EKS-CAF-00381
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00381
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK316.12.1E-94161396236
StatusUnreviewed
Ensembl ProteinENSCAFP00000010290
UniProt AccessionE2RLX4;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K12
Gene Synonyms/Alias MAP3K12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000006918ENSCAFP00000010290ENSCAFT00000011109
OrganismCanis familiaris
Functional Description
Protein Length893
Protein Sequence
(FASTA)
MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLSGQGG 60
GGPSPSPGGE PPPEPFANSV LQLHEQDAGG PGGATGSPES RASRVRADEV RLQCQSGSGF 120
LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180
EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240
VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300
MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360
HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420
EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480
LQLELKEREL LRREQALERR CPGLLKPHPS RSLLHGNTME KLIKKRNVPQ KLSPHSKRPD 540
ILKTESLLPK LDAALSGVGL PGCPKGPPSP GRSRRGKTRH RKASAKGSCG DLPGLRAALP 600
PHEPGGPGSP GGLGGGPSAW EACPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGATG 660
GAGDPGSPPP ARGDTPPSEG SAPGSTSPDS PGGAKGEPPP PVGPGDVVGL LGTGREGTAG 720
RGGSRAGSQH LTPAALLYRA AVTRSQKRGI SSEEEEGEVD SEVELTSSQR WPQGLNMRQS 780
RSTFSSENPS DGEEGTASEP SPSGTPEVGS TNTDERPDER SDDMCSQGSE IPLDPPASEV 840
VPGPEPSSLP IPPQDLPRGE QGPPSIEDSD CDSTELDNSN SGEALQPPAS LPP 893
Nucleotide Sequence
(FASTA)
ATGGCCTGCC TCCATGAGAC CCGCACGCCC TCCCCTTCCT TCGGGGGTTT CGTGTCCACC 60
CTAAGTGAGG CGTCTATGCG CAAGCTCGAC CCAGACACTT CCGACTGCAC CCCGGAGAAG 120
GACCTGACGC CTACCCAGTG TGTACTTCGA GATGTAGTGC CGCTCAGTGG GCAGGGTGGG 180
GGCGGACCCA GCCCCTCCCC AGGTGGAGAG CCGCCCCCTG AGCCTTTTGC CAATAGTGTC 240
CTTCAGCTCC ACGAGCAGGA TGCAGGGGGC CCAGGGGGAG CCACTGGGTC CCCTGAGAGT 300
AGAGCATCCA GAGTTCGAGC CGACGAGGTA CGGCTGCAGT GCCAGAGTGG CAGTGGCTTC 360
CTGGAAGGGC TCTTCGGCTG CCTGCGTCCT GTCTGGACCA TGATTGGCAA AGCCTACTCT 420
ACAGAGCACA AGCAGCAGCA GGAAGACCTT TGGGAGGTCC CCTTTGAGGA AATCCTGGAC 480
CTGCAGTGGG TGGGCTCAGG GGCCCAGGGC GCTGTCTTCC TGGGGCGCTT CCATGGGGAG 540
GAGGTGGCTG TAAAGAAGGT GCGGGACCTG AAGGAGACTG ACATCAAGCA CCTGCGAAAG 600
CTGAAGCACC CCAACATCAT CACCTTCAAG GGCGTGTGCA CCCAGGCTCC CTGCTACTGC 660
ATCCTCATGG AGTTCTGCGC CCAGGGCCAG CTGTATGAGG TACTGCGGGC CGGCCGCCCC 720
GTCACCCCCT CGCTGCTGGT CGACTGGTCC ATGGGCATTG CCGGTGGCAT GAACTACCTG 780
CACCTGCACA AGATCATCCA TAGAGACCTC AAGTCCCCCA ACATGCTAAT CACGTACGAC 840
GATGTGGTGA AGATCTCCGA TTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 900
ATGTCCTTTG CAGGGACAGT GGCCTGGATG GCCCCCGAAG TGATCCGCAA TGAGCCTGTG 960
TCTGAGAAGG TCGACATCTG GTCCTTTGGT GTGGTGCTGT GGGAACTGCT GACTGGCGAG 1020
ATCCCCTACA AGGACGTAGA CTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTC 1080
CATCTGCCTG TGCCCTCCAG CTGCCCCGAC GGCTTCAAAA TCCTGCTTCG CCAGTGTTGG 1140
AACAGCAAAC CAAGAAACCG CCCATCGTTC CGCCAGATCC TGCTGCACTT GGACATCGCC 1200
TCAGCCGACG TCCTCTCCAC ACCCCAGGAG ACCTATTTCA AGTCCCAGGC AGAGTGGCGC 1260
GAAGAGGTAA AGCTGCACTT TGAAAAAATT AAGTCAGAAG GGACGTGTCT GCACCGCCTA 1320
GAAGAGGAGC TGGTGATGCG GAGGAGGGAG GAGCTCAGAC ACGCCTTGGA CATCAGGGAG 1380
CACTACGAAC GGAAGCTGGA GAGAGCCAAC AACCTGTACA TGGAACTTAA TGCCCTCATG 1440
CTGCAGCTGG AGCTCAAGGA GCGGGAGCTG CTCAGGAGGG AGCAAGCTTT AGAGCGGAGA 1500
TGCCCGGGTC TGCTGAAGCC ACACCCTTCC CGAAGCCTCC TGCATGGCAA CACAATGGAG 1560
AAGCTCATCA AGAAGAGGAA TGTCCCACAG AAACTGTCAC CACACAGTAA AAGGCCAGAT 1620
ATCCTCAAGA CCGAATCTTT GCTACCTAAA CTTGATGCTG CCCTGAGTGG GGTGGGGCTT 1680
