EKS-CAF-00269
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00269
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK413.06.1E-12462314253
StatusUnreviewed
Ensembl ProteinENSCAFP00000007056
UniProt AccessionE2RGK9;
Protein Name
Protein Synonyms/Alias
Gene NamePLK3
Gene Synonyms/Alias PLK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000004713ENSCAFP00000007056ENSCAFT00000007621
OrganismCanis familiaris
Functional Description
Protein Length646
Protein Sequence
(FASTA)
MEPAAGCQSP RPFPRAAAPP APPAGPGPPG SPGPGPALDV LAGPPAADPG RLITDPRSGR 60
TYFKGRLLGK GGFARCYEAT DTESGSAYAV KVISQSRITK PHQREKILNE IELHRGLQHR 120
HIVRFSHHFE DADNIYIFLE LCSRKSLAHI WKARHTLLEP EVRYYLRQIL SGLKYLHQQG 180
ILHRDLKLGN FFITENMELK MGDFGLATRL EPPEHRKKTI CGTPNYVAPE VLQRQGHGPE 240
SDVWSLGCVM YTLLCGNPPF ETVDLKETYR CIKQVHYTLP ASLSLPARQL LAAILRASPQ 300
DRPSIDQILR HDFFTKGYTP DRLPVSSCVT VPDLTPLNPA RILFVKVTKS LFGRKKKSKN 360
CPEERDEVSC LVSGLTRTSI GHQDARPEAP AASGPAPLGL AETAPEDSSP RGTLASSGDG 420
FEEGLTVATV VESALCALRN CLAFMPPAEQ NPAPLAQPEP LVWVSKWVDY SNKFGFGYQL 480
SSRRVAVLFN NGTHMALSAN RKTVHYNPTS TKHFSFSVGA VPPALQPQLG VLRYFASYME 540
QRLMKGGDLP SVEEVEVRVP PLLLQWVKTD QALLMLFSDG TVQVNFYGDH TKLILSGWEP 600
LLVTFVARNR SACTYLASHL RQLGCSPDLR QRLRYALRLL RDRCPA 646
Nucleotide Sequence
(FASTA)
ATGGAGCCCG CCGCCGGCTG CCAGTCCCCG CGCCCCTTCC CGCGTGCGGC CGCCCCGCCC 60
GCGCCCCCTG CCGGGCCCGG GCCGCCTGGG AGCCCCGGGC CGGGCCCCGC GCTGGACGTG 120
CTGGCGGGGC CACCGGCGGC GGACCCGGGG CGCCTCATCA CCGACCCGCG CAGCGGCCGC 180
ACCTACTTCA AAGGCCGCCT GTTGGGCAAG GGGGGCTTTG CCCGCTGCTA CGAGGCCACT 240
GACACGGAGA GCGGCAGCGC CTACGCGGTC AAAGTCATCT CGCAGAGCCG CATCACCAAG 300
CCGCATCAGC GCGAGAAGAT CCTAAACGAG ATTGAGCTGC ACCGCGGCCT GCAGCACCGC 360
CACATCGTGC GTTTCTCCCA CCACTTTGAG GATGCGGACA ACATCTACAT CTTCCTGGAG 420
CTCTGCAGCC GAAAGTCCTT GGCCCACATC TGGAAGGCCC GGCACACTCT GTTGGAGCCA 480
GAGGTACGCT ACTACCTGCG TCAGATCCTT TCCGGACTCA AGTACTTGCA CCAGCAGGGC 540
ATCCTGCATC GAGATCTCAA GCTGGGAAAT TTTTTTATCA CTGAGAATAT GGAACTGAAG 600
ATGGGGGACT TTGGGCTGGC AACCCGGTTG GAACCCCCGG AACATAGGAA GAAAACCATC 660
TGTGGCACCC CCAACTATGT GGCCCCAGAA GTGCTGCAGA GACAGGGTCA CGGCCCCGAG 720
TCAGACGTGT GGTCCCTGGG CTGTGTCATG TACACACTGC TGTGTGGGAA TCCCCCCTTT 780
GAGACAGTTG ACCTGAAGGA GACGTATCGC TGCATCAAAC AGGTTCACTA CACACTGCCC 840
GCCAGCCTCT CACTGCCTGC CCGGCAGCTC CTGGCTGCCA TCCTTCGAGC TTCGCCCCAA 900
GACCGCCCCT CAATTGACCA GATCCTGCGC CACGACTTCT TTACCAAGGG CTACACCCCC 960
GACCGGCTCC CTGTCAGCAG CTGCGTGACA GTCCCAGACC TGACACCCCT TAACCCAGCT 1020
AGGATTCTGT TTGTCAAAGT TACCAAGAGC CTATTTGGCA GGAAGAAGAA GAGTAAAAAC 1080
TGTCCTGAGG AGCGGGACGA GGTCTCCTGT TTGGTGAGCG GCCTCACTCG GACGTCCATT 1140
GGCCATCAAG ACGCCAGACC CGAGGCTCCA GCAGCTTCTG GTCCAGCCCC GCTCGGCCTG 1200
GCAGAGACAG CACCTGAAGA CAGCTCACCC CGTGGGACAC TGGCGAGCAG TGGAGATGGG 1260
TTTGAAGAAG GTCTGACTGT GGCCACAGTG GTGGAGTCGG CCCTCTGCGC TCTGAGAAAC 1320
TGCCTGGCCT TCATGCCCCC AGCGGAACAG AACCCAGCTC CCCTTGCACA GCCAGAGCCT 1380
CTGGTATGGG TCAGCAAGTG GGTTGACTAC TCCAACAAAT TTGGCTTTGG GTATCAACTG 1440
TCCAGCCGCC GTGTGGCTGT GCTTTTCAAC AATGGCACAC ACATGGCCCT TTCAGCCAAC 1500
AGAAAGACCG TGCACTACAA CCCCACCAGC ACAAAGCACT TCTCTTTCTC TGTGGGTGCT 1560
