EKS-CAF-00194

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00194

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ryk	490.6	1.3E-147	297	563	267

Status

Unreviewed

Ensembl Protein

ENSCAFP00000010007

UniProt Accession

F1PKW2;

Protein Name

Protein Synonyms/Alias

Gene Name

RYK

Gene Synonyms/Alias

RYK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000006715	ENSCAFP00000010007	ENSCAFT00000010802

Organism

Canis familiaris

Functional Description

Protein Length

574

Protein Sequence
(FASTA)

MSAALPVLPA GRVFCRKPQS LSHCIWYLYR ITKAMPPKKC SFPLGLDAEL YYVRNDLISH 60

YALSFNLLVP SETNFLHFTW HAKSKVEYKL GFQVDNFVAM DMPQVNISAQ GEVPRTLSVF 120

RVELSCTGKV DSEVMILMQL NLTVNSSKNF TVLNFKRRKM CYKKLEEVKT SALDKNTSRT 180

IYDPVHAAPT TSTRVFYISV GVCCAVIFLV AIILAVLHLH SMKRIELDDS ISASSSSQGL 240

SQPSTQTTQY LRADTPNNAT PITSYPTLRI EKNDLRSVTL LEAKAKVKDI AISRERITLK 300

DVLQEGTFGR IFHGILVDEK DPNKEKQAFV KTVKDQASEI QVTMMLTESC KLRGLHHRNL 360

LPITHVCIEE GEKPMVILPY MNWGNLKLFL RQCKLVEANN PQAISQQDLV HMAIQIACGM 420

SYLARREVIH KDLAARNCVI DDTLQVKITD NALSRDLFPM DYHCLGDNEN RPVRWMALES 480

LVNNEFSSAS DVWAFGVTLW ELMTLGQTPY VDIDPFEMAA YLKDGYRIAQ PINCPDELFA 540

VMACCWALDP EERPKFQQLV QCLTEFHAAL GAYV 574

Nucleotide Sequence
(FASTA)

