EKS-CAF-00394

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00394

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	324.8	6.0E-97	1398	1662	265

Status

Unreviewed

Ensembl Protein

ENSCAFP00000010286

UniProt Accession

F1PT92;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000006917	ENSCAFP00000010286	ENSCAFT00000011105

Organism

Canis familiaris

Functional Description

Protein Length

1667

Protein Sequence
(FASTA)

MTGRTPSRRH PPDAPTHRIS KRNLPTGRAE IAAERKRRTA AAEAPPLAGA AREHLAAGRG 60

RHAKPRAPLR RLRPRPPRPA ARAPGPLAPP ARRRPRSSPA AGPRAPARPS GPSARRAPLT 120

QLAQAALRQR RSARRPALPL RSPRPLPPSQ GPSECSPREK MAAAAGNRAS SSGFPGAGAA 180

SPEAGGGGAA LKASSAPAAA AGLLREGGSG GRERADWRRR QLRKVRSVEL DQLPEPPLFL 240

AASPPSSSPS PSPEPSDAAA GGSAFQPLAA PQPHGAASRG GARPPEPAAA PDSGAPSPAG 300

AEPGEKRTPA AEPPPAAAPA GREMENKETL KGLHKMDDRP EERMIREKLK ATCMPAWKHE 360

WLERRNRRGP VVVKPIPTKG DGSEIHNLAT ESQGEGQAST ASPTAKGRRS PSPGSSPSGR 420

TVKSESPGVR RKRVSPVPFQ SGRITPPRRA PSPDGFSPYS PEETNRRVNK VMRARLYLLQ 480

QIGPNSFLIG GDSPDNKYRV FIGPQNCSCG RGTFCIHLLF VMLRVFQLEP SDPMLWRKTL 540

KNFEVESLFQ KYHSRRSSRI KAPSRNTIQK FVSRMSNSHT LSSSSTSTSS SENSIKDEEE 600

QMCPICLLGM LDEESLTVCE DGCRNKLHHH CMSIWAEECR RNREPLICPL CRSKWRSHDF 660

YSHELSSPVD SPSSLRAAQQ QTIQQQPLAG SQRRSQESNF NLTHYGTQQI PPAYKDLAEP 720

WIQVFGMELV GCLFSKNWNV REMALRRLSH DVSGALLLAN GESTGNSGSN GRSSPSAGAS 780

SGSSQTSISG DVVEACCNVL SMVCADPVYK VYVAALKTLR AMLVYTPCHS LAERIKLQRL 840

LRPVVDTILV KCADANSRTS QLSISTLLEL CKGQAGELAV GREILKAGSI GIGGVDYVLS 900

CILGNQTESN NWQELLGRLC LVDRLLLEFP AEFYPHIVST DVSQAEPVEV RYKKLLSLLT 960

FALQSIDNSH SMVGKLSRRI YLSSARMVTA VPHVFSKLLE MLNVSSSTHF TRMRRRLMAI 1020

ADEVEIAEAI HLGIGDTLDD RHDSFLQASV PTSYPEATEN SPLERTDHLE KTGKGLCATK 1080

LSANSEDITD RLGSISVGLP SSTMEQPKPM VQTKGRPHSQ CLNSSPLSHH SPLMFPPLST 1140

PPSSAPSAPP GTGTDVSKHR PQGFTPCKIP SASPQTQRKF SLQFQRNCSE NRDSDKLSPI 1200

FTQSRPLPSS NIHRPKPSRP TPGNTSKQGD ASKNSMTLDL NSTSKCDDSF GSSSNSSNAL 1260

IPSDETVFTP VEEKCRLDVN TELNSSIEDL LEASMPSSDT TVTFKSEVAV LSPEKDENDD 1320

TYKDDVNHNQ KCKEKMEAEE EEALAIAMAM SASQDALPIV PQLQVENGED IIIIQQDTPE 1380

TLPGHTKAKQ PYREDTEWLK GQQIGLGAFS SCYQAQDVGT GTLMAVKQVT YVRNTSSEQE 1440

EVVEALREEI RMMSHLNHPN IIRMLGATCE KSNYNLFIEW MAGGSVAHLL SKYGAFKESV 1500

VINYTEQLLR GLSYLHENQI IHRDVKGANL LIDSTGQRLR IADFGAAARL ASKGTGAGEF 1560

QGQLLGTIAF MAPEVLRGQQ YGRSCDVWSV GCAIIEMACA KPPWNAEKHS NHLALIFKIA 1620

SATTAPSIPS HLSPGLRDVA LRCLELQPQD RPPSRELLKH PVFRTTW 1667

Nucleotide Sequence
(FASTA)

