EKS-CAF-00173

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00173

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	496.2	2.2E-149	453	711	259

Status

Unreviewed

Ensembl Protein

ENSCAFP00000013072

UniProt Accession

E2QZL8;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000008898	ENSCAFP00000013072	ENSCAFT00000014131

Organism

Canis familiaris

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MGNGSVKPKH PKHPDGHPGN LSTHALRSKV VELERELRRK EAEIQEREYH LKELREQLSR 60

QTAAVAELTE ELQNKCIQLN KLQDVVHLQG GSLPQASPDK VPLEVHRKAS GLVSLHSRRG 120

AKAGVSAEPT SRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPLWTT FGELAILYNC 240

TRTASVKALT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQVIKTLQ KGEYFGEKAL 360

ISEDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 420

MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 540

ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDADGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGIDQMMTYN 660

LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK 720

ARNLPSPLQR ELSGPTDHSY FDKYPPEKGV PPDELSGWDK DF 762

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCAGTGAA ACCCAAACAT CCTAAGCATC CCGATGGCCA CCCGGGGAAC 60

CTCAGTACCC ACGCGCTGCG GAGCAAGGTG GTAGAGCTGG AGAGAGAGCT GAGGAGGAAG 120

GAGGCTGAGA TCCAGGAGCG GGAATACCAC TTGAAGGAGC TTCGGGAACA GCTGTCGAGG 180

CAGACAGCGG CCGTCGCCGA GCTCACGGAG GAGCTCCAGA ACAAGTGCAT CCAGCTGAAC 240

AAGCTTCAGG ATGTGGTGCA CCTGCAGGGA GGAAGCCTGC CGCAGGCCTC TCCAGATAAA 300

GTGCCTCTTG AGGTGCACCG CAAGGCCTCA GGATTGGTGT CCCTTCATAG CAGGAGGGGG 360

GCAAAAGCTG GAGTGTCTGC TGAGCCAACA AGCCGAACCT ATGACCTCAA TAAACCCCCC 420

GAATTTTCTT TTGAGAAAGC CAGAGTCAGA AAGGACTCCA GTGAGAAGAA GCTCATTACA 480

GATGCCCTTA ATAAAAATCA GTTTCTAAAG AGACTAGATC CTCAGCAGAT CAAAGACATG 540

GTGGAATGCA TGTATGGGAG AAACTACCAG CAAGGGAGTT ACATTATTAA GCAAGGAGAA 600

CCAGGAAACC ATATCTTTGT GCTAGCAGAG GGCCGACTAG AAGTATTCCA AGGGGAGAAA 660

TTACTATCAT CCATCCCTTT GTGGACTACG TTTGGGGAAC TAGCCATTTT ATACAACTGT 720

ACAAGAACTG CCTCCGTGAA AGCTCTTACC AATGTTAAGA CTTGGGCACT AGATCGAGAG 780

GTATTCCAGA ACATAATGAG AAGGACAGCT CAAGCTAGAG ATGAACAGTA CAGAAACTTC 840

CTCAGAAGTG TATCCTTGCT GAAGAATTTA CCTGAAGATA AATTAACCAA GATCATTGAC 900

TGCTTGGAAG TGGAATACTA TGACAAAGGA GATTATATTA TTAGAGAGGG TGAGGAAGGA 960

AGTACCTTCT TCATCTTAGC AAAAGGAAAG GTAAAAGTCA CCCAGAGCAC AGAGGGCCAT 1020

GATCAACCAC AAGTGATAAA AACACTGCAG AAAGGAGAAT ACTTTGGAGA AAAAGCTCTT 1080

ATCAGTGAGG ATGTCAGATC AGCTAACATT ATTGCTGAAG AAAATGATGT CGCATGCCTA 1140

GTTATAGATC GAGAAACATT CAACCAAACA GTTGGGACTT TCGAAGAACT CCAAAAATAC 1200

CTTGAAGGGT ATGTGGCAAA CCTGAACCGT GATGATGAGA AAAGACATGC AAAGAGATCC 1260

ATGTCTAACT GGAAGCTGTC TAAAGCACTG TCTCTGGAGA TGATTCAGCT GAAGGAGAAG 1320

GTGGCCAGAT TTTCCTCATC ATCCCCTTTC CAGAACCTTG AGATTATCGC AACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT TGAGCTTGTT AAAGTGAAAA ATGAGAATGT TGCTTTTGCT 1440

ATGAAATGTA TAAGGAAGAA GCATATTGTT GACACAAAGC AGCAGGAGCA CGTCTACTCA 1500

GAAAAGAGAA TTCTAGAAGA GTTGTGTTCT CCATTCATTG TGAAATTATA TCGTACTTTC 1560

AAGGACAATA AGTATGTCTA CATGCTTCTG GAGGCCTGCT TAGGTGGGGA GCTATGGAGC 1620

ATATTAAGGG ACAGAGGCAG TTTTGATGAA CCCACCTCCA AGTTCTGTGT CGCTTGCGTG 1680

ACAGAAGCAT TTGATTACCT GCATCGACTC GGTATTATTT ACAGAGACCT GAAACCAGAA 1740

AACTTAATTC TAGATGCTGA TGGTTATCTG AAATTGGTTG ACTTTGGATT TGCTAAGAAA 1800

ATAGGATCTG GACAGAAAAC ATGGACATTC TGTGGGACTC CTGAGTATGT AGCTCCTGAA 1860

GTCATTCTCA ACAAAGGTCA TGACTTCAGT GTGGATTTTT GGTCCCTGGG AATTCTAGTG 1920

TATGAGCTCC TAACTGGCAA CCCTCCCTTT TCTGGGATTG ACCAGATGAT GACCTACAAC 1980

TTGATTCTCA AAGGAATTGA GAAAATGGAT TTTCCCAGAA AGATAACAAG ACGACCGGAA 2040

GATTTGATTC GGAGGCTTTG CAGGCAAAAT CCAACAGAAA GACTTGGAAA TCTGAAGAAT 2100

GGAATTAATG ATATTAAGAA ACACAGGTGG TTAAACGGTT TCAATTGGGA GGGCCTGAAA 2160

GCGCGGAACC TTCCATCACC TTTACAGAGA GAGCTCAGTG GACCCACAGA CCACAGCTAC 2220

TTCGACAAGT ATCCCCCTGA AAAAGGAGTG CCTCCAGATG AGCTGTCAGG CTGGGATAAA 2280

GACTTCTGA 2289

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+

Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd+ t+kf+vacv+ea++ylh+ +

Q: 512   FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld++gylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np

Q: 632   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  691

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+w+

Q: 692   TERLGNLKNGINDIKKHRWL  711

         *******************7

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60

IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDADGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKKHRWL 259

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 1.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013