EKS-CAF-00393

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00393

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	338.6	3.8E-101	844	1107	264

Status

Unreviewed

Ensembl Protein

ENSCAFP00000007499

UniProt Accession

F1PHN0;

Protein Name

Protein Synonyms/Alias

Gene Name

YSK4

Gene Synonyms/Alias

YSK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000005038	ENSCAFP00000007499	ENSCAFT00000008098

Organism

Canis familiaris

Functional Description

Protein Length

1111

Protein Sequence
(FASTA)

MKPGLQTIPP NHKDQKEKER NIPDFVSFLP KLSEPRSRSE EFRPSNKQQE APFKVFVDQT 60

LRSSDSSIWS RNMCSFWEAN HHRPHMETEE NRKSKETEGS DKIAICHFEK GQSLVSFENC 120

KESSFPTDRE VDIDCPGHEM RKAEENSQHF LSGKKERLVA RNCKQDYAVG CTMPIKFQEA 180

QHSEIILNQD EETRNDKADS KSASVHKSEA IEPKHILEGH TALKSLSNVV PDGPTEKVPQ 240

DHRGTETNIK VSVADTIKPE MNGMVPLIHI TFPGHGTPKE LAIAKPSLPK RKGTLHNNNS 300

FNILAHQEND RHKMKTHRNK LDSKTKTSNR TPQNFMISIE GSIKPTMHKT SIKTQAFPAL 360

ELVDPRPRQS PKFQRRMPQI EKKQSTYRAL KPKKQSFPCI CKNPGIKKSS VPLSAQPTEP 420

RLSCLDLKYS DMFKEINSTA NGPGIYEMFG TPVYCHIREA ERHENKYYQE ICSAPSGRCI 480

TNKCRSSHSE RSSNSRTRFS QKRPHIKPAK ALLGIKQKNK SLISKEKGYK AVGSNQKGIE 540

NGDGISDPEW QIKSSANDFL SSSDEGQPMN LALPCERSTE QSEFLPVSHL STVEEVSMEE 600

SADEEDISNN QILATSLRDL HKLEELHHQT SFILSENSWA VPSEKSSNKH ILQEKQNTAS 660

LGKISANQIL TNDIGFESVL EKSETLMSFS FQEKQQSASS QAYQHWADSL DDDSLANESI 720

TYQSFGQTLN EANSISQETL DSVKNEELTD ELLGCLAAEL LALDERDKTS HQIMANETDP 780

ENLNLVFSRR GKNTQELSRE TTNVKIQKYS NGFRIYNKEE KFLNSNEKKI FSENSLKNEE 840

SILWTKGEIL GKGAYGTVYC GLTSQGQLIA VKQVALDTSD KLATEKEYRK LQEEVDLLKA 900

LKHVNIVAYL GTCLEENIVS IFMEFVPGGS ISSIINRFGP LLEMVFCKYT RQILQGVAYL 960

HENCVVHRDI KGNNVMLMPT GIIKLIDFGC AKRLAWAGLN GTHSDMLKSM HGTPYWMAPE 1020

VINESGYGRK SDIWSIGCTV FEMATGKPPL ASMDRMAAMF YIGAHRGLMP PLPEHFSENA 1080

VDFVRVCLTR DQHERPSAAQ LLKHSFLTRS H 1111

Nucleotide Sequence
(FASTA)

