EKS-CAF-00289

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00289

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	408.6	1.7E-122	185	472	288

Status

Unreviewed

Ensembl Protein

ENSCAFP00000007500

UniProt Accession

F1PGW4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000005035	ENSCAFP00000007500	ENSCAFT00000008099

Organism

Canis familiaris

Functional Description

Protein Length

507

Protein Sequence
(FASTA)

MWDAQSSHLP GSGSGRGEAE TRECIYYNAN WELERTNQSG LERCEGEQDK RLHCYASWRN 60

SSGTIELVKK GCWLDDFNCY DRQECVATEE NPQVYFCCCE GNFCNERFTH LPEAGGPEVT 120

YEPPPTAPTL LTVLAYSLLP IGGLSLIVLL AFWMYRHRKP PYGHVDIHED PGPPPPSPLV 180

GLKPLQLLEI KARGRFGCVW KAQLMNDFVA VKIFPLQDKQ SWQSEREIFS TPGMKHENLL 240

QFIAAEKRGS NLEVELWLIT AFHDKGSLTD YLKGNIITWN ELCHVAETMS RGLSYLHEDV 300

PWCRGEGHKP SIAHRDFKSK NVLLKSDLTA VLADFGLAVR FEPGKPPGDT HGQVGTRRYM 360

APEVLEGAIN FQRDAFLRID MYAMGLVLWE LVSRCKAADG PVDEYMLPFE EEIGQHPSLE 420

ELQEVVVHKK MRPTIKDHWL KHPGLAQLCV TIEECWDHDA EARLSAGCVE ERVALIRRSV 480

NGTTSDCLVS LVTSVTNVDL PPKESSI 507

Nucleotide Sequence
(FASTA)

ATGTGGGATG CTCAGTCCTC TCACCTCCCG GGCTCAGGTT CCGGGCGCGG GGAGGCCGAG 60

ACTCGGGAGT GCATTTACTA CAACGCCAAC TGGGAGCTGG AGCGCACCAA CCAGAGTGGC 120

CTGGAACGCT GCGAGGGTGA GCAAGACAAG CGGCTGCACT GCTACGCCTC CTGGCGCAAC 180

AGCTCTGGCA CCATCGAGCT GGTCAAGAAG GGCTGCTGGC TGGACGACTT CAACTGCTAC 240

GACAGGCAGG AGTGCGTGGC CACCGAGGAG AACCCCCAGG TGTACTTCTG CTGCTGTGAA 300

GGCAACTTTT GCAACGAGCG CTTCACCCAC TTGCCGGAGG CTGGGGGCCC GGAAGTCACG 360

TACGAGCCAC CCCCGACAGC CCCCACCCTG CTCACGGTGC TGGCCTACTC GCTGCTGCCC 420

ATCGGGGGCC TCTCCCTCAT CGTCCTGCTG GCCTTCTGGA TGTACCGGCA TCGCAAGCCT 480

CCCTACGGCC ATGTGGACAT CCACGAGGAC CCTGGACCTC CTCCTCCGTC CCCTCTGGTG 540

GGCCTGAAGC CTCTGCAACT GCTGGAGATT AAGGCTCGGG GGCGCTTTGG CTGTGTCTGG 600

AAGGCACAGC TCATGAATGA CTTTGTGGCT GTCAAGATCT TCCCACTCCA GGACAAGCAG 660

TCGTGGCAGA GTGAGCGGGA GATCTTCAGC ACGCCTGGCA TGAAGCATGA GAACCTGCTG 720

CAGTTCATTG CTGCTGAGAA GCGAGGCTCC AACCTTGAGG TGGAGCTCTG GCTCATCACG 780

GCCTTCCATG ACAAGGGCTC CCTCACGGAT TACCTCAAGG GGAACATCAT CACGTGGAAT 840

GAACTGTGTC ATGTGGCAGA GACAATGTCA AGAGGCCTCT CATACCTTCA TGAGGACGTG 900

CCGTGGTGCC GTGGTGAGGG CCACAAGCCG TCTATTGCCC ACAGGGACTT CAAAAGCAAG 960

AATGTATTGC TCAAGAGTGA CCTCACAGCC GTGCTGGCTG ACTTTGGTCT GGCTGTTCGG 1020

TTTGAGCCAG GGAAACCTCC GGGGGACACT CACGGGCAGG TGGGCACACG GCGGTACATG 1080

GCTCCTGAGG TGCTTGAGGG AGCCATCAAC TTCCAGAGAG ATGCCTTCCT GCGCATTGAT 1140

ATGTACGCCA TGGGGCTGGT GCTGTGGGAG CTTGTGTCCC GCTGCAAGGC TGCAGATGGA 1200

CCCGTGGATG AGTACATGCT GCCGTTTGAG GAAGAGATTG GCCAGCACCC ATCACTGGAG 1260

GAGCTGCAAG AGGTGGTTGT GCACAAGAAG ATGCGGCCTA CCATTAAGGA TCACTGGCTG 1320

AAGCACCCGG GCCTGGCCCA GCTCTGCGTG ACCATCGAGG AGTGCTGGGA CCATGATGCC 1380

GAGGCTCGTC TGTCTGCAGG CTGCGTGGAG GAGCGGGTGG CCCTGATCAG GAGGTCGGTC 1440

AACGGCACTA CCTCGGACTG TCTTGTCTCC CTGGTGACCT CCGTCACCAA TGTGGACCTG 1500

CCCCCTAAGG AGTCGAGCAT CTAA 1524

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+++ vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 185   LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA  244

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 245   AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR  304

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +Kp+iaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 305   GeGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  362

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Pslee

Q: 363   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE  421

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP+i+++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 422   LQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  472

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDFVAVKIF PLQDKQSWQS EREIFSTPGM KHENLLQFIA 60

AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG QHPSLEELQE 240

VVVHKKMRPT IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0032147	; P:activation of protein kinase activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0060840	; P:artery development
GO:0001974	; P:blood vessel remodeling
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048617	; P:embryonic foregut morphogenesis
GO:0001702	; P:gastrulation with mouth forming second
GO:0007507	; P:heart development
GO:0030073	; P:insulin secretion
GO:0001822	; P:kidney development
GO:0030324	; P:lung development
GO:0001946	; P:lymphangiogenesis
GO:0060836	; P:lymphatic endothelial cell differentiation
GO:0007498	; P:mesoderm development
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0035265	; P:organ growth
GO:0060021	; P:palate development
GO:0031016	; P:pancreas development
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0009791	; P:post-embryonic development
GO:0009749	; P:response to glucose stimulus
GO:0061298	; P:retina vasculature development in camera-type eye
GO:0023014	; P:signal transduction by phosphorylation
GO:0048705	; P:skeletal system morphogenesis
GO:0060841	; P:venous blood vessel development

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013