EKS-CAF-00267
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00267
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK428.01.5E-12883335253
StatusUnreviewed
Ensembl ProteinENSCAFP00000010386
UniProt AccessionE2RGZ7;
Protein Name
Protein Synonyms/Alias
Gene NamePLK2
Gene Synonyms/Alias PLK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000006975ENSCAFP00000010386ENSCAFT00000011211
OrganismCanis familiaris
Functional Description
Protein Length686
Protein Sequence
(FASTA)
MELLRTITYQ PAAGTKMCEQ ALDKACGGDS KKKRPPQPPE EPPPPPQPAG QGPPAAPHHH 60
HHHAHSGAEV SRIIVDPTTG KRYCRGKVLG KGGFAKCYEM TDLTNNKVYA AKIIPHSRVA 120
KPHQREKIDK EIELHRILHH KHVVQFYHYF EDKENIYILL EYCSRRSMAH ILKARKVLTE 180
PEVRYYLRQI VSGLKYLHEQ EILHRDLKLG NFFINEAMEL KVGDFGLAAR LEPLEHRRRT 240
ICGTPNYLSP EVLNKQGHGC ESDIWALGCV MYTMLLGRPP FETTNLKETY RCIREARYTM 300
PSSLLAPAKH LIASMLSKNP EDRPSLDDII RHEFFLQGFT PDRLSSSCCH TVPDFHLSSP 360
AKNFFKKAAA ALFGGKKDKA RYIDTHNRVS KEDEEIYKLR HDLKKTSITQ QPSKHRTDEE 420
LQPPTTTVAR SGTPAVENKQ QIGDAIRMIV RGTLGSCSSS SECLEDSTMG SVADTVARVL 480
RGCLENMPEA DCIPKEQLST SFQWVTKWVD YSNKYGFGYQ LSDHTVGVLF NNGAHMSLLP 540
DKKTVHYYAE LGQCSVFPAT DAPEQFISQV TVLKYFSHYM EENLMDGGDL PSVTDIRRPR 600
LYLLQWLKSD KALMMLFNDG TFQVNFYHDH TKIIICSQNE EYLLTYINED RISTTFRLTT 660
LLMSGCSSEL KNRMEYALNM LLQRCN 686
Nucleotide Sequence
(FASTA)
ATGGAGCTCT TGCGGACTAT CACGTACCAG CCGGCCGCCG GCACCAAGAT GTGCGAGCAG 60
GCGCTGGACA AGGCTTGCGG CGGGGACTCC AAGAAGAAGC GGCCGCCGCA GCCCCCCGAG 120
GAGCCGCCGC CGCCGCCGCA GCCCGCGGGC CAGGGGCCGC CGGCGGCGCC GCACCACCAC 180
CACCACCACG CGCACTCGGG CGCCGAGGTC TCGCGGATTA TCGTGGACCC CACGACGGGG 240
AAGCGCTACT GCCGGGGCAA AGTGCTGGGC AAGGGTGGCT TTGCCAAATG TTACGAGATG 300
ACAGATTTGA CAAACAACAA AGTGTATGCT GCAAAAATCA TTCCTCACAG CAGAGTAGCT 360
AAACCTCATC AAAGGGAAAA GATCGACAAA GAAATAGAGC TTCACAGAAT CCTCCATCAT 420
AAGCACGTAG TGCAATTTTA CCACTACTTT GAGGACAAAG AAAACATTTA CATTCTCTTG 480
GAATACTGCA GTAGAAGGTC CATGGCTCAT ATCTTGAAAG CAAGGAAGGT GTTGACAGAG 540
CCAGAAGTCC GATACTACCT CAGGCAGATT GTGTCTGGAC TGAAGTACCT TCATGAACAA 600
GAAATCTTAC ACCGAGATCT CAAACTAGGG AACTTTTTTA TTAACGAAGC CATGGAATTA 660
AAAGTCGGGG ACTTCGGTTT GGCAGCCAGG CTGGAACCCT TGGAGCACAG AAGGAGAACA 720
ATATGTGGTA CCCCAAACTA TCTCTCTCCT GAAGTCCTCA ACAAACAAGG ACATGGCTGT 780
GAATCAGATA TTTGGGCCTT AGGTTGTGTA ATGTATACAA TGTTACTAGG AAGACCCCCC 840
TTCGAAACTA CAAATCTGAA AGAAACTTAC AGGTGCATAA GAGAAGCAAG GTATACAATG 900
CCATCGTCAT TGCTGGCTCC TGCTAAGCAC TTGATAGCTA GCATGTTGTC CAAAAATCCA 960
GAGGATCGTC CCAGTTTGGA TGACATCATT CGACATGAAT TTTTTTTGCA GGGCTTCACT 1020
CCAGACAGAC TCTCTTCTAG CTGTTGTCAT ACAGTTCCAG ATTTCCACTT GTCAAGCCCG 1080
GCTAAGAATT TCTTTAAGAA AGCAGCTGCT GCTCTTTTTG GTGGCAAAAA AGACAAAGCA 1140
AGATATATTG ACACACATAA TAGAGTGTCT AAAGAAGATG AAGAAATTTA CAAGCTTAGG 1200
CATGATTTGA AAAAGACTTC GATAACTCAG CAGCCCAGCA AACACAGGAC AGATGAGGAG 1260
CTCCAGCCAC CTACCACTAC AGTTGCCAGA TCTGGAACAC CTGCAGTAGA AAATAAGCAG 1320
CAGATTGGAG ATGCTATTCG CATGATAGTC AGAGGGACTC TTGGCAGCTG CAGCAGTAGC 1380
AGTGAATGCC TTGAAGACAG TACCATGGGA AGTGTCGCAG ACACAGTGGC AAGAGTCCTT 1440
CGAGGATGTC TAGAAAACAT GCCAGAAGCT GACTGCATTC CCAAAGAGCA GCTGAGCACT 1500