ATGAAACCTG GTCTTCAGAC TATCCCTCCA AATCACAAAG ATCAAAAAGA GAAAGAAAGA 60

AATATTCCAG ACTTCGTATC CTTCTTACCT AAGCTCTCAG AGCCCAGAAG TCGATCTGAG 120

GAGTTTAGAC CATCAAATAA GCAGCAGGAA GCTCCATTTA AGGTGTTTGT GGATCAGACT 180

CTCAGGTCCT CTGACAGCTC TATTTGGTCC AGAAACATGT GCTCTTTTTG GGAGGCTAAC 240

CATCACAGAC CACACATGGA GACGGAAGAG AACAGAAAAT CTAAAGAAAC AGAAGGAAGT 300

GACAAAATTG CAATCTGTCA CTTCGAAAAA GGACAATCTT TGGTGTCCTT TGAGAATTGT 360

AAGGAAAGCA GTTTTCCTAC AGATAGGGAA GTGGACATTG ACTGCCCTGG TCATGAAATG 420

AGAAAAGCAG AAGAGAATTC TCAACATTTT TTGTCAGGAA AGAAAGAGAG GTTAGTAGCT 480

AGAAACTGTA AACAAGACTA TGCAGTTGGA TGTACCATGC CAATCAAGTT CCAAGAAGCC 540

CAGCATTCAG AAATAATCCT AAACCAGGAT GAAGAGACAA GAAATGATAA GGCTGATTCA 600

AAAAGTGCTT CAGTACATAA AAGTGAAGCA ATTGAGCCAA AGCATATTTT AGAAGGGCAT 660

ACTGCACTTA AGAGTTTGTC CAACGTAGTC CCTGACGGCC CCACTGAAAA GGTCCCACAA 720

GATCACAGAG GCACGGAGAC AAACATAAAA GTATCAGTAG CAGACACAAT CAAACCAGAA 780

ATGAATGGGA TGGTGCCTCT TATCCACATC ACTTTCCCTG GACATGGAAC TCCCAAGGAA 840

CTGGCAATAG CCAAACCAAG CCTCCCAAAA AGAAAGGGCA CTCTTCATAA CAACAATAGC 900

TTCAACATAC TCGCACACCA AGAAAATGAC AGGCATAAGA TGAAAACCCA CAGAAATAAG 960

CTGGATTCGA AGACAAAGAC CAGTAACAGG ACACCCCAGA ATTTCATGAT TTCCATCGAA 1020

GGTTCCATTA AGCCTACCAT GCATAAAACC AGCATAAAAA CTCAAGCTTT CCCTGCTCTG 1080

GAGCTTGTTG ACCCCAGACC TCGGCAATCA CCCAAGTTTC AAAGAAGAAT GCCACAGATA 1140

GAAAAGAAGC AATCAACTTA CCGGGCTCTG AAACCTAAAA AGCAGTCTTT TCCTTGCATC 1200

TGTAAGAATC CAGGAATAAA AAAGTCTTCT GTCCCTCTCT CTGCTCAACC AACAGAGCCA 1260

AGACTAAGTT GCTTAGATCT TAAGTATAGT GACATGTTCA AAGAGATCAA TTCAACAGCT 1320

AATGGGCCTG GAATCTACGA AATGTTTGGG ACTCCTGTTT ATTGTCACAT AAGAGAGGCT 1380

GAACGTCATG AGAACAAATA TTATCAAGAG ATATGCTCTG CTCCATCTGG CAGGTGTATT 1440

ACCAATAAAT GTCGATCTTC ACACAGTGAG AGGAGCAGCA ATAGCAGAAC AAGATTTTCT 1500

CAGAAGAGAC CACATATTAA ACCTGCAAAG GCTTTGCTTG GCATCAAACA AAAGAACAAA 1560

AGTTTAATTT CTAAAGAAAA GGGTTACAAA GCTGTAGGTA GCAACCAAAA GGGCATTGAA 1620

AATGGTGATG GTATTTCAGA TCCAGAGTGG CAGATAAAGT CTTCAGCAAA TGACTTTCTC 1680

TCTTCCAGTG ATGAAGGTCA GCCCATGAAC TTGGCTCTGC CTTGTGAGCG GTCCACTGAA 1740

CAGAGTGAAT TCCTTCCTGT TTCACATTTG TCCACTGTTG AAGAAGTTTC TATGGAAGAG 1800

TCTGCTGATG AAGAAGACAT TTCTAACAAT CAAATACTTG CCACGAGCCT CAGAGATCTG 1860

CATAAACTTG AAGAACTGCA TCACCAGACG TCATTTATCC TTTCAGAAAA CAGCTGGGCA 1920

GTGCCCAGCG AGAAGAGTTC CAACAAACAT ATACTGCAAG AAAAACAGAA TACAGCATCT 1980

CTTGGTAAAA TAAGTGCCAA CCAAATTTTA ACTAATGATA TAGGGTTTGA AAGTGTTTTA 2040

GAGAAGTCTG AAACACTTAT GAGTTTCTCT TTCCAAGAGA AACAACAGAG TGCATCTTCC 2100

CAAGCATATC AACATTGGGC AGATTCTTTG GATGATGATA GTTTAGCTAA TGAGTCAATT 2160

ACATATCAGT CATTTGGACA AACTTTAAAT GAAGCAAATT CAATTTCACA AGAAACTCTA 2220

