EKS-CAF-00423

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00423

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	377.0	5.4E-113	300	570	271

Status

Unreviewed

Ensembl Protein

ENSCAFP00000011018

UniProt Accession

E2RIU0;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE1

Gene Synonyms/Alias

WEE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000007416	ENSCAFP00000011018	ENSCAFT00000011883

Organism

Canis familiaris

Functional Description

Protein Length

665

Protein Sequence
(FASTA)

MSFLSRQQPP PPRRRPGASC TLRQKLIFSP CSDCEEEEEE EEEEGSGHST GEDSAFQEPD 60

SPLPPARSPT EPGPERRRSP GPAPGSPGEL EEDMLLRGAC PGADAPGGGA EGDSWEEEGF 120

GSSSPVKSPA AAYFLGSSFS PVRCGGAGDA SPRGCGARRA SEGPCSPLPD HPGTPPHKTF 180

RKLRLFDTPH TPKSLLSKAR GIDSSSVKLR GGSLFMDTEK SGKREFDMRQ TPQVNINPFT 240

PDSVLLHSSG QCRRRKRTHW NDSCGEDMEA SDYELEDETR PAKRITITES NMKSRYTTEF 300

HELEKIGSGE FGSVFKCVKR LDGCIYAIKR SKKPLAGSVD EQNALREVYA HAVLGQHSHV 360

VRYFSAWAED DHMLIQNEYC NGGSLADAIS ENYRSMSYFT EAELKDLLLQ VGRGLRYIHS 420

MSLVHMDIKP SNIFISRTSI PNAASEEGDE DDWASNKVMF KIGDLGHVTR ISSPQVEEGD 480

SRFLANEVLQ ENYTHLPKAD IFALALTVVC AAGAEPLPRN GDQWHEIRQG RLPRIPQVLS 540

QEFTELLKVM IHPDPERRPS AMALVKHSVL LSASRKSAEQ LRIELNAEKF KNSLLQKELK 600

KAQMAKAAAE ERALFTDRMT TRSTTQNDPN FQCSSKVSGI RKNIYVCSRK IYQEKMVCSV 660

QTSLN 665

Nucleotide Sequence
(FASTA)

