EKS-CAF-00081

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00081

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	446.8	3.9E-134	119	402	284

Status

Unreviewed

Ensembl Protein

ENSCAFP00000007287

UniProt Accession

F1PAE3;

Protein Name

Protein Synonyms/Alias

Gene Name

GSK3A

Gene Synonyms/Alias

GSK3A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000004882	ENSCAFP00000007287	ENSCAFT00000007861

Organism

Canis familiaris

Functional Description

Protein Length

490

Protein Sequence
(FASTA)

SGGAPSGGGP GGSGRARTSS FAEPGAGGGG GGGGPGGSAS GPGGSGGGKA SVGAMGGGVG 60

ASSSGGGPTG SGGGGSGGPG AGTSFPPPGV KLGRDSGKVT TVVATLGQGP ERSQEVAYTD 120

IKVIGNGSFG VVYQARLAET RELVAIKKVL QDKRFKNREL QIMRKLVHCN IVRLRYFFYS 180

SGEKKDELYL NLVLEYVPET VYRVARHFTK AKLTIPIIYV KVYMYQLFRS LAYIHSQGVC 240

HRDIKPQNLL VDPDTAVLKL CDFGSAKQLV RGEPNVSYIC SRYYRAPELI FGATDYTSSI 300

DVWSAGCVLA ELLLGQPIFP GDSGVDQLVE IIKVLGTPTR EQIREMNPNY TEFKFPQIKA 360

HPWTKVFKSR TPPEAIALCS SLLEYTPSSR LSPLEACAHS FFDELRCHGT QLPNNRPLPP 420

LFNFSPGELS IQPSLNAILI PPHLRSPAGT ASLTPSSQAL SEAQTGPDWQ TTDATAAYTP 480

PTPPPLLCPL 490

Nucleotide Sequence
(FASTA)

AGCGGCGGAG CTCCTTCAGG GGGCGGCCCT GGGGGCTCGG GCCGGGCGCG GACCAGCTCG 60

TTCGCGGAGC CAGGCGCAGG AGGCGGCGGC GGCGGCGGCG GCCCCGGGGG CTCGGCCTCC 120

GGCCCGGGCG GCAGCGGCGG TGGGAAGGCG TCAGTCGGAG CCATGGGTGG GGGCGTGGGG 180

GCCTCGAGCT CCGGGGGCGG CCCCACCGGC AGCGGCGGAG GAGGCAGCGG CGGCCCGGGT 240

GCGGGCACTA GCTTCCCGCC GCCGGGAGTG AAGCTGGGCC GTGACAGCGG GAAGGTGACC 300

ACAGTGGTAG CCACTCTAGG CCAAGGCCCG GAGCGCTCCC AGGAGGTGGC TTACACAGAC 360

ATCAAAGTGA TTGGCAATGG CTCATTTGGG GTCGTGTACC AGGCACGGCT GGCTGAGACC 420

AGGGAACTGG TGGCCATCAA GAAGGTTCTC CAGGACAAAA GGTTCAAGAA CCGAGAGCTG 480

CAGATTATGC GTAAGCTGGT CCACTGCAAT ATTGTAAGGC TGAGATACTT CTTCTACTCC 540

AGTGGGGAGA AGAAAGATGA GCTTTATCTA AATCTGGTGC TGGAATACGT GCCCGAGACA 600

GTGTACCGGG TGGCCCGCCA TTTCACCAAG GCCAAGTTGA CCATCCCTAT CATCTATGTC 660

AAGGTGTACA TGTACCAGCT CTTCCGGAGC TTGGCCTACA TCCACTCCCA GGGGGTGTGT 720

CACCGTGACA TCAAGCCCCA GAACCTGCTG GTGGACCCTG ACACAGCTGT CCTCAAGCTC 780

TGCGATTTTG GCAGTGCAAA GCAGTTGGTC CGGGGGGAGC CCAACGTCTC CTACATCTGT 840

TCTCGCTACT ACAGGGCCCC GGAGCTGATC TTCGGAGCCA CTGATTACAC CTCGTCCATT 900

GATGTGTGGT CAGCTGGCTG CGTCCTGGCC GAGCTCCTCC TGGGCCAGCC CATCTTCCCT 960

GGGGACAGCG GGGTAGATCA GCTGGTGGAG ATCATCAAGG TGCTGGGTAC ACCAACCCGG 1020

GAACAGATCC GAGAGATGAA CCCTAACTAC ACGGAGTTCA AGTTTCCCCA GATTAAAGCT 1080

CACCCCTGGA CAAAGGTGTT CAAATCTCGA ACGCCGCCAG AGGCCATTGC ACTCTGCTCT 1140

AGCCTGCTGG AGTACACACC GTCCTCGAGG CTCTCCCCTC TGGAAGCCTG CGCCCACAGC 1200

TTCTTTGATG AACTGCGATG TCACGGAACC CAGCTCCCCA ACAACCGCCC GCTTCCCCCC 1260

CTCTTCAACT TCAGTCCTGG AGAACTCTCC ATCCAGCCAT CTCTCAACGC CATTCTCATC 1320

CCTCCTCACT TGAGGTCCCC AGCGGGCACT GCCTCCCTCA CTCCATCCTC ACAAGCTTTA 1380

AGTGAGGCTC AGACCGGCCC AGACTGGCAG ACGACCGATG CCACGGCTGC CTACACTCCT 1440

CCAACCCCTC CTCCCCTCCT GTGTCCCTTG TAA 1473

Domain Profile

S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61

         +++k+ig+GsFg+Vyqa+l+e++e  vaiKkvlqdk++kn+El+i+rkl H+nivrL+yf

Q: 119   TDIKVIGNGSFGVVYQARLAETREL-VAIKKVLQDKRFKNRELQIMRKLVHCNIVRLRYF  177

         789**********************.**********************************

S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121

         f++s ekkd++ylnlvley+Pet+++v+r+++++k ++++++vk+y+yQlfr+lay+hs+

Q: 178   FYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQ  237

         ************************************************************

S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181

         +++HrDiKPqNllvd++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++yt

Q: 238   GVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT  297

         ************************************************************

S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241

         ++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf++

Q: 298   SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ  357

         ************************************************************

S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         ik+++++kv+k+++++ea++l++++l+y+p++Rls+le++ah+ff

Q: 358   IKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF  402

         ********************************************9

Domain Sequence
(FASTA)

TDIKVIGNGS FGVVYQARLA ETRELVAIKK VLQDKRFKNR ELQIMRKLVH CNIVRLRYFF 60

YSSGEKKDEL YLNLVLEYVP ETVYRVARHF TKAKLTIPII YVKVYMYQLF RSLAYIHSQG 120

VCHRDIKPQN LLVDPDTAVL KLCDFGSAKQ LVRGEPNVSY ICSRYYRAPE LIFGATDYTS 180

SIDVWSAGCV LAELLLGQPI FPGDSGVDQL VEIIKVLGTP TREQIREMNP NYTEFKFPQI 240

KAHPWTKVFK SRTPPEAIAL CSSLLEYTPS SRLSPLEACA HSFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013