTTGTGGA CTCGCTGGAC 180

ATTGAGAGCA TGACCATTGA GGATGAGTAC AGTGGGCCCA AGCTCGAGGA TGGCAAAGTG 240

ACAATCACCT TCATGAAGGA GCTCATGCAG TGGTACAAGG ACCAGAAGAA ACTGCACCGG 300

AAATGCGCCT ACCAGATCCT GGTACAGGTC AAAGAGGCCC TCTCCAAGCT GAGCACGCTC 360

GTAGAGACCA CACTCAAAGA GACAGAGAAG ATTACGGTGT GCGGGGACAC TCATGGCCAG 420

TTCTATGACC TCCTCAACAT ATTTGAGCTC AATGGTTTAC CCTCGGAGAC CAACCCCTAT 480

ATATTTAATG GCGACTTTGT GGACCGCGGC TCCTTTTCCG TAGAAGTGAT CCTCACCCTG 540

TTTGGCTTTA AGCTCCTGTA CCCAGATCAC TTTCACCTAC TTCGAGGCAA CCACGAGACG 600

GACAACATGA ACCAGATCTA TGGCTTCGAG GGAGAGGTGA AGGCCAAATA CACAGCCCAG 660

ATGTATGAAC TCTTCAGCGA AGTGTTCGAG TGGCTCCCAC TGGCCCAGTG TATCAACGGC 720

AAAGTACTGA TCATGCATGG GGGCTTATTC AGTGAGGACG GCGTCACCCT GGACGATATC 780

AGGAAGATCG AGCGGAACCG GCAGCCCCCA GATTCAGGTC CCATGTGCGA CCTGCTCTGG 840

TCAGACCCAC AGCCGCAGAA CGGACGCTCG GTCAGCAAGC GGGGTGTGAG CTGCCAGTTT 900

GGCCCTGATG TCACCAAGGC TTTCCTGGAA GAGAACCACC TGGACTACAT CATCCGCAGC 960

CACGAAGTCA AGGCCGAGGG CTACGAGGTG GCGCACGGTG GCCGCTGTGT CACAGTCTTC 1020

TCCGCACCCA ACTACTGTGA CCAGATGGGG AATAAAGCCT CCTACATCCA CCTCCGGGGC 1080

TCCGATCTGC GACCCCAGTT CCACCAGTTC ACAGCAGTGC CTCATCCCGA CGTCAAGCCC 1140

ATGGCCTACG CCAGCACGCT GCTGCAGTTA GGGATGATGT GA 1182

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+i f+k+l++++k++kkl+rk+a++ilv+v+++l+kl++++e+++ke++kitvcGdth

Q: 79    KVTITFMKELMQWYKDQKKLHRKCAYQILVQVKEALSKLSTLVETTLKETEKITVCGDTH  138

         799*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 139   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  198

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 199   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  258

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkiern+qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvtk+fleen+ldyii

Q: 259   DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENHLDYII  318

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+as+ih+r++dlr+++++f+av+hpdv

Q: 319   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLRGSDLRPQFHQFTAVPHPDV  378

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+ +ll+l

Q: 379   KPMAYASTLLQL  390

         ********9987

Domain Sequence
(FASTA)

KVTITFMKEL MQWYKDQKKL HRKCAYQILV QVKEALSKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENHLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL RGSDLRPQFH QFTAVPHPDV 300

KPMAYASTLL QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0004871	; F:signal transducer activity
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006470	; P:protein dephosphorylation
GO:0043278	; P:response to morphine

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013