TCCTTTCAGT GGGTCACCAA ATGGGTCGAT TACTCTAACA AATATGGCTT TGGGTACCAG 1560
CTCTCAGACC ACACTGTAGG TGTCCTTTTC AACAATGGTG CTCACATGAG CCTCCTTCCA 1620
GACAAAAAAA CAGTTCACTA TTATGCAGAG CTTGGCCAGT GCTCTGTTTT CCCAGCAACA 1680
GATGCTCCTG AACAATTCAT TAGTCAAGTG ACGGTGCTCA AATACTTCTC TCATTACATG 1740
GAGGAGAACC TCATGGATGG TGGAGATCTG CCTAGCGTTA CCGATATTCG AAGACCTCGG 1800
CTCTACCTCC TTCAGTGGCT GAAATCTGAT AAGGCCTTAA TGATGCTCTT CAATGATGGC 1860
ACCTTTCAGG TGAATTTCTA CCACGATCAT ACGAAAATAA TCATCTGTAG CCAAAATGAA 1920
GAATATCTTC TCACCTACAT TAACGAGGAC AGGATATCTA CAACGTTCAG ACTGACAACT 1980
CTGCTGATGT CCGGCTGTTC ATCAGAATTA AAAAATCGGA TGGAATATGC TCTGAACATG 2040
CTCTTACAGA GATGTAACTA A 2061
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+
Q: 83    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  142
         99**********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i
Q: 143   VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  202
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180
         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+
Q: 203   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  262
         ************************************************************
S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240
         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+
Q: 263   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  322
         ************************************************************
S: 241   rpsleevlkdefl  253
         rpsl++++++ef+
Q: 323   RPSLDDIIRHEFF  335
         ************8
Domain Sequence
(FASTA)
YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60
VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120
LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180
DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240
RPSLDDIIRH EFF 253
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00243
EKS-ANC-00250
EKS-BOT-00260
EKS-CAJ-00266
EKS-CAP-00295
EKS-CHH-00011
EKS-DAR-00595
EKS-DAN-00009
EKS-ECT-00011
EKS-EQC-00252
EKS-FEC-00246
EKS-GAM-00160
EKS-GAG-00218
EKS-GOG-00258
EKS-HOS-00267
EKS-ICT-00245
EKS-LAC-00272
EKS-LOA-00270
EKS-MAM-00262
EKS-MEG-00208
EKS-MIM-00016
EKS-MOD-00259
EKS-MUM-00292
EKS-MYL-00263
EKS-NOL-00241
EKS-ORN-00338
EKS-ORC-00246
EKS-OTG-00266
EKS-PAT-00247
EKS-PES-00232
EKS-PEM-00136
EKS-POA-00253
EKS-PRC-00018
EKS-RAN-00275
EKS-SUS-00226
EKS-TAG-00276
EKS-TAR-00334
EKS-TEN-00329
EKS-VIP-00009
EKS-XET-00335
EKS-XIM-00330
EKS-SAC-00030
EKS-SCP-00027
Gene Ontology
GO:0005814; C:centriole
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004871; F:signal transducer activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0007613; P:memory
GO:0007093; P:mitotic cell cycle checkpoint
GO:0007052; P:mitotic spindle organization
GO:0043066; P:negative regulation of apoptotic process
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046599; P:regulation of centriole replication
GO:0048167; P:regulation of synaptic plasticity
KEGG
cfa:478063;
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013