EKS-CAF-00284

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00284

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.3	8.1E-136	144	431	288

Status

Unreviewed

Ensembl Protein

ENSCAFP00000013635

UniProt Accession

E2RLG0; F1PTG0;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000009269	ENSCAFP00000013637	ENSCAFT00000014743
ENSCAFG00000009269	ENSCAFP00000013635	ENSCAFT00000014741

Organism

Canis familiaris

Functional Description

Protein Length

442

Protein Sequence
(FASTA)

MLTNGKEQVI KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TASADAPGLG 60

PVQLAAAVSV PGALLAAAAL TLCARRGRRC GRRKRRRRNV EEAVPERALV GAGKTLQDLI 120

CDVAASGSGS GLPLLVQRTI ARTIVLQEIV GKGRFGEVWH GRWCGEDVAV KIFSSRDERS 180

WFREAEIYQT VMLRHENILG FIAADNKDNG TWTQLWLVSE YHELGSLYDY LNRNIVTVAG 240

MIKLALSIAS GLAHLHMEIV GTQGKPAIAH RDIKSKNILV KKCETCAIAD LGLAVKHDSL 300

LNTIDIPQNP KVGTKRYMAP EMLDDTMNVN IFESFKRADI YSVGLVYWEI ARRCSVGGIV 360

EEYQLPYYDM VPSDPSIEEM RKVVCDQKFR PSIPNQWQSC EALRVMGRIM RECWYANGAA 420

RLTALRIKKT ISQLCVKEDC KA 442

Nucleotide Sequence
(FASTA)

ATGCTGACCA ATGGAAAAGA ACAAGTGATC AAGTCCTGTG TCTCTCTCCC AGAACTGAAT 60

GCTCAAGTCT TCTGTCATAG TTCCAACAAT GTTACCAAAA CAGAATGCTG CTTCACAGAC 120

TTTTGCAACA ACATAACACT GCACCTTCCC ACAGCCTCCG CAGACGCCCC GGGGCTCGGG 180

CCCGTGCAGC TGGCGGCCGC CGTCTCGGTG CCGGGGGCCC TGCTGGCGGC CGCCGCCCTG 240

ACCCTGTGCG CCCGCCGGGG GCGCCGCTGC GGCCGCAGGA AGAGGAGGCG GCGGAACGTG 300

GAGGAGGCGG TCCCCGAGCG CGCCCTCGTC GGCGCCGGCA AGACCCTGCA AGACCTCATC 360

TGCGACGTGG CGGCCTCTGG ATCCGGCTCC GGTCTACCTC TGTTGGTTCA AAGAACAATT 420

GCAAGGACGA TTGTGCTTCA GGAGATAGTA GGAAAAGGTA GATTTGGTGA GGTCTGGCAT 480

GGAAGATGGT GTGGGGAAGA TGTGGCTGTA AAGATATTCT CCTCCAGAGA TGAAAGATCT 540

TGGTTTCGTG AGGCAGAGAT TTACCAGACG GTTATGCTGA GACACGAAAA CATACTTGGC 600

TTCATTGCTG CTGACAACAA AGATAACGGA ACTTGGACTC AACTTTGGCT TGTCTCCGAA 660

TATCACGAGC TGGGCTCTTT ATATGACTAT TTGAATAGAA ACATAGTGAC AGTGGCTGGC 720

ATGATCAAAC TGGCACTTTC AATAGCTAGT GGTCTGGCCC ACCTACATAT GGAGATTGTT 780

GGGACACAAG GTAAACCTGC TATTGCTCAT CGAGATATAA AATCAAAGAA TATCTTAGTG 840

AAAAAATGTG AAACTTGTGC CATAGCAGAC TTAGGGTTGG CTGTGAAGCA TGATTCACTA 900

CTGAACACGA TAGATATACC TCAGAATCCT AAAGTGGGAA CCAAAAGGTA TATGGCTCCT 960

GAAATGCTTG ACGATACAAT GAATGTGAAT ATCTTTGAGT CCTTCAAACG AGCTGACATC 1020

TATTCTGTTG GTCTGGTTTA CTGGGAAATA GCCCGAAGGT GTTCAGTTGG AGGAATTGTT 1080

GAGGAGTACC AGTTGCCTTA TTATGACATG GTGCCTTCAG ATCCCTCAAT AGAAGAAATG 1140

AGGAAAGTTG TTTGTGACCA GAAATTTCGA CCAAGTATCC CAAACCAGTG GCAAAGCTGT 1200

GAAGCACTCC GAGTCATGGG GAGAATAATG AGAGAGTGTT GGTATGCCAA TGGGGCAGCC 1260

CGCCTAACGG CCCTTCGTAT TAAGAAGACG ATCTCTCAAC TTTGTGTCAA AGAAGACTGC 1320

AAAGCCTAA 1329

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 144   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  203

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe gsL+dyL+r++++v  +++lals+asGlahLH+eivgt+

Q: 204   ADNKDNGTWTQLWLVSEYHELGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQ  263

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE

Q: 264   G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSLLNTIDIPQNPKVGTKRYMAPE  321

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem

Q: 322   MLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSIEEM  380

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 381   RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  431

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE LGSLYDYLNR NIVTVAGMIK LALSIASGLA HLHMEIVGTQ 120

GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSLLNT IDIPQNPKVG TKRYMAPEML 180

DDTMNVNIFE SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSIEEMRKV 240

VCDQKFRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013