EKS-CAF-00399
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00399
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl547.65.7E-165585849265
StatusUnreviewed
Ensembl ProteinENSCAFP00000010599
UniProt AccessionF1PJY4;
Protein Name
Protein Synonyms/Alias
Gene NameMERTK
Gene Synonyms/Alias MERTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000007131ENSCAFP00000010599ENSCAFT00000011439
ENSCAFG00000007131ENSCAFP00000039976ENSCAFT00000049014
OrganismCanis familiaris
Functional Description
Protein Length997
Protein Sequence
(FASTA)
CGPILLEIFV GQDKNPSFCF AAVAEVREET MPDLPLPGGL QADRTSFSLP HTSGYQVEPA 60
LFSPAQPGGA HTENAAHPGV TSAGLKLLPP LAFNHTIGHI ILSEHKDVKF NCSINIPNMY 120
QDIAVISWWK DGKELLGAHH AITQFYPDDE VTAIIASFSI TSVQRSDNGS YICKMKINNE 180
EIVSDPIYIE VQGLPHFTRQ PESLNVTRNT AFNLTCQAVG PPEPVNIFWV QNSSRVNEQP 240
ERSPSVLTVP GLTETAVFSC EAHNDKGLTV SKGVQINIKV IPSPPTEVSV YNSTAHSVLI 300
SWVPGFDGYS PFRSCSIQVK EVDPLSNGSV MVFNTSASPH LYQIEQLQAL ANYSIGVSCM 360
NEIGWSAMSA WILASTTEGA PSVAPSNVTV SLNESSHKVD VRWIKPPIKR QDGELVGYRI 420
SHMWQSADTS KELSEEVGQN GSRAQISVQV HNATCTVRIA AITKGGVGPF SDPVKMFIPP 480
HGWVDFAPSS TPAPGNTDPV LIILGCFCGF VLIGLVLYIS LVIRKRIQET KFGNAFTEED 540
SELVVNYIAK KSFCRRAIEL TLRSLGVSEE LQNKLEDVVI DRNLLILGKI LGEGEFGSVM 600
EGNLKEQDGT SQKVAVKTMK LDNFSQREIE EFLSEAACMK DFNHPNVIRL LGVCIEMSSQ 660
GIPKPMVILP FMKYGDLHTY LLYSRLDTGP KHIPVQILLK FMVDIAQGME YLSNRNFLHR 720
DLAARNCMLR DDMTVCVADF GLSKKIYSGD YYRQGRIAKM PVKWIAIESL ADRVYTSKSD 780
VWAFGVTMWE IATRGMTPYP GVQNHEMYDY LLHGHRLKQP EDCLDELYEI MHSCWRADPL 840
DRPTFSVLRL QLEKFLESLP EVQDKADVIY INTQFPESCE DPGEGPALAQ LDMNIDVDSI 900
IGSCAPSAAV SVVTAEVHEN RAHEERYILN GGSEEWGDLA SAAPATGTTG KNCVLPEDRL 960
VKNGVSWSQS STLPLGSPSP DGLLFADDSS EDSEVLI 997
Nucleotide Sequence
(FASTA)
TGTGGGCCAA TACTTTTAGA AATATTTGTG GGTCAGGATA AAAATCCGTC ATTCTGTTTT 60
GCAGCTGTTG CAGAGGTGAG AGAAGAAACC ATGCCTGACC TGCCATTGCC AGGAGGCCTG 120
CAAGCTGACC GCACATCATT TTCCCTTCCT CACACCAGTG GGTACCAGGT GGAGCCTGCC 180
TTGTTTTCAC CAGCCCAGCC TGGAGGAGCC CATACAGAAA ATGCAGCTCA TCCTGGGGTG 240
ACCTCTGCTG GATTAAAGCT CCTACCGCCT CTTGCATTTA ATCATACGAT TGGCCACATA 300
ATACTTTCTG AACATAAAGA TGTCAAATTT AATTGCTCCA TCAATATACC TAACATGTAC 360
CAGGACATTG CAGTTATTTC CTGGTGGAAA GATGGGAAGG AGTTGCTTGG GGCACATCAT 420
GCAATTACTC AGTTTTATCC GGATGACGAA GTTACAGCAA TAATTGCTTC CTTCAGCATA 480
ACCAGTGTAC AGCGTTCAGA CAATGGGTCA TATATCTGTA AGATGAAAAT AAACAATGAA 540
GAGATTGTGT CTGACCCCAT CTACATCGAG GTACAAGGAC TTCCTCACTT TACTAGACAG 600
CCCGAGAGCC TGAATGTCAC GAGAAACACA GCCTTCAACC TCACCTGTCA GGCTGTGGGC 660