CCTGGGTGTC CTAAGGGCCC CCCCTCACCA GGACGGAGTC GTCGTGGCAA GACTCGGCAC 1740
CGGAAGGCCA GCGCCAAGGG CAGCTGCGGA GACCTGCCTG GGCTTCGCGC GGCTTTGCCA 1800
CCCCATGAAC CCGGGGGACC AGGAAGCCCG GGGGGGCTAG GAGGGGGACC CTCAGCCTGG 1860
GAGGCTTGCC CTCCAGCCCT GCGTGGGCTC CACCACGACC TCCTGCTACG CAAGATGTCT 1920
TCATCGTCCC CGGATCTGCT GTCAGCAGCA CTGGGAGCCC GGGGCCGCGG GGCCACAGGG 1980
GGAGCCGGGG ATCCTGGCTC ACCACCTCCA GCCCGGGGAG ACACCCCGCC AAGTGAGGGC 2040
TCAGCACCTG GCTCCACCAG CCCAGACTCA CCTGGGGGAG CCAAAGGGGA GCCACCTCCC 2100
CCAGTAGGGC CTGGTGACGT TGTGGGGCTC CTGGGAACTG GAAGGGAAGG GACGGCGGGA 2160
CGGGGAGGAA GCCGGGCTGG GTCCCAGCAC TTGACTCCAG CTGCACTGCT GTACAGGGCT 2220
GCTGTCACCC GAAGCCAGAA ACGTGGCATT TCATCAGAGG AAGAGGAAGG AGAGGTGGAC 2280
AGTGAAGTAG AGCTGACATC AAGCCAGAGG TGGCCTCAAG GCCTGAACAT GCGCCAATCG 2340
CGGTCCACCT TCAGCTCAGA GAATCCATCT GATGGGGAGG AGGGCACAGC CAGTGAGCCT 2400
TCCCCCAGTG GCACACCTGA AGTCGGCAGT ACCAACACCG ATGAGCGGCC AGATGAGCGG 2460
TCTGACGACA TGTGTTCCCA GGGCTCAGAA ATCCCACTGG ACCCCCCTGC ATCGGAAGTG 2520
GTTCCTGGCC CCGAACCCAG CTCCCTACCC ATCCCCCCCC AGGACCTACC CAGAGGGGAG 2580
CAGGGCCCCC CCAGTATCGA GGACTCAGAC TGTGACAGCA CGGAACTGGA CAACTCCAAC 2640
AGTGGCGAAG CCTTGCAGCC TCCGGCCTCC CTCCCTCCAT GA 2682
Domain Profile
S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63
          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G
Q: 161   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  211
         689**************************9999.........******************
S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123
         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii
Q: 212   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  266
         **************************..99************************...9**
S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182
         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D
Q: 267   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  325
         ***********.99****************99****************************
S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242
         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+
Q: 326   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  385
         ************************************************************
S: 243   kRpsfseivks  253
         +Rpsf++i+ +
Q: 386   NRPSFRQILLH  396
         ********876
Domain Sequence
(FASTA)
LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60
ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120
DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180
IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00355
EKS-ANC-00369
EKS-BOT-00381
EKS-CAE-00303
EKS-CAJ-00386
EKS-CAP-00413
EKS-DIO-00060
EKS-DRM-00177
EKS-EQC-00370
EKS-FEC-00368
EKS-GAA-00464
EKS-GOG-00371
EKS-HOS-00388
EKS-ICT-00359
EKS-LAC-00398
EKS-LOA-00389
EKS-MAM-00380
EKS-MUM-00414
EKS-MUP-00373
EKS-MYL-00378
EKS-NOL-00348
EKS-OCP-00078
EKS-ORN-00489
EKS-ORC-00358
EKS-ORL-00451
EKS-OTG-00383
EKS-PAT-00361
EKS-PEM-00201
EKS-POA-00371
EKS-PRC-00080
EKS-PTV-00100
EKS-RAN-00396
EKS-SAH-00348
EKS-SUS-00332
EKS-TAR-00485
EKS-TEN-00482
EKS-XET-00494
EKS-XIM-00478
Gene Ontology
GO:0033267; C:axon part
GO:0005829; C:cytosol
GO:0030426; C:growth cone
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0016572; P:histone phosphorylation
GO:0000165; P:MAPK cascade
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046777; P:protein autophosphorylation
KEGG
cfa:607170;
InterPros
IPR011009; Kinase-like_dom.
IPR017419; MAP3K12_MAP3K13.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013