EKS-CAF-00183
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00183
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC437.81.8E-131345599255
StatusUnreviewed
Ensembl ProteinENSCAFP00000012799
UniProt AccessionF1PDX2;
Protein Name
Protein Synonyms/Alias
Gene NameCfa.16226
Gene Synonyms/Alias Cfa.16226;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000008689ENSCAFP00000012799ENSCAFT00000013836
OrganismCanis familiaris
Functional Description
Protein Length672
Protein Sequence
(FASTA)
MAPFLRIAFT SYELGSLQAA DEASQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKSTFD 60
AHIYEGRVIQ IVLMRAAEEP MSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY 120
FLEDIDCRQS MHGEDEAKLP TMNRRGAIKQ AKIHYIKNHE FIATFFGQPT FCSVCKDFVW 180
GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVYNYMS 240
PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCQKKVANLC GINQKLLAEA LNQVTQRSSR 300
KSETESVGIY QNFERKPGVS GDIAPDNGTY GKIWEGSTRC NIDNFIFHKV LGKGSFGKVL 360
LVELKGKKEF FAIKALKKDV VLIDDDVECT MVEKRVLALA WENPFLTHLF CTFQTKDHLF 420
FVMEFLNGGD LMYHIQDKGR FELYRATFYA AEIVCGLQFL HNKGIIYRDL KLDNVMLDQD 480
GHIKIADFGM CKENIFGEKQ ASTFCGTPDY IAPEILQGLK YSFSVDWWSF GVLLYEMLIG 540
QSPFHGDDED ELFESIRVDT PHYPRWITKE SKDILEKLLE RDTTKRLGVT GNIKIHPFFK 600
TINWTLLEKR AVEPPFKPKV KSPGDYSNFD QEFLNEKARL SYTDKNLIDS MDQTAFAGFS 660
FVNPKFERFL EK 672
Nucleotide Sequence
(FASTA)
ATGGCCCCGT TCCTGCGCAT CGCCTTCACC TCCTATGAGC TGGGCTCCCT GCAGGCCGCC 60
GATGAGGCCA GCCAGCCCTT CTGTGCCGTG AAGATGAAGG AGGCACTCAG CACAGAGCGC 120
GGGAAGACGC TGGTGCAGAA GAAGCCCACC ATGTACCCTG AGTGGAAGTC CACATTCGAC 180
GCCCACATCT ACGAGGGCCG AGTCATCCAG ATCGTGCTGA TGCGGGCAGC TGAAGAGCCG 240
ATGTCCGAGG TGACGGTGGG CGTGTCGGTG CTGGCCGAGC GCTGCAAGAA GAACAACGGG 300
AAGGCCGAGT TCTGGCTGGA CCTGCAACCC CAGGCCAAGG TGTTGATGTC TGTGCAGTAT 360
TTTCTGGAAG ACATAGATTG CAGACAGTCT ATGCATGGTG AAGACGAGGC CAAGTTACCA 420
ACAATGAACC GCCGTGGAGC CATCAAACAG GCCAAAATCC ACTACATCAA GAACCACGAG 480
TTTATTGCCA CCTTCTTCGG ACAGCCTACT TTCTGTTCTG TGTGCAAAGA CTTTGTTTGG 540
GGTCTCAACA AGCAAGGCTA CAAATGCAGG CAATGCAACG CTGCCATCCA CAAGAAATGC 600
ATCGACAAGA TCATCGGCCG GTGCACGGGC ACCGCAGCCA ACAGCCGGGA CACCATATTC 660
CAGAAAGAAC GTTTCAACAT CGACATGCCG CACCGATTCA AGGTTTACAA CTACATGAGC 720
CCCACCTTCT GTGACCACTG TGGCAGTCTG CTCTGGGGGC TGGTGAAGCA GGGATTAAAA 780
TGTGAAGACT GTGGCATGAA TGTACACCAT AAGTGCCAGA AGAAAGTGGC CAACCTCTGT 840
GGCATTAACC AGAAGCTCTT GGCTGAGGCA TTGAACCAAG TGACCCAGAG ATCCTCCCGG 900
AAGTCAGAAA CAGAGTCTGT TGGAATCTAC CAGAATTTTG AGAGAAAGCC AGGAGTCTCT 960
GGAGACATTG CCCCAGACAA CGGGACGTAC GGCAAGATCT GGGAGGGCAG CACCAGGTGC 1020
AACATTGACA ACTTCATCTT CCACAAGGTC CTGGGCAAAG GCAGCTTTGG GAAGGTGCTG 1080
CTTGTAGAGC TGAAGGGCAA GAAGGAGTTC TTTGCTATCA AGGCTCTTAA GAAGGACGTG 1140
GTTCTGATCG ACGATGACGT GGAGTGCACC ATGGTGGAGA AGCGGGTGCT GGCGCTCGCC 1200
TGGGAGAATC CCTTTCTCAC CCACCTGTTC TGCACATTTC AGACCAAGGA CCACCTGTTC 1260
TTCGTGATGG AGTTCCTCAA TGGTGGGGAC CTCATGTACC ACATCCAGGA CAAAGGCCGC 1320
TTCGAGCTCT ATCGGGCCAC GTTTTATGCA GCTGAGATAG TCTGTGGATT GCAGTTTCTG 1380
CACAACAAAG GGATCATTTA CAGGGACCTC AAGCTGGACA ATGTGATGCT GGACCAGGAT 1440
GGCCACATCA AGATTGCTGA CTTTGGGATG TGCAAGGAGA ACATATTTGG GGAGAAACAG 1500
GCTAGCACCT TCTGTGGCAC CCCTGACTAT ATTGCCCCCG AGATCCTGCA GGGCCTAAAG 1560
TACTCCTTCT CTGTGGACTG GTGGTCCTTT GGAGTCCTTC TCTACGAGAT GCTCATTGGT 1620
CAGTCCCCCT TCCACGGTGA CGATGAGGAC GAACTCTTCG AGTCCATCCG TGTGGACACG 1680
CCACATTATC CCCGCTGGAT CACCAAGGAG TCCAAGGACA TCCTGGAGAA GCTGCTTGAA 1740
AGAGATACAA CCAAGAGGCT GGGAGTGACG GGCAACATCA AAATCCACCC GTTCTTCAAG 1800
ACCATTAACT GGACCCTGCT GGAGAAACGG GCTGTGGAGC CGCCCTTCAA GCCCAAAGTG 1860
