EKS-CAF-00283

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00283

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	453.6	3.3E-136	168	455	288

Status

Unreviewed

Ensembl Protein

ENSCAFP00000013675

UniProt Accession

E2RKJ3;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1

Gene Synonyms/Alias

ACVR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000009287	ENSCAFP00000013675	ENSCAFT00000014782

Organism

Canis familiaris

Functional Description

Protein Length

469

Protein Sequence
(FASTA)

MVDGVMMLPV LMMIAFPSPS MEDEKPKKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN 60

RNITAQLPTK GKSFPETQNF HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR 120

DVEYGTIEGL ITTNVGDSTL ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG 180

EVWRGSWQGE NVAVKIFSSR DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW 240

LITHYHEMGS LYDYLQLTTL DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK 300

NILVKKNGQC CIADLGLAVM HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK 360

RVDIWAFGLV LWEVARRMVS NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR 420

WFSDPTLTSL AKLMKECWYQ NPSARLTALR IKKTLTKIDN SLDKLKTDC 469

Nucleotide Sequence
(FASTA)

ATGGTAGATG GAGTGATGAT GCTTCCTGTG CTAATGATGA TCGCCTTCCC TTCCCCTAGT 60

ATGGAAGATG AGAAGCCCAA GAAAGGCTGC TTCