EKS-CAF-00369

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00369

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	442.7	4.3E-133	247	497	251

Status

Unreviewed

Ensembl Protein

ENSCAFP00000010452

UniProt Accession

E2RBB8;

Protein Name

Protein Synonyms/Alias

Gene Name

LYN

Gene Synonyms/Alias

LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000007034	ENSCAFP00000010452	ENSCAFT00000011282

Organism

Canis familiaris

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MGCIKSKRKD NLNDEGIDLK TQPVRNTDRT IYVRDPTSNK QQRPVSESQL LPGQRFQTKD 60

PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEELGEWW KAKSLSTKRE GFIPSNYVAK 120

VNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSYSLSVR DYDPVHGDVI 180

KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQSDGLCR RLEKACISPK PQKPWDKDAW 240

EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300

KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER 360

KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 420

TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRMENCPD ELYDIMKMCW 480

KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP 512

Nucleotide Sequence
(FASTA)

ATGGGATGTA TAAAATCAAA AAGGAAAGAC AATCTGAATG ACGAAGGAAT AGATTTGAAG 60

ACTCAACCAG TACGTAATAC TGACCGAACT ATTTATGTGA GAGATCCAAC GTCCAATAAA 120

CAGCAAAGGC CAGTTTCAGA ATCTCAGCTT TTACCAGGAC AGAGGTTTCA AACTAAAGAT 180

CCAGAGGAGC AAGGAGACAT CGTGGTAGCC TTGTACCCCT ATGATGGCAT CCATCCAGAT 240

GACTTGTCTT TCAAGAAAGG AGAGAAAATG AAAGTCCTGG AGGAACTTGG AGAATGGTGG 300

AAAGCTAAAT CTCTTTCAAC AAAGAGAGAA GGGTTCATCC CCAGCAACTA TGTAGCCAAA 360

GTGAACACGT TGGAAACAGA AGAGTGGTTT TTCAAGGATA TAACCAGGAA AGATGCAGAA 420

CGGCAGCTTC TGGCGCCAGG GAACAGTGCT GGAGCTTTTC TTATCAGAGA AAGCGAAACA 480

TTAAAAGGAA GCTACTCTCT TTCCGTCAGA GATTATGACC CTGTGCATGG TGATGTTATT 540

AAGCACTACA AAATTAGAAG TCTGGACAAT GGGGGATATT ACATCTCTCC ACGAATCACT 600

TTTCCTTGTA TCAGCGACAT GATTAAACAT TACCAAAAGC AGTCAGATGG CTTGTGCAGA 660

AGATTGGAGA AGGCATGTAT TAGCCCCAAA CCACAAAAGC CATGGGACAA AGATGCCTGG 720

GAAATCCCAC GGGAATCCAT CAAGTTGGTG AAAAGGCTTG GTGCCGGGCA GTTCGGGGAA 780

GTCTGGATGG GTTACTATAA CAATAGTACC AAAGTGGCTG TAAAAACCCT GAAACCAGGC 840

ACTATGTCTG TGCAAGCATT CCTGGAGGAA GCAAACCTCA TGAAGACCCT TCAACATGAC 900

AAGCTGGTGA GGCTGTATGC CGTGGTCACC AGAGAGGAGC CTATCTACAT CATCACCGAG 960

TACATGGCCA AGGGCAGTTT GCTGGATTTC CTGAAGAGCG ATGAGGGGGG GAAAGTGCTG 1020

CTTCCAAAGC TAATCGACTT TTCTGCCCAG ATTGCAGAGG GAATGGCATA CATCGAGAGA 1080

AAGAACTACA TCCACCGAGA TCTACGAGCA GCAAACGTTC TGGTTTCTGA GTCACTCATG 1140

TGCAAAATTG CAGATTTTGG TCTTGCTCGA GTCATCGAAG ATAATGAATA CACAGCAAGA 1200

GAAGGTGCCA AATTCCCCAT TAAGTGGACA GCTCCAGAAG CAATCAACTT TGGATGTTTC 1260

ACCATTAAGT CTGATGTGTG GTCCTTTGGC ATTCTCCTGT ATGAAATCGT CACCTATGGG 1320

AAGATTCCTT ACCCAGGGAG AACTAATGCC GATGTGATGA CCGCCCTGTC GCAGGGCTAC 1380

AGGATGCCCC GCATGGAGAA CTGCCCAGAC GAGCTCTACG ACATCATGAA AATGTGCTGG 1440

AAGGAGAAAG CAGAAGAGAG GCCAACGTTT GATTACCTGC AGAGTGTCCT GGATGATTTC 1500

TACACTGCCA CAGAAGGGCA GTATCAGCAG CAGCCTTAA 1539

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvk+lG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly

Q: 247   IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  306

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr

Q: 307   AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  366

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 367   DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  426

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr+e+cp+ely+++++cwk+++ee

Q: 427   WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRMENCPDELYDIMKMCWKEKAEE  486

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 487   RPTFDYLQSVL  497

         ********986

Domain Sequence
(FASTA)

IKLVKRLGAG QFGEVWMGYY NNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60

AVVTREEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120

DLRAANVLVS ESLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180

WSFGILLYEI VTYGKIPYPG RTNADVMTAL SQGYRMPRME NCPDELYDIM KMCWKEKAEE 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013