EKS-CAF-00466

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00466

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	414.4	2.6E-124	26	321	296

Status

Unreviewed

Ensembl Protein

ENSCAFP00000009816

UniProt Accession

E2QZN1;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK8

Gene Synonyms/Alias

MAPK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000006551	ENSCAFP00000009816	ENSCAFT00000010587

Organism

Canis familiaris

Functional Description

Protein Length

384

Protein Sequence
(FASTA)

MSRSKRDSNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 240

LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300

MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360

MDLEERTKNG VIRGQPSPLA QVQQ 384

Nucleotide Sequence
(FASTA)

ATGAGCAGAA GCAAGCGTGA CAGCAATTTT TATAGTGTAG AGATTGGAGA TTCCACATTT 60

ACAGTCTTGA AACGATATCA GAATTTAAAA CCTATAGGCT CAGGAGCTCA AGGAATAGTA 120

TGTGCAGCTT ATGATGCCAT TCTTGAAAGA AATGTTGCAA TCAAGAAACT AAGCCGGCCA 180

TTTCAGAATC AGACTCATGC TAAACGGGCT TACAGAGAGC TAGTTCTTAT GAAATGTGTT 240

AATCACAAAA ATATAATTGG CCTTTTGAAT GTTTTCACAC CACAGAAATC CCTAGAAGAA 300

TTTCAAGATG TTTACATAGT CATGGAGCTC ATGGACGCAA ATCTTTGCCA AGTGATTCAG 360

ATGGAACTAG ATCATGAAAG AATGTCCTAC CTGCTCTATC AGATGCTGTG TGGAATCAAG 420

CACCTTCACT CTGCTGGAAT TATTCATCGG GACTTAAAGC CCAGTAATAT AGTGGTAAAA 480

TCAGACTGCA CTTTGAAGAT TCTTGACTTT GGACTGGCCA GGACTGCAGG AACTAGTTTT 540

ATGATGACAC CTTATGTAGT GACTCGCTAC TACAGAGCAC CTGAGGTCAT CCTAGGGATG 600

GGCTACAAAG AAAACGTTGA CATTTGGTCA GTTGGGTGCA TCATGGGAGA AATGATCAAA 660

GGTGGTGTTT TGTTCCCAGG TACAGATCAT ATTGATCAGT GGAATAAAGT TATTGAACAG 720

CTTGGAACAC CATGCCCTGA ATTCATGAAG AAACTACAGC CAACAGTAAG GACTTATGTT 780

GAAAACAGAC CTAAATATGC TGGATATAGC TTTGAGAAAC TCTTCCCCGA TGTACTTTTC 840

CCAGCTGACT CAGAACACAA CAAACTTAAA GCCAGTCAGG CAAGGGATTT GTTATCCAAA 900

ATGTTGGTAA TTGATGCATC TAAAAGGATC TCTGTAGATG AAGCTCTCCA GCACCCATAT 960

ATCAATGTCT GGTATGATCC TTCTGAAGCA GAAGCTCCAC CACCAAAGAT ACCTGACAAG 1020

CAGTTAGATG AAAGGGAACA TACAATAGAA GAGTGGAAAG AGTTGATATA CAAAGAAGTT 1080

ATGGACTTGG AGGAGAGAAC CAAGAATGGA GTTATACGGG GGCAGCCCTC TCCTTTAGCA 1140

CAGGTGCAGC AGTGA 1155

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i ll+vftp+++lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    IGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+

Q: 202   YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY

Q: 261   ENRPKYAGYSFEKLFPDvlfpadsehnklKASQARDLLSKMLVIDASKRISVDEALQHPY  320

         *****************************99*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

IGLLNVFTPQ KSLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMIKGGVLF PGTDHIDQWN KVIEQLGTPC PEFMKKLQPT VRTYVENRPK 240

YAGYSFEKLF PDVLFPADSE HNKLKASQAR DLLSKMLVID ASKRISVDEA LQHPYI 296

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

cfa:477746

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013