EKS-CAF-00282

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00282

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.9	3.3E-137	155	442	288

Status

Unreviewed

Ensembl Protein

ENSCAFP00000036838

UniProt Accession

F1PPK6;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000007357	ENSCAFP00000036838	ENSCAFT00000047968
ENSCAFG00000007357	ENSCAFP00000010923	ENSCAFT00000011784

Organism

Canis familiaris

Functional Description

Protein Length

453

Protein Sequence
(FASTA)

MVSIFNLDGM EHHVRTCIPK VELVPAGKPF YCLSSEDLRN THCCYTDFCN KIDLRVPSGH 60

LKESEHPSMW GPVELVGIIA GPVFLLFLII IIVFLVINYH QRVYHNRQRL DMEDPSCEMC 120

LSKDKTLQDL VYDLSTSGSG SGLPLFVQRT VARTIVLQEI IGKGRFGEVW RGRWRGGDVA 180

VKIFSSREER SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD 240

YLNRYTVTIE GMIKLALSAA SGLAHLHMEI VGTQGKPGIA HRDLKSKNIL VKKNGMCAIA 300

DLGLAVRHDA VTDTIDIAPN QRVGTKRYMA PEVLDETINM KHFDSFKCAD IYALGLVYWE 360

IARRCNSGGV HEEYQLPYYD LVPSDPSIEE MRKVVCDQKL RPNIPNWWQS YEALRVMGKM 420

MRECWYANGA ARLTALRIKK TLSQLSVQED VKI 453

Nucleotide Sequence
(FASTA)

ATGGTTTCCA TTTTCAACCT GGATGGGATG GAGCACCACG TGCGCACCTG CATCCCCAAA 60

GTGGAGCTGG TCCCCGCTGG GAAGCCCTTC TACTGTCTGA GCTCTGAGGA TCTCCGCAAC 120

ACCCACTGCT GCTATACTGA CTTCTGTAAC AAGATCGACC TGAGGGTGCC CAGTGGTCAC 180

CTCAAGGAGT CTGAGCACCC TTCCATGTGG GGCCCCGTGG AGCTGGTAGG CATTATTGCT 240

GGCCCAGTGT TCCTCCTGTT TCTCATCATC ATCATTGTTT TCCTTGTCAT TAACTATCAT 300

CAGCGTGTCT ATCACAACCG CCAGAGACTG GACATGGAAG ATCCCTCGTG TGAGATGTGT 360

CTCTCCAAAG ACAAGACGCT CCAGGATCTT GTCTACGATC TCTCCACATC AGGGTCTGGC 420

TCAGGGTTGC CCCTGTTCGT CCAGCGCACC GTGGCCCGAA CCATCGTTTT ACAGGAGATT 480

ATTGGCAAGG GCCGATTTGG GGAAGTGTGG CGCGGCCGCT GGAGGGGTGG TGATGTGGCT 540

GTGAAGATTT TCTCTTCTCG TGAAGAACGG TCTTGGTTCC GGGAAGCAGA GATATACCAG 600

ACGGTCATGC TGCGCCACGA AAACATCCTT GGATTTATTG CTGCTGACAA TAAAGATAAT 660

GGCACCTGGA CACAGCTGTG GCTCGTCTCA GACTACCATG AGCATGGCTC CCTGTTTGAT 720

TATCTTAACC GATACACGGT GACGATCGAG GGGATGATTA AGCTGGCCTT GTCTGCGGCT 780

AGCGGGCTAG CACACCTGCA CATGGAGATC GTGGGTACCC AAGGGAAGCC TGGAATTGCT 840

CATCGAGACT TAAAATCCAA GAACATCCTG GTGAAGAAAA ATGGCATGTG CGCCATAGCA 900

GACCTGGGCC TGGCCGTCCG CCATGATGCG GTCACTGACA CCATTGACAT TGCCCCAAAT 960

CAGAGGGTGG GAACCAAACG ATACATGGCC CCCGAAGTGC TCGATGAAAC CATTAACATG 1020

AAGCACTTTG ACTCCTTCAA ATGTGCTGAT ATCTATGCCC TCGGGCTCGT ATACTGGGAG 1080

ATTGCTCGGA GATGCAATTC TGGAGGAGTC CATGAAGAAT ATCAGCTGCC ATATTACGAC 1140

TTAGTGCCCT CTGACCCTTC CATTGAGGAA ATGCGGAAGG TCGTGTGTGA CCAGAAGCTA 1200

CGTCCCAACA TCCCCAACTG GTGGCAGAGC TATGAGGCGC TGCGGGTGAT GGGGAAGATG 1260

ATGCGGGAGT GCTGGTACGC CAACGGCGCG GCCCGCCTGA CCGCCCTGCG CATTAAGAAG 1320

ACCCTGTCTC AGCTCAGCGT GCAGGAAGAT GTGAAGATCT AA 1362

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 155   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  214

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 215   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  274

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 275   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  332

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 333   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  391

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 392   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  442

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013