EKS-CAF-00367
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAF-00367
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src448.47.7E-135270519250
StatusUnreviewed
Ensembl ProteinENSCAFP00000012903
UniProt AccessionE2RSH8;
Protein Name
Protein Synonyms/Alias
Gene NameSRC
Gene Synonyms/Alias SRC;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSCAFG00000008755ENSCAFP00000012903ENSCAFT00000013946
OrganismCanis familiaris
Functional Description
Protein Length536
Protein Sequence
(FASTA)
MGSNKSKPKD ASQRRRSLEP AENTHGGGGG AFPTSQTPSK PASADGHRGP STAFPSAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTEGD 120
WWLAHSLSTG QTGYIPSNYV APSDSIQAEE WYFGKITRRE SERLLLNAEN PRGTFLVRES 180
ETTKGAYCLS VSDFDNAKGL NVKHYKIRKL DSGGFYITSR TQFNSLQQLV AYYSKHADGL 240
CHRLTTVCPT SKPQTQGLAK DAWEIPRESL RLEVKLGQGC FGEVWMGTWN GTTRVAIKTL 300
KPGTMSPEAF LQEAQVMKKL RHEKLVQLYA VVSEEPIYIV TEYMSKGSLL DFLKGETGKY 360
LRLPQLVDMA AQIASGMAYV ERMNYVHRDL RAANILVGEN LVCKVADFGL ARLIEDNEYT 420
ARQGAKFPIK WTAPEAALYG RFTIKSDVWS FGILLTELTT KGRVPYPGMV NREVLDQVER 480
GYRMPCPPEC PESLHDLMCQ CWRKEPEERP TFEYLQAFLE DYFTSTEPQY QPGENL 536
Nucleotide Sequence
(FASTA)
ATGGGCAGCA ACAAGAGCAA GCCCAAGGAT GCCAGCCAAC GGCGCCGCAG CCTAGAGCCA 60
GCTGAGAACA CCCACGGTGG CGGCGGGGGT GCCTTCCCCA CCTCACAGAC ACCCAGCAAG 120
CCAGCCTCCG CTGATGGCCA CCGAGGCCCC AGTACAGCCT TCCCTTCCGC AGCTGCTGAG 180
CCCAAGCTGT TTGGGGGCTT CAACTCCTCG GACACGGTCA CCTCCCCGCA GCGGGCGGGG 240
CCGCTGGCTG GTGGAGTGAC CACCTTTGTG GCCCTCTATG ACTATGAGTC TCGGACAGAG 300
ACCGATCTGT CCTTCAAGAA AGGGGAGCGG CTCCAGATTG TCAACAACAC AGAGGGTGAC 360
TGGTGGCTGG CCCACTCGCT CAGCACGGGA CAGACAGGCT ACATCCCCAG CAACTACGTG 420
GCGCCCTCTG ACTCTATCCA GGCTGAGGAG TGGTACTTTG GCAAGATCAC CAGACGGGAG 480
TCAGAGCGGT TATTGCTCAA TGCAGAGAAC CCGAGAGGGA CCTTCCTGGT GCGAGAAAGC 540
GAGACCACGA AAGGCGCCTA CTGCCTCTCT GTGTCGGATT TCGACAACGC CAAGGGCCTC 600
AATGTGAAGC ACTACAAGAT CCGCAAGCTC GACAGTGGTG GCTTCTACAT CACCTCGCGC 660
ACACAGTTCA ACAGCCTGCA GCAGCTGGTG GCCTACTACT CCAAACATGC CGATGGCCTG 720
TGCCACCGCC TCACCACCGT GTGCCCCACA TCCAAGCCAC AGACTCAGGG GCTGGCCAAG 780
GATGCCTGGG AGATCCCTCG GGAGTCTCTG CGGCTGGAGG TCAAACTGGG CCAGGGCTGT 840
TTCGGAGAGG TGTGGATGGG AACCTGGAAC GGAACCACCA GGGTGGCCAT CAAAACCCTG 900
AAGCCAGGCA CGATGTCTCC AGAGGCCTTC CTGCAGGAGG CTCAGGTCAT GAAGAAACTG 960
AGGCACGAGA AGCTGGTGCA GCTGTACGCG GTGGTGTCTG AGGAGCCCAT CTACATCGTC 1020
ACAGAGTACA TGAGCAAGGG GAGTCTGCTG GACTTCCTCA AGGGGGAGAC AGGCAAGTAC 1080
CTGCGACTAC CTCAGCTGGT GGACATGGCC GCTCAGATCG CCTCAGGCAT GGCCTACGTG 1140
GAACGGATGA ACTACGTCCA CCGTGACCTC CGTGCTGCCA ACATTCTGGT TGGAGAGAAT 1200
CTCGTGTGCA AAGTGGCCGA CTTTGGGCTG GCCCGGCTCA TTGAAGACAA CGAGTACACC 1260
GCCCGGCAAG GTGCCAAATT CCCCATCAAG TGGACAGCTC CGGAAGCGGC CCTCTATGGC 1320
CGATTCACCA TCAAGTCAGA TGTGTGGTCC TTTGGGATCC TGCTGACGGA GCTCACGACA 1380
AAGGGGCGGG TGCCCTACCC CGGGATGGTC AACCGTGAGG TGCTTGACCA GGTGGAACGG 1440
GGCTACCGGA TGCCCTGCCC GCCTGAGTGT CCCGAGTCCC TGCACGACCT CATGTGCCAG 1500
TGCTGGCGGA AGGAGCCTGA GGAACGACCC ACCTTTGAGT ACCTGCAGGC CTTCCTGGAG 1560
GACTACTTCA CATCCACCGA GCCCCAGTAC CAGCCGGGAG AGAACCTATA G 1611
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 270   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  329
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr
Q: 330   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  388
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 389   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  448
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee
Q: 449   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  508
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 509   RPTFEYLQAFL  519
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120
LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00340
EKS-ANC-00356
EKS-BOT-00366
EKS-CAJ-00371
EKS-CAP-00399
EKS-CII-00206
EKS-CIS-00121
EKS-DAR-00747
EKS-DIO-00054
EKS-EQC-00357
EKS-FEC-00354
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MAM-00366
EKS-MEG-00302
EKS-MIM-00048
EKS-MOD-00355
EKS-MUM-00398
EKS-MUP-00360
EKS-MYL-00367
EKS-NOL-00334
EKS-ORN-00475
EKS-ORC-00344
EKS-ORL-00435
EKS-OTG-00369
EKS-PAT-00346
EKS-PES-00326
EKS-POA-00356
EKS-RAN-00380
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0016477; P:cell migration
GO:0030900; P:forebrain development
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477; P:oogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555; P:response to interleukin-1
GO:0060065; P:uterus development
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013