EKS-CAF-00313

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00313

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	534.3	6.6E-161	1131	1400	270

Status

Unreviewed

Ensembl Protein

ENSCAFP00000007913

UniProt Accession

F1PZ19;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

LTK

Gene Synonyms/Alias

LTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000005297	ENSCAFP00000007913	ENSCAFT00000008540

Organism

Canis familiaris

Functional Description

Protein Length

1627

Protein Sequence
(FASTA)

MGSVGLLGLL LLRLSVTASG SGAGTGSGTG SGTGTGTGQL VGSPATGPAL QPREPLSYSR 60

LQRKSLAVDF VVPSLFRVYA RDLLLPPWSS SEPRAGWTEA RGSLALDCAP LLRLLGPPPG 120

VSWAEGASSP APAQARTLTR VLKGGSVRKL RRAKQLVLEL GEEAILEGCV GPSPEEVTAG 180

LLQFNLSELF SWWIRHGEGR LRIRLMPEKK ASAVGREGRL SAAIRASQPR LLFQILGTGH 240

SSLESPTSLP SPPPDPFAWN LTWIMKDSFP FLSHRSRYGL ECSFDFPCEL EYSPPLHDLG 300

NQSWSWRRVP SEEASQMDLL DGPETEHSKE MPRGSFLLLN TSANSKHTIL SPWMRSSSEH 360

CKLAVSVHRH LQPSGRYVAQ LLPHNEPGRE ILLVPTPGKH GWTVLQGRIG RPENPFRVAL 420

EYISSGNRSL SAVDFFALKN CSEGTSPGSK MALQSSFTCW NGTVLQLGQA CDFHQDCAQG 480

EDEGQLCSQL PAGFYCNFEN GFCGWSQGIL TPHNPRWQVR TLKDARVQDH RGHALSLSTT 540

DVPTSESATV TSATFPAPMK NSPCELRMSW LIHGVLRGNV SLVLVENKTG KEQSRMVWHV 600

ATNEGLSLWQ WTVLPLLDVA DRFWLQIVAW WGQGSRATVA FDNISISLDC YLTISGEEKM 660

LQNTAPKSRN LFERNPNKDP RPWENTRETP VFDPTVHWLF TTCGASGPHG PTQAQCNNAY 720

RNSNLSVVVG SEGPLKGIQT WKVPATDTYS ISGYGAAGGK GGKNTMMRSH GVSVLGIFNL 780

EKGDTLYILV GQQGEDACPS TNRLIQKVCI GENNVIEEEI RVNRSVHEWA GGGGGGGGAT 840

YVFKMKDGVP VPLIIAAGGG GRAYGAKTDT FHPERLENNS SVLGLNGNSG AAGGGGGWND 900

NTSLLWSGKS LLEGATGGHS CPQAMKKWGW ETRGGFGGGG GGCSSGGGGG GYIGGNAASN 960

NDPEMDGEDG VSFISPLGIL YTPALKVMEG HGEVNIKHYL NCSHCEGDEC HMDPESHKVI 1020

CFCDHGTVLA EDGVSCIVSP TPEPHLPLSL VLSVVTSALV AALVLAFSGI MIVYRRKHQE 1080

LQAMQMELQS PEYKLSKLRT STIMTDYNPN YCFAGKTSSI SDLKEVPRKN ITLIRGLGHG 1140

AFGEVYEGQV SGVPSDPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN HQNIVRCIGV 1200

SLQALPRFIL LELMAGGDLK SFLRETRPRP NQPSSLAMLD LLHVAQDIAC GCQYLEENHF 1260

IHRDIAARNC LLTCPGPGRV AKIGDFGMAR DIYRASYYRK GGCAMLPVKW MPPEAFMEGI 1320

FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTSG GRMDPPKNCP GPVYRIMTQC 1380

WQHQPEDRPN FAIILERIEY CTQDPDVINT ALPVEYGPLM EEEEKVPMRP QDPEGIPPLL 1440

VSPPQAKREE GPDPAAPPPL PSTSSGKAAK KPTAAELSGR VTRGPAVEGG HVNMAFSQSN 1500

PASELHKVQG SRNKPTSLWN PTYGSWFTEK PTKKNNPPAT KGHHDRGNLG REGSCTVPPN 1560

VAAGRLPGAS LLLEPSSLTA SMKEVPLFRL RHFPCGNVNY GYQQQGLPFE GTTAPGSSQY 1620

EDALLKT 1627

Nucleotide Sequence
(FASTA)

ATGGGATCCG TAGGGCTCCT AGGGCTGCTG CTGCTGCGGC TCTCAGTGAC AGCCTCGGGC 60

TCCGGGGCCG GGACCGGGAG CGGGACCGGG AGCGGGACCG GGACCGGGAC CGGCCAGCTC 120

GTGGGTTCAC CCGCCACGGG GCCGGCTCTG CAGCCTCGGG AGCCGCTCAG CTACTCACGT 180

CTGCAGAGGA AGAGCCTGGC GGTGGACTTT GTCGTGCCCT CGCTCTTCCG CGTCTACGCC 240

CGGGACCTGC TGCTGCCGCC TTGGTCCTCC TCGGAGCCCA GGGCCGGCTG GACGGAGGCG 300

CGCGGCTCCC TGGCCCTCGA CTGCGCCCCG CTGCTTCGGC TGCTGGGGCC ACCGCCCGGG 360

GTCTCCTGGG CCGAAGGCGC CAGCTCGCCG GCCCCGGCCC AGGCTCGGAC GCTGACCAGG 420

GTGCTGAAGG GCGGCTCGGT CCGCAAGCTC CGACGCGCCA AGCAGCTGGT GCTGGAGCTG 480

GGAGAGGAGG CGATCCTTGA GGGCTGCGTC GGGCCCTCCC CCGAGGAGGT GACTGCGGGA 540

CTGCTCCAGT TCAACCTCAG CGAGCTGTTC AGCTGGTGGA TTCGCCACGG CGAAGGACGG 600

CTGAGGATCC GCCTGATGCC TGAGAAGAAG GCTTCGGCAG TGGGCAGAGA GGGAAGGCTG 660

TCCGCGGCGA TCCGCGCCTC CCAGCCCCGC CTTCTCTTCC AGATCTTGGG GACCGGTCAC 720

AGCTCCTTGG AATCCCCAAC AAGCCTGCCT TCTCCTCCTC CTGATCCTTT TGCATGGAAT 780

CTGACCTGGA TAATGAAAGA TTCCTTCCCT TTCCTGTCTC ATCGCAGTCG ATATGGTCTG 840

GAGTGCAGCT TTGACTTTCC CTGTGAGCTG GAGTATTCCC CGCCCCTACA CGACCTTGGC 900

AACCAGAGCT GGTCCTGGCG CCGCGTCCCC TCTGAGGAGG CCTCCCAGAT GGACCTGTTG 960

GATGGGCCTG AGACAGAGCA CTCCAAGGAG ATGCCCAGAG GCTCTTTCCT CCTCCTCAAT 1020

ACCTCAGCAA ACTCCAAGCA CACCATCCTG AGCCCGTGGA TGAGGAGCAG CAGTGAGCAC 1080

TGCAAGCTGG CTGTCTCCGT GCACAGGCAT CTGCAACCTT CTGGGAGGTA CGTCGCCCAG 1140

CTGCTGCCCC ACAACGAGCC TGGAAGAGAG ATCCTCCTGG TACCCACTCC AGGAAAGCAT 1200

GGTTGGACAG TGCTCCAGGG AAGAATTGGG CGCCCAGAGA ATCCCTTCCG AGTGGCCCTG 1260

GAATACATCT CGAGTGGCAA CCGAAGCTTG TCTGCAGTGG ACTTCTTTGC CCTGAAGAAC 1320

TGCAGTGAAG GAACATCCCC AGGCTCCAAG ATGGCCTTGC AGAGCTCCTT CACCTGCTGG 1380

AATGGGACGG TGCTCCAGCT AGGCCAGGCC TGTGACTTCC ACCAGGACTG CGCCCAGGGA 1440

GAAGACGAGG GCCAGCTGTG CAGTCAACTC CCTGCTGGCT TTTACTGCAA CTTCGAGAAT 1500

GGCTTCTGTG GCTGGAGCCA GGGCATACTC ACACCCCACA ACCCCCGGTG GCAGGTCAGG 1560

ACTCTGAAGG ATGCCCGGGT CCAGGATCAT CGAGGCCACG CCCTGTCGCT CAGCACCACT 1620

GACGTCCCTA CTTCTGAAAG TGCTACAGTG ACCAGTGCTA CGTTTCCTGC CCCAATGAAG 1680

AACTCTCCAT GTGAGCTCCG AATGTCCTGG CTCATCCATG GAGTCTTGAG GGGAAATGTC 1740

TCCTTGGTGC TGGTGGAGAA CAAAACTGGG AAGGAACAAA GCAGAATGGT CTGGCATGTT 1800

GCCACCAATG AAGGCTTGAG CCTGTGGCAG TGGACAGTGT TGCCTCTTCT CGATGTGGCT 1860

GACAGGTTCT GGCTGCAGAT TGTTGCGTGG TGGGGGCAAG GATCCAGAGC CACCGTGGCT 1920

TTTGACAATA TCTCCATCAG CCTGGACTGC TACCTCACCA TCAGTGGAGA GGAGAAGATG 1980

CTACAGAATA CAGCACCCAA ATCAAGAAAT CTATTTGAGA GAAACCCAAA CAAGGACCCA 2040

AGACCCTGGG AAAATACAAG AGAGACCCCC GTCTTTGACC CTACAGTTCA CTGGCTGTTC 2100

ACCACGTGTG GGGCCAGTGG GCCCCATGGC CCCACACAGG CCCAGTGTAA CAACGCCTAC 2160

CGGAATTCCA ACCTGAGCGT GGTGGTGGGG AGCGAGGGCC CCCTGAAGGG CATCCAGACC 2220

TGGAAGGTGC CAGCCACCGA CACCTACAGC ATCTCAGGCT ACGGAGCTGC TGGTGGGAAA 2280

GGCGGGAAGA ACACCATGAT GCGGTCCCAC GGTGTGTCTG TGCTGGGCAT CTTCAACCTT 2340

GAGAAAGGCG ACACATTGTA CATCTTGGTT GGGCAGCAGG GGGAAGACGC CTGCCCCAGC 2400

ACAAACCGAT TAATCCAGAA AGTCTGCATT GGAGAGAACA ACGTGATAGA AGAAGAAATC 2460

CGCGTGAACA GAAGTGTGCA TGAGTGGGCA GGAGGGGGCG GAGGAGGAGG TGGAGCCACC 2520

TACGTATTTA AGATGAAGGA CGGCGTGCCA GTGCCCCTGA TCATTGCAGC CGGCGGGGGC 2580

GGCAGGGCCT ACGGCGCCAA GACAGACACG TTCCACCCAG AGAGACTGGA GAATAACTCC 2640

TCGGTCCTGG GGCTGAACGG CAACTCCGGA GCGGCAGGTG GTGGAGGTGG CTGGAATGAT 2700

AATACTTCCT TGCTCTGGTC TGGAAAATCT TTGCTGGAGG GTGCCACCGG AGGACATTCC 2760

TGCCCCCAGG CCATGAAGAA GTGGGGGTGG GAGACAAGAG GGGGTTTCGG AGGGGGTGGC 2820

GGGGGGTGCT CCTCAGGTGG AGGAGGCGGA GGATATATAG GCGGCAACGC GGCCTCAAAC 2880

AATGACCCCG AGATGGACGG GGAGGACGGG GTTTCCTTCA TCAGTCCGCT GGGCATCCTG 2940

TACACCCCAG CTTTAAAAGT GATGGAGGGC CACGGGGAAG TGAATATTAA GCATTATCTA 3000

AACTGCAGCC ACTGTGAGGG AGACGAGTGC CACATGGACC CAGAAAGCCA CAAGGTCATC 3060

TGCTTCTGTG ATCACGGGAC AGTGCTGGCT GAGGATGGCG TCTCCTGCAT CGTATCCCCC 3120

ACCCCAGAGC CCCACCTGCC ACTCTCACTG GTCCTGTCCG TCGTGACCTC AGCCCTCGTG 3180

GCCGCCCTGG TCCTGGCTTT CTCCGGCATC ATGATTGTGT ACCGCCGGAA ACACCAGGAG 3240

CTGCAGGCCA TGCAGATGGA GCTCCAGAGC CCCGAGTATA AGCTGAGCAA GCTCCGTACC 3300

TCGACCATCA TGACTGACTA CAACCCCAAC TACTGCTTTG CTGGCAAGAC CTCGTCCATC 3360

AGTGACCTGA AGGAGGTGCC TCGGAAAAAC ATCACCCTCA TCCGGGGACT GGGCCATGGT 3420

GCGTTTGGGG AGGTGTATGA GGGTCAGGTG TCTGGAGTGC CCAGCGACCC GAGCCCCCTG 3480

CAAGTGGCCG TAAAGACGCT GCCTGAGGTG TGTTCTGAAC AGGACGAACT GGATTTCCTC 3540

ATGGAAGCCC TGATAATCAG CAAATTCAAC CACCAGAACA TCGTGCGCTG TATCGGGGTG 3600

AGTCTGCAAG CCCTGCCTCG ATTTATCCTC CTGGAGCTCA TGGCAGGAGG AGACCTCAAG 3660

TCCTTCCTCC GGGAGACCCG CCCTCGCCCG AACCAGCCTT CCTCCCTGGC CATGCTGGAC 3720

CTTCTGCATG TGGCTCAGGA CATCGCCTGT GGCTGTCAGT ATTTGGAGGA AAATCACTTC 3780

ATCCACCGGG ACATTGCTGC CAGAAACTGC CTCTTAACCT GTCCAGGCCC TGGCAGAGTG 3840

GCCAAGATTG GAGACTTTGG AATGGCCCGG GACATCTACA GAGCGAGCTA CTACCGAAAA 3900

GGAGGCTGTG CAATGCTGCC AGTCAAATGG ATGCCTCCCG AGGCCTTCAT GGAAGGGATC 3960

TTTACCTCTA AAACAGACAC CTGGTCCTTT GGAGTGCTGC TGTGGGAAAT ATTTTCTCTT 4020

GGATACATGC CATACCCTAG CAAAAGCAAC CAGGAAGTTC TGGAGTTCGT CACCAGCGGA 4080

GGACGGATGG ACCCACCTAA GAACTGTCCT GGGCCTGTGT ACCGGATAAT GACCCAGTGC 4140

TGGCAACATC AGCCTGAAGA TAGGCCCAAC TTTGCCATTA TTTTGGAGAG GATTGAATAC 4200

TGTACCCAGG ACCCAGATGT GATCAACACT GCTTTGCCCG TAGAGTATGG CCCACTCATG 4260

GAAGAGGAGG AGAAGGTGCC CATGAGGCCC CAAGACCCTG AGGGAATTCC TCCTCTACTC 4320

GTCTCTCCTC CACAAGCTAA ACGGGAGGAA GGGCCAGATC CAGCTGCCCC GCCTCCCCTG 4380

CCTTCCACTT CCTCTGGCAA AGCTGCCAAG AAGCCCACGG CTGCGGAGCT CTCTGGTCGA 4440

GTCACTAGGG GACCAGCTGT GGAAGGAGGA CACGTGAACA TGGCATTCTC TCAGTCCAAC 4500

CCAGCGTCAG AGCTGCACAA AGTCCAGGGA TCCAGAAACA AACCCACCAG CCTATGGAAC 4560

CCAACTTACG GCTCATGGTT TACAGAGAAA CCCACCAAAA AGAACAATCC TCCAGCAACG 4620

AAGGGGCACC ACGACAGGGG GAACCTGGGG CGTGAGGGAA GCTGTACTGT CCCACCTAAC 4680

GTGGCAGCTG GCAGACTCCC AGGTGCCTCT CTGCTCCTAG AACCATCCTC GCTGACTGCC 4740

AGCATGAAGG AAGTGCCTCT GTTCAGGCTG CGTCACTTCC CGTGTGGCAA CGTCAACTAC 4800

GGCTACCAGC AACAGGGCTT ACCCTTCGAG GGCACCACCG CGCCCGGAAG CAGCCAGTAC 4860

GAGGACGCCC TCCTGAAAAC C 4881

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfn

Q: 1131  ITLIRGLGHGAFGEVYEGQVSGVPSDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  1190

         799*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+sslam dll+va+d+a+

Q: 1191  HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPSSLAMLDLLHVAQDIAC  1250

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvkw

Q: 1251  GCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW  1310

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p

Q: 1311  MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP  1370

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pedrp+f++iler+++

Q: 1371  GPVYRIMTQCWQHQPEDRPNFAIILERIEY  1400

         ***************************986

Domain Sequence
(FASTA)

ITLIRGLGHG AFGEVYEGQV SGVPSDPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP NQPSSLAMLD LLHVAQDIAC 120

GCQYLEENHF IHRDIAARNC LLTCPGPGRV AKIGDFGMAR DIYRASYYRK GGCAMLPVKW 180

MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTSG GRMDPPKNCP 240

GPVYRIMTQC WQHQPEDRPN FAIILERIEY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013