EKS-CAF-00277
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00277
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK444.52.7E-133205533329
StatusUnreviewed
Ensembl ProteinENSCAFP00000038768
UniProt AccessionE2R937;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK3
Gene Synonyms/Alias HIPK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000007235ENSCAFP00000010754ENSCAFT00000011605
ENSCAFG00000007235ENSCAFP00000038768ENSCAFT00000045084
OrganismCanis familiaris
Functional Description
Protein Length1202
Protein Sequence
(FASTA)
MESYQRGGMA SQVLVYPPYV YQTQSSAFCS VKKLKIEPSS CVFQERNYPR TYVNGKNVGN 60
SHPPTKGSVF QTKIPFNRPR GHNFSLQTSA VVLKNTAGAT KVIAAQAQQA QVEAPQIGAW 120
RHRLHFLEGP QRCGLKRKSE ELDNHSSAMQ IVDELSILPA MLQTNMGNPV TVVTTTTGTK 180
QNCTTGEGDY QLVQHEVLCS MKNTYEVLDF LGRGTFGQVV KCWKRGTNEI VAIKILKNHP 240
SYARQGQIEV SILARLSTEN ADEYNFVRAY ECFQHRNHTC LVFEMLEQNL YDFLKQNKFS 300
PLPLKVIRPI LQQVATALKK LKSLGLIHAD LKPENIMLVD PVRQPYRVKV IDFGSASHVS 360
KTVCSTYLQS RYYRAPEIIL GLPFCEAIDM WSLGCVIAEL FLGWPLYPGA LEYDQIRYIS 420
QTQGLPGEQL LNVGTKSTRF FCRETEISHS GWRLKTLEEH EAETGMKSKE ARKYIFNSLD 480
DIVHVNTVMD LEGSDLLAEK ADRREFVSLL KKMLLIDADL RITPAETLNH PFVNMKHLLD 540
FPHSNHVKSC FHIMDICKSH PNSCDTNNHN KTSLLRPVAS GNTANLTANF TKIGTLRNQA 600
LTTSAHSVVH HGIPLQAGTA HFGCGDAFQQ TLIICPPAIQ GIPATHGKPT SYSIRVDNTV 660
PLVTQAPAVQ PLQIRPGVLS QTWSGRTQQM LVPAWQQVTP MAPATTALTS EGVAGSQRLG 720
DWGKMISHSN HYSSVMPQPL LTNQITLSAP QPISVGIAHV VWPQPATAKK NKLCQNRSNS 780
LQNTNVPHST FISPKIVNGK DVEEVRCVET QDNHNSEGGA RDCCETSVQQ DSDSSVSDKQ 840
RQTIIIADSP SPAVSVITIS SDTDEEETSQ RHSLRECKDS LDCEACQSTL NIDRMCSLSS 900
PDSTLSTSSS GQSSPSPCKR PNSMSDEEQE SGCDTVDGSP TSDSSGHDSP FAESSFVEDA 960
HQNTELVTSA NTETKPAVCT VVVPPMGLEN GLNADEHMSN TDSICQPLIK GRSAPGRLNQ 1020
PSTVGNRQQK LTSAFQQQHL NFSQVQHFGS GHQEWNGNFG HRRQQAYIPT SVTSNPFTLS 1080
HGSPNHTAVH AHLAGSAHLG GQPTLLPYPS SATLSSAAPV AHLLASPCTS RPMLQHPTYN 1140
ISHPSGIVHQ VPVGINPRLL PSPTIHQTQY KPIFPPHSYI AASPAYTGFP LSPTKLSQYP 1200
YM 1202
Nucleotide Sequence
(FASTA)
ATGGAGAGTT ACCAACGCGG AGGTATGGCC TCACAAGTCT TGGTCTACCC ACCGTATGTT 60
TATCAAACTC AGTCAAGTGC CTTTTGTAGT GTGAAGAAAC TCAAAATAGA GCCAAGCAGT 120
TGTGTATTCC AGGAAAGAAA CTATCCACGG ACCTATGTGA ATGGTAAAAA CGTTGGAAAT 180
TCTCATCCTC CCACGAAGGG TAGTGTTTTT CAGACAAAGA TACCATTTAA CAGACCTCGA 240
GGACACAACT TTTCGTTGCA GACAAGTGCT GTTGTTTTAA AAAACACTGC GGGTGCTACA 300
AAGGTGATAG CAGCTCAGGC GCAACAAGCT CAAGTGGAGG CACCTCAGAT TGGGGCGTGG 360
CGACACAGAT TACATTTCCT AGAAGGCCCC CAGCGATGTG GATTGAAGCG CAAGAGTGAA 420
GAGTTGGATA ATCATAGCAG CGCAATGCAG ATTGTTGATG AATTGTCCAT ACTTCCTGCA 480
ATGTTGCAAA CCAACATGGG AAATCCAGTG ACAGTTGTGA CAACTACCAC AGGAACAAAA 540
CAGAATTGTA CCACTGGAGA AGGTGACTAT CAGTTAGTAC AGCACGAAGT CTTATGCTCC 600
ATGAAAAACA CTTATGAAGT CCTTGATTTT CTTGGTCGAG GCACTTTTGG CCAGGTAGTC 660
AAATGCTGGA AAAGAGGGAC AAATGAAATT GTAGCAATCA AAATTTTGAA GAATCACCCA 720
TCTTATGCAC GTCAAGGTCA AATAGAAGTG AGCATATTAG CAAGGCTCAG TACTGAAAAT 780
