EKS-CAF-00370

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00370

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	438.3	9.5E-132	363	612	250

Status

Unreviewed

Ensembl Protein

ENSCAFP00000032817

UniProt Accession

F1PSI2;

Protein Name

Protein Synonyms/Alias

Gene Name

HCK

Gene Synonyms/Alias

HCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000007122	ENSCAFP00000032817	ENSCAFT00000037329

Organism

Canis familiaris

Functional Description

Protein Length

627

Protein Sequence
(FASTA)

MRVHAVGSES SGAGLGYTGV GLASLRARLR SPDGLWVPPS PRSQPERTAE AEASRRGRRG 60

FSARGAREAA RRPSPSEAAL CLFSKVSPSP FGCGRPGSPG AAELGGRSSC EDPGCPQEEE 120

RAPRMGCMKS KFLQDRGKVS KTEPSANSHS PVYVPDPTSA NKRRPDHSND NLPGSKEGPD 180

DIIVIALYDY EAIHHEDLSF QKGDQMVVLE ESGEWWKARS LTTRKEGYIP SNYVARVDSL 240

ETEEWFFKGI SRKDAERQLL APGNVLGSFM IRDSETTKGS YSLSVRDYDP QHRDSVKHYK 300

IRTLDSGGFY ISPRSTFNSL QELVAHYKKG SDGLCQKLTV PCMSSKPQKP WEKDAWEIPR 360

ESLKLEKKLG AGQFGEVWMA TYNKHTKVAV KTMKPGSMSV EAFLAEANLM KTLQHDKLVK 420

LHAVVTEEPI YIITEFMAKG SLLDFLKSSE GSKQPLPKLI DFSAQIAEGM AFIEQRNYIH 480

RDLRAANILV SASLVCKIAD FGLARVIEDN EYTAREGAKF PIKWTAPEAI NFGSFTIKSD 540

VWSFGVLLME IVTYGRIPYP GMSNPEVIRA LERGYRMPRP EHCPEELYNI MTRCWKNRPE 600

ERPTFEYIQS VLEDFYTATE SQYQQQP 627

Nucleotide Sequence
(FASTA)