ATGACAGGCC GTACGCCCTC TCGCCGGCAC CCGCCCGACG CACCAACACA CCGAATTTCG 60

AAACGCAACC TCCCGACCGG CCGGGCCGAG ATTGCGGCCG AGAGGAAGCG GCGCACGGCC 120

GCCGCGGAGG CTCCTCCTCT CGCCGGTGCA GCCCGGGAGC ACCTGGCGGC CGGGCGAGGG 180

CGGCACGCAA AGCCCAGGGC GCCTTTGCGG CGGCTGCGTC CCCGCCCGCC TCGCCCGGCC 240

GCGCGGGCGC CGGGCCCACT CGCTCCACCT GCTCGGCGCC GGCCCCGCTC CTCCCCCGCG 300

GCCGGGCCCC GTGCGCCCGC CCGGCCGTCC GGGCCCAGCG CCCGGCGGGC CCCGCTCACG 360

CAGTTGGCGC AGGCTGCCCT ACGCCAGCGG CGCAGCGCCC GCCGGCCCGC CCTCCCCCTG 420

CGCTCTCCCC GCCCCCTCCC TCCCTCGCAG GGGCCGAGCG AATGTAGCCC GCGAGAGAAA 480

ATGGCGGCGG CGGCGGGGAA TCGCGCCTCG TCGTCGGGAT TCCCGGGCGC CGGGGCGGCG 540

AGCCCCGAGG CGGGCGGCGG CGGAGCGGCT CTCAAGGCGA GCAGCGCGCC CGCGGCAGCC 600

GCGGGGCTGC TGCGGGAGGG GGGCAGCGGG GGCCGCGAGC GGGCTGACTG GCGGCGGCGG 660

CAGCTGCGCA AAGTGCGGAG CGTGGAGCTG GACCAGCTGC CGGAGCCGCC GCTCTTCCTC 720

GCCGCCTCGC CGCCGTCCTC CTCCCCTTCC CCGTCGCCGG AGCCCTCGGA CGCCGCGGCG 780

GGCGGGAGCG CCTTCCAGCC TCTGGCGGCG CCGCAGCCGC ACGGAGCCGC GAGCCGTGGC 840

GGCGCCCGCC CTCCGGAGCC CGCGGCCGCC CCGGACAGCG GCGCCCCGAG CCCCGCGGGG 900

GCCGAGCCCG GGGAGAAGCG GACGCCCGCC GCCGAGCCGC CTCCTGCAGC GGCCCCCGCC 960

GGTCGTGAGA TGGAGAATAA AGAAACTCTC AAGGGGTTGC ACAAGATGGA CGATCGCCCA 1020

GAAGAACGAA TGATTAGGGA GAAACTGAAG GCAACCTGTA TGCCTGCCTG GAAGCACGAG 1080

TGGCTGGAAA GGAGAAACAG GAGAGGCCCT GTGGTGGTAA AACCAATCCC TACTAAAGGA 1140

GATGGTTCTG AAATTCACAA TCTGGCTACT GAGTCTCAAG GAGAAGGCCA GGCAAGCACT 1200

GCATCACCCA CTGCTAAAGG CCGACGCAGT CCTTCTCCTG GCAGCTCCCC ATCTGGTCGC 1260

ACAGTGAAGT CCGAATCTCC GGGAGTTCGG AGAAAAAGAG TTTCCCCGGT GCCTTTTCAG 1320

AGTGGGAGAA TCACACCACC TCGAAGAGCC CCTTCACCAG ATGGCTTCTC ACCATATAGC 1380

CCAGAGGAGA CAAACCGCCG TGTAAACAAA GTTATGAGAG CCAGGCTGTA CTTATTGCAA 1440

CAAATAGGAC CCAACTCTTT CCTGATTGGA GGAGACAGCC CGGACAATAA ATACCGGGTG 1500

TTTATTGGGC CTCAGAACTG CAGCTGTGGG CGTGGAACAT TTTGTATTCA TCTGTTGTTT 1560

GTTATGCTCC GGGTATTTCA ACTGGAACCT TCAGATCCAA TGTTATGGAG AAAAACTTTA 1620

AAGAATTTTG AGGTTGAAAG TTTGTTCCAG AAATATCACA GTAGGCGTAG CTCAAGGATC 1680

AAAGCTCCAT CTCGTAACAC CATCCAGAAG TTTGTTTCAC GCATGTCAAA TTCTCATACA 1740

TTGTCATCAT CTAGTACTTC TACATCTAGT TCAGAAAACA GTATAAAAGA TGAGGAGGAG 1800

CAGATGTGTC CTATTTGCTT GTTGGGCATG CTAGATGAAG AGAGCCTCAC GGTGTGTGAA 1860

