EPS-CAF-00093

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAF-00093

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2A	419.6	1.8E-126	51	243	193

Status

Unreviewed

Ensembl Protein

ENSCAFP00000009667

UniProt Accession

E2QV40;

Protein Name

Protein Synonyms/Alias

Gene Name

PPP2CB

Gene Synonyms/Alias

PPP2CB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000006453	ENSCAFP00000009667	ENSCAFT00000010425

Organism

Canis familiaris

Functional Description

Protein Length

309

Protein Sequence
(FASTA)

MDDKAFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG 60

QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER ITILRGNHES 120

RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI 180

RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA 240

HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV 300

TRRTPDYFL 309

Nucleotide Sequence
(FASTA)

ATGGACGACA AGGCGTTCAC CAAGGAGCTG GACCAGTGGG TCGAGCAGCT CAACGAGTGT 60

AAGCAGCTGA ACGAGAACCA GGTGCGGACG CTGTGCGAGA AGGCTAAGGA AATTTTAACA 120

AAAGAATCAA ATGTGCAAGA GGTTCGTTGT CCTGTAACCG TATGCGGAGA TGTGCATGGT 180

CAATTTCATG ATCTTATGGA ACTCTTTCGA ATTGGTGGAA AATCACCAGA TACAAACTAT 240

CTGTTCATGG GCGACTATGT AGACAGAGGC TATTACTCAG TGGAGACTGT GACTCTTCTT 300

GTGGCATTAA AGGTGCGTTA TCCAGAACGC ATTACAATAT TGAGAGGAAA CCATGAAAGC 360

CGACAAATTA CCCAAGTATA TGGCTTTTAC GATGAATGTC TACGAAAGTA TGGAAATGCC 420

AATGTTTGGA AATATTTCAC AGATCTATTT GATTATCTTC CACTTACAGC TTTAGTAGAT 480

GGACAGATAT TCTGCCTCCA CGGTGGCCTC TCTCCATCCA TAGATACACT GGATCATATC 540

AGAGCTTTGG ATCGTTTACA AGAAGTTCCA CATGAGGGCC CAATGTGTGA TCTGTTGTGG 600

TCAGATCCAG ATGATCGTGG TGGGTGGGGT ATTTCACCTC GTGGTGCTGG CTACACATTT 660

GGACAAGACA TTTCTGAAAC ATTTAACCAC GCCAATGGTC TCACACTGGT TTCTCGAGCT 720

CACCAACTTG TAATGGAGGG ATACAATTGG TGTCATGATC GGAATGTGGT TACCATTTTC 780

AGTGCACCCA ATTACTGTTA TCGTTGTGGG AACCAGGCTG CTATCATGGA ATTAGATGAC 840

ACTTTAAAAT ATTCCTTCCT TCAGTTTGAC CCAGCACCTC GTCGTGGAGA GCCTCATGTT 900

ACCCGGCGCA CCCCAGACTA CTTCTTGTAA 930

Domain Profile

S: 1     pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer  60

         pvtvcgdvhgqfhdl+elfriggkspdtnylf+gdyvdrgyysvetvtllvalkvry+er

Q: 51    PVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYPER  110

         9***********************************************************

S: 61    itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl  120

         itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdg+ifclhggl

Q: 111   ITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGL  170

         ************************************************************

S: 121   spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh  180

         spsidtld+iraldrlqevphegp+cdllwsdpddr+gwgisprgagytfgqdise+fnh

Q: 171   SPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNH  230

         ************************************************************

S: 181   angleliarahql  193

         angl+l++rahql

Q: 231   ANGLTLVSRAHQL  243

         ************8

Domain Sequence
(FASTA)

PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER 60

ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL 120

SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH 180

ANGLTLVSRA HQL 193

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0000159	; C:protein phosphatase type 2A complex
GO:0016787	; F:hydrolase activity
GO:0043066	; P:negative regulation of apoptotic process
GO:0043161	; P:proteasomal ubiquitin-dependent protein catabolic process
GO:0010468	; P:regulation of gene expression
GO:0046677	; P:response to antibiotic
GO:0042542	; P:response to hydrogen peroxide

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013