EKS-CAF-00328

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00328

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	324.5	6.0E-97	453	700	248

Status

Unreviewed

Ensembl Protein

ENSCAFP00000008503

UniProt Accession

E2R481;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK7

Gene Synonyms/Alias

PAK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000005685	ENSCAFP00000008503	ENSCAFT00000009167

Organism

Canis familiaris

Functional Description

Protein Length

719

Protein Sequence
(FASTA)

MFGKKKKKIE ISGPSNFEHR VHTGFDPQEQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT 60

PIQLAPMKTI VRGNKPCKET SINGLLEDFD NISVTRSNSL RKESPPTPDQ GASSHGQGHR 120

EENGFITFSQ YSSESDTTAD YTTEKYREKS LYGDDLDPFY KGSHVAKQNG HVMKTKHGEA 180

HYPEMKPWKS DLARFPLDYH THLDSLSKPS EYSDLKWEYQ RASSSSPLDY PFQFTPSRTA 240

GTSGCSKESL VFSESEWGPS LDDYDRRPKS SYLNQTSPQP TMRQRSRSGS GLQEPMMPFG 300

ASAFKTHPQG HSYNSYTYPR LSEPTMCIPK VDYDRAQMVL SPPLSGSDTY PRGPAKLPQS 360

QSKAGYSSSS HQYPSGYHKA TLYHHPSLQT SSQYISTASY LSSLSISSST YPPPSWGSSS 420

DQQPSRVSHE QFRAALQLVV SPGDPREYLD NFIKIGEGST GIVCIATEKH TGKQVAVKKM 480

DLRKQQRREL LFNEVVIMRD YHHDNVVDMY NSYLVGDELW VVMEFLEGGA LTDIVTHTRM 540

NEEQIATVCL SVLRALSYLH NQGVIHRDIK SDSILLTSDG RIKLSDFGFC AQVSKEVPKR 600

KSLVGTPYWM APEVISRLPY GTEVDIWSLG IMVIEMIDGE PPYFNEPPLQ AMRRIRDSLP 660

PRVKDLHKVS SVLRGFLDLM LVREPSQRAT AQELLGHPFL KLAGPPSCIV PLMRQYRHH 719

Nucleotide Sequence
(FASTA)

