EKS-CAF-00182
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00182
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC438.21.4E-131380634255
StatusUnreviewed
Ensembl ProteinENSCAFP00000007725
UniProt AccessionE2RNP2;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCQ
Gene Synonyms/Alias PRKCQ;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000005169ENSCAFP00000007725ENSCAFT00000008336
OrganismCanis familiaris
Functional Description
Protein Length706
Protein Sequence
(FASTA)
MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP TMYPPWDSTF 60
DAHINKGRVM QIIVKGKNVD LISETTVELS SLAERCRKNN GKAEIWLELK PQGRMLMNAR 120
YFLEMSDTKD MSEFETEGFF ALHHRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 180
WGLNKQGYQC RQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 240
SPTFCEHCGT LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 300
ARCLRDTEHI FREGPVEIGL PCSIKGEARL PCVPAPGKKE PQGISWESPL DGMEKICHRP 360
EPEPNVERPS VHMKLKIEDF ILHKMLGKGS FGKVFLAEFK KTNQFFAIKA LKKDVVLMDD 420
DVECTMVEKR VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QSCHKFDLSR 480
ATFYAAEIIL GLQFLHSKGI VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC 540
GTPDYIAPEI LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 600
WLEKEAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP FRPKVKSPYD 660
CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFINPG MEKLIS 706
Nucleotide Sequence
(FASTA)
ATGTCACCAT TTCTTCGAAT TGGTTTGTCC AACTTTGACT GTGGATCCTG CCAGTCATGT 60
CAAGGAGAGG CTGTTAACCC TTACTGCGCT GTGCTTGTCA AAGAATACGT TGAATCGGAG 120
AATGGGCAGA TGTATATCCA GAAGAAACCA ACTATGTACC CACCCTGGGA CAGCACTTTT 180
GATGCTCACA TCAACAAGGG AAGAGTAATG CAGATCATTG TGAAGGGCAA GAACGTGGAC 240
CTGATATCTG AAACTACTGT GGAGCTCTCC TCTCTGGCAG AGCGATGTCG GAAGAACAAT 300
GGGAAGGCAG AGATATGGTT AGAGCTGAAA CCTCAAGGCC GAATGCTAAT GAATGCCAGA 360
TACTTTCTGG AAATGAGTGA CACAAAGGAC ATGAGTGAAT TTGAGACTGA AGGCTTCTTT 420
GCTTTGCATC ACCGCCGAGG AGCCATCAAA CAGGCCAAAG TCCATCATGT CAAGTGCCAT 480
GAGTTCACCG CCACCTTTTT CCCACAACCC ACATTTTGCT CTGTCTGCCA TGAGTTTGTC 540
TGGGGTCTGA ACAAACAAGG CTACCAGTGT CGACAGTGTA ATGCGGCAAT TCACAAGAAG 600
TGTATCGATA AAGTTATAGC TAAGTGCACA GGATCAGCTA TCAATAGCCG AGAAACCATG 660
TTCCACAAGG AGAGGTTCAA AATTGACATG CCGCATAGAT TTAAAGTCTA CAATTACAAA 720
AGCCCGACCT TCTGTGAGCA CTGTGGGACC CTGCTGTGGG GCCTGGCCAG GCAAGGACTC 780
AAGTGTGATG CATGTGGCAT GAACGTACAT CACAGATGCC AGACAAAGGT GGCCAACCTT 840
TGTGGCATAA ATCAGAAGCT AATGGCTGAA GCACTGGCAA TGATCGAGAG CACTCAACAG 900
GCTCGCTGCT TAAGAGATAC TGAACACATC TTCAGAGAAG GTCCGGTTGA AATTGGTCTC 960
CCATGCTCCA TAAAAGGTGA AGCAAGGCTG CCATGTGTAC CAGCACCTGG GAAAAAAGAG 1020
CCTCAGGGAA TCTCTTGGGA GTCTCCTTTG GATGGGATGG AGAAAATATG CCATCGTCCG 1080
GAACCTGAAC CGAATGTAGA AAGACCATCT GTACATATGA AATTAAAAAT TGAGGATTTT 1140
ATCTTGCACA AAATGTTGGG GAAAGGAAGT TTTGGCAAGG TCTTCCTAGC AGAGTTCAAG 1200
AAAACCAATC AATTTTTCGC AATAAAAGCC TTAAAGAAAG ATGTGGTTTT GATGGATGAC 1260
GATGTTGAGT GTACAATGGT AGAAAAGAGA GTTCTCTCCT TGGCCTGGGA GCATCCGTTC 1320
TTAACGCACA TGTTCTGTAC ATTCCAGACC AAGGAAAACC TCTTTTTTGT GATGGAGTAT 1380
CTCAATGGAG GAGACTTAAT GTACCACATC CAAAGCTGCC ACAAGTTTGA TCTTTCCAGA 1440
GCAACATTCT ATGCTGCTGA AATCATTCTC GGTCTACAAT TCCTTCATTC CAAAGGAATT 1500
GTGTACAGAG ACCTGAAGCT AGATAACATC CTGTTAGACA AAGATGGACA TATCAAAATA 1560
