EKS-CAF-00349
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00349
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK290.61.5E-86263517255
StatusUnreviewed
Ensembl ProteinENSCAFP00000009092
UniProt AccessionQ2KM13;
Protein Name
Protein Synonyms/Alias Eukaryotic translation initiation factor 2-alpha kinase 2;
Gene NameEIF2AK2
Gene Synonyms/Alias EIF2AK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000006051ENSCAFP00000009092ENSCAFT00000009794
OrganismCanis familiaris
Functional Description
Protein Length532
Protein Sequence
(FASTA)
MANQRPPSFF IEELNIFCQK HRKVLKYNEL SKEGPAHNLR FTFQAIIDER EYPEAEGKSK 60
KEARNTAAKL ALEILHKENK AVSSLSLPTT DTSEGLGLEG VGNYIGRMNR LAQKEQLSVN 120
YEQWELKDCG PERFHCRCKI GQKEYDIGKG ATKQEAKHLA AKFAYEQIQS EQTLMNADSG 180
SWTTSPSDSR NNTLMRSLCA SKSPLENNFS PNCNRDNVDN SPSSLSNARY SEKKVKRTLA 240
PTFSSPMTKE HKYTVELRFA SDFTEIEPIG SGGYGQVFKA KHKIDGKIYV IKRVKYDSDK 300
KVEREVKALA ALDHVNIVHY RSCWAGEDYN PEDSVNPSRT TKCLFIQMEF CDKGTLEQWI 360
DNRRGKEQDK PLALELFEQI VAGVNYIHSK QLIHRDLKPG NIFLVDTKHI KIGDFGLVTS 420
LKDFANRTSN KGTLRYMSPE QISSQEYGKE VDIFALGLIL AELLYICPTV SETLKIFKEL 480
RAGKFSDVFD AREKQLLQKL LSLEPMKRPN ASEILETLKD WKNVAGKKSR TY 532
Nucleotide Sequence
(FASTA)
ATGGCCAATC AGCGTCCACC AAGTTTTTTT ATTGAAGAAC TTAATATATT CTGTCAGAAG 60
CACAGAAAGG TACTTAAGTA TAATGAACTG TCTAAGGAAG GACCTGCACA TAACTTAAGA 120
TTTACATTCC AAGCTATCAT AGATGAGAGA GAATATCCAG AAGCTGAAGG TAAATCAAAG 180
AAGGAGGCCA GAAATACTGC AGCCAAATTA GCTCTTGAAA TACTTCATAA AGAAAACAAG 240
GCGGTTAGTT CTTTATCACT GCCAACAACA GATACTTCAG AAGGATTAGG ATTAGAAGGC 300
GTTGGGAATT ACATAGGCCG TATGAATAGG CTTGCCCAGA AGGAACAACT ATCTGTAAAT 360
TATGAACAAT GGGAATTGAA GGATTGTGGG CCAGAAAGAT TTCATTGCAG ATGCAAAATT 420
GGACAGAAAG AATATGATAT TGGTAAAGGT GCTACTAAAC AAGAGGCAAA ACATTTGGCT 480
GCTAAATTTG CATATGAACA GATACAGTCA GAGCAAACCT TAATGAATGC TGATTCTGGT 540
TCTTGGACTA CTTCACCTAG TGACTCCAGG AACAACACTT TGATGAGAAG CCTATGTGCT 600
TCAAAATCAC CACTTGAAAA TAATTTCTCA CCAAATTGTA ACAGGGACAA TGTAGACAAC 660
TCTCCATCTT CTCTGAGCAA TGCCAGATAC AGTGAAAAGA AGGTGAAAAG AACTTTAGCA 720
CCTACCTTTA GCTCTCCTAT GACCAAAGAA CACAAGTACA CAGTGGAACT CAGGTTTGCC 780
AGTGATTTTA CAGAAATAGA ACCAATTGGC TCAGGTGGAT ATGGTCAAGT TTTCAAAGCA 840
AAACACAAAA TTGATGGGAA GATTTATGTT ATTAAACGTG TTAAATACGA TAGCGACAAG 900
AAGGTAGAAC GGGAAGTAAA AGCTTTGGCA GCGCTTGATC ACGTAAATAT CGTGCACTAC 960
CGTAGTTGCT GGGCTGGGGA AGATTACAAT CCTGAGGACA GTGTAAATCC TTCAAGAACA 1020
ACTAAGTGCC TTTTCATCCA AATGGAATTC TGTGATAAAG GAACATTGGA GCAATGGATT 1080
GACAACAGAA GAGGCAAGGA ACAAGACAAA CCTTTGGCTC TGGAATTATT TGAACAAATA 1140
GTAGCAGGTG TGAATTATAT ACACAGCAAA CAGCTAATTC ACAGAGACCT TAAGCCAGGA 1200
AACATATTTT TAGTAGATAC AAAACACATA AAGATTGGAG ATTTTGGACT TGTGACATCC 1260
TTGAAAGATT TTGCAAATCG GACAAGTAAT AAAGGAACTC TTCGGTACAT GAGCCCAGAG 1320
CAGATTTCTT CACAAGAATA TGGAAAAGAA GTGGATATCT TTGCTTTGGG GCTAATTCTT 1380
GCAGAACTTC TTTACATATG TCCCACTGTT TCAGAAACAC TGAAGATTTT TAAAGAGCTA 1440
AGGGCTGGCA AGTTCTCAGA TGTGTTTGAT GCCAGAGAAA AACAACTTCT GCAAAAATTA 1500
CTATCACTTG AGCCCATGAA ACGACCTAAT GCATCTGAAA TACTGGAGAC TTTGAAGGAT 1560
TGGAAGAATG TTGCAGGAAA AAAGTCAAGG ACATATTAG 1599