ATGTTTGGAA AGAAAAAGAA AAAGATTGAA ATATCTGGTC CCTCTAACTT TGAACACAGG 60

GTTCATACTG GCTTTGATCC ACAAGAACAG AAGTTTACGG GCCTCCCCCA GCAGTGGCAC 120

AGCCTGTTAG CAGACACGGC CAACAGGCCG AAGCCCATGG TAGACCCCTC CTGCATCACA 180

CCCATCCAGC TGGCGCCTAT GAAGACAATC GTTAGAGGAA ATAAACCGTG CAAGGAAACC 240

TCCATCAACG GCCTGCTGGA GGACTTTGAC AACATCTCCG TGACTCGCTC CAACTCCCTA 300

CGGAAGGAAA GTCCGCCCAC CCCAGACCAG GGGGCCTCCA GCCACGGTCA AGGCCATCGT 360

GAAGAAAATG GCTTTATCAC CTTCTCACAG TATTCCAGCG AATCCGATAC CACTGCTGAC 420

TACACAACTG AGAAGTATCG AGAAAAGAGT CTCTATGGTG ATGATCTGGA TCCATTTTAT 480

AAGGGCAGCC ATGTGGCCAA GCAAAATGGG CATGTCATGA AGACAAAACA TGGGGAGGCC 540

CACTATCCTG AGATGAAGCC TTGGAAATCT GATCTTGCCA GATTTCCCCT TGATTATCAC 600

ACCCACTTGG ACTCCCTGAG CAAACCAAGT GAATACAGCG ACCTCAAGTG GGAGTACCAG 660

AGAGCCTCAA GCAGCTCCCC TCTAGATTAT CCGTTCCAAT TCACGCCTTC TAGAACTGCG 720

GGGACCAGTG GGTGCTCCAA GGAGAGTCTG GTGTTCAGCG AAAGTGAGTG GGGACCCAGC 780

CTGGATGACT ATGATAGGAG GCCAAAGTCG TCCTACCTGA ATCAGACCAG CCCTCAGCCT 840

ACCATGCGGC AGAGGTCCAG ATCAGGCTCG GGGCTCCAGG AACCCATGAT GCCCTTCGGA 900

GCAAGTGCAT TTAAAACCCA CCCCCAAGGA CACTCGTACA ACTCCTACAC CTACCCTCGC 960

TTGTCCGAGC CCACAATGTG CATTCCAAAG GTGGATTATG ATCGAGCACA GATGGTCCTC 1020

AGCCCTCCGC TGTCAGGGTC TGACACCTAC CCCAGGGGCC CCGCCAAACT ACCTCAAAGT 1080

CAAAGCAAAG CGGGCTATTC CTCAAGCAGC CACCAGTACC CATCTGGGTA CCACAAAGCC 1140

ACCCTGTACC ACCACCCCTC CCTGCAGACC AGTTCACAGT ACATCTCTAC AGCTTCTTAC 1200

CTGAGCTCTC TGAGTATCTC ATCCAGCACC TACCCCCCAC CCAGCTGGGG ATCATCTTCA 1260

GACCAGCAGC CCTCCAGGGT GTCCCATGAA CAGTTTCGGG CTGCTTTGCA GTTGGTGGTC 1320

AGCCCAGGAG ACCCCAGGGA ATACTTGGAC AACTTTATCA AAATCGGAGA AGGGTCAACC 1380

GGCATTGTAT GCATTGCAAC TGAGAAACAC ACAGGGAAAC AAGTCGCAGT GAAGAAGATG 1440

GACCTCCGAA AGCAACAGAG ACGAGAACTG CTTTTTAATG AGGTTGTTAT AATGCGAGAT 1500

TACCACCATG ACAATGTGGT TGACATGTAC AACAGCTACC TTGTCGGCGA TGAGCTCTGG 1560

GTGGTCATGG AATTTCTAGA AGGCGGTGCC TTGACAGACA TTGTCACTCA TACCAGAATG 1620

AATGAAGAAC AGATAGCTAC CGTCTGTCTG TCAGTTCTGA GAGCTCTCTC CTACCTTCAC 1680

AATCAAGGAG TGATTCACAG GGACATAAAG AGTGACTCCA TCCTCCTGAC AAGTGATGGC 1740

CGGATAAAGT TATCTGACTT TGGTTTCTGT GCTCAAGTTT CTAAAGAGGT GCCAAAAAGG 1800

AAATCACTGG TTGGCACTCC CTACTGGATG GCGCCCGAGG TGATTTCGAG GCTACCTTAT 1860

GGGACAGAGG TGGACATCTG GTCCCTTGGG ATCATGGTGA TAGAAATGAT CGATGGCGAA 1920

CCCCCCTACT TCAATGAGCC TCCCCTCCAG GCAATGCGGA GGATTCGGGA CAGTTTACCT 1980

CCAAGAGTGA AGGACCTACA CAAGGTTTCT TCAGTGCTCC GGGGATTCCT AGACCTGATG 2040

CTGGTGAGGG AACCCTCACA AAGAGCCACA GCCCAGGAAC TCCTTGGACA TCCATTCTTG 2100

AAACTGGCAG GTCCACCATC TTGCATCGTT CCCCTCATGA GACAATACAG ACACCACTGA 2160

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a+ek+tg++va+kk++l+kq++ e+l++e+ ++++++h n+v++++s

Q: 453   IKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYNS  512

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vl+aL+ylH+++viHrdi

Q: 513   YLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDI  569

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g++kLsdfg++aq++k++ krk++vgtpywmAPEvi+  +  Y +++Diw

Q: 570   KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS--RLPYGTEVDIW  627

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slGI++ie+++gepP+++++pl+a+ +i ++ pp++k+ +k+s+ ++ f++ +l ++p++

Q: 628   SLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQ  687

         ************************************************************

S: 245   RpsasellkhkFl  257

         R++a+ell h+Fl

Q: 688   RATAQELLGHPFL  700

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCIATEKHTG KQVAVKKMDL RKQQRRELLF NEVVIMRDYH HDNVVDMYNS 60

YLVGDELWVV MEFLEGGALT DIVTHTRMNE EQIATVCLSV LRALSYLHNQ GVIHRDIKSD 120

SILLTSDGRI KLSDFGFCAQ VSKEVPKRKS LVGTPYWMAP EVISRLPYGT EVDIWSLGIM 180

VIEMIDGEPP YFNEPPLQAM RRIRDSLPPR VKDLHKVSSV LRGFLDLMLV REPSQRATAQ 240

ELLGHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

cfa:485772

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013