GTGCCTCCGG CCCTGCAGCC TCAGCTGGGT GTCCTCCGGT ATTTTGCCTC CTACATGGAG 1620
CAGCGTCTCA TGAAGGGTGG AGACCTGCCC AGCGTGGAAG AGGTGGAGGT GCGGGTCCCT 1680
CCACTCCTGC TGCAGTGGGT CAAGACTGAT CAGGCGCTCC TCATGCTGTT TAGTGATGGC 1740
ACCGTCCAGG TGAACTTCTA CGGAGACCAC ACCAAGCTGA TCCTCAGTGG CTGGGAGCCC 1800
CTCCTTGTGA CTTTTGTGGC TCGCAATCGC AGTGCTTGTA CTTACCTCGC TTCCCACCTT 1860
CGGCAGCTGG GCTGCTCCCC AGACCTGCGG CAGCGGCTCC GCTATGCTCT ACGTCTGCTC 1920
CGGGACCGCT GCCCAGCCTA G 1941
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y +g+llGkGgfa+cye++d+e+++++avkv+++s+++k++qrek+ +eie+hr l+h++
Q: 62    YFKGRLLGKGGFARCYEATDTESGSAYAVKVISQSRITKPHQREKILNEIELHRGLQHRH  121
         789*********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         iv+++++fed++n+y++lelcsr+sla+++k+r++l epevryylrqi+sglkylh++ i
Q: 122   IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQQGI  181
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180
         lhrdlklgn+f++e++e+k+gdfGlatrle++e+rkkt+cGtPny+aPevl+++gh+ e+
Q: 182   LHRDLKLGNFFITENMELKMGDFGLATRLEPPEHRKKTICGTPNYVAPEVLQRQGHGPES  241
         ************************************************************
S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240
         d+WslGc++ytll+G+PPfet +lkety++ik+ +y+lP+sls +a++l+a++l+++P++
Q: 242   DVWSLGCVMYTLLCGNPPFETVDLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPQD  301
         ************************************************************
S: 241   rpsleevlkdefl  253
         rps++++l+++f+
Q: 302   RPSIDQILRHDFF  314
         ************8
Domain Sequence
(FASTA)
YFKGRLLGKG GFARCYEATD TESGSAYAVK VISQSRITKP HQREKILNEI ELHRGLQHRH 60
IVRFSHHFED ADNIYIFLEL CSRKSLAHIW KARHTLLEPE VRYYLRQILS GLKYLHQQGI 120
LHRDLKLGNF FITENMELKM GDFGLATRLE PPEHRKKTIC GTPNYVAPEV LQRQGHGPES 180
DVWSLGCVMY TLLCGNPPFE TVDLKETYRC IKQVHYTLPA SLSLPARQLL AAILRASPQD 240
RPSIDQILRH DFF 253
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00245
EKS-ANC-00251
EKS-BOT-00262
EKS-CAJ-00268
EKS-CAP-00297
EKS-CII-00157
EKS-DAR-00597
EKS-EQC-00253
EKS-FEC-00248
EKS-GAM-00162
EKS-GAG-00219
EKS-GAA-00323
EKS-GOG-00260
EKS-HOS-00269
EKS-ICT-00247
EKS-LAC-00274
EKS-LOA-00272
EKS-MAM-00264
EKS-MAE-00013
EKS-MEG-00206
EKS-MOD-00261
EKS-MUM-00293
EKS-MUP-00259
EKS-ORN-00339
EKS-ORC-00248
EKS-ORL-00316
EKS-OTG-00268
EKS-PAT-00249
EKS-PTV-00033
EKS-RAN-00277
EKS-SAH-00246
EKS-SUS-00227
EKS-TAG-00277
EKS-TEN-00330
EKS-XET-00337
EKS-XIM-00331
Gene Ontology
GO:0005813; C:centrosome
GO:0005795; C:Golgi stack
GO:0005730; C:nucleolus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0090166; P:Golgi disassembly
GO:0043066; P:negative regulation of apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:2000777; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
GO:0006974; P:response to DNA damage stimulus
GO:0006970; P:response to osmotic stress
GO:0009314; P:response to radiation
GO:0000302; P:response to reactive oxygen species
GO:0000084; P:S phase of mitotic cell cycle
KEGG
cfa:475380;
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR020658; Ser/Thr_kinase_Plk3.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013