EKS-CAF-00458

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00458

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	502.5	3.6E-151	26	310	285

Status

Unreviewed

Ensembl Protein

ENSCAFP00000009079

UniProt Accession

E2QZF5;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000006049	ENSCAFP00000009079	ENSCAFT00000009780

Organism

Canis familiaris

Functional Description

Protein Length

1358

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLHS AQNCLPFQKA VEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 180

ADFNYFFDTS RRRTCYIAPE RFVDGGLFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD 240

IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG QFFPEQVLNK IEDRSIRELV TQMIHREPDK 300

RLGAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH 360

DLPEKAEGEP KENGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP 420

YLLHFSNDSV PRVRAEALRT LTKVLALVKE VPRNDVNIYP EYILPGIAHL AQDDATIVRL 480

AYAENIALLA ETALRFLELV QLKNLNMEND PNSEEIGEVT HPNGNYDTEL QALHEMVQQK 540

VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 600

IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALNALT CMCQLGLLQK PHVYEFASDI 660

APFLCHPNLW IRYGAVGFIT VVAHQISTAD VYCKLMPYLE PYITQPIIQI ERKLVLLSVL 720

KEPVSRSIFD YALRSKDITS LFRHLHMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT 780

EEEEDKLLAL KDFMMKSNKA KANIVDQSHL HDSSQKGVID LAALGITGRQ VDLVKTKQEP 840

DDKRARKHVK QDSNVNEEWK SMFGSLEPPN IPQALPKGSE QEVIQTGKPP RSESSAGICV 900

PLSTSPQLPE VTNVQNRKPA IQVLSSAILP STYQIRITTC KTELQQLIQQ KREQCNAERI 960

AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW 1020

NSQKMEGKTT TTRSTLTYSR IGGRVKTLTF CQGSHYLAIA SDNGAVQLLA IEASKLPKSP 1080

KIQPLQSRIL DQKDDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 1140

SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHC HPSRARIRRL SMHPHYQSWV 1200

IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG 1260

SDMKIRFWDL AYPERSYIVA GSTSSSSVSY YRKIIEGTEV VQEIQNKQKV GPSDDTPRKG 1320

PESLPVGHHD IITDVATFQT TQGFIVTASR DGIVKVWK 1358

Nucleotide Sequence
(FASTA)

ATGGGAAATC AGCTTGCTGG CATTGCTCCT TCCCAGATCC TTTCTGTGGA GAGTTATTTC 60

TCAGACATCC ATGACTTTGA ATATGATAAG AGCCTGGGAA GCACTCGGTT TTTTAAAGTT 120

GCTCGAGCGA AGCACCGAGA AGGCCTGGTG GTTGTGAAGG TCTTTGCAAT TCAGGATCCC 180

ACATTGCCTT TAACCAGCTA TAAACAAGAG CTGGAGGAAC TGAAAATCAG GCTTCATTCT 240

GCACAGAACT GTCTGCCTTT TCAGAAAGCA GTGGAAAAAG CATCTGAGAA AGCAGCCATG 300

CTCTTTAGGC AGTATGTGCG AGACAACCTC TATGATCGCA TCAGTACCCG TCCCTTCTTA 360

AATAACATTG AGAAGCGTTG GATTGCTTTC CAGATCCTGA CAGCTGTGGA CCAAGCACAC 420

AAATCTGGAG TCCGTCATGG GGACATCAAG ACTGAGAACG TTATGGTCAC CAGTTGGAAT 480

TGGGTCCTCC TAACTGATTT TGCAAGTTTT AAGCCCACTT ACCTTCCGGA GGACAACCCA 540

GCAGATTTCA ACTATTTCTT TGACACTTCA CGTAGGAGAA CTTGCTATAT TGCTCCTGAA 600

CGTTTTGTTG ATGGTGGATT GTTTGCTACT GAGTTAGAAT ATATGAGGGA TCCTTCAACT 660

CCACTTGTAG ACTTAAATAG TAATCAGAGA ACAAGAGGAG AGTTGAAGCG CGCAATGGAT 720

ATCTTTTCAG CAGGTTGTGT TATAGCTGAA CTTTTTACAG AAGGTGTACC ACTGTTTGAT 780

CTCTCTCAAC TTCTCGCTTA TAGAAATGGA CAGTTTTTCC CGGAACAAGT GCTAAATAAA 840

ATTGAAGATC GCAGTATCAG AGAATTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 900

