EPS-CAF-00049

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAF-00049

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	439.5	7.2E-132	129	460	332

Status

Unreviewed

Ensembl Protein

ENSCAFP00000012487

UniProt Accession

E2R7D2;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF2

Gene Synonyms/Alias

PPEF2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000008501	ENSCAFP00000012487	ENSCAFT00000013495

Organism

Canis familiaris

Functional Description

Protein Length

664

Protein Sequence
(FASTA)

PGGPSLLARI STHFTAFKAA ALIQRWYRRY MARLETRRRC TWRIFQSIEY AGQQDQVKLH 60

DFFSYLVDHF TPNSNHESEY ELPSNKSQYF KIKDSEMEKG SDYESIEVPD NYTGPRLSFP 120

LLPDHATALV EAFRLKQQLH ARYVLNLLHE TRKHLVQLPN INRVSTCYSE EITVCGDLHG 180

QLDDLIFIFH KNGLPSPERA YVFNGDFVDR GKESVEILMI LFAFMLVYPK EFRLNRGNHE 240

DHMVNLRSRY GLTKEVMHKY KTHGKKILKI LQDVFCWLHL ATLVDEKVLI LHGGVSDMPD 300

LELLAKLDRH KCKSVLYETP EESRDHLGEK HKSGGEPPAL HARSRLGSPE PLQPTQEAWK 360

QVVDILWSDP MAQEGCQANT VRGGGCYFGP SVTEQLLQKY NLQFLIRSHE HKPEGYGFCH 420

RRKVLTIFSA SNYYEVGSNR GAYVKLGPAL TPYIVQYQAN KETHRLTMRQ RISRVEESAL 480

RSLWEKLFAS SLDLLAKYRW GDERSSSLII LSAWAEAVES VLHLGLPWRM LKPQLVNSST 540

DNTLEYKSWL EDLAKEQLSR ENIQSNLLET LYRNRSNLEA IFRITDSDHS GFISLDEFRQ 600

TWKLFSSHMN IDITDDCICD LARIIDFNRD GHIDINEFLE AFCIVEQSST EGDTSDCPQA 660

TNTD 664

Nucleotide Sequence
(FASTA)