GATTCCGTAA AGAATGAAGA ATTGACAGAT GAACTATTAG GATGCCTAGC TGCAGAACTA 2280

TTAGCTCTTG ATGAGAGAGA TAAGACCTCT CACCAAATAA TGGCAAATGA AACAGATCCT 2340

GAAAACCTAA ATCTTGTCTT CAGTAGGAGA GGAAAAAACA CTCAAGAATT GAGCAGAGAG 2400

ACAACAAATG TTAAAATACA GAAATATAGT AATGGGTTCA GGATATACAA TAAGGAGGAG 2460

AAATTTCTCA ACTCAAACGA AAAGAAGATA TTTTCTGAGA ATAGTTTAAA GAATGAAGAA 2520

TCTATCCTGT GGACTAAGGG CGAGATCCTT GGGAAGGGAG CCTATGGCAC AGTATATTGT 2580

GGTCTCACTA GCCAAGGACA GCTAATAGCT GTAAAACAGG TGGCTTTGGA TACCTCTGAT 2640

AAATTAGCTA CTGAAAAAGA ATACCGGAAA CTGCAGGAAG AAGTAGATTT GCTCAAAGCA 2700

CTGAAACATG TCAACATTGT GGCCTATTTG GGGACGTGCT TGGAAGAGAA CATTGTAAGC 2760

ATTTTCATGG AGTTTGTTCC TGGTGGCTCA ATTTCTAGTA TTATAAATCG TTTTGGGCCA 2820

TTGCTTGAGA TGGTGTTCTG TAAATATACA AGACAAATTC TGCAAGGTGT TGCTTATCTC 2880

CATGAGAACT GTGTGGTGCA TCGAGACATC AAAGGAAATA ATGTTATGCT CATGCCAACC 2940

GGAATAATAA AGCTAATTGA CTTTGGCTGT GCCAAGCGCT TGGCCTGGGC TGGTTTAAAT 3000

GGCACCCACA GTGACATGCT TAAGTCCATG CATGGGACTC CATATTGGAT GGCCCCGGAA 3060

GTCATCAATG AGTCTGGCTA CGGAAGGAAG TCGGACATCT GGAGCATTGG CTGCACCGTG 3120

TTTGAGATGG CCACAGGGAA GCCTCCACTG GCTTCCATGG ACAGGATGGC AGCCATGTTT 3180

TACATTGGAG CACACAGAGG GCTAATGCCT CCATTGCCAG AACACTTCTC AGAAAACGCA 3240

GTGGACTTTG TGCGTGTGTG CCTAACCAGG GACCAGCATG AGCGACCTTC TGCTGCCCAG 3300

CTCCTGAAGC ATTCCTTCTT GACAAGAAGT CACTGA 3336

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikp.ekksekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ +k +++ke+++l+eE++llk+lk

Q: 844   WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVALDTsDKLATEKEYRKLQEEVDLLKALK  902

         89*****************8.89***********8614556778****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ ee+ ++if+E+v+gGs+ss+++++g+l e+v++kyt+qil+g+ayLHe

Q: 903   HVNIVAYLGTCLEENIVSIFMEFVPGGSISSIINRFGPLLEMVFCKYTRQILQGVAYLHE  962

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG++krla++  + ++   l+s++Gt+++maPEvi

Q: 963   NCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHsdmLKSMHGTPYWMAPEVI  1022

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +ga++  +P++pe++se+

Q: 1023  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRgLMPPLPEHFSEN  1079

         988..****************************.9**********9979***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa++LLkh+fl

Q: 1080  AVDFVRVCLTRDQHERPSAAQLLKHSFL  1107

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSDKLA TEKEYRKLQE EVDLLKALKH 60

VNIVAYLGTC LEENIVSIFM EFVPGGSISS IINRFGPLLE MVFCKYTRQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCAKR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP EHFSENAVDF 240

VRVCLTRDQH ERPSAAQLLK HSFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013