ATGAGCTTCC TGAGCCGGCA ACAGCCGCCG CCGCCCCGCC GCCGTCCCGG GGCTTCCTGC 60

ACTTTGAGGC AGAAGCTGAT CTTCTCGCCC TGCAGCGACT GTGAGGAGGA GGAGGAGGAG 120

GAAGAGGAGG AGGGCAGCGG CCACAGCACG GGAGAGGACT CGGCCTTCCA AGAGCCCGAC 180

TCGCCGCTGC CGCCCGCGCG TAGCCCCACA GAGCCCGGGC CCGAGCGCCG CCGCTCGCCG 240

GGCCCGGCCC CCGGCAGCCC CGGGGAGCTG GAGGAGGACA TGTTGCTGCG GGGCGCCTGT 300

CCCGGCGCCG ACGCGCCGGG CGGCGGGGCC GAGGGCGACT CGTGGGAGGA GGAGGGCTTC 360

GGCTCCTCGT CGCCGGTCAA GTCGCCGGCA GCCGCCTACT TTCTGGGCAG CTCGTTCTCG 420

CCGGTGCGCT GCGGCGGCGC GGGGGACGCG TCCCCGCGCG GCTGCGGGGC GCGCAGGGCC 480

AGCGAGGGCC CCTGCTCGCC GCTGCCGGAC CACCCCGGCA CCCCGCCGCA CAAGACCTTC 540

CGCAAGCTGC GGCTCTTCGA CACGCCGCAC ACGCCCAAGA GTTTACTCTC CAAAGCTCGA 600

GGAATCGATT CCAGCTCTGT TAAACTCCGA GGTGGTTCTT TATTCATGGA TACAGAAAAA 660

TCAGGAAAAA GGGAATTTGA CATGCGACAG ACGCCTCAAG TGAATATTAA TCCTTTTACC 720

CCAGATTCTG TGTTACTTCA TTCCTCAGGA CAGTGTCGTA GAAGAAAACG AACACACTGG 780

AATGATTCTT GTGGTGAAGA CATGGAAGCC AGTGATTATG AGTTAGAAGA TGAAACAAGA 840

CCTGCTAAAA GAATTACAAT TACTGAAAGC AATATGAAGT CACGGTATAC AACAGAATTT 900

CATGAGCTAG AGAAAATTGG CTCTGGAGAG TTTGGTTCTG TGTTTAAGTG TGTGAAGAGG 960

CTGGATGGAT GCATTTATGC CATTAAGCGA TCAAAAAAGC CATTGGCCGG CTCTGTCGAT 1020

GAGCAGAACG CTTTGAGGGA AGTATATGCC CATGCAGTGC TCGGACAGCA TTCTCACGTA 1080

GTTCGATATT TCTCTGCATG GGCAGAAGAT GATCATATGC TTATACAGAA TGAATATTGT 1140

AATGGTGGAA GTTTAGCGGA TGCCATAAGT GAAAACTATA GAAGCATGAG TTACTTTACA 1200

GAGGCAGAGT TGAAGGATCT CCTTTTGCAA GTTGGCCGGG GCTTGAGGTA TATCCATTCA 1260

ATGTCTTTGG TTCATATGGA TATAAAGCCT AGTAATATTT TCATATCTCG AACCTCAATC 1320

CCAAATGCTG CCTCTGAAGA AGGAGATGAA GATGACTGGG CATCCAACAA AGTTATGTTT 1380

AAAATAGGTG ATCTTGGACA TGTAACAAGA ATCTCTAGTC CACAAGTTGA AGAGGGTGAT 1440

AGCCGTTTTC TTGCAAATGA AGTTTTACAG GAGAACTATA CTCATCTGCC AAAAGCGGAT 1500

ATTTTTGCCC TTGCCCTCAC AGTGGTGTGT GCTGCTGGTG CTGAACCTCT TCCGAGAAAT 1560

GGAGACCAAT GGCATGAAAT CAGACAGGGT AGATTACCTC GAATTCCCCA AGTGCTTTCC 1620

CAAGAATTTA CAGAGTTGCT AAAAGTTATG ATTCATCCAG ATCCAGAGAG AAGACCATCA 1680

GCAATGGCAC TGGTAAAGCA TTCGGTATTG CTGTCTGCTT CTAGAAAAAG TGCAGAACAA 1740

TTACGAATAG AATTGAACGC TGAAAAATTC AAAAATTCAC TTTTGCAGAA AGAACTCAAG 1800

AAAGCCCAGA TGGCAAAAGC TGCAGCTGAG GAAAGAGCAC TCTTCACTGA TCGGATGACC 1860

ACTAGGTCCA CCACCCAGAA TGACCCTAAT TTTCAATGCA GTTCAAAGGT CTCTGGAATA 1920

AGGAAAAATA TCTATGTATG CTCTAGGAAG ATTTACCAGG AAAAGATGGT ATGTTCTGTC 1980

CAAACTTCAT TAAACTAA 1998

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F+e+ekiG+Gefg+vfk+vkr+dg++yAik+skkpl+g+++e++alrEv+ahavlgqh++

Q: 300   FHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSH  359

         99**********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+ggsL++a++e+++++++++eaelk++ll++ +glry+H

Q: 360   VVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRSMSYFTEAELKDLLLQVGRGLRYIH  419

         ************************************************************

S: 121   ssslvHlDikpenifi...................tkevtlklgDlGlvtelnsedkskv  161

         s+slvH+Dikp+nifi                   +++v++k+gDlG+vt++   ++++v

Q: 420   SMSLVHMDIKPSNIFIsrtsipnaaseegdeddwaSNKVMFKIGDLGHVTRI---SSPQV  476

         ****************************************************...9****

S: 162   eEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpdei  220

         eEGDsr+la+E+lqe+y++l kaDiF+l+lt++++a++++lP+nG++Wh++R+g+lp +i

Q: 477   EEGDSRFLANEVLQENYTHLpKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLP-RI  535

         *********************************************************.**

S: 221   lkelsedlrellklmlepdperRptaeellkhevl  255

          ++ls++++ellk+m++pdperRp+a++l+kh+vl

Q: 536   PQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL  570

         ********************************986

Domain Sequence
(FASTA)

FHELEKIGSG EFGSVFKCVK RLDGCIYAIK RSKKPLAGSV DEQNALREVY AHAVLGQHSH 60

VVRYFSAWAE DDHMLIQNEY CNGGSLADAI SENYRSMSYF TEAELKDLLL QVGRGLRYIH 120

SMSLVHMDIK PSNIFISRTS IPNAASEEGD EDDWASNKVM FKIGDLGHVT RISSPQVEEG 180

DSRFLANEVL QENYTHLPKA DIFALALTVV CAAGAEPLPR NGDQWHEIRQ GRLPRIPQVL 240

SQEFTELLKV MIHPDPERRP SAMALVKHSV L 271

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007067	; P:mitosis

KEGG

cfa:476847

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013