EKS-CAF-00372

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00372

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	423.6	2.9E-127	236	485	250

Status

Unreviewed

Ensembl Protein

ENSCAFP00000011788

UniProt Accession

E2R5S6;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000007963	ENSCAFP00000011788	ENSCAFT00000012727

Organism

Canis familiaris

Functional Description

Protein Length

500

Protein Sequence
(FASTA)

MGVGSSKKQV KEKEKGQWSP VKVSTQSKDP PPLPPLILFN HLTPAPPDAC LDQEERFVVA 60

LYDYSSVNDR DLQMLKGEKL QILKEAGDWW WARSLITGRE GYVPSNFVTR VETLEVEKWF 120

FRSISRKDAE RQLLAPVNKA GSFLIRESET NKGAFSLTVK DVTTQGEMIK HYKIRSLDEG 180

GYYISPRITF PTLQALVQHY SQKGDGLCQR LTQPCVSLAP QNPWAQDEWE IPRQSLKLVR 240

KLGSGQFGEV WMGYYKNNVK VAIKTLKEGT MSPEAFLGEA NLMKTLQHER LVRLYAVVTK 300

EPIYIVTEYM ARGCLLDFLK TVEGSRLSLP RLIDMSAQIA EGMAYIEQMN SIHRDLRAAN 360

ILVSETLCCK IADFGLARII DSEYTAQEGA KFPIKWTAPE AIHFGVFTIK ADVWSFGILL 420

MEIVTYGRVP YPGMSNPEVI RSLERGYRMP RPDSCPPELY HGVIAECWRS RPEERPTFEF 480

LQSVLEDFHT ATEQQYELQP 500

Nucleotide Sequence
(FASTA)

ATGGGAGTGG GGAGCAGCAA AAAGCAGGTG AAGGAGAAGG AGAAGGGTCA ATGGAGCCCT 60

GTGAAGGTCA GCACCCAGAG CAAAGATCCT CCACCACTGC CACCTCTGAT CCTGTTTAAC 120

CACCTGACTC CTGCACCTCC AGACGCATGC TTGGACCAAG AGGAGCGTTT CGTGGTGGCC 180

CTGTATGACT ACAGCTCAGT GAATGACAGG GACCTGCAGA TGCTGAAGGG AGAGAAGCTG 240

CAGATACTGA AGGAAGCTGG GGACTGGTGG TGGGCCAGGT CTCTCATCAC GGGAAGAGAA 300

GGCTACGTGC CCAGCAACTT TGTGACCCGA GTGGAGACCC TGGAGGTGGA AAAATGGTTC 360

TTTAGGTCAA TTAGCCGGAA AGATGCTGAG AGACAGCTTC TGGCTCCAGT CAATAAGGCG 420

GGCTCCTTTC TTATCAGAGA GAGTGAAACC AACAAAGGTG CCTTTTCCTT GACTGTGAAG 480

GATGTGACCA CCCAGGGGGA GATGATCAAA CACTACAAGA TCCGCTCCCT GGATGAAGGG 540

GGCTATTACA TCTCCCCCCG CATCACCTTC CCTACTCTCC AGGCTTTGGT GCAGCACTAT 600

TCTCAGAAGG GGGATGGCTT ATGCCAGAGG CTGACCCAAC CCTGTGTGAG CCTGGCTCCT 660

CAAAACCCCT GGGCCCAGGA TGAATGGGAA ATCCCTCGGC AGTCTCTCAA GCTGGTCAGG 720

AAACTCGGGT CTGGGCAGTT TGGCGAAGTC TGGATGGGTT ATTACAAGAA CAACGTGAAA 780

GTGGCCATCA AGACGTTAAA GGAGGGAACC ATGTCTCCGG AGGCTTTTCT GGGTGAGGCC 840

AACCTGATGA AAACTCTCCA GCATGAGCGG CTCGTTCGTC TCTACGCTGT GGTCACCAAG 900

GAGCCCATCT ACATCGTGAC GGAGTACATG GCCAGAGGAT GCTTACTGGA TTTCCTGAAG 960

ACGGTTGAAG GCAGCAGACT GTCCCTCCCA AGACTGATCG ACATGTCAGC CCAGATTGCT 1020

GAAGGAATGG CGTATATTGA GCAAATGAAT TCAATCCACC GCGACCTGAG GGCGGCCAAC 1080

ATCCTGGTGT CTGAGACCCT GTGCTGCAAG ATTGCTGACT TCGGCTTGGC CCGCATCATC 1140

GACAGTGAAT ACACTGCCCA AGAGGGGGCC AAGTTCCCCA TCAAGTGGAC TGCCCCAGAG 1200

GCCATCCACT TTGGAGTGTT CACCATCAAA GCAGACGTGT GGTCATTTGG AATCCTCCTG 1260

ATGGAAATCG TCACTTACGG GCGTGTACCA TACCCAGGAA TGAGCAACCC CGAGGTCATC 1320

CGCAGCCTGG AGCGTGGCTA CCGCATGCCG CGCCCCGACT CGTGCCCGCC CGAGCTGTAC 1380

CACGGTGTCA TCGCCGAGTG CTGGCGGAGC CGGCCGGAGG AGCGGCCCAC CTTCGAGTTC 1440

CTGCAGTCGG TGCTCGAGGA CTTCCACACG GCCACCGAGC AGCAGTACGA GCTGCAGCCC 1500

TAG 1503

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv+klG+GqfGevw+g++k++vkva+ktlkegt+speafl ea+++k+l+he+lv+ly

Q: 236   LKLVRKLGSGQFGEVWMGYYKNNVKVAIKTLKEGTMSPEAFLGEANLMKTLQHERLVRLY  295

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+ma+G+lldflk+ eg++l+lp+l+d++aq+aeGmay+e++n ihr

Q: 296   AVVTK-EPIYIVTEYMARGCLLDFLKTVEGSRLSLPRLIDMSAQIAEGMAYIEQMNSIHR  354

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e+l++k+adfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv

Q: 355   DLRAANILVSETLCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  413

         **************************.899******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239

         WsfGill+eivt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+++pe

Q: 414   WSFGILLMEIVTYGRVPYPGMSNPEVIRSLERGYRMPRPDSCPPELYHgVIAECWRSRPE  473

         ************************************************9***********

S: 240   erPtfetlqevl  251

         erPtfe+lq+vl

Q: 474   ERPTFEFLQSVL  485

         ********9986

Domain Sequence
(FASTA)

LKLVRKLGSG QFGEVWMGYY KNNVKVAIKT LKEGTMSPEA FLGEANLMKT LQHERLVRLY 60

AVVTKEPIYI VTEYMARGCL LDFLKTVEGS RLSLPRLIDM SAQIAEGMAY IEQMNSIHRD 120

LRAANILVSE TLCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180

FGILLMEIVT YGRVPYPGMS NPEVIRSLER GYRMPRPDSC PPELYHGVIA ECWRSRPEER 240

PTFEFLQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853	; P:B cell receptor signaling pathway
GO:0032024	; P:positive regulation of insulin secretion

KEGG

cfa:486080

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013