AAGTCCCCTG GAGACTACAG TAACTTTGAC CAGGAGTTCC TGAACGAGAA GGCACGCCTC 1920
TCCTACACCG ATAAGAACCT CATCGACTCC ATGGACCAAA CAGCATTCGC TGGCTTCTCC 1980
TTTGTGAACC CCAAATTTGA GAGATTCCTG GAAAAGTGA 2019
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f ++kvlGkGsfgkvll+elk+++e++aik lkkdvvl dddve+t+vekrvlala+++p
Q: 345   FIFHKVLGKGSFGKVLLVELKGKKEFFAIKALKKDVVLIDDDVECTMVEKRVLALAWENP  404
         889*********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl++lf++fqt+d+lffv+e++nGGdlm+hiq++++++  ra+fyaaei+++l+flh+kg
Q: 405   FLTHLFCTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIVCGLQFLHNKG  464
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld++Ghik+adfG+cke+i+ +k++stfcGtPdyiaPeil++ +y++s
Q: 465   IIYRDLKLDNVMLDQDGHIKIADFGMCKENIFGEKQASTFCGTPDYIAPEILQGLKYSFS  524
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdww++Gvllyeml+gqsPf+g+dedelfesi+ ++++yP++++ke+++il++ll++d++
Q: 525   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLLERDTT  584
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlGv  +g  +ik h+ff
Q: 585   KRLGV--TG--NIKIHPFF  599
         *****..56..79999998
Domain Sequence
(FASTA)
FIFHKVLGKG SFGKVLLVEL KGKKEFFAIK ALKKDVVLID DDVECTMVEK RVLALAWENP 60
FLTHLFCTFQ TKDHLFFVME FLNGGDLMYH IQDKGRFELY RATFYAAEIV CGLQFLHNKG 120
IIYRDLKLDN VMLDQDGHIK IADFGMCKEN IFGEKQASTF CGTPDYIAPE ILQGLKYSFS 180
VDWWSFGVLL YEMLIGQSPF HGDDEDELFE SIRVDTPHYP RWITKESKDI LEKLLERDTT 240
KRLGVTGNIK IHPFF 255
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00166
EKS-ANC-00168
EKS-BOT-00176
EKS-CAE-00133
EKS-CAJ-00179
EKS-CAP-00173
EKS-CIS-00207
EKS-DAR-00471
EKS-DRM-00086
EKS-EQC-00174
EKS-FEC-00164
EKS-GAM-00094
EKS-GAG-00150
EKS-GAA-00213
EKS-GOG-00175
EKS-HOS-00182
EKS-ICT-00169
EKS-LAC-00183
EKS-LOA-00173
EKS-MAM-00172
EKS-MEG-00108
EKS-MOD-00172
EKS-MUM-00180
EKS-MYL-00181
EKS-NOL-00169
EKS-OCP-00109
EKS-ORN-00221
EKS-ORC-00160
EKS-ORL-00208
EKS-OTG-00181
EKS-PES-00154
EKS-PEM-00089
EKS-POA-00169
EKS-RAN-00172
EKS-SAH-00166
EKS-SUS-00150
EKS-TAG-00204
EKS-TAR-00227
EKS-TEN-00221
EKS-XET-00163
EKS-XIM-00214
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005829; C:cytosol
GO:0005783; C:endoplasmic reticulum
GO:0016363; C:nuclear matrix
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0008047; F:enzyme activator activity
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0006915; P:apoptotic process
GO:0042100; P:B cell proliferation
GO:0090398; P:cellular senescence
GO:0016064; P:immunoglobulin mediated immune response
GO:0032613; P:interleukin-10 production
GO:0032615; P:interleukin-12 production
GO:0035556; P:intracellular signal transduction
GO:0030837; P:negative regulation of actin filament polymerization
GO:0051490; P:negative regulation of filopodium assembly
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0043407; P:negative regulation of MAP kinase activity
GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0090331; P:negative regulation of platelet aggregation
GO:0042119; P:neutrophil activation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:2000304; P:positive regulation of ceramide biosynthetic process
GO:2000753; P:positive regulation of glucosylceramide catabolic process
GO:1900163; P:positive regulation of phospholipid scramblase activity
GO:0035307; P:positive regulation of protein dephosphorylation
GO:2001022; P:positive regulation of response to DNA damage stimulus
GO:2000755; P:positive regulation of sphingomyelin catabolic process
GO:0032930; P:positive regulation of superoxide anion generation
GO:0023021; P:termination of signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013