EKS-CAF-00199

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00199

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	414.6	1.9E-124	61	309	249

Status

Unreviewed

Ensembl Protein

ENSCAFP00000006870

UniProt Accession

E2RGD8;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK2

Gene Synonyms/Alias

TESK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000004592	ENSCAFP00000006870	ENSCAFT00000007414

Organism

Canis familiaris

Functional Description

Protein Length

573

Protein Sequence
(FASTA)

MDRSKRNSIA GFPPRVERLE DFEGGGGGDG NMTQVGRVRP SSYRALISAF SRLTRLDDFT 60

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRFMGVC 120

VHQGQLHALT EYINSGNLEQ LLDSNLHLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 180

NCLIKRDENG YSAVVADFGL AEKIPDVSMG NEKLAVVGSP FWMAPEVLRD EPYNEKADVF 240

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 300

TFAEIGKTLE EILSHLQEEE LQTDRKLQPT AKGLLEKGPG VKRLSTLDDK IPPKSPRPRR 360

TIWLSRSQSD IFSRKPLRTV NVLDPYYRPQ QGGAAHTPKV NPFSARQDLK GGKIKFFDLP 420

SKSVISLVFD LDAPGPGTLP VADWQEPLAP PARGWRSLPG SPEFLHQEAC PFVGREESLS 480

DGPPPRLNSL KYRVREIPPF RASALPTALA HEAMDCSSPQ EENGFGPRPR GASPCLAGTS 540

EEMEVEEERP RGLAPVPFCV SGMGLKTQGE HDG 573

Nucleotide Sequence
(FASTA)

ATGGATCGGA GCAAACGGAA TTCAATTGCA GGCTTTCCTC CACGTGTGGA GCGTCTTGAA 60

GATTTTGAAG GAGGTGGTGG AGGAGATGGG AACATGACCC AAGTGGGAAG AGTTCGGCCA 120

TCTTCATATC GAGCTCTTAT AAGTGCCTTT TCTAGACTGA CTCGTTTAGA TGACTTCACC 180

TGTGAAAAAA TAGGGTCTGG CTTCTTCTCT GAAGTGTTCA AGGTGCGCCA CCGAGCTTCT 240

GGCCAGGTGA TGGCTCTTAA GATGAACACT TTGAGCAGTA ACCGGGCAAA CATGCTGAAA 300

GAAGTTCAGC TCATGAACAG ACTGTCCCAT CCCAACATCC TCAGGTTCAT GGGTGTGTGT 360

GTACATCAAG GACAGTTGCA TGCACTCACA GAGTATATCA ACTCTGGAAA TCTGGAACAG 420

TTGCTAGACA GTAACCTGCA TTTGCCGTGG ACTGTGAGGG TGAAACTGGC TTATGATATA 480

GCAGTGGGTC TCAGCTACCT TCACTTCAAA GGCATTTTCC ATCGGGACCT CACATCTAAG 540

AACTGCCTGA TAAAGAGGGA TGAGAATGGT TACTCTGCAG TGGTAGCTGA CTTTGGCCTG 600

GCTGAGAAGA TTCCTGACGT CAGCATGGGG AATGAGAAAC TGGCCGTGGT GGGCTCACCC 660

TTTTGGATGG CACCTGAGGT TCTCCGAGAT GAGCCCTACA ATGAAAAGGC CGACGTGTTC 720

TCTTATGGTA TCATCCTCTG TGAGATCATC GCCCGCATCC AGGCTGATCC AGACTATCTT 780

CCCCGCACAG AGAACTTCGG GCTAGACTAT GACGCTTTCC AGCATATGGT GGGAGACTGT 840

CCCCCGGACT TTCTGCAGCT CACCTTCAAC TGCTGTAATA TGGACCCCAA ACTGCGCCCA 900

ACCTTCGCGG AGATTGGGAA GACCCTGGAG GAAATTCTGA GCCATCTACA GGAAGAAGAG 960

CTGCAGACAG ACAGGAAGCT GCAGCCCACA GCTAAGGGAC TCTTGGAGAA AGGACCTGGG 1020

GTGAAGCGAC TGAGCACACT GGATGACAAA ATACCTCCCA AGTCTCCACG CCCAAGACGT 1080

ACTATCTGGT TATCCCGAAG CCAGTCTGAC ATCTTCTCCC GTAAGCCCTT GCGTACAGTG 1140

AATGTCTTGG ACCCATACTA CCGGCCACAA CAAGGTGGTG CTGCCCATAC CCCCAAAGTC 1200

AACCCTTTCA GTGCTCGCCA GGACCTCAAG GGTGGCAAGA TCAAGTTCTT TGACCTGCCC 1260

AGCAAGTCGG TCATCTCCCT GGTATTTGAC CTGGACGCAC CAGGGCCGGG AACTCTGCCC 1320

GTGGCTGACT GGCAGGAGCC CCTGGCCCCA CCTGCTCGTG GGTGGCGTTC TTTGCCCGGT 1380

TCACCAGAGT TCTTACATCA AGAGGCCTGT CCATTTGTGG GCCGAGAAGA ATCACTATCT 1440

GATGGGCCCC CACCACGCCT CAATAGTCTC AAGTACAGAG TGAGAGAGAT CCCACCATTC 1500

CGAGCATCTG CCCTACCAAC TGCTCTAGCC CATGAAGCCA TGGACTGCTC CAGTCCCCAG 1560

GAAGAAAATG GTTTCGGGCC CAGGCCCCGG GGTGCCAGTC CATGCCTTGC AGGTACCTCT 1620

GAGGAAATGG AGGTAGAAGA AGAAAGACCA AGAGGCTTGG CTCCAGTCCC CTTCTGTGTC 1680

TCAGGCATGG GCCTGAAAAC CCAGGGAGAA CACGATGGGT GA 1722

Domain Profile

S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63

          ek+G+Gffsevfkv+hrasG+vm+lk  ++++++nr+n+lkev+l+++l+hpn+l+f+G

Q: 61    CEKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSHPNILRFMG  118

         59*************************..*******************************

S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123

         v+v++++lh+lteyi++G+l++ll+s+ +lpwt+rv+la+dia+Glsylh+kgi+hrdl+

Q: 119   VCVHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT  178

         ************************************************************

S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180

         skncl+++   ++s+vvadfGla          ek+++++++  +++l+vvGsP+wmaPe

Q: 179   SKNCLIKRdenGYSAVVADFGLA----------EKIPDVSMG--NEKLAVVGSPFWMAPE  226

         *******9887899*********..........9****9999..899*************

S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240

         vl+++ y+ek+dvfs+Gi+lceiiar++adPdylPrte+fgld++af++ +v+ dcP++f

Q: 227   VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQH-MVG-DCPPDF  284

         *************************************************.999.******

S: 241   lklavvccdldpesrpsfeelekkl  265

         l+l+++cc++dp+ rp+f e+ k+l

Q: 285   LQLTFNCCNMDPKLRPTFAEIGKTL  309

         *********************9876

Domain Sequence
(FASTA)

CEKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANMLK EVQLMNRLSH PNILRFMGVC 60

VHQGQLHALT EYINSGNLEQ LLDSNLHLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 120

NCLIKRDENG YSAVVADFGL AEKIPDVSMG NEKLAVVGSP FWMAPEVLRD EPYNEKADVF 180

SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PPDFLQLTFN CCNMDPKLRP 240

TFAEIGKTL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

cfa:608657

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013