CCAGGGGGTC CCAGCTTACT GGCTCGCATC TCCACCCATT TCACAGCCTT CAAGGCAGCA 60

GCCCTGATCC AGAGATGGTA CCGGCGCTAC ATGGCACGCC TGGAGACGAG GCGGCGCTGC 120

ACCTGGCGCA TCTTCCAGTC TATCGAGTAT GCTGGGCAGC AGGACCAGGT CAAGCTCCAT 180

GATTTCTTCA GCTACCTTGT GGATCACTTT ACCCCCAACA GCAATCATGA GAGTGAGTAT 240

GAGCTGCCGT CTAACAAATC TCAATATTTT AAAATAAAAG ACTCTGAGAT GGAGAAAGGC 300

AGTGACTATG AATCTATAGA GGTACCAGAC AATTACACGG GGCCACGCCT CTCCTTCCCA 360

CTCCTTCCTG ACCACGCAAC TGCCCTGGTG GAAGCTTTCA GACTGAAACA ACAGCTCCAT 420

GCTCGCTATG TCTTGAATCT TTTGCATGAA ACCAGGAAAC ACCTGGTACA ACTGCCAAAC 480

ATCAACCGGG TCTCCACCTG TTACAGCGAG GAGATCACAG TGTGTGGAGA CTTGCACGGC 540

CAGTTGGATG ACTTAATATT TATATTTCAT AAGAATGGCC TTCCGTCACC AGAGAGGGCC 600

TATGTCTTCA ATGGTGACTT CGTGGATCGA GGCAAAGAAT CAGTAGAGAT CCTGATGATT 660

CTTTTTGCCT TCATGTTGGT TTACCCAAAA GAGTTCCGTC TTAACCGAGG AAACCATGAG 720

GACCATATGG TGAACTTACG ATCTAGATAT GGCCTTACCA AGGAAGTGAT GCATAAATAT 780

AAGACACATG GCAAGAAAAT ACTAAAAATA CTGCAGGATG TTTTCTGTTG GCTTCATCTG 840

GCTACTCTGG TTGATGAGAA AGTCCTGATT CTTCATGGCG GAGTGTCAGA CATGCCTGAC 900

CTGGAGCTTT TGGCTAAACT AGACAGGCAC AAGTGTAAGT CTGTGTTATA TGAGACACCA 960

GAGGAGTCCA GGGATCACTT GGGAGAGAAA CACAAAAGCG GAGGGGAGCC CCCTGCCCTC 1020

CACGCCAGAA GCAGGCTGGG AAGCCCGGAG CCCCTGCAGC CCACTCAGGA GGCCTGGAAG 1080

CAGGTGGTCG ATATACTGTG GAGCGATCCC ATGGCCCAGG AGGGCTGCCA AGCCAATACC 1140

GTTCGAGGAG GAGGCTGTTA TTTTGGACCT AGTGTAACAG AACAGTTGCT ACAGAAATAC 1200

AACCTGCAGT TCCTGATCCG CTCCCACGAG CACAAGCCTG AAGGCTACGG GTTCTGCCAC 1260

AGACGCAAGG TGTTAACAAT CTTTTCTGCC TCCAACTACT ATGAAGTTGG CAGTAACAGA 1320

GGGGCCTATG TCAAACTGGG ACCGGCCCTG ACCCCATACA TCGTGCAGTA TCAAGCTAAC 1380

AAGGAGACCC ACAGGCTGAC TATGAGGCAA AGGATTAGCA GAGTAGAGGA GTCAGCTCTG 1440

AGATCTCTGT GGGAAAAGTT ATTTGCTTCT TCTTTGGATC TTCTTGCAAA ATATAGATGG 1500

GGAGATGAAA GGAGCAGTAG TTTAATCATT CTTAGTGCCT GGGCAGAAGC TGTGGAGTCT 1560

GTGCTGCATC TAGGACTGCC ATGGCGGATG CTGAAGCCAC AGCTGGTGAA CAGTTCAACA 1620

GATAACACAC TGGAGTACAA GTCCTGGCTG GAGGACTTGG CCAAAGAACA ACTGAGCCGT 1680

GAGAACATAC AGTCAAATTT GCTGGAAACA TTGTATCGAA ACCGATCCAA CTTAGAGGCC 1740

ATTTTTAGGA TCACAGATAG TGATCATTCA GGGTTCATCT CACTGGATGA GTTCAGGCAG 1800

ACCTGGAAGC TGTTCAGCTC TCATATGAAC ATTGACATCA CAGATGACTG CATCTGTGAC 1860

CTTGCCCGGA TCATTGACTT CAACAGGGAT GGCCACATCG ACATCAATGA GTTCCTGGAG 1920

GCTTTCTGCA TTGTGGAGCA ATCCTCCACA GAGGGTGATA CTTCAGACTG CCCCCAAGCC 1980

ACAAACACAG AT 1992

Domain Profile

S: 4     llevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlllv  63

         l+e+f+ k++lha+yvl++l+e++k l qlpni++vst+ s+e+tv+GdlhG+lddl+++

Q: 129   LVEAFRLKQQLHARYVLNLLHETRKHLVQLPNINRVSTCYSEEITVCGDLHGQLDDLIFI  188

         89**********************************************************

S: 64    lkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmn..a  121

         ++knGlPs +++yvfnGdfvdrGk+++e+l++l +++lv+P++  lnrGnhed+++n  +

Q: 189   FHKNGLPSPERAYVFNGDFVDRGKESVEILMILFAFMLVYPKEFRLNRGNHEDHMVNlrS  248

         *******************************************************99445

S: 122   ryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksve  181

         ryG++kev++kyk++gk+il+il++v+ wl l+++vd++vl++hGG+s+ ++l+ll +++

Q: 249   RYGLTKEVMHKYKTHGKKILKILQDVFCWLHLATLVDEKVLILHGGVSDMPDLELLAKLD  308

         7***********************************************************

S: 182   rkkrksvllpPeessrd...............lgrldtdgepr.eslteteweqiidilw  225

         r+k ksvl +  e srd               +      g+p   + t++ w+q++dilw

Q: 309   RHKCKSVLYETPEESRDhlgekhksggeppalH-ARSRLGSPEpLQPTQEAWKQVVDILW  367

         *********988888888*********999953.44455666313447889*********

S: 226   sdPratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvti  285

         sdP a++G+  nt+rG+G+yfGP vte++l+ky+l+++irshe kpegy ++h  kv+ti

Q: 368   SDPMAQEGCQANTVRGGGCYFGPSVTEQLLQKYNLQFLIRSHEHKPEGYGFCHRRKVLTI  427

         ************************************************************

S: 286   fsasnyyeegsnkgayiklnsqltprfvqyiva  318

         fsasnyye+gsn+gay+kl   ltp +vqy++

Q: 428   FSASNYYEVGSNRGAYVKLGPALTPYIVQYQAN  460

         ******************************986

Domain Sequence
(FASTA)

LVEAFRLKQQ LHARYVLNLL HETRKHLVQL PNINRVSTCY SEEITVCGDL HGQLDDLIFI 60

FHKNGLPSPE RAYVFNGDFV DRGKESVEIL MILFAFMLVY PKEFRLNRGN HEDHMVNLRS 120

RYGLTKEVMH KYKTHGKKIL KILQDVFCWL HLATLVDEKV LILHGGVSDM PDLELLAKLD 180

RHKCKSVLYE TPEESRDHLG EKHKSGGEPP ALHARSRLGS PEPLQPTQEA WKQVVDILWS 240

DPMAQEGCQA NTVRGGGCYF GPSVTEQLLQ KYNLQFLIRS HEHKPEGYGF CHRRKVLTIF 300

SASNYYEVGS NRGAYVKLGP ALTPYIVQYQ AN 332

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 2.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 2.
PS50222	; EF_HAND_2; 2.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013