ATGAGAGTCC ACGCTGTGGG GTCAGAGTCT TCAGGGGCGG GGTTAGGATA CACGGGGGTG 60

GGGTTAGCAT CGCTCAGGGC GCGGCTAAGG AGCCCAGATG GCCTGTGGGT GCCACCGAGT 120

CCCCGGTCCC AGCCCGAGCG CACCGCTGAG GCCGAGGCGA GCAGGAGGGG GCGCCGGGGG 180

TTCAGCGCCA GGGGAGCCCG AGAAGCCGCG CGGCGCCCAA GCCCCTCAGA GGCCGCCCTT 240

TGCCTTTTCT CCAAAGTCAG CCCGTCTCCC TTCGGGTGCG GGCGCCCCGG GAGTCCGGGG 300

GCTGCTGAGC TGGGGGGGCG TTCGAGCTGC GAAGATCCGG GCTGCCCGCA GGAGGAGGAG 360

CGGGCGCCCA GGATGGGGTG TATGAAGTCC AAGTTTCTCC AGGACAGAGG CAAGGTCTCA 420

AAAACTGAGC CCAGCGCCAA CTCACACAGC CCTGTGTATG TGCCAGATCC CACATCTGCA 480

AACAAGCGGC GTCCTGATCA CAGTAACGAC AACCTACCAG GGTCCAAGGA AGGTCCTGAT 540

GACATAATTG TGATCGCCCT GTATGATTAT GAGGCCATTC ACCATGAAGA CCTCAGTTTC 600

CAGAAGGGAG ATCAGATGGT GGTCCTGGAA GAGTCTGGGG AGTGGTGGAA GGCTCGATCA 660

CTGACCACCC GGAAAGAAGG CTACATCCCA AGCAACTACG TCGCCCGCGT TGACTCTCTG 720

GAGACAGAGG AGTGGTTCTT CAAGGGCATC AGCCGGAAGG ATGCAGAGCG CCAACTCCTG 780

GCCCCCGGCA ACGTGTTGGG CTCCTTCATG ATTCGGGACA GCGAGACCAC CAAAGGAAGC 840

TACTCTTTGT CTGTGCGAGA CTACGACCCC CAGCACAGGG ACTCGGTGAA ACATTACAAG 900

ATCCGGACCC TGGACAGCGG AGGCTTCTAC ATCTCCCCAC GGAGCACCTT CAATAGCCTG 960

CAGGAGCTGG TGGCCCACTA CAAGAAGGGG AGTGATGGAC TCTGCCAGAA GCTGACAGTG 1020

CCCTGCATGT CCTCCAAGCC CCAGAAGCCA TGGGAGAAAG ATGCCTGGGA GATCCCCCGG 1080

GAATCTCTCA AGCTGGAGAA GAAACTCGGA GCTGGGCAGT TTGGGGAAGT GTGGATGGCC 1140

ACCTACAACA AGCACACCAA GGTGGCCGTG AAGACGATGA AGCCAGGGAG CATGTCTGTG 1200

GAGGCCTTCC TGGCAGAGGC CAACCTGATG AAGACTCTGC AGCATGACAA GCTGGTGAAG 1260

CTGCACGCGG TAGTCACAGA GGAACCCATC TACATCATCA CTGAGTTCAT GGCCAAAGGA 1320

AGCCTGCTGG ATTTCCTGAA AAGTTCAGAG GGCAGCAAGC AGCCATTGCC AAAACTCATT 1380

GACTTCTCAG CCCAGATTGC AGAAGGCATG GCCTTCATTG AGCAGAGGAA CTACATTCAC 1440

CGAGACCTCC GAGCCGCCAA CATCCTGGTC TCTGCGTCCC TGGTGTGTAA GATTGCAGAC 1500

TTTGGCCTGG CGCGTGTCAT CGAGGACAAC GAATACACCG CTCGGGAAGG GGCCAAGTTC 1560

CCCATCAAGT GGACAGCTCC TGAAGCTATC AACTTTGGCT CTTTCACCAT CAAGTCAGAT 1620

GTCTGGTCCT TTGGTGTTCT GCTGATGGAG ATCGTCACCT ACGGCCGGAT CCCTTACCCA 1680

GGGATGTCAA ACCCTGAGGT GATCCGGGCA CTGGAGCGCG GATACCGGAT GCCTCGACCA 1740

GAGCACTGCC CTGAGGAGCT CTACAACATT ATGACACGCT GCTGGAAGAA CCGCCCTGAG 1800

GAGCGGCCCA CCTTTGAATA TATCCAGAGT GTGCTGGAGG ACTTCTACAC AGCCACTGAG 1860

AGCCAGTACC AACAGCAGCC ATGA 1884

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+

Q: 363   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLH  422

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv+e ePiyi+te+makGslldflk++eg+k++lpkl+d++aq+aeGma++e++n+ihr

Q: 423   AVVTE-EPIYIITEFMAKGSLLDFLKSSEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR  481

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 482   DLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  541

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+ll+eivt+G++PypGm+n ev++++ergyr+prpe+cpeely+++++cwk++pee

Q: 542   WSFGVLLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEHCPEELYNIMTRCWKNRPEE  601

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q+vl

Q: 602   RPTFEYIQSVL  612

         *******9976

Domain Sequence
(FASTA)

LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 60

AVVTEEPIYI ITEFMAKGSL LDFLKSSEGS KQPLPKLIDF SAQIAEGMAF IEQRNYIHRD 120

LRAANILVSA SLVCKIADFG LARVIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180

SFGVLLMEIV TYGRIPYPGM SNPEVIRALE RGYRMPRPEH CPEELYNIMT RCWKNRPEER 240

PTFEYIQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013