EKS-CAF-00069

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00069

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	347.3	7.4E-104	12	295	284

Status

Unreviewed

Ensembl Protein

ENSCAFP00000011477

UniProt Accession

E2R8R2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000007748	ENSCAFP00000011477	ENSCAFT00000012387
ENSCAFG00000007748	ENSCAFP00000011478	ENSCAFT00000012388

Organism

Canis familiaris

Functional Description

Protein Length

346

Protein Sequence
(FASTA)

MAVDVKSRAK RYEKLDFLGE GQIAPVYRPE TKNTHQIVAI KKIKLGHRSE AKDGINRTAL 60

REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM 120

TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA 180

PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM 240

CSLPDFVTFK SFPGIPLQHI FIAAGDDLLD LIQGLFLFNP CTRITATQAL KTKYFSNRPG 300

PTPGCQLPRP NCPLETLKEQ SNPAVATKRK RTQALEQGGL PKKLIF 346

Nucleotide Sequence
(FASTA)

ATGGCGGTGG ACGTGAAGTC GCGAGCGAAG CGTTATGAGA AGCTGGACTT CCTCGGGGAG 60

GGACAGATTG CCCCGGTTTA CCGGCCCGAG ACCAAGAACA CCCACCAAAT TGTCGCCATT 120

AAGAAGATTA AACTTGGACA TAGATCAGAA GCTAAAGATG GTATAAACAG AACAGCTTTA 180

AGAGAGATAA AATTATTACA GGAGCTAAGC CATCCAAATA TAATTGGTCT CCTTGATGCT 240

TTTGGGCATA AATCTAATAT TAGCCTTGTC TTTGATTTTA TGGAAACTGA TCTAGAGGTT 300

ATAATAAAGG ATAATAGTCT TGTGCTGACC CCATCACACA TCAAAGCCTA CATGTTGATG 360

ACTCTTCAAG GGTTGGAATA TTTACATCAA CACTGGATTC TACATAGGGA TCTAAAACCA 420

AACAACTTGT TGCTAGATGA AAATGGTGTT CTAAAACTAG CAGATTTTGG CCTGGCCAAA 480

TCATTTGGGA GCCCCAATAG AGCTTATACA CATCAGGTTG TAACCAGATG GTATCGGGCC 540

CCTGAGTTAC TCTTTGGAGC TAGAATGTAT GGTGTAGGTG TCGACATGTG GGCTGTTGGC 600

TGTATATTAG CAGAGTTGCT TCTAAGGGTT CCTTTTTTGC CGGGAGATTC AGACCTTGAT 660

CAACTAACAA GAATATTTGA AACTTTGGGC ACACCAACTG AGGAACAGTG GCCTGACATG 720

TGTAGTCTTC CAGATTTCGT GACATTTAAA AGTTTTCCTG GAATCCCGTT ACAACACATC 780

TTCATTGCAG CAGGAGACGA CTTGCTAGAT CTCATACAAG GCTTATTCTT ATTTAACCCA 840

TGTACTCGAA TTACGGCCAC ACAGGCATTG AAAACTAAAT ATTTCAGTAA TCGGCCAGGT 900

CCAACACCTG GATGTCAGCT GCCAAGACCA AACTGTCCCC TGGAAACTTT AAAGGAGCAG 960

TCAAATCCAG CTGTAGCAAC AAAACGGAAG CGAACACAGG CCTTGGAACA AGGAGGATTA 1020

CCCAAGAAGC TAATTTTT 1038

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG+ + vy+ ++k+t+++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQIAPVYRPETKNTHQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  71

         89********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+ylH

Q: 72    PNIIGLLDAFG-HKSNISLVFDFMETDLEVIIKDNSL-VLTPSHIKAYMLMTLQGLEYLH  129

         ***********.99**********************9.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla++f+sp+++yt++vvT+wYraPelL+ga+

Q: 130   QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM  189

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql+rif++lgtp+e++wp++ +lp++  +

Q: 190   YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDFV-T  248

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ +   l++ + ++ ++ ldl++ l+ ++p +Ri+a++al++kyf

Q: 249   FKSFPGIPLQHIFIAAGDDLLDLIQGLFLFNPCTRITATQALKTKYF  295

         9999999******99999****************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QIAPVYRPET KNTHQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNIIGLLDAF GHKSNISLVF DFMETDLEVI IKDNSLVLTP SHIKAYMLMT LQGLEYLHQH 120

WILHRDLKPN NLLLDENGVL KLADFGLAKS FGSPNRAYTH QVVTRWYRAP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRVP FLPGDSDLDQ LTRIFETLGT PTEEQWPDMC SLPDFVTFKS 240

FPGIPLQHIF IAAGDDLLDL IQGLFLFNPC TRITATQALK TKYF 284

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005675	; C:holo TFIIH complex
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0008094	; F:DNA-dependent ATPase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366	; P:transcription from RNA polymerase II promoter

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013