EKS-CAF-00443
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00443
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/DMPK458.68.1E-13871339269
StatusUnreviewed
Ensembl ProteinENSCAFP00000006540
UniProt AccessionE2RJF1;
Protein Name
Protein Synonyms/Alias
Gene NameDMPK
Gene Synonyms/Alias DMPK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000004392ENSCAFP00000006540ENSCAFT00000007064
OrganismCanis familiaris
Functional Description
Protein Length648
Protein Sequence
(FASTA)
MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASD LAQDKYVADF LQWVEPIAAR 60
LKEARLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 120
DVLVNGDRRW ITELHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 180
MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP 240
EILQAVGGGP GMGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP 300
LVDAGVPEEA RDLIQQLLCP PETRLGRDGA GDFQNHPFFF GLDWDGLRDS VPPFTPDFEG 360
ATDTCNFDVV EDGLTAMVSG GGETLSDMRE GMPLGVHLPF VGYSYSCMAL RDEEVLGPTA 420
MELEAEPLPE PPVQAPSPEP PMSPPEETAE AAVLEALPEA FPAVAAAAAA AAAAVEAQVT 480
QVTQVTLREL QEALEEEVLT RQSLSQELEA IRTANQNFAS QLREAEARNQ DLEARVQQLQ 540
ERMELLQAGA DAAVTGVPSP RATDAPSHLD GPQAVARGQC PLVGPGPMHR RHLLLPARVP 600
KPDLSEARSL LQFAVALAAA AALGCTGLVA RADHLAPVWR QPGAAFAP 648
Nucleotide Sequence
(FASTA)
ATGTCAGCCG AGGTGCGGCT GAGGCGGCTC CAGCAGCTGG TGCTGGACCC TGGCTTCCTG 60
GGGCTGGAGC CCCTGCTCGA CCTTCTCCTG GGCGTCCACC AGGAGCTGGG TGCCTCCGAC 120
CTGGCCCAGG ACAAGTATGT GGCCGACTTC TTGCAGTGGG TGGAGCCCAT CGCGGCGAGG 180
CTTAAGGAGG CCCGACTGCA GAGGGATGAC TTCGAGATTC TGAAGGTGAT CGGACGCGGG 240
GCGTTCAGCG AGGTAGCGGT GGTGAAGATG AAGCAGACGG GCCAGGTGTA TGCGATGAAG 300
ATCATGAATA AATGGGACAT GCTGAAGAGA GGCGAGGTGT CGTGCTTCCG CGAAGAGAGG 360
GACGTGTTGG TGAACGGGGA CCGGCGCTGG ATCACGGAGC TGCACTTCGC CTTCCAGGAC 420
GAGAACTACT TGTACCTGGT CATGGAGTAC TACGTGGGCG GGGACCTGCT AACGCTGCTG 480
AGCAAGTTTG GGGAGCGGAT CCCGGCCGAA ATGGCGCGCT TCTATCTGGC CGAGATTGTC 540
ATGGCCATAG ACTCAGTGCA CCGGCTGGGC TATGTACACA GGGACATCAA ACCCGACAAC 600
ATCCTACTAG ACCGGTGTGG CCACATCCGT TTGGCCGACT TCGGCTCCTG CCTCAAGTTG 660
CGGGCAGATG GAACGGTGCG GTCGCTGGTG GCTGTGGGCA CTCCGGACTA CTTGTCCCCC 720
GAGATCCTGC AGGCCGTAGG CGGTGGGCCT GGGATGGGCA GCTATGGGCC GGAGTGTGAC 780
TGGTGGGCGC TGGGAGTGTT CGCCTATGAG ATGTTCTACG GGCAGACGCC CTTCTACGCC 840
GACTCCACGG CTGAGACCTA CGGCAAGATC GTGCACTATA AGGAGCACCT GTCTCTGCCG 900
CTGGTCGATG CGGGGGTCCC TGAGGAGGCT CGAGACCTCA TCCAGCAACT GCTGTGTCCC 960
CCTGAGACGC GGCTGGGCCG GGACGGAGCA GGTGATTTCC AGAATCATCC TTTTTTCTTT 1020
GGCCTTGACT GGGACGGTCT CCGAGACAGC GTGCCCCCTT TTACGCCGGA TTTTGAGGGT 1080
GCCACTGACA CGTGCAACTT CGATGTGGTG GAAGATGGGC TCACTGCCAT GGTGAGCGGG 1140
GGCGGGGAGA CGCTGTCTGA CATGCGGGAA GGCATGCCAC TGGGAGTCCA CCTGCCATTT 1200
GTGGGCTACT CCTACTCCTG CATGGCCCTC AGGGACGAGG AGGTCCTAGG CCCCACGGCC 1260
ATGGAACTGG AGGCCGAGCC ATTGCCTGAG CCACCTGTGC AAGCGCCCAG TCCGGAGCCC 1320
CCAATGTCCC CACCAGAGGA AACAGCTGAA GCTGCGGTTC TGGAGGCCCT TCCGGAGGCC 1380
TTTCCGGCGG TGGCGGCGGC GGCGGCGGCG GCGGCGGCCG CGGTGGAAGC CCAGGTGACC 1440
CAGGTGACCC AGGTGACGCT GCGGGAGCTC CAGGAGGCCC TGGAGGAGGA GGTGCTCACA 1500
CGGCAGAGCC TGAGCCAGGA GCTGGAGGCC ATCCGCACAG CTAACCAAAA CTTTGCCAGT 1560
CAGCTCCGGG AGGCCGAGGC CCGGAACCAG GACCTGGAGG CGCGCGTCCA GCAGCTGCAG 1620
GAGCGGATGG AGCTGCTGCA GGCGGGGGCA GATGCAGCTG TCACGGGGGT CCCCAGTCCC 1680