GATGGCTGCA GAAACAAGCT GCATCACCAC TGCATGTCAA TCTGGGCAGA AGAATGTAGA 1920

AGAAATAGAG AGCCTTTAAT ATGTCCCCTT TGTAGGTCTA AGTGGAGATC TCACGATTTC 1980

TACAGCCATG AATTGTCAAG CCCTGTGGAT TCCCCTTCTT CCCTGCGAGC TGCACAGCAG 2040

CAAACCATAC AACAGCAGCC TTTGGCTGGA TCACAACGAA GGAGTCAGGA GAGCAATTTT 2100

AACCTTACTC ATTATGGAAC TCAGCAGATT CCTCCTGCTT ATAAAGATTT AGCTGAGCCA 2160

TGGATTCAGG TATTTGGAAT GGAACTTGTT GGCTGCTTAT TTTCTAAAAA CTGGAATGTA 2220

AGAGAGATGG CTCTCAGGCG TCTTTCACAC GATGTTAGTG GGGCTTTGCT CTTGGCAAAT 2280

GGGGAGAGCA CTGGAAACTC TGGGAGCAAC GGTAGAAGCA GTCCGAGTGC TGGAGCCAGC 2340

AGTGGGTCTT CCCAGACCAG TATCTCAGGA GACGTGGTAG AGGCATGCTG CAACGTTTTG 2400

TCAATGGTCT GTGCTGACCC TGTCTACAAA GTGTACGTTG CTGCTTTAAA AACATTGAGA 2460

GCCATGCTAG TATATACTCC TTGCCATAGT TTGGCAGAAA GAATCAAACT GCAGAGACTT 2520

CTCCGGCCAG TGGTAGACAC CATCCTAGTC AAGTGTGCAG ATGCCAATAG TCGTACAAGT 2580

CAGCTGTCTA TATCAACACT GTTGGAATTA TGCAAAGGCC AAGCAGGAGA GTTGGCAGTT 2640

GGCAGAGAAA TACTTAAAGC TGGATCCATT GGTATTGGTG GCGTGGATTA CGTCTTAAGT 2700

TGTATTCTTG GAAACCAAAC TGAGTCAAAC AACTGGCAAG AACTTCTGGG CCGCCTTTGT 2760

CTTGTAGACA GACTGCTGTT GGAATTTCCT GCTGAATTTT ACCCTCATAT TGTCAGTACT 2820

GATGTTTCAC AAGCTGAGCC TGTTGAAGTC AGGTATAAAA AGCTGCTGTC CCTCTTAACC 2880

TTTGCTTTGC AGTCCATTGA TAATTCCCAC TCAATGGTTG GTAAACTCTC CCGAAGGATA 2940

TATTTGAGTT CTGCAAGAAT GGTTACTGCA GTACCCCACG TATTTTCAAA ACTATTAGAA 3000

ATGCTGAATG TTTCCAGTTC CACTCATTTT ACCAGGATGC GTCGTCGTTT GATGGCTATT 3060

GCAGATGAGG TGGAAATCGC TGAGGCCATC CATCTGGGCA TAGGAGACAC TTTGGATGAT 3120

CGACATGACA GCTTTTTGCA GGCATCCGTC CCCACCAGCT ATCCAGAAGC CACAGAGAAC 3180

AGCCCCCTTG AGCGTACAGA CCATTTAGAG AAAACTGGAA AAGGACTGTG TGCTACAAAA 3240

CTGAGTGCCA ATTCAGAGGA CATTACTGAC AGACTGGGCA GCATTTCCGT AGGACTTCCC 3300

AGTTCAACAA TGGAGCAACC AAAGCCAATG GTTCAAACAA AAGGCAGACC GCACAGTCAG 3360

TGTTTGAACT CCTCTCCTTT ATCTCATCAT TCCCCGTTAA TGTTTCCACC CTTGTCAACT 3420

CCTCCTTCAT CTGCCCCATC TGCACCACCT GGCACTGGAA CAGATGTCTC TAAGCATAGA 3480

CCTCAGGGAT TCACTCCCTG CAAAATACCT TCTGCATCTC CTCAAACACA GCGCAAGTTT 3540

TCTCTACAGT TCCAGAGAAA CTGTTCCGAA AACAGAGACT CAGATAAACT TTCCCCCATT 3600

TTTACTCAAT CAAGACCCCT GCCCTCTAGT AACATACACA GGCCAAAGCC ATCTCGACCT 3660