GCTGATGAAT ATAACTTTGT ACGAGCTTAT GAATGCTTTC AGCACCGTAA CCATACTTGT 840
TTAGTCTTTG AGATGCTGGA ACAAAACTTG TATGACTTTC TGAAGCAAAA TAAATTTAGT 900
CCCCTGCCAC TAAAAGTAAT TCGACCTATT CTTCAACAAG TGGCCACTGC ACTGAAAAAA 960
TTGAAAAGTC TTGGTTTAAT TCATGCTGAC CTCAAACCAG AGAATATTAT GTTGGTGGAT 1020
CCTGTCCGGC AGCCATATAG GGTTAAGGTG ATAGACTTTG GGTCGGCCAG TCATGTATCA 1080
AAGACTGTCT GTTCAACATA TCTACAGTCT CGGTACTACA GAGCTCCAGA GATTATATTG 1140
GGGTTGCCAT TTTGTGAAGC CATAGACATG TGGTCATTGG GATGCGTGAT TGCAGAATTA 1200
TTCCTTGGAT GGCCACTCTA CCCAGGAGCC TTGGAGTATG ACCAGATTCG ATATATTTCT 1260
CAGACTCAAG GTTTACCAGG AGAACAGTTG TTAAATGTGG GCACAAAATC CACAAGATTT 1320
TTTTGCAGAG AAACAGAGAT TTCTCATTCT GGTTGGAGAT TAAAGACACT AGAAGAACAT 1380
GAAGCAGAGA CAGGAATGAA GTCTAAAGAA GCCAGAAAGT ACATATTCAA CAGTCTGGAT 1440
GATATAGTGC ATGTGAACAC AGTGATGGAT TTGGAAGGAA GTGATCTTTT GGCTGAGAAA 1500
GCTGATAGAA GAGAATTTGT TAGTCTTTTG AAGAAAATGT TGCTGATTGA TGCAGATTTA 1560
AGAATTACTC CAGCTGAGAC TCTGAACCAT CCTTTTGTTA ATATGAAACA TCTTCTAGAC 1620
TTCCCTCATA GCAACCATGT AAAGTCCTGT TTTCATATTA TGGATATTTG TAAGTCCCAC 1680
CCAAATTCAT GTGACACAAA TAATCATAAT AAAACTTCAC TTTTAAGACC AGTTGCTTCA 1740
GGCAATACTG CTAATCTGAC AGCAAATTTT ACTAAAATTG GCACATTAAG AAATCAGGCA 1800
TTAACCACGT CTGCTCATTC AGTGGTGCAC CATGGAATTC CTCTGCAGGC TGGAACTGCT 1860
CATTTTGGTT GTGGTGATGC TTTTCAGCAG ACTCTGATTA TCTGTCCCCC AGCTATTCAA 1920
GGTATTCCTG CAACACATGG TAAACCCACT AGTTATTCAA TAAGAGTAGA TAATACAGTT 1980
CCACTTGTAA CACAGGCCCC AGCTGTACAG CCACTACAGA TCCGACCAGG AGTTCTTTCT 2040
CAGACGTGGT CTGGCAGGAC ACAGCAGATG CTCGTACCTG CCTGGCAGCA GGTAACACCC 2100
ATGGCTCCTG CTACTACTGC ATTAACTTCT GAGGGGGTGG CTGGTTCACA AAGGCTTGGA 2160
GACTGGGGGA AAATGATTTC ACACAGTAAT CATTATAGCT CAGTGATGCC ACAACCTCTT 2220
CTAACCAATC AGATAACTTT ATCAGCCCCG CAGCCAATTA GTGTGGGCAT TGCACATGTC 2280
GTCTGGCCTC AGCCTGCCAC TGCAAAGAAA AATAAACTGT GCCAGAACAG GAGTAATTCG 2340
TTGCAGAATA CGAATGTCCC TCATTCAACA TTTATTTCTC CAAAGATAGT AAATGGGAAA 2400
GATGTCGAGG AAGTACGTTG TGTAGAAACA CAGGACAATC ATAACTCAGA AGGAGGGGCA 2460
AGAGATTGTT GTGAAACATC TGTCCAGCAG GACTCTGATT CATCAGTTTC AGACAAACAG 2520
CGGCAAACCA TCATCATTGC TGACTCCCCA AGCCCTGCAG TGAGTGTGAT TACTATTAGC 2580
AGTGACACGG ATGAGGAGGA GACGTCGCAG AGACACTCAC TCAGAGAATG TAAAGATAGT 2640
TTGGATTGTG AAGCTTGCCA GAGCACTTTG AATATAGATC GGATGTGTTC ATTAAGTAGT 2700
CCTGATAGTA CTCTGAGCAC CAGCTCCTCA GGGCAGTCCA GCCCATCCCC TTGCAAGAGA 2760
CCGAACAGTA TGTCAGATGA AGAACAGGAA AGTGGCTGTG ATACTGTGGA TGGCTCTCCA 2820
ACATCAGACT CTTCCGGACA TGACAGTCCC TTTGCAGAGA GCAGCTTTGT GGAGGACGCT 2880
CACCAAAACA CAGAACTGGT AACCTCTGCC AACACAGAAA CCAAACCAGC TGTTTGTACT 2940
GTTGTGGTGC CACCAATGGG ACTAGAGAAT GGATTAAATG CCGATGAGCA TATGTCAAAC 3000
ACAGATTCTA TATGCCAGCC ATTGATAAAA GGCCGATCCG CTCCCGGGAG ATTAAACCAG 3060
CCTTCCACGG TGGGTAATCG TCAGCAGAAA CTGACATCAG CATTCCAGCA GCAGCATTTG 3120
AACTTCAGTC AGGTTCAGCA CTTTGGATCT GGGCATCAAG AGTGGAATGG AAACTTCGGA 3180
