EKS-CAF-00297

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00297

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	376.7	6.0E-113	788	1053	266

Status

Unreviewed

Ensembl Protein

ENSCAFP00000037890

UniProt Accession

J9NX78;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000007062	ENSCAFP00000010489	ENSCAFT00000011319
ENSCAFG00000007062	ENSCAFP00000037890	ENSCAFT00000044974

Organism

Canis familiaris

Functional Description

Protein Length

1086

Protein Sequence
(FASTA)

VHIFLFSRMF EAHMQSYKGD DPLGEWESYM QWVEENFPEN KEYLTTLLEH LMKEFLDKKK 60

YHNDPRFINY CLKFAEYNSD LHQFFEFLYN HGIGTMSSPL YVAWAGHLEG QGELQHASAV 120

FRRGLQNQAE PRELLQQHYS FTECYAIFKP PILIVRTSEP LHNTQILNQM MTSKSNPGNN 180

SACISKNQGS EVSGVMSSAC DKESKKEQRV ILISKSGYSA QASAAARTDV QQVVMYCKEK 240

LIRGESEFSF EELRAQKYNQ RRKHEQKKKK KINEDRHYMK RKEANAFEEQ LLKQKMDELH 300

KKLYQVVETS QENLPEFQER PNFTEHEHIN MANAVTAAFV SPAISQSLFP PVPLPAQPVT 360

DSMFTEARKD ASEWHLSASL TCSAVSRTAL TEYIQLTMAE KRLFHCSFLR ISISQEFSLS 420

DATEWSRDKN HSDFSTGNAF CPISFIGSET HKVVNAGSFH TTPNTSLGTV QATPSRVQPS 480

PTVHTKEALG FIMNMFQAPT LPDISDDKDE WPSLDQNEDA FEAQFQKNAS SSGAWGVNKI 540

ISSLSSAFPV FEDGNKENYG LPQPKNKPAG ARTFGERSIL NSINEEVPHT EEFSDDSTVW 600

GVRCNKTLAP SPKSPGHFTA AAQLASTPFH RPPTDLVPAL EDKDSKFESE SQYWLFLEYL 660

HLKGMMLRIA RYLPHISENV AARECTHVTL DSREENVEPS KERKFRDLAF NTVCYELLSN 720

THEAHRTQFQ ASGTDFTVEN PWDDELILKL LSGLSKPVRS YPNTYEWQCK LPAIKPKTEF 780

QLGSLLVYVD HLLGEGAFAQ VYEVTHGEVN DTKNKQKFVL KVQKPANPWE FYIGTQLMER 840

LKPSMRHMFI KFYSAHLFQN GSVLVGDLYS YGTLLNAINL YKNTPEKVMP QALVLSFAIR 900

MLCMIEQVHD CEIIHGDIKP DNFILGSRFL EQDGEDDDIS AGLALIDLGQ SIDMKLFPKG 960

TTFTGKCETS GFQCIEMLSN KPWNYQIDYF GVAATVYCML FGTYMKVKNE GGVWKPEGLF 1020

RRLPHLDMWS EFFHIMLNIP DCHHLPSLDL LKQNLKKTFQ QHYSSKIKTL RNRLIVLLLE 1080

YKRSRK 1086

Nucleotide Sequence
(FASTA)