GCAGACTTTG GAATGTGCAA GGAGAACATG TTAGGAGATG CCAAGACAAA CACTTTCTGC 1620
GGAACCCCTG ACTACATTGC CCCAGAGATC TTGCTGGGTC AGAAATATAA CCATTCTGTT 1680
GACTGGTGGT CATTTGGAGT TCTCCTCTAT GAGATGCTAA TTGGTCAGTC ACCCTTCCAT 1740
GGGCAAGATG AAGAAGAGCT TTTCCACTCC ATCCGCATGG ACAATCCCTT TTACCCTCGA 1800
TGGCTTGAGA AGGAGGCGAA GGACCTTTTA GTGAAGCTGT TCGTGAGGGA ACCTGAAAAG 1860
AGGCTGGGAG TGAGGGGAGA CATCCGCCAG CATCCTTTGT TTCGGGAGAT CAACTGGGAA 1920
GAGCTTGAAA GAAAGGAGAT TGACCCACCA TTCCGGCCTA AAGTGAAATC ACCGTATGAC 1980
TGCAGCAATT TCGACAAAGA ATTCTTAAAT GAGAAACCCC GGCTGTCATT TGCTGACAGA 2040
GCCCTGATCA ACAGCATGGA CCAGAACATG TTCAGAAACT TTTCCTTCAT TAACCCAGGG 2100
ATGGAGAAGT TGATATCCTG A 2121
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f l+k+lGkGsfgkv+lae kkt++++aik lkkdvvl+dddve+t+vekrvl+la+++p
Q: 380   FILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP  439
         7899********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+++f++fqt+++lffv+ey+nGGdlm+hiq+++k++ +ra+fyaaeiil+l+flh+kg
Q: 440   FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKG  499
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         i+yrdlkldn+lld++Ghik+adfG+cke++l +++t+tfcGtPdyiaPeil +++y++s
Q: 500   IVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHS  559
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdww++Gvllyeml+gqsPf+g+de+elf+si++++++yP++l+kea+++l +l+ ++pe
Q: 560   VDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPE  619
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlGv  +g  di++h++f
Q: 620   KRLGV--RG--DIRQHPLF  634
         *****..55..89999987
Domain Sequence
(FASTA)
FILHKMLGKG SFGKVFLAEF KKTNQFFAIK ALKKDVVLMD DDVECTMVEK RVLSLAWEHP 60
FLTHMFCTFQ TKENLFFVME YLNGGDLMYH IQSCHKFDLS RATFYAAEII LGLQFLHSKG 120
IVYRDLKLDN ILLDKDGHIK IADFGMCKEN MLGDAKTNTF CGTPDYIAPE ILLGQKYNHS 180
VDWWSFGVLL YEMLIGQSPF HGQDEEELFH SIRMDNPFYP RWLEKEAKDL LVKLFVREPE 240
KRLGVRGDIR QHPLF 255
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00175
EKS-CAP-00174
EKS-DAR-00470
EKS-EQC-00171
EKS-FEC-00165
EKS-GAM-00093
EKS-GAA-00211
EKS-GOG-00174
EKS-HOS-00181
EKS-LAC-00186
EKS-LOA-00174
EKS-MAM-00171
EKS-MOD-00173
EKS-MUM-00181
EKS-MUP-00179
EKS-MYL-00184
EKS-NOL-00167
EKS-ORN-00220
EKS-ORA-00152
EKS-ORC-00162
EKS-ORL-00206
EKS-OTG-00180
EKS-PAT-00165
EKS-PES-00155
EKS-POA-00168
EKS-RAN-00171
EKS-SUS-00153
EKS-TAG-00203
EKS-TEN-00220
EKS-XIM-00215
Gene Ontology
GO:0005737; C:cytoplasm
GO:0001772; C:immunological synapse
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0035556; P:intracellular signal transduction
GO:0006509; P:membrane protein ectodomain proteolysis
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0070233; P:negative regulation of T cell apoptotic process
GO:0032740; P:positive regulation of interleukin-17 production
GO:0045086; P:positive regulation of interleukin-2 biosynthetic process
GO:0032753; P:positive regulation of interleukin-4 production
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0042102; P:positive regulation of T cell proliferation
GO:2000318; P:positive regulation of T-helper 17 type immune response
GO:2000570; P:positive regulation of T-helper 2 cell activation
GO:0090330; P:regulation of platelet aggregation
KEGG
cfa:478013;
InterPros
IPR000961; AGC-kinase_C.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013