EKS-CAF-00325

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00325

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	328.2	4.4E-98	17	291	275

Status

Unreviewed

Ensembl Protein

ENSCAFP00000007406

UniProt Accession

E2RAI8;

Protein Name

Protein Synonyms/Alias

Gene Name

OXSR1

Gene Synonyms/Alias

OXSR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000004972	ENSCAFP00000007406	ENSCAFT00000007999

Organism

Canis familiaris

Functional Description

Protein Length

527

Protein Sequence
(FASTA)

MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK EKVAIKRINL EKCQTSMDEL 60

LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV LDIIKHIVAK GEHKSGVLDE 120

PTIATILKEV LEGLEYLHKN GQIHRDVKAG NILLGEDGSV QIADFGVSAF LATGGDITRN 180

KVRKTFVGTP CWMAPEVMEQ VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL 240

QNDPPSLETG VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL 300

QEKILQRAPT ISERAKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG KAAISQLRSP 360

RVKESLSNSE LFSTTDPVGT LLQVPEQISA HLPQPAGHMP AQPTPVSPPP PAEPAKTAQT 420

LPSGAGSQET KIPISLVLRL RNSKKELNDI RFEFTPGRDT AEGVSQELIS AGLVDGRDLV 480

IVAANLQKIV EEPQSNRSVT FKLASGVEGS DIPDDGKLIG FAQLSIS 527

Nucleotide Sequence
(FASTA)

ATGTCCGAGG ACTCGAGCGC CCTGCCCTGG TCCATCAACA GGGACGATTA CGAGCTGCAG 60

GAGGTGATCG GGAGTGGAGC AACGGCTGTG GTCCAAGCAG CATATTGTGC CCCTAAGAAG 120

GAGAAAGTGG CAATCAAACG GATAAACCTT GAGAAATGTC AAACTAGCAT GGATGAACTC 180

CTGAAAGAAA TTCAAGCCAT GAGTCAGTGC CATCATCCTA ATATTGTGTC TTACTACACG 240

TCTTTTGTGG TAAAAGATGA GCTATGGCTA GTCATGAAGT TGCTAAGTGG AGGTTCTGTT 300

CTAGATATTA TTAAGCACAT TGTGGCAAAG GGGGAGCACA AAAGTGGAGT CCTAGATGAA 360

CCTACCATTG CCACAATACT CAAAGAAGTG CTGGAAGGGT TGGAATACCT GCATAAAAAT 420

GGACAGATTC ACAGAGATGT GAAAGCTGGA AATATTCTTC TTGGAGAAGA TGGCTCAGTA 480

CAGATTGCAG ACTTTGGGGT TAGTGCTTTT TTAGCAACTG GTGGTGATAT TACCCGAAAT 540

AAAGTGAGAA AGACCTTTGT TGGAACTCCT TGCTGGATGG CACCTGAAGT TATGGAACAG 600

GTCCGAGGCT ATGATTTCAA AGCTGACATC TGGAGTTTCG GGATCACAGC AATTGAACTG 660

GCCACAGGGG CGGCTCCTTA TCATAAGTAT CCCCCAATGA AGGTTCTAAT GCTGACACTA 720

CAAAATGATC CTCCTTCTTT GGAAACTGGT GTTCAAGACA AAGAAATGCT GAAAAAATAT 780

GGAAAATCAT TTAGGAAAAT GATTTCATTG TGCCTTCAAA AGGATCCGGA AAAAAGACCA 840

ACAGCAGCAG AACTGTTAAG GCACAAATTT TTCCAAAAAG CAAAGAATAA AGAATTTCTT 900

CAAGAAAAAA TACTGCAGAG GGCACCAACT ATTTCTGAAA GAGCTAAAAA GGTTCGGAGA 960

GTACCAGGTT CCAGTGGCCG CCTTCATAAG ACAGAAGATG GTGGCTGGGA GTGGAGTGAT 1020

GATGAATTTG ATGAAGAAAG TGAGGAAGGG AAAGCAGCAA TTTCACAACT CAGATCTCCC 1080

AGAGTGAAAG AATCATTATC AAATTCTGAG CTATTTTCAA CAACTGATCC CGTGGGTACT 1140

TTACTCCAAG TTCCAGAACA AATTTCTGCT CATCTACCTC AGCCAGCCGG GCACATGCCT 1200

GCACAACCAA CTCCCGTCTC TCCCCCACCC CCGGCAGAGC CAGCAAAAAC AGCTCAGACT 1260

CTGCCTTCAG GAGCAGGCTC ACAAGAGACC AAGATCCCAA TCAGCCTAGT ACTCAGATTA 1320

AGGAATTCAA AAAAAGAACT AAATGATATT CGATTCGAGT TCACTCCTGG GAGAGATACA 1380

GCAGAGGGTG TCTCTCAGGA ACTCATTTCT GCCGGCCTGG TTGATGGAAG GGATTTAGTA 1440

ATAGTGGCAG CGAATTTGCA GAAAATTGTG GAAGAACCTC AGTCAAATCG ATCTGTCACT 1500

TTCAAACTGG CATCTGGTGT TGAAGGCTCG GATATTCCTG ATGATGGTAA ACTAATAGGA 1560

TTTGCCCAGC TCAGCATCAG CTAA 1584

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.ekleelqkeisvlkklkhpniv  59

         yel+e+ig+Ga++ v++a++ +++e+vaik+inlek+ ++++el kei+++++++hpniv

Q: 17    YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCqTSMDELLKEIQAMSQCHHPNIV  76

         99***********************************8899*******************

S: 60    eylesflkeeelwlvmeylagGslsdlvk......eelkselkEeqiayilrevlkaLey  113

         +y++sf++++elwlvm++l+gGs+ d++k      e+++  l+E +ia+il+evl++Ley

Q: 77    SYYTSFVVKDELWLVMKLLSGGSVLDIIKhivakgEHKSGVLDEPTIATILKEVLEGLEY  136

         *****************************9*99999999*********************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlek....trkk.rktvvgtpywmAPE  168

         lH++++iHrd+ka+niLl e+g+V+++dfgv+a l++    tr+k rkt+vgtp+wmAPE

Q: 137   LHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATggdiTRNKvRKTFVGTPCWMAPE  196

         ***********************************99999988899**************

S: 169   viaqeekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklksk.....  223

         v++q  +gYd kaDiws+GItaiela+g++P+++++p+k+l+++l+n+pp+l++

Q: 197   VMEQ-VRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGvqdke  255

         ***5.9*********************************************976677778

S: 224   ..kkfskefkefvekclqknpekRpsasellkhkFl  257

           kk++k+f+++++ clqk+pekRp+a+ell+hkF+

Q: 256   mlKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF  291

         8899*******************************7

Domain Sequence
(FASTA)

YELQEVIGSG ATAVVQAAYC APKKEKVAIK RINLEKCQTS MDELLKEIQA MSQCHHPNIV 60

SYYTSFVVKD ELWLVMKLLS GGSVLDIIKH IVAKGEHKSG VLDEPTIATI LKEVLEGLEY 120

LHKNGQIHRD VKAGNILLGE DGSVQIADFG VSAFLATGGD ITRNKVRKTF VGTPCWMAPE 180

VMEQVRGYDF KADIWSFGIT AIELATGAAP YHKYPPMKVL MLTLQNDPPS LETGVQDKEM 240

LKKYGKSFRK MISLCLQKDP EKRPTAAELL RHKFF 275

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006979	; P:response to oxidative stress

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR024678	; Kinase_OSR1/WNK_CCT.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF12202	; OSR1_C; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013