GTGCATATTT TTCTCTTTTC TAGAATGTTT GAAGCCCATA TGCAGAGCTA CAAGGGCGAT 60

GACCCACTTG GTGAATGGGA AAGTTACATG CAGTGGGTAG AAGAGAATTT TCCTGAGAAT 120

AAGGAATACT TGACAACTTT ATTAGAACAT TTAATGAAGG AGTTTTTGGA TAAGAAGAAA 180

TACCACAATG ACCCAAGATT CATCAATTAT TGTTTAAAAT TTGCTGAGTA CAACAGTGAT 240

CTTCATCAGT TCTTTGAGTT TCTGTACAAC CATGGGATCG GGACCATGTC ATCTCCTCTC 300

TATGTAGCCT GGGCAGGGCA TCTGGAAGGT CAGGGAGAGC TGCAGCATGC CAGTGCTGTG 360

TTTCGAAGAG GACTTCAAAA CCAGGCCGAA CCAAGAGAGC TGCTGCAACA ACACTACAGT 420

TTTACAGAAT GTTATGCCAT TTTCAAACCT CCAATTTTAA TAGTAAGAAC CTCAGAACCT 480

CTGCATAATA CTCAGATTTT AAACCAAATG ATGACATCAA AATCAAATCC AGGAAATAAC 540

TCAGCCTGCA TTTCTAAGAA TCAGGGTTCA GAAGTTTCTG GGGTAATGTC TTCAGCTTGT 600

GATAAAGAGT CAAAAAAGGA ACAAAGGGTG ATCCTGATTT CTAAATCAGG TTATTCTGCA 660

CAAGCATCTG CAGCAGCCAG AACTGATGTT CAGCAGGTTG TTATGTATTG CAAGGAGAAG 720

CTTATTCGTG GAGAATCAGA ATTTTCCTTT GAAGAGCTGA GAGCCCAGAA ATACAATCAA 780

CGGAGAAAAC ATGAACAAAA AAAAAAAAAA AAAATAAATG AAGACAGACA TTATATGAAA 840

AGAAAAGAAG CAAATGCTTT TGAAGAACAA CTGTTAAAAC AGAAAATGGA TGAACTTCAT 900

AAGAAATTGT ATCAGGTGGT GGAGACTTCC CAGGAGAATC TGCCTGAGTT CCAGGAAAGA 960

CCTAATTTTA CTGAGCATGA ACACATAAAT ATGGCAAATG CTGTCACTGC TGCTTTCGTG 1020

TCCCCAGCCA TCAGCCAGAG TCTGTTTCCT CCTGTTCCTT TGCCAGCTCA ACCAGTGACA 1080

GACTCCATGT TTACAGAGGC CAGAAAAGAT GCCAGTGAAT GGCATTTGTC AGCTTCTTTA 1140

ACATGTTCTG CAGTGTCAAG AACAGCTTTA ACTGAATACA TACAGCTTAC CATGGCAGAG 1200

AAAAGACTTT TTCACTGTTC TTTTTTGAGA ATTAGTATAT CTCAAGAGTT TTCTCTTTCA 1260

GATGCCACAG AGTGGAGCAG AGATAAAAAT CACTCTGATT TCTCTACTGG TAATGCATTT 1320

TGCCCCATTT CTTTTATAGG GTCTGAAACA CATAAGGTTG TTAACGCAGG TTCTTTTCAT 1380

ACAACTCCAA ACACATCGCT GGGAACGGTT CAGGCGACCC CATCCAGGGT GCAGCCATCA 1440

CCCACCGTAC ACACAAAAGA AGCATTAGGT TTCATCATGA ATATGTTTCA GGCTCCTACA 1500

CTTCCTGATA TTTCTGATGA CAAGGATGAA TGGCCATCTC TAGATCAAAA TGAAGATGCA 1560

TTTGAGGCCC AGTTTCAAAA AAATGCAAGT TCTTCTGGGG CTTGGGGAGT CAATAAGATC 1620

ATCTCCTCTT TGTCATCTGC TTTTCCTGTG TTTGAAGATG GAAACAAAGA AAATTATGGA 1680

TTACCACAGC CTAAAAATAA ACCCGCAGGA GCCAGGACCT TTGGAGAACG CTCTATCTTA 1740

AACAGTATCA ATGAGGAAGT ACCTCACACT GAAGAGTTTT CCGATGACTC AACTGTCTGG 1800

GGTGTCCGCT GCAACAAAAC CCTGGCACCC AGTCCGAAGA GCCCTGGACA CTTCACAGCT 1860

GCCGCACAGC TTGCATCCAC ACCTTTCCAC AGACCACCAA CAGATTTAGT ACCTGCTCTG 1920

GAGGATAAAG ATTCCAAATT TGAGTCAGAG AGTCAATATT GGCTGTTCTT GGAGTATTTG 1980

CACTTAAAAG GAATGATGTT AAGAATTGCC AGGTATCTTC CTCATATTTC AGAAAATGTG 2040

GCAGCAAGAG AGTGTACCCA TGTGACTTTG GATTCTCGTG AAGAAAACGT AGAACCCTCA 2100

AAAGAGAGAA AGTTCAGAGA TCTTGCCTTT AACACAGTCT GTTACGAATT ACTGTCTAAC 2160

ACACATGAAG CACACAGGAC ACAATTCCAG GCAAGTGGAA CAGACTTTAC TGTTGAGAAT 2220

CCATGGGATG ATGAGTTGAT TCTCAAACTT TTATCTGGGC TTTCTAAACC AGTGAGATCC 2280

TATCCAAATA CTTATGAATG GCAGTGTAAA CTTCCAGCCA TCAAGCCCAA GACTGAGTTT 2340