CCTCCTGAGC CCGTCAACAT TTTCTGGGTT CAGAACAGCA GCCGTGTGAA TGAACAGCCG 720
GAAAGATCCC CCTCTGTTCT AACTGTTCCT GGTCTGACCG AGACAGCAGT CTTTAGCTGT 780
GAAGCCCACA ATGACAAAGG GTTGACCGTG TCCAAGGGTG TGCAGATCAA CATCAAAGTA 840
ATTCCCTCCC CACCAACTGA AGTCAGTGTC TACAACAGCA CGGCACACAG TGTGCTGATC 900
TCCTGGGTCC CGGGTTTTGA TGGATACTCC CCGTTCAGGA GTTGCAGCAT TCAGGTCAAG 960
GAAGTTGATC CGCTGAGTAA TGGCTCTGTC ATGGTTTTTA ACACCTCTGC TTCACCACAT 1020
CTGTATCAAA TTGAGCAGCT GCAAGCTCTG GCTAATTACA GCATTGGTGT GTCCTGCATG 1080
AATGAAATTG GCTGGTCTGC AATGAGCGCT TGGATTCTGG CCAGCACAAC TGAAGGAGCC 1140
CCATCAGTAG CACCTTCGAA TGTCACTGTG TCTCTGAATG AATCTAGTCA TAAGGTGGAT 1200
GTCAGATGGA TCAAGCCTCC AATTAAGCGG CAGGATGGGG AGCTGGTGGG CTACCGGATA 1260
TCTCACATGT GGCAGAGTGC AGACACTTCC AAAGAGCTGT CTGAAGAAGT TGGCCAGAAT 1320
GGCAGCCGTG CTCAAATTTC TGTTCAAGTC CACAACGCGA CATGCACAGT GAGGATTGCT 1380
GCCATCACCA AAGGGGGCGT CGGGCCGTTC AGTGACCCAG TGAAAATGTT CATCCCCCCA 1440
CACGGCTGGG TAGATTTTGC CCCCTCGTCA ACCCCAGCAC CTGGCAATAC AGATCCTGTG 1500
CTCATCATCC TTGGCTGCTT TTGTGGATTT GTTTTGATTG GATTAGTTTT ATATATTTCT 1560
CTGGTCATCA GAAAAAGAAT CCAGGAGACA AAGTTTGGGA ACGCCTTCAC AGAGGAGGAC 1620
TCCGAATTAG TTGTCAATTA TATAGCAAAG AAGTCCTTCT GTCGGCGAGC CATTGAACTT 1680
ACCTTGCGTA GCTTGGGAGT CAGCGAGGAA CTGCAAAATA AACTAGAAGA TGTTGTGATT 1740
GACAGGAATC TATTAATTCT TGGAAAAATC CTGGGTGAAG GAGAGTTTGG GTCTGTGATG 1800
GAAGGAAATC TAAAGGAGCA AGATGGGACC TCTCAGAAAG TGGCCGTGAA GACCATGAAG 1860
TTGGACAACT TTTCTCAGCG AGAGATTGAG GAGTTTCTCA GTGAGGCAGC GTGCATGAAA 1920
GACTTCAACC ACCCAAATGT CATCCGACTC CTAGGTGTGT GTATAGAAAT GAGCTCTCAA 1980
GGCATCCCAA AGCCCATGGT GATTTTACCC TTCATGAAGT ATGGGGATCT GCATACCTAC 2040
TTACTCTATT CCCGACTAGA CACAGGACCC AAGCATATTC CTGTGCAGAT ACTACTGAAG 2100
TTCATGGTGG ACATTGCCCA GGGAATGGAG TATCTGAGCA ACAGGAATTT TCTTCATCGA 2160
GATTTAGCTG CTCGAAATTG CATGTTACGA GATGATATGA CTGTCTGTGT TGCGGATTTT 2220
GGCCTCTCTA AGAAGATTTA CAGTGGTGAT TACTACCGCC AAGGCCGCAT TGCTAAGATG 2280
CCTGTGAAAT GGATCGCCAT AGAGAGTCTT GCGGACAGAG TCTACACAAG TAAAAGTGAT 2340
GTGTGGGCCT TTGGCGTAAC CATGTGGGAA ATAGCAACAC GCGGAATGAC TCCATACCCT 2400
GGGGTCCAGA ACCACGAAAT GTATGACTAT CTTCTCCATG GCCACAGGCT GAAGCAGCCC 2460
GAGGACTGCC TGGATGAACT GTATGAAATC ATGCATTCTT GCTGGAGAGC TGACCCCTTG 2520
GACCGACCTA CCTTTTCAGT GTTGAGGCTG CAGCTAGAAA AGTTCTTGGA AAGTTTGCCT 2580
GAAGTTCAGG ACAAAGCTGA TGTCATTTAC ATCAACACAC AGTTTCCCGA GAGCTGTGAG 2640
GACCCTGGAG AGGGCCCCGC ACTTGCTCAG CTAGACATGA ACATCGATGT GGACTCTATC 2700
ATCGGTTCTT GTGCTCCCAG CGCTGCCGTC AGTGTGGTCA CGGCAGAGGT TCACGAGAAC 2760
AGAGCTCACG AGGAGAGGTA CATCCTGAAC GGGGGCAGTG AGGAATGGGG AGATCTGGCT 2820
