EKS-CAF-00427

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00427

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	533.0	1.8E-160	156	413	258

Status

Unreviewed

Ensembl Protein

ENSCAFP00000010912

UniProt Accession

D7NGX9; F1PPK9;

Protein Name

Protein Synonyms/Alias

Serum glucocorticoid regulated kinase 3;

Gene Name

SGK3

Gene Synonyms/Alias

SGK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000007353	ENSCAFP00000010912	ENSCAFT00000011773

Organism

Canis familiaris

Functional Description

Protein Length

490

Protein Sequence
(FASTA)

MDYKESCPSV SIPSSDEHRE KKKRFTVYKV LVSVGRSEWF VFRRYAEFDK LYNTLKKQFP 60

AMALKIPAKR IFGDNFDPDF IKQRRAGLNE FIQNLVRYPE LYNHPDVRAF LQMDSPKHQS 120

DPSEDEDERS TQKLHSTSQN INLGPSGNPH AKPTDFDFLK VIGKGSFGKV LLAKRKLDGK 180

FYAVKVLQKK VVLNRKEQKH IMAERNVLLK NVKHPFLVGL HYSFQTTEKL YFVLDFVNGG 240

ELFFHLQRER SFPEHRARFY AAEIASALGY LHSIKIVYRD LKPENILLDS VGHVVLTDFG 300

LCKEGIAISD TTTTFCGTPE YLAPEVIRKQ PYDNTVDWWC LGAVLYEMLY GLPPFYCRDV 360

AEMYDNILHK PLSLRPGVSL TAWSILEELL EKNRQNRLGA KEDFLEIQNH PFFESLSWTD 420

LVQKRIPPPF NPNVAGPDDI RNFDAAFTEE TVPYSVCVSS DYSIVNASVL EADDAFVGFS 480

YAPPSEDLFL 490

Nucleotide Sequence
(FASTA)

ATGGACTACA AAGAAAGCTG CCCAAGTGTA AGCATTCCCA GCTCTGATGA ACACAGAGAG 60

AAGAAGAAGA GGTTTACTGT TTATAAAGTT CTGGTCTCAG TGGGTAGGAG TGAGTGGTTT 120

GTCTTCAGGA GATATGCGGA GTTTGATAAG CTTTACAATA CTTTAAAGAA ACAATTTCCT 180

GCTATGGCCC TGAAGATCCC TGCCAAGAGA ATATTTGGTG ATAATTTTGA TCCAGATTTT 240

ATTAAACAAA GAAGAGCAGG ACTGAATGAA TTCATTCAGA ACTTAGTTAG GTATCCAGAA 300

CTTTACAACC ATCCAGACGT CAGAGCATTT CTTCAAATGG ACAGTCCAAA ACATCAGTCA 360

GATCCATCTG AAGATGAGGA TGAAAGAAGT ACTCAGAAGC TACACTCTAC CTCACAGAAC 420

ATCAACCTGG GACCATCTGG AAATCCTCAT GCTAAACCAA CAGACTTTGA TTTCCTGAAA 480

GTTATTGGAA AAGGCAGCTT TGGCAAGGTT CTTCTTGCAA AACGGAAACT GGATGGAAAA 540

TTTTATGCTG TCAAAGTGTT ACAGAAAAAA GTAGTTCTGA ACAGAAAAGA GCAAAAACAT 600

ATTATGGCTG AACGTAATGT GCTTTTGAAA AATGTGAAAC ATCCATTTTT GGTTGGATTA 660

CATTATTCTT TCCAAACAAC TGAAAAGCTT TATTTTGTTC TGGATTTTGT TAATGGAGGG 720

GAGCTGTTTT TCCACTTACA GAGAGAACGA TCCTTTCCCG AACACAGAGC TAGGTTTTAT 780

GCTGCTGAAA TTGCCAGTGC ATTGGGTTAC TTGCACTCCA TCAAAATAGT GTACAGAGAC 840

TTGAAACCAG AAAATATTCT TTTGGATTCA GTAGGACATG TTGTCTTAAC AGATTTTGGG 900

CTTTGTAAAG AAGGAATTGC TATTTCTGAC ACAACAACAA CATTTTGTGG GACACCAGAG 960

TACCTTGCTC CTGAAGTAAT CAGAAAACAG CCCTATGACA ATACTGTAGA TTGGTGGTGC 1020

CTTGGTGCTG TTCTCTATGA AATGCTGTAT GGATTGCCTC CCTTTTATTG CCGAGATGTT 1080

GCTGAAATGT ATGACAATAT TCTTCACAAG CCTCTGAGTT TGAGGCCAGG AGTGAGCCTC 1140

ACAGCCTGGT CCATTCTGGA AGAACTCCTA GAAAAGAATA GGCAAAATCG ACTTGGTGCC 1200

AAAGAAGACT TTCTTGAAAT TCAGAATCAT CCTTTTTTTG AATCACTCAG CTGGACTGAT 1260

CTTGTACAAA AGAGGATTCC ACCACCATTT AATCCTAATG TGGCAGGACC AGATGATATC 1320

AGGAACTTTG ATGCAGCGTT TACAGAAGAA ACAGTTCCGT ATTCTGTGTG TGTATCTTCT 1380

GACTATTCTA TAGTGAATGC CAGTGTACTG GAGGCAGATG ATGCATTCGT TGGCTTCTCT 1440

TACGCACCTC CTTCAGAAGA TTTATTTTTG TGA 1473

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         fdflkvigkgsfgkvllakrk d+kfyavkvlqkk +l++ke+khimaernvllknvkhp

Q: 156   FDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKVVLNRKEQKHIMAERNVLLKNVKHP  215

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglhysfqt+eklyfvld+vnggelffhlqrersf+e+rarfyaaeiasalgylhs++

Q: 216   FLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIK  275

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds ghvvltdfglcke+i+++dtt+tfcgtpeylapev+rk+pyd+t

Q: 276   IVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNT  335

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfy+rdvaemydnil+kpl+l+pg+s++a+++leellek+r+

Q: 336   VDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKNRQ  395

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         +rlgakedflei+nh+ff

Q: 396   NRLGAKEDFLEIQNHPFF  413

         *****************9

Domain Sequence
(FASTA)

FDFLKVIGKG SFGKVLLAKR KLDGKFYAVK VLQKKVVLNR KEQKHIMAER NVLLKNVKHP 60

FLVGLHYSFQ TTEKLYFVLD FVNGGELFFH LQRERSFPEH RARFYAAEIA SALGYLHSIK 120

IVYRDLKPEN ILLDSVGHVV LTDFGLCKEG IAISDTTTTF CGTPEYLAPE VIRKQPYDNT 180

VDWWCLGAVL YEMLYGLPPF YCRDVAEMYD NILHKPLSLR PGVSLTAWSI LEELLEKNRQ 240

NRLGAKEDFL EIQNHPFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016023	; C:cytoplasmic membrane-bounded vesicle
GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007154	; P:cell communication

KEGG

cfa:486981

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR001683	; Phox.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.
PF00787	; PX; 1.

SMARTs

SM00312	; PX; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50195	; PX; 1.

Prints

Created Date

20-Feb-2013