CGTTTAGGGG CAGAAGATTA CCTAAAGCAG CAGCGTGGCA ATGCCTTTCC TGAAATATTT 960

TACACATTCC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACCTTTCT TTCTGCAGAT 1020

GAGCGCATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGACAT 1080

GATCTGCCAG AAAAAGCAGA AGGAGAGCCT AAGGAAAATG GGCTGGTTAT CTTGGTGTCT 1140

GTTATAACGT CCTGTCTGCA GACCCTTAAA TACTGTGATT CCAAACTTGC TGCTTTGGAA 1200

CTTATTCTCC ATTTGGCCCC AAGATTAAGT GTAGAAATTC TTTTGGATCG TATTACTCCA 1260

TATCTTTTGC ATTTCAGCAA TGACTCTGTT CCTAGAGTGA GGGCTGAAGC CTTGAGGACG 1320

TTGACCAAAG TTCTTGCTCT TGTCAAAGAG GTTCCTCGCA ATGATGTCAA TATATACCCG 1380

GAATATATTC TTCCAGGCAT AGCCCACTTA GCCCAAGATG ATGCTACTAT TGTTAGACTA 1440

GCCTATGCTG AAAACATAGC TCTGCTGGCA GAAACAGCTT TGAGATTCCT GGAATTAGTA 1500

CAGTTAAAAA ATCTCAATAT GGAAAATGAC CCAAATAGTG AAGAAATCGG TGAAGTTACG 1560

CATCCCAATG GAAATTATGA CACAGAGTTG CAAGCCTTAC ATGAAATGGT CCAGCAGAAA 1620

GTTGTCACTT TGCTAAGTGA CCCTGAAAAT ATTGTGAAAC AAACCTTAAT GGAAAATGGA 1680

ATAACACGGT TGTGTGTATT CTTTGGACGT CAGAAAGCCA ATGATGTTTT ATTGTCCCAC 1740

ATGATCACTT TCCTAAATGA TAAGAATGAT TGGCATCTGC GTGGAGCTTT TTTTGATAGT 1800

ATAGTTGGTG TTGCTGCCTA TGTTGGTTGG CAAAGCTCCT CAATTCTCAA ACCCCTGCTG 1860

CAACAAGGTC TTAGTGATGC TGAGGAATTT GTTATTGTTA AAGCTCTTAA TGCCCTTACC 1920

TGTATGTGCC AGTTAGGGCT GCTACAAAAA CCCCATGTCT ATGAATTTGC CAGTGATATT 1980

GCCCCATTTC TGTGTCATCC CAATCTATGG ATACGCTATG GTGCCGTAGG ATTTATCACA 2040

GTGGTAGCTC ATCAAATAAG TACAGCTGAT GTATATTGCA AACTGATGCC TTACCTTGAG 2100

CCATATATTA CTCAACCAAT AATACAGATT GAAAGGAAAC TTGTTCTACT CAGTGTTTTA 2160

AAAGAGCCAG TAAGTCGGTC TATATTTGAT TATGCTTTGA GGTCTAAAGA TATTACTAGT 2220

TTGTTCAGAC ATCTTCACAT GCGCCAGAAG AAACGAAATG GATCTCTTCC TGACTGCCCT 2280

CCACCAGAGG ATCCTGCCAT AGCACAGCTT CTGAAGAAAT TACTCTCACA GGGAATGACA 2340

GAAGAAGAAG AAGATAAACT TTTGGCACTG AAAGACTTCA TGATGAAATC TAACAAAGCA 2400

AAGGCCAATA TAGTTGACCA GAGCCATCTT CATGATAGTA GTCAGAAAGG TGTAATTGAC 2460

TTAGCAGCAT TAGGTATAAC TGGGAGACAA GTTGATCTCG TTAAAACCAA ACAGGAACCT 2520

GATGACAAAC GAGCTAGAAA ACATGTAAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 2580

