EKS-CAF-00388

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00388

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	366.7	1.0E-109	357	617	261

Status

Unreviewed

Ensembl Protein

ENSCAFP00000006768

UniProt Accession

E2RN16;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K2

Gene Synonyms/Alias

MAP3K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000004528	ENSCAFP00000006768	ENSCAFT00000007306

Organism

Canis familiaris

Functional Description

Protein Length

620

Protein Sequence
(FASTA)

MMDDQQALNS IMQDLAVLHK ASRPALSLQE TRKTKSSSPT KQNDVRVKFE HRGEKRILQF 60

SRPVKLEDLR SKAKIAFGQS MDLHYTNNEL VIPLTTQDDL DKAVELLDRS IHMKSLKILL 120

VINGSTQATN LEPLPSLEDL DNTVFGAERK KRLSIIGPTS RDRSSPPPGY IPDELHQVAR 180

NGSFTSINSE GEFIPESMDQ MLDPLSLSSP ENSGSGSCPS LDSPLDGESY PKSRMPRAQS 240

YPDNHQEFSD YDNPIFEKFG KGGTYPRRYH VSYHHQDYND GRKTFPRARR TQGTSFRSPV 300

SFSPTDHSLS TSSGSSIFTP EYDDSRIRRR GSDIDNPTLT VMDISPPSRS PRAPTNWRLG 360

KLLGQGAFGR VYLCYDVDTG RELAVKQVQF DPDSPETSKE VNALECEIQL LKNLLHERIV 420

QYYGCLRDPQ EKTLSIFMEY MPGGSIKDQL KAYGALTENV TRKYTRQILE GVHYLHSNMI 480

VHRDIKGANI LRDSTGNVKL GDFGASKRLQ TICLSGTGMK SVTGTPYWMS PEVISGEGYG 540

RKADIWSVGC TVVEMLTEKP PWAEFEAMAA IFKIATQPTN PKLPPHVSDY TRDFLKRIFI 600

EAKLRPSADE LLRHMFVHYH 620

Nucleotide Sequence
(FASTA)