ACCCCAGGTA ATACAAGTAA ACAGGGAGAT GCCTCAAAGA ATAGCATGAC ACTTGATCTG 3720

AACAGTACTT CCAAATGTGA TGACAGCTTT GGCAGCAGCA GCAATAGTAG TAATGCTCTT 3780

ATACCCAGTG ATGAGACAGT GTTCACCCCA GTAGAAGAGA AATGCAGGTT AGATGTCAAC 3840

ACAGAACTCA ACTCCAGTAT TGAGGACCTT CTTGAAGCAT CCATGCCTTC AAGTGACACG 3900

ACAGTAACTT TTAAGTCAGA AGTTGCTGTC CTCTCTCCTG AAAAGGATGA AAATGATGAT 3960

ACCTACAAAG ATGATGTGAA TCATAATCAG AAATGCAAAG AAAAGATGGA AGCTGAAGAA 4020

GAAGAAGCTT TAGCAATTGC CATGGCAATG TCAGCGTCTC AGGATGCCCT CCCCATAGTT 4080

CCTCAACTAC AGGTTGAAAA TGGAGAAGAT ATCATCATTA TTCAACAGGA TACACCGGAA 4140

ACTCTACCAG GACATACCAA AGCAAAACAA CCTTACAGAG AAGACACTGA ATGGCTGAAA 4200

GGTCAGCAGA TAGGCCTTGG AGCATTTTCT TCTTGTTACC AGGCTCAGGA TGTGGGAACT 4260

GGAACTTTAA TGGCTGTTAA ACAGGTGACA TATGTCAGAA ATACATCTTC TGAACAAGAA 4320

GAAGTAGTGG AAGCATTAAG AGAAGAGATC AGAATGATGA GCCATTTGAA TCATCCCAAC 4380

ATCATTAGGA TGTTGGGAGC CACATGTGAG AAGAGCAATT ATAATCTCTT CATTGAATGG 4440

ATGGCAGGGG GATCTGTGGC TCATTTGCTC AGTAAATACG GGGCCTTCAA GGAATCAGTA 4500

GTTATTAACT ATACTGAACA GTTACTTCGT GGCCTTTCCT ATCTCCATGA AAACCAGATC 4560

ATTCATAGAG ATGTCAAAGG TGCCAATTTG CTAATTGACA GCACAGGTCA GAGACTGAGA 4620

ATTGCAGATT TTGGAGCTGC AGCCAGGTTG GCATCAAAAG GAACTGGTGC AGGAGAGTTT 4680

CAGGGACAGT TATTGGGAAC AATTGCATTT ATGGCACCTG AGGTACTGAG AGGTCAGCAG 4740

TATGGTAGGA GCTGTGATGT ATGGAGTGTT GGCTGTGCTA TTATAGAAAT GGCTTGTGCT 4800

AAACCACCTT GGAATGCAGA AAAACACTCC AATCATCTTG CTTTGATATT TAAGATTGCA 4860

AGTGCGACGA CTGCTCCATC AATCCCCTCA CATTTGTCTC CTGGTTTACG AGATGTGGCT 4920

CTTCGGTGTT TAGAACTTCA ACCTCAGGAC AGACCCCCGT CAAGAGAGCT ACTGAAGCAT 4980

CCGGTCTTCC GTACTACATG GTAG 5004

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1398  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1457

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1458  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1517

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1518  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1577

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1578  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1635

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1636  LRDVALRCLELQPQDRPPSRELLKHPV  1662

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013