AGCATGTTTG GATCACTGGA ACCACCGAAC ATCCCACAGG CTCTACCTAA AGGGAGTGAA 2640

CAGGAGGTGA TTCAGACTGG GAAACCACCT CGTTCTGAGT CCTCTGCTGG GATTTGTGTC 2700

CCTCTGTCAA CTTCTCCACA GCTTCCAGAA GTGACAAATG TCCAAAATAG AAAACCAGCA 2760

ATACAAGTTT TAAGTAGTGC GATTTTACCA TCTACCTACC AGATTCGGAT CACAACTTGT 2820

AAAACAGAAC TTCAGCAGCT CATACAGCAA AAGCGGGAGC AGTGTAACGC TGAGAGGATA 2880

GCTAAACAAA TGATGGAAAA TGCTGAATGG GAGAGTAAAC CACCACCACC TGGGTGGCGT 2940

CCTAAAGGGC TACTAGTTGC ACATCTCCAT GAACACAAAT CTGCTGTAAA TCGAATTAGA 3000

GTCTCTGATG AACATTCACT TTTTGCAACA TGTTCAAACG ATGGCACGGT GAAAATCTGG 3060

AATAGTCAAA AGATGGAGGG GAAGACCACC ACTACCAGAT CTACTCTTAC ATATAGCCGA 3120

ATTGGAGGAC GTGTCAAGAC ACTTACATTC TGCCAGGGGT CCCACTACTT AGCCATTGCA 3180

TCCGACAATG GTGCCGTTCA GCTTCTTGCA ATTGAAGCTT CTAAGCTTCC CAAGTCTCCT 3240

AAGATTCAGC CTCTGCAAAG CAGAATTCTA GATCAGAAGG ATGATGGCTG TGTTGTGGAT 3300

ATGCATCACT TCAACTCCGG GGCACAGTCT GTTCTGGCCT ATGCCACTGT GAATGGCTCT 3360

CTAGTTGGTT GGGACCTCAG GTCTTCAAGC AATGCATGGA CACTAAAGCA CGATCTGAAG 3420

TCAGGCCTCA TCACTTCTTT TGCTGTGGAC ATCCATCAGT GCTGGCTCTG CATTGGTACA 3480

AGCAGCGGTA CTATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC CAGTCACTGT 3540

CATCCTTCCA GGGCTCGAAT CAGACGCCTC TCAATGCACC CTCATTATCA GTCCTGGGTG 3600

ATTGCAGCTG TGCAGGGCAA CAATGAAGTA TCCATGTGGG ACATGGAGAC TGGCGACAGA 3660

AGATTCACTC TCTGGGCTAG CAGTGCACCA CCACTCTCTG AGTTACAGCC TTCTCCTCAC 3720

AGTGTCCATG GTATCTACTG TAGTCCTGCA GATGGAAATC CCATCCTTCT AACAGCTGGC 3780

TCAGACATGA AAATAAGGTT TTGGGACTTG GCTTACCCCG AGAGGTCCTA TATTGTTGCA 3840

GGAAGTACTA GTTCTTCATC TGTATCGTAC TATAGGAAAA TAATTGAAGG CACTGAAGTT 3900

GTCCAGGAGA TCCAGAATAA GCAGAAAGTA GGACCGAGTG ATGACACCCC ACGGAAGGGC 3960

CCAGAATCTC TGCCTGTGGG ACACCATGAT ATCATCACAG ATGTGGCCAC GTTCCAGACA 4020

ACACAGGGCT TCATTGTAAC TGCATCTAGA GATGGAATTG TTAAGGTGTG GAAATGA 4077

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCL  85

         68**********************************************************

S: 61    pfqkvlek..ekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvv  118

         pfqk++ek  ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+

Q: 86    PFQKAVEKasEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVR  145

         ******9999**************************************************

S: 119   hGdiktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsa  178

         hGdiktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++

Q: 146   HGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDG  205

         ************************************************************

S: 179   lasdekl...rdgstelvdldsiqrlrgelkkamdifsaGcvilelftegrplfelsqll  235

         + ++++l   rd+st+lvdl+s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqll

Q: 206   GLFATELeymRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLL  265

         ******9999**************************************************

S: 236   ayrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         ayr+g+f++e+vl+kied+++r+lv+q+i++ep+kr+ aed+lk+

Q: 266   AYRNGQFFPEQVLNKIEDRSIRELVTQMIHREPDKRLGAEDYLKQ  310

         *******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPTLPLT SYKQELEELK IRLHSAQNCL 60

PFQKAVEKAS EKAAMLFRQY VRDNLYDRIS TRPFLNNIEK RWIAFQILTA VDQAHKSGVR 120

HGDIKTENVM VTSWNWVLLT DFASFKPTYL PEDNPADFNY FFDTSRRRTC YIAPERFVDG 180

GLFATELEYM RDPSTPLVDL NSNQRTRGEL KRAMDIFSAG CVIAELFTEG VPLFDLSQLL 240

AYRNGQFFPE QVLNKIEDRS IRELVTQMIH REPDKRLGAE DYLKQ 285

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005770	; C:late endosome
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

cfa:477064

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 6.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013