CAACTGGGTT CCTTGCTGGT CTATGTCGAT CACCTTCTTG GAGAAGGGGC CTTTGCCCAA 2400

GTCTATGAAG TTACCCATGG AGAGGTGAAT GATACCAAAA ATAAACAGAA ATTTGTTTTA 2460

AAGGTCCAGA AGCCCGCCAA CCCCTGGGAG TTCTACATTG GGACCCAGCT GATGGAGAGA 2520

TTAAAGCCGA GCATGCGACA CATGTTCATC AAATTCTATT CTGCCCACTT ATTCCAGAAT 2580

GGCAGTGTGT TAGTAGGAGA TCTCTACAGC TATGGCACGT TGCTAAATGC TATTAACCTC 2640

TATAAAAACA CCCCAGAAAA AGTGATGCCT CAAGCTCTAG TCCTCTCCTT TGCGATCAGG 2700

ATGCTCTGCA TGATTGAACA AGTGCATGAC TGTGAAATTA TTCATGGAGA CATTAAGCCA 2760

GACAATTTCA TACTTGGGAG CAGATTTTTG GAACAGGATG GTGAAGATGA TGATATATCT 2820

GCTGGCTTGG CACTGATTGA CCTGGGTCAG AGTATAGATA TGAAACTTTT TCCCAAAGGA 2880

ACTACATTTA CAGGAAAGTG TGAAACATCT GGTTTTCAGT GTATTGAGAT GCTCAGTAAC 2940

AAACCATGGA ACTACCAGAT TGATTACTTT GGAGTTGCTG CAACAGTGTA CTGCATGCTT 3000

TTTGGCACTT ACATGAAAGT GAAAAATGAA GGAGGAGTCT GGAAGCCTGA AGGGCTTTTT 3060

AGGAGGCTTC CTCATCTGGA CATGTGGAGT GAATTTTTTC ACATCATGTT GAACATACCA 3120

GATTGTCATC ATCTTCCATC TTTGGATTTG TTAAAGCAAA ATCTGAAGAA AACATTTCAA 3180

CAACACTATT CAAGCAAGAT TAAGACCCTA CGTAATAGGC TGATTGTACT GCTCTTAGAA 3240

TATAAGCGTT CTAGAAAATA A 3261

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         ++++++geGa+a+vy+ +h    d+k++++++lKv+kpan+WefYI +ql+eRlk +++

Q: 788   YVDHLLGEGAFAQVYEVTHgevnDTKNKQKFVLKVQKPANPWEFYIGTQLMERLK-PSMR  846

         799****************************************************.77**

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         +++i+++sa+lfq++s+lv +++sygtll++in++k++ +kvm+++lv+++++++l ++e

Q: 847   HMFIKFYSAHLFQNGSVLVGDLYSYGTLLNAINLYKNTPEKVMPQALVLSFAIRMLCMIE  906

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkad.kdkeekglkliDfgrsiDmkllpdgtkfkgk  176

         ++H++eIiHgD+kPdnf+lg r+ ++   +d+ ++gl+liD+g+siDmkl+p+gt+f+gk

Q: 907   QVHDCEIIHGDIKPDNFILGSRFLEQDGeDDDISAGLALIDLGQSIDMKLFPKGTTFTGK  966

         ************************998825555778************************

S: 177   aktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkk  236

         ++t++f+cieml++k+w+Yq+D+fg+aa+++++lfg+y++v++egg wk++  ++rl++

Q: 967   CETSGFQCIEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGVWKPEGLFRRLPHL  1026

         ************************************************************

S: 237   elwekiferlLNisdastlpsleelve  263

         ++w ++f+ +LNi+d+++lpsl+ l +

Q: 1027  DMWSEFFHIMLNIPDCHHLPSLDLLKQ  1053

         ***********************9985

Domain Sequence
(FASTA)

YVDHLLGEGA FAQVYEVTHG EVNDTKNKQK FVLKVQKPAN PWEFYIGTQL MERLKPSMRH 60

MFIKFYSAHL FQNGSVLVGD LYSYGTLLNA INLYKNTPEK VMPQALVLSF AIRMLCMIEQ 120

VHDCEIIHGD IKPDNFILGS RFLEQDGEDD DISAGLALID LGQSIDMKLF PKGTTFTGKC 180

ETSGFQCIEM LSNKPWNYQI DYFGVAATVY CMLFGTYMKV KNEGGVWKPE GLFRRLPHLD 240

MWSEFFHIML NIPDCHHLPS LDLLKQ 266

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013