ATGATGGATG ATCAGCAAGC TTTGAACTCA ATCATGCAAG ATTTGGCTGT TCTTCATAAA 60

GCCAGTCGAC CAGCATTATC TTTACAGGAA ACCAGAAAAA CAAAGTCTTC ATCACCAACA 120

AAGCAGAATG ATGTTCGAGT CAAATTTGAA CATAGAGGGG AAAAAAGAAT CCTTCAGTTC 180

TCCAGACCAG TTAAACTGGA AGATCTGAGA TCTAAGGCTA AAATTGCCTT TGGACAGTCT 240

ATGGATCTCC ATTATACCAA TAATGAGTTG GTAATTCCAT TAACTACCCA AGATGACTTG 300

GACAAAGCTG TGGAATTGCT GGATCGTAGT ATTCATATGA AGAGCCTCAA GATATTACTT 360

GTGATAAATG GAAGTACACA GGCTACTAAC TTAGAACCAT TACCATCACT AGAAGATTTG 420

GATAACACAG TATTTGGAGC AGAGAGGAAA AAGCGACTTT CTATAATAGG TCCCACTAGT 480

AGAGATAGAA GCTCCCCTCC CCCGGGATAC ATTCCAGATG AATTACACCA AGTTGCCCGG 540

AATGGGTCAT TCACCAGTAT CAACAGTGAA GGAGAGTTCA TTCCAGAGAG CATGGACCAA 600

ATGCTGGATC CATTGTCTTT AAGCAGCCCT GAAAATTCTG GCTCAGGAAG TTGTCCATCA 660

CTTGATAGTC CTTTGGATGG GGAGAGCTAT CCAAAATCAC GAATGCCTAG GGCACAGAGC 720

TATCCAGATA ATCATCAGGA ATTTTCAGAC TATGATAACC CTATCTTTGA GAAATTTGGA 780

AAAGGGGGAA CATACCCAAG AAGGTATCAT GTTTCATATC ACCATCAAGA CTATAATGAT 840

GGTCGTAAAA CTTTTCCAAG AGCTAGAAGG ACTCAGGGGA CCAGCTTCCG GTCTCCTGTG 900

AGTTTCAGTC CTACCGATCA CTCTTTAAGC ACTAGTAGTG GAAGCAGTAT CTTTACCCCA 960

GAGTATGATG ATAGTCGAAT AAGAAGAAGG GGAAGTGACA TAGACAATCC TACTTTGACT 1020

GTAATGGACA TCAGCCCACC CAGCCGCTCA CCTCGTGCTC CAACAAACTG GAGATTGGGC 1080

AAACTGCTTG GCCAAGGAGC ATTTGGCAGG GTCTACCTCT GTTATGATGT CGATACAGGA 1140

AGAGAATTGG CAGTTAAGCA AGTTCAGTTT GACCCTGATA GCCCTGAGAC CAGCAAGGAA 1200

GTAAATGCAC TTGAGTGTGA AATTCAGTTG TTGAAAAACT TGCTGCATGA GCGAATTGTT 1260

CAGTATTATG GCTGTTTGAG GGATCCCCAG GAAAAAACAC TTTCCATATT TATGGAATAT 1320

ATGCCAGGGG GTTCAATTAA GGACCAATTA AAAGCATATG GAGCTCTTAC TGAGAATGTG 1380

ACTAGGAAAT ACACTCGTCA GATCCTGGAG GGCGTACATT ATTTGCACAG TAATATGATT 1440

GTTCATAGAG ATATCAAAGG TGCAAATATT TTGCGGGATT CAACAGGCAA CGTCAAACTA 1500

GGAGATTTTG GGGCCAGCAA ACGGCTTCAA ACCATCTGTC TTTCAGGGAC AGGGATGAAG 1560

TCTGTCACAG GCACACCATA CTGGATGAGC CCTGAAGTAA TTAGTGGAGA AGGCTATGGC 1620

AGAAAAGCAG ACATCTGGAG TGTGGGCTGT ACTGTGGTGG AAATGCTAAC TGAAAAGCCT 1680

CCTTGGGCAG AATTTGAAGC TATGGCTGCC ATCTTTAAAA TCGCCACTCA GCCAACAAAC 1740

CCAAAGCTGC CACCTCATGT CTCAGACTAT ACTCGAGATT TCCTCAAAAG GATCTTTATA 1800

GAGGCCAAAC TGAGACCTTC AGCTGATGAA CTGTTAAGGC ACATGTTTGT GCATTATCAC 1860

TAG 1863

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         w+ ++++g+G+fg+vy+++dvdtg+ lavK+v+++p++ +++kev+al++Ei+llk+l H

Q: 357   WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLH  416

         78899*******************************************************

S: 61    enivkyyGv..eveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLH  118

         e+iv+yyG+  + +e++l+if+Ey++gGs++++l++yg+l+e+v++kyt+qileg++yLH

Q: 417   ERIVQYYGClrDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLH  476

         *********777899*********************************************

S: 119   ekkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         +++ivHRDiKgaNil ds+g+vkl+DFGaskrl++++ + + ++s+tGt+++m+PEvi++

Q: 477   SNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISG  536

         **********************************************************99

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         +  gygrkaDiWs+gc+v+emlt+k+P+ae+ e++a++fk++++ t+P++p ++s+ ++d

Q: 537   E--GYGRKADIWSVGCTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRD  593

         8..****************************.9***************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++++ +++k rpsa+eLL+h+f+

Q: 594   FLKRIF-IEAKLRPSADELLRHMFV  617

         ******.899*************96

Domain Sequence
(FASTA)

WRLGKLLGQG AFGRVYLCYD VDTGRELAVK QVQFDPDSPE TSKEVNALEC EIQLLKNLLH 60

ERIVQYYGCL RDPQEKTLSI FMEYMPGGSI KDQLKAYGAL TENVTRKYTR QILEGVHYLH 120

SNMIVHRDIK GANILRDSTG NVKLGDFGAS KRLQTICLSG TGMKSVTGTP YWMSPEVISG 180

EGYGRKADIW SVGCTVVEML TEKPPWAEFE AMAAIFKIAT QPTNPKLPPH VSDYTRDFLK 240

RIFIEAKLRP SADELLRHMF V 261

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013