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         f ei+ +G+Gg+g+V+kak+k+d+k y ikr+k+++ k    kverevkaLa l+h niv
Q: 263   FTEIEPIGSGGYGQVFKAKHKIDGKIYVIKRVKYDSDK----KVEREVKALAALDHVNIV  318
         678999******************************76....******************
S: 61    rYfaawleekeesltdsseveaeaeleesesseesdtkllyiqmelceketLkdwiderk  120
         +Y ++w+ e++++                + +++  tk+l+iqme+c+k tL++wid+r+
Q: 319   HYRSCWAGEDYNPE--------------DSVNPSRTTKCLFIQMEFCDKGTLEQWIDNRR  364
         ***********888..............3556778899*********************9
S: 121   llesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLatalaea  180
          +e+ + l ++lf+q++ g++y+Hsk liHrdLkp niFl +++++KigDFgL+t+l++ 
Q: 365   GKEQDKPLALELFEQIVAGVNYIHSKQLIHRDLKPGNIFLVDTKHIKIGDFGLVTSLKDF  424
         9999999999**********************************************8887
S: 181   lkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypfstem  240
          +             +t++ gt +ymsPeq+++++Y+k+vDif+LGlil+eLly + t +
Q: 425   AN-------------RTSNKGTLRYMSPEQISSQEYGKEVDIFALGLILAELLYICPTVS  471
         66.............599******************************************
S: 241   ervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellks  289
         e+ ++++elr gk+++ fd+    ek+llqklls +p++Rp+ase+l++
Q: 472   ETLKIFKELRAGKFSDVFDA---REKQLLQKLLSLEPMKRPNASEILET  517
         ********************...99*********************986
Domain Sequence
(FASTA)
FTEIEPIGSG GYGQVFKAKH KIDGKIYVIK RVKYDSDKKV EREVKALAAL DHVNIVHYRS 60
CWAGEDYNPE DSVNPSRTTK CLFIQMEFCD KGTLEQWIDN RRGKEQDKPL ALELFEQIVA 120
GVNYIHSKQL IHRDLKPGNI FLVDTKHIKI GDFGLVTSLK DFANRTSNKG TLRYMSPEQI 180
SSQEYGKEVD IFALGLILAE LLYICPTVSE TLKIFKELRA GKFSDVFDAR EKQLLQKLLS 240
LEPMKRPNAS EILET 255
KeywordATP-binding; Complete proteome; Initiation factor; Kinase; Nucleotide-binding; Protein biosynthesis; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00319
EKS-ANC-00333
EKS-BOT-00341
EKS-CAE-00276
EKS-CAJ-00350
EKS-CAP-00375
EKS-DAR-00705
EKS-EQC-00333
EKS-FEC-00332
EKS-GAM-00207
EKS-GAG-00287
EKS-GAA-00425
EKS-GOG-00337
EKS-HOS-00348
EKS-ICT-00325
EKS-LAC-00355
EKS-LOA-00352
EKS-MOD-00337
EKS-MUM-00376
EKS-MUP-00336
EKS-MYL-00341
EKS-NOL-00311
EKS-ORN-00446
EKS-ORA-00298
EKS-ORC-00320
EKS-ORL-00412
EKS-OTG-00346
EKS-PAT-00324
EKS-PES-00301
EKS-POA-00334
EKS-RAN-00356
EKS-SAH-00320
EKS-TAG-00417
EKS-TAR-00448
EKS-TAS-00033
EKS-TEN-00445
EKS-TUT-00088
EKS-VIP-00042
EKS-XET-00436
EKS-XIM-00433
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0003725; F:double-stranded RNA binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0003743; F:translation initiation factor activity
GO:0030968; P:endoplasmic reticulum unfolded protein response
GO:0033689; P:negative regulation of osteoblast proliferation
GO:0046777; P:protein autophosphorylation
GO:0006926; P:virus-infected cell apoptotic process
KEGG
cfa:611397;
InterPros
IPR001159; Ds-RNA-bd.
IPR014720; dsRNA-bd-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00035; dsrm; 2.
PF00069; Pkinase; 1.
SMARTs
SM00358; DSRM; 2.
Prosites
PS50137; DS_RBD; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013