EKS-CAF-00156

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00156

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.1	2.7E-167	478	754	277

Status

Unreviewed

Ensembl Protein

ENSCAFP00000009012

UniProt Accession

E2R186;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000005970	ENSCAFP00000009012	ENSCAFT00000009709

Organism

Canis familiaris

Functional Description

Protein Length

822

Protein Sequence
(FASTA)

MWSWKCLLFW AVLVTATLCT ARPAPTLPEQ AQSWGAPVEV ESFLVHPGDL LQLRCRLRDD 60

VQSINWLRDG VQLVESNRTR ITGEEVEVRD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD 120

ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS 180

SGTPNPTLRW LKNGKEFKPD HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN 240

HTYQLDVVER SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI 300

GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS HHSAWLTVLE 360

ALEERPAAMT SPLYLEIIIY CTGAFLISCM VGSVIIYKMK SGTKKSDFHS QMAVHKLAKS 420

IPLRRQVTVS ADSSASMNSG VLLVRPSRLS SSGTPMLAGV SEYELPEDPR WELPRDRLVL 480

GKPLGEGCFG QVVLAEAIGL DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK 540

HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL 600

VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH IDYYKKTTNG 660

RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP YPGVPVEELF KLLKEGHRMD 720

KPSNCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRIVAL TSNQEYLDLS VPLDQYSPSF 780

PDTRSSTCSS GEDSVFSHEP LPEEPCLPRH PAQLANGGLK RR 822

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC ACTGTGCACT 60

GCCAGGCCGG CCCCGACCTT GCCTGAACAA GCCCAGTCCT GGGGAGCCCC TGTGGAAGTG 120

GAGTCCTTCC TGGTCCACCC TGGTGACCTG CTGCAGCTTC GCTGTCGGCT GCGGGACGAT 180

GTGCAGAGCA TCAACTGGCT GCGGGACGGG GTGCAGCTGG TGGAGAGCAA CCGTACCCGC 240

ATCACGGGGG AGGAGGTGGA GGTGCGGGAT TCCGTGCCTG CTGACTCCGG CCTCTACGCT 300

TGTGTGACCA GCAGTCCCTC GGGCAGTGAC ACCACCTACT TCTCCGTCAA TGTCTCAGAT 360

GCTCTCCCCT CCTCAGAGGA CGACGATGAT GATGATGACT CCTCTTCAGA GGAGAAAGAG 420

ACAGATAACA CCAAACCAAA CCGTATGCCC GTGGCTCCGT ACTGGACATC CCCAGAAAAG 480

ATGGAAAAGA AATTGCACGC GGTGCCGGCT GCCAAGACCG TGAAGTTCAA ATGCCCTTCC 540

AGTGGGACTC CCAACCCCAC GCTGCGCTGG TTGAAAAATG GCAAAGAATT CAAACCTGAC 600

CACAGGATTG GAGGCTATAA GGTCCGTTAC GCCACCTGGA GCATCATAAT GGACTCCGTG 660

GTGCCTTCTG ATAAGGGCAA CTACACCTGC ATTGTGGAGA ACGAATATGG CAGCATTAAC 720

CACACCTACC AGCTCGATGT CGTGGAGCGG TCCCCTCACC GGCCCATCCT GCAGGCGGGG 780

CTGCCTGCCA ACAAGACAGT GGCCCTGGGC AGCAATGTGG AGTTCATGTG TAAGGTGTAC 840

AGTGACCCAC AGCCGCATAT CCAGTGGCTC AAGCACATCG AGGTGAATGG GAGTAAGATT 900

GGTCCCGACA ACCTGCCTTA TGTCCAGATC TTGAAGACTG CCGGAGTTAA TACCACCGAC 960

AAAGAGATGG AAGTGCTTCA CTTAAGGAAT GTCTCCTTTG AGGACGCGGG GGAGTATACG 1020

TGCTTGGCGG GTAACTCTAT CGGACTCTCC CATCACTCTG CATGGTTGAC CGTTTTGGAA 1080

GCCCTGGAAG AGAGGCCAGC AGCGATGACC TCGCCCCTAT ACCTGGAGAT CATCATCTAC 1140

TGCACAGGGG CCTTCCTCAT CTCCTGCATG GTGGGCTCTG TCATCATCTA CAAGATGAAG 1200

AGTGGCACCA AAAAGAGCGA CTTCCACAGC CAAATGGCTG TGCACAAGCT GGCCAAGAGC 1260

ATCCCTCTGC GCAGACAGGT AACAGTGTCG GCCGATTCTA GTGCATCCAT GAACTCTGGG 1320

GTTCTGCTGG TTCGGCCCTC ACGTCTCTCC TCAAGTGGAA CACCCATGCT GGCTGGGGTC 1380

TCTGAATATG AGCTTCCCGA AGACCCTCGC TGGGAACTGC CTCGAGACAG GCTGGTTTTA 1440

GGCAAACCCC TGGGAGAGGG CTGCTTTGGG CAGGTGGTAT TGGCAGAAGC CATTGGGCTG 1500

GACAAGGACA AACCCAACCG TGTGACCAAA GTGGCCGTGA AGATGTTGAA GTCGGATGCT 1560

ACAGAGAAAG ACCTGTCAGA CCTGATCTCA GAAATGGAGA TGATGAAGAT GATCGGAAAG 1620

CACAAGAACA TCATCAACCT GCTGGGGGCG TGCACGCAGG ACGGTCCCTT GTATGTCATC 1680

GTGGAGTATG CTTCCAAAGG CAACTTACGG GAGTACCTGC AGGCCCGGAG GCCTCCTGGG 1740

CTGGAGTACT GTTACAATCC CAGCCACAAC CCAGAGGAGC AGCTCTCCTC CAAGGACCTG 1800

GTATCCTGCG CCTATCAGGT GGCCCGAGGC ATGGAATATC TCGCCTCAAA GAAGTGCATA 1860

CACCGAGACC TGGCTGCCAG GAATGTGCTG GTGACGGAGG ACAACGTGAT GAAGATCGCA 1920

GACTTTGGCC TTGCAAGGGA CATTCACCAC ATCGACTACT ATAAAAAGAC AACCAACGGC 1980

CGGCTGCCTG TGAAGTGGAT GGCACCTGAG GCCTTGTTTG ACCGGATCTA CACCCACCAG 2040

AGTGACGTCT GGTCTTTTGG GGTGCTCCTT TGGGAAATCT TCACTCTGGG AGGCTCCCCG 2100

TATCCTGGTG TGCCTGTGGA GGAGCTTTTC AAGCTGCTGA AGGAGGGTCA TCGAATGGAC 2160

AAGCCCAGTA ACTGCACCAA TGAACTGTAC ATGATGATGC GGGATTGCTG GCATGCAGTG 2220

CCCTCTCAGA GACCTACCTT CAAGCAGCTG GTGGAAGACC TGGATCGCAT CGTGGCCTTG 2280

ACCTCCAACC AGGAGTACCT GGACCTGTCA GTGCCCCTGG ACCAATACTC TCCAAGCTTC 2340

CCTGACACCC GAAGCTCCAC CTGCTCCTCG GGGGAGGATT CCGTCTTCTC TCATGAGCCG 2400

TTGCCTGAGG AGCCGTGTCT GCCCCGACAC CCAGCCCAGC TTGCCAATGG CGGACTCAAA 2460

CGACGCTGA 2469

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 478   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  537

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 538   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  597

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 598   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  657

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 658   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  717

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 718   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  754

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013