ATGTCTGCAG CGCTACCTGT CCTGCCAGCA GGGAGGGTCT TTTGTAGAAA ACCCCAGAGT 60

TTGTCCCATT GCATTTGGTA CCTCTATAGG ATAACTAAAG CAATGCCACC CAAAAAGTGC 120

AGCTTTCCCC TAGGTCTTGA TGCAGAACTT TATTATGTGA GAAATGACCT TATTAGTCAC 180

TACGCTCTAT CCTTTAACCT GTTAGTACCC AGTGAGACAA ATTTCCTGCA CTTCACTTGG 240

CATGCAAAGT CTAAGGTTGA ATATAAGCTG GGATTCCAAG TAGACAATTT TGTGGCTATG 300

GACATGCCCC AGGTCAACAT TTCTGCTCAG GGGGAAGTTC CACGCACTTT ATCAGTGTTT 360

CGGGTCGAGC TTTCCTGTAC TGGCAAAGTA GATTCTGAGG TTATGATACT AATGCAGCTC 420

AACTTGACAG TAAATTCTTC AAAAAACTTT ACAGTTTTAA ACTTTAAGCG AAGGAAAATG 480

TGCTACAAAA AACTTGAAGA AGTTAAAACT TCAGCCTTGG ACAAAAACAC TAGCAGAACT 540

ATTTATGATC CTGTACATGC AGCTCCGACC ACTTCTACTC GTGTGTTTTA TATCAGCGTG 600

GGAGTTTGCT GTGCAGTAAT ATTTCTTGTA GCAATAATAT TAGCTGTTTT GCACCTTCAT 660

AGTATGAAAA GAATTGAACT GGATGACAGC ATCAGTGCCA GCAGTAGTTC CCAAGGGCTT 720

TCTCAGCCAT CTACCCAGAC GACTCAGTAT CTGAGAGCCG ACACACCCAA CAATGCAACT 780

CCTATCACCA GTTATCCTAC CTTGCGGATA GAGAAGAACG ATCTGAGAAG TGTCACTCTT 840

TTGGAGGCCA AAGCTAAGGT GAAGGATATA GCAATATCCA GGGAGAGGAT AACTTTAAAA 900

GATGTACTCC AAGAAGGTAC TTTTGGACGT ATTTTCCATG GGATTTTAGT AGATGAAAAG 960

GATCCAAATA AAGAAAAACA AGCATTTGTA AAAACAGTTA AAGATCAAGC TTCTGAAATT 1020

CAGGTGACAA TGATGCTCAC AGAAAGTTGT AAGCTACGAG GTCTTCATCA CAGAAATCTT 1080

CTTCCTATTA CGCATGTATG TATAGAAGAA GGAGAAAAGC CCATGGTGAT ACTGCCTTAC 1140

ATGAATTGGG GGAATCTTAA ATTGTTTTTA CGGCAGTGCA AATTAGTAGA GGCCAATAAT 1200

CCTCAGGCAA TTTCTCAACA AGACCTGGTA CACATGGCAA TTCAGATTGC CTGTGGAATG 1260

AGCTATCTGG CCAGAAGGGA AGTTATCCAC AAAGACCTGG CTGCTAGAAA CTGTGTCATT 1320

GATGACACAC TTCAAGTTAA GATCACAGAT AATGCTCTCT CCAGAGACTT GTTCCCCATG 1380

GACTATCATT GTCTAGGGGA CAACGAAAAC AGGCCAGTTC GGTGGATGGC TCTGGAAAGT 1440

CTGGTTAATA ATGAGTTCTC CAGCGCTAGT GATGTGTGGG CCTTCGGAGT GACGCTGTGG 1500

GAGCTCATGA CTCTGGGCCA GACGCCCTAT GTGGACATTG ATCCCTTTGA GATGGCTGCA 1560

TACCTGAAGG ATGGTTACCG AATAGCCCAA CCAATCAACT GTCCTGATGA GCTATTTGCT 1620

GTGATGGCTT GTTGCTGGGC CTTAGATCCG GAGGAGAGGC CCAAGTTCCA GCAGCTGGTA 1680

CAGTGTCTCA CGGAGTTCCA CGCAGCCCTG GGGGCCTATG TCTGA 1725

Domain Profile

S: 1     lrlkellqeGtfGriyrGkledekdtnkekavlvktvkdqaseiqvalllqealllygvs  60

         ++lk++lqeGtfGri++G+l dekd+nkek+++vktvkdqaseiqv+++l+e+++l+g++

Q: 297   ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLH  356

         6799********************************************************

S: 61    hrnilsvllvsieeaekPlvvypalnkgnlkkflricklkdkekaqalstkqlvelaiqi  120

         hrn+l++++v+iee ekP+v++p++n+gnlk flr+ckl++++++qa+s+++lv++aiqi

Q: 357   HRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQI  416

         ************************************************************

S: 121   asalaylhkrevvhkdiaarncviddelqvkltdsalsrdlfPadydclGdnenrPlkWl  180

         a++++yl++rev+hkd+aarncvidd+lqvk+td+alsrdlfP+dy+clGdnenrP++W+

Q: 417   ACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWM  476

         ************************************************************

S: 181   slealqkeeyssasdvWalGvllWelvtlgksPyaeidpfeleaylkdGyrlaqPvncPd  240

         +le+l+++e+ssasdvWa+Gv+lWel+tlg++Py++idpfe++aylkdGyr+aqP+ncPd

Q: 477   ALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPD  536

         ************************************************************

S: 241   elftvmaccWallpeerPsfeqlvscl  267

         elf+vmaccWal+peerP+f+qlv+cl

Q: 537   ELFAVMACCWALDPEERPKFQQLVQCL  563

         **************************8

Domain Sequence
(FASTA)

ITLKDVLQEG TFGRIFHGIL VDEKDPNKEK QAFVKTVKDQ ASEIQVTMML TESCKLRGLH 60

HRNLLPITHV CIEEGEKPMV ILPYMNWGNL KLFLRQCKLV EANNPQAISQ QDLVHMAIQI 120

ACGMSYLARR EVIHKDLAAR NCVIDDTLQV KITDNALSRD LFPMDYHCLG DNENRPVRWM 180

ALESLVNNEF SSASDVWAFG VTLWELMTLG QTPYVDIDPF EMAAYLKDGY RIAQPINCPD 240

ELFAVMACCW ALDPEERPKF QQLVQCL 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR003306	; WIF.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF02019	; WIF; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50814	; WIF; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013