CGGGCCACGG ATGCACCTTC CCATCTAGAT GGCCCCCAGG CCGTGGCTCG GGGCCAATGC 1740
CCGCTGGTGG GGCCAGGCCC CATGCACCGC CGCCACCTGC TGCTCCCTGC CAGGGTCCCT 1800
AAGCCTGACC TATCGGAGGC GCGTTCCCTG CTCCAGTTCG CCGTTGCTCT GGCTGCTGCC 1860
GCCGCCTTGG GCTGCACTGG GTTGGTGGCC CGCGCCGACC ATCTCGCCCC GGTCTGGCGC 1920
CAGCCGGGAG CCGCCTTCGC CCCCTGA 1947
Domain Profile
S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60
         feilkviGrGaf+evavv++k+t++vyamki++k+++lkr e+++freerdvlv++d++w
Q: 71    FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRW  130
         89**********************************************************
S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120
         i++l++afqde+ylylvmey+vGGdlltllsk+++++p+e+arfylae+v+a+dsvh+lg
Q: 131   ITELHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLG  190
         ************************************************************
S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkalee..  178
         yvhrdikpdnilld++Ghi+ladfGsclkl++dgtv+s vavGtpdy+spe+l+a++   
Q: 191   YVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGgp  250
         ********************************************************9978
S: 179   gkgeygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseea  237
         g+g+yg+ecdww+lGv++ye+++g+tpfya+s++ety+ki+++ke+l++p  +  v+eea
Q: 251   GMGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDaGVPEEA  310
         899***********************************************86659*****
S: 238   kdlikklltsreerlgregiedlkkhpff  266
         +dli++ll+ +e+rlgr+g  d+++hpff
Q: 311   RDLIQQLLCPPETRLGRDGAGDFQNHPFF  339
         ****************************9
Domain Sequence
(FASTA)
FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER DVLVNGDRRW 60
ITELHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV MAIDSVHRLG 120
YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP EILQAVGGGP 180
GMGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP LVDAGVPEEA 240
RDLIQQLLCP PETRLGRDGA GDFQNHPFF 269
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00413
EKS-ANC-00430
EKS-BOT-00444
EKS-CAJ-00448
EKS-CAP-00476
EKS-GOG-00435
EKS-HOS-00451
EKS-ICT-00425
EKS-LAC-00458
EKS-LOA-00453
EKS-MAM-00443
EKS-MOD-00432
EKS-MUM-00476
EKS-MUP-00435
EKS-OTG-00447
EKS-PAT-00419
EKS-POA-00433
EKS-PTV-00150
EKS-RAN-00457
EKS-SAH-00411
EKS-XET-00596
Gene Ontology
GO:0031307; C:integral to mitochondrial outer membrane
GO:0031965; C:nuclear membrane
GO:0005886; C:plasma membrane
GO:0033017; C:sarcoplasmic reticulum membrane
GO:0005524; F:ATP binding
GO:0017020; F:myosin phosphatase regulator activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0006874; P:cellular calcium ion homeostasis
GO:0010657; P:muscle cell apoptotic process
GO:0006998; P:nuclear envelope organization
GO:0014853; P:regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
GO:0008016; P:regulation of heart contraction
GO:0010830; P:regulation of myotube differentiation
GO:0014722; P:regulation of skeletal muscle contraction by calcium ion signaling
GO:0002028; P:regulation of sodium ion transport
GO:0051823; P:regulation of synapse structural plasticity
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR014930; Myotonic_dystrophy_kinase_coil.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF08826; DMPK_coil; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013