TCTGCTGCTC CAGCAACAGG CACGACGGGA AAGAACTGTG TTTTACCAGA GGACAGACTT 2880
GTGAAGAATG GAGTCTCCTG GTCCCAATCA AGCACGCTGC CCTTGGGGAG CCCGTCACCA 2940
GATGGACTTC TATTTGCCGA CGACTCCTCA GAAGACTCAG AAGTCCTCAT ATGA 2994
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         l+lgk+lgegefgsvmeg+lk++dg+++kvavkt+kld+++++eieeflseaacmk+f+h
Q: 585   LILGKILGEGEFGSVMEGNLKEQDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFNH  644
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnvirl+gv++e+s++g +pkp+vilpfmkygdlh++llysrl+++p+++p+q+l+kfmv
Q: 645   PNVIRLLGVCIEMSSQG-IPKPMVILPFMKYGDLHTYLLYSRLDTGPKHIPVQILLKFMV  703
         ****************9.******************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeyls+rnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvk
Q: 704   DIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  763
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesladrvytsksdvwafgvtmweiatrg+tpy+gv+n+e+ydyll+g+rlkqpedc
Q: 764   WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC  823
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ldely++m++cw+adp drp+fsvlr
Q: 824   LDELYEIMHSCWRADPLDRPTFSVLR  849
         *************************9
Domain Sequence
(FASTA)
LILGKILGEG EFGSVMEGNL KEQDGTSQKV AVKTMKLDNF SQREIEEFLS EAACMKDFNH 60
PNVIRLLGVC IEMSSQGIPK PMVILPFMKY GDLHTYLLYS RLDTGPKHIP VQILLKFMVD 120
IAQGMEYLSN RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180
IAIESLADRV YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL 240
DELYEIMHSC WRADPLDRPT FSVLR 265
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00370
EKS-ANC-00383
EKS-BOT-00400
EKS-CAJ-00403
EKS-CAP-00426
EKS-CII-00235
EKS-DAR-00776
EKS-EQC-00388
EKS-GAM-00236
EKS-GAG-00337
EKS-GAA-00487
EKS-GOG-00385
EKS-HOS-00401
EKS-ICT-00376
EKS-LAC-00414
EKS-LOA-00404
EKS-MAM-00397
EKS-MEG-00328
EKS-MOD-00384
EKS-MUM-00430
EKS-MUP-00389
EKS-MYL-00395
EKS-NOL-00363
EKS-ORN-00510
EKS-ORC-00375
EKS-OTG-00400
EKS-PAT-00373
EKS-PES-00354
EKS-PEM-00218
EKS-POA-00390
EKS-RAN-00412
EKS-TAG-00470
EKS-TAR-00501
EKS-TAS-00047
EKS-TEN-00499
EKS-XET-00510
EKS-XIM-00502
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0016028; C:rhabdomere
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0001779; P:natural killer cell differentiation
GO:0051250; P:negative regulation of lymphocyte activation
GO:0030168; P:platelet activation
GO:0050766; P:positive regulation of phagocytosis
GO:0043491; P:protein kinase B signaling cascade
GO:0060041; P:retina development in camera-type eye
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013