CATCGAAGGC AGCAAGCTTA TATACCTACT AGTGTTACCA GTAATCCATT CACTCTTTCC 3240
CATGGAAGTC CCAATCACAC AGCCGTGCAT GCCCATCTGG CTGGAAGTGC GCATCTTGGA 3300
GGACAGCCTA CTCTACTTCC ATACCCATCA TCAGCTACCC TCAGTAGTGC TGCACCAGTG 3360
GCCCACCTCT TAGCCTCTCC ATGTACCTCA AGACCTATGT TACAGCATCC AACTTACAAT 3420
ATCTCTCATC CCAGTGGCAT AGTTCACCAA GTCCCAGTGG GCATAAATCC CCGTCTGTTA 3480
CCATCCCCAA CCATTCATCA GACTCAGTAC AAACCAATCT TCCCACCACA TTCTTACATT 3540
GCAGCATCAC CTGCATATAC TGGATTTCCA TTGAGTCCAA CAAAACTCAG CCAGTATCCA 3600
TATATGTGA 3609
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevl+++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 205   YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ENADE  263
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr++e+f++rnh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aLk+Lk+
Q: 264   YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS  323
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 324   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP  383
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG+ e+dq+++i++++glp e+ll+ ++k+++ff  
Q: 384   FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFcr  443
         **********************************************************99
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
          t+ +++ ++lkt          ks++++k+++n  +++ ++++ ++ e ++ l+ek+d+
Q: 444   eTEISHSGWRLKTLeeheaetgmKSKEARKYIFNSLDDIVHVNTVMDLEGSDLLAEKADR  503
         8889999999999999*******************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + f++llk+ml +d++ Ritp+e+l+hpfv
Q: 504   ReFVSLLKKMLLIDADLRITPAETLNHPFV  533
         99***************************7
Domain Sequence
(FASTA)
YEVLDFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTENADEY 60
NFVRAYECFQ HRNHTCLVFE MLEQNLYDFL KQNKFSPLPL KVIRPILQQV ATALKKLKSL 120
GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKTVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGALEYD QIRYISQTQG LPGEQLLNVG TKSTRFFCRE 240
TEISHSGWRL KTLEEHEAET GMKSKEARKY IFNSLDDIVH VNTVMDLEGS DLLAEKADRR 300
EFVSLLKKML LIDADLRITP AETLNHPFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00252
EKS-ANC-00259
EKS-BOT-00270
EKS-CAJ-00276
EKS-CAP-00305
EKS-DAR-00610
EKS-DIO-00021
EKS-EQC-00262
EKS-FEC-00256
EKS-GAG-00227
EKS-GAA-00333
EKS-GOG-00269
EKS-HOS-00276
EKS-ICT-00259
EKS-LAC-00281
EKS-LOA-00280
EKS-MAM-00272
EKS-MEG-00215
EKS-MOD-00267
EKS-MUM-00301
EKS-MUP-00267
EKS-MYL-00272
EKS-NOL-00247
EKS-ORN-00349
EKS-ORA-00234
EKS-ORC-00255
EKS-ORL-00325
EKS-OTG-00276
EKS-PAT-00255
EKS-PES-00240
EKS-POA-00260
EKS-RAN-00285
EKS-SAH-00254
EKS-SUS-00232
EKS-TAG-00285
EKS-TAR-00346
EKS-VIP-00012
EKS-XET-00344
EKS-XIM-00341
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0009299; P:mRNA transcription
GO:0043508; P:negative regulation of JUN kinase activity
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013