EKS-CAF-00290

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00290

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	396.5	8.1E-119	238	531	294

Status

Unreviewed

Ensembl Protein

ENSCAFP00000008129

UniProt Accession

F1PNA9;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000005449	ENSCAFP00000008129	ENSCAFT00000008766

Organism

Canis familiaris

Functional Description

Protein Length

561

Protein Sequence
(FASTA)

MMCHVTPSYA ERSCPCSLPL VNDFLVNNDM MVTDSNGVIK FPQLCKFCDV RSSTCDNQKS 60

CMSNCSITSI CEKPHEVCLA VWRKNDENIT LETLCHDPKD TYHGIVLEDA ASSKCIMKEK 120

KVLGETFFMC SCSSDECNDY IIFSEEYATN NPDLLLVIFQ VTGVSLLPPL GIAIAVIVTF 180

YCYRVHRQQK LSPSWETSKP RKLMEFSEHL AIILEDDRSD ISSTCANNIN HNTELLPIEL 240

DTLVGKGRFA EVYKAKLKQN TSEQFETVAV KIFPYEEYAS WKTEKDIFSD INLKHENILQ 300

FLTAEERKTE LGKQYWLITA FHAKGNLQEY LTRHVISWED LRKLGSSLAR GIAHLHSDHT 360

LCGRPKMPIV HRDLKSSNIL VKNDLTCCLC DFGLSLRLDP TLSVDDLANS GQVGTARYMA 420

PEVLESRMNL ENVESFKQTD VYSMALVLWE MTSRCNAVGE VKDYEPPFGS KVREHPCVES 480

MKDNVLRDRG RPEIPSSWLN HQGIQMVCET LTECWDHDPE ARLTAQCVAE RFSELEHLDR 540

LSGRSCSEEK IPEDGSLNTT K 561

Nucleotide Sequence
(FASTA)

ATGATGTGCC ATGTGACCCC ATCATATGCT GAAAGAAGCT GCCCATGCTC ACTTCCTTTA 60

GTGAATGACT TTCTAGTTAA TAATGACATG ATGGTCACTG ACAGCAATGG TGTCATCAAA 120

TTTCCACAAT TGTGTAAATT TTGTGATGTG AGATCTTCCA CCTGTGACAA CCAGAAATCT 180

TGCATGAGCA ACTGCAGCAT TACATCCATC TGTGAGAAGC CACATGAAGT CTGTCTGGCT 240

GTCTGGAGAA AGAATGATGA GAACATAACA CTAGAGACTC TCTGCCATGA CCCCAAGGAT 300

ACCTACCATG GAATTGTTCT CGAAGATGCT GCCTCTTCGA AGTGCATTAT GAAAGAAAAG 360

AAGGTGCTGG GGGAGACTTT CTTTATGTGT TCCTGTAGCT CCGACGAGTG CAACGACTAC 420

ATCATCTTCT CTGAAGAATA TGCCACCAAC AACCCTGACT TGTTGTTAGT CATATTCCAA 480

GTGACAGGCG TCAGCCTCCT GCCGCCCCTG GGAATCGCCA TAGCCGTCAT TGTCACCTTC 540

TACTGTTACC GCGTTCATCG GCAGCAGAAG CTGAGCCCAT CATGGGAGAC CAGCAAGCCA 600

CGGAAGCTCA TGGAGTTCAG CGAGCACCTG GCCATCATTC TGGAAGACGA CCGGTCCGAC 660

ATCAGCTCTA CCTGCGCCAA CAACATCAAC CACAACACGG AGCTGCTGCC CATTGAGCTG 720

GACACCCTGG TGGGGAAAGG TCGCTTTGCT GAGGTCTACA AGGCCAAGCT GAAGCAGAAC 780

ACTTCAGAGC AGTTCGAGAC TGTGGCAGTC AAGATCTTCC CTTACGAGGA GTATGCCTCC 840

TGGAAGACGG AGAAGGACAT CTTCTCAGAC ATCAATCTGA AGCACGAGAA CATACTGCAG 900

TTCCTGACAG CCGAGGAGCG GAAGACGGAG CTGGGAAAGC AGTATTGGCT GATCACGGCC 960

TTCCATGCCA AGGGCAACCT GCAGGAGTAC CTCACTCGGC ATGTCATCAG CTGGGAGGAC 1020

CTGCGAAAGC TGGGCAGCTC CCTCGCCCGG GGCATTGCTC ACCTGCACAG TGACCACACC 1080

CTGTGTGGGA GGCCCAAGAT GCCTATTGTG CACAGGGACC TCAAGAGCTC CAATATCCTG 1140

GTGAAGAACG ACCTGACCTG CTGCCTGTGT GACTTTGGCC TTTCCCTGCG CCTGGACCCA 1200

ACTCTGTCTG TGGATGACCT GGCCAACAGT GGGCAAGTGG GAACTGCAAG ATACATGGCT 1260

CCCGAAGTCC TAGAGTCCAG GATGAATTTG GAGAACGTTG AATCCTTTAA GCAGACTGAT 1320

GTCTACTCCA TGGCCCTGGT ACTCTGGGAA ATGACATCTC GCTGTAATGC AGTGGGAGAA 1380

GTGAAAGATT ATGAGCCCCC GTTTGGTTCC AAGGTGCGAG AGCATCCCTG CGTTGAGAGC 1440

ATGAAGGACA ATGTGCTGAG AGACCGAGGA CGACCAGAAA TTCCCAGCTC CTGGCTCAAC 1500

CACCAGGGCA TCCAGATGGT GTGCGAGACT CTGACCGAGT GCTGGGACCA CGACCCGGAG 1560

GCCCGGCTCA CGGCCCAGTG CGTGGCGGAG CGCTTCAGTG AACTGGAGCA CCTGGACAGG 1620

CTCTCAGGGA GGAGCTGCTC TGAGGAGAAG ATTCCCGAAG ATGGCTCGCT GAACACTACC 1680

AAATAG 1686

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 238   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  297

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+

Q: 298   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS  357

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 358   D-HTLCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  416

         *.7888******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 417   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  475

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip++w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 476   PCVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  531

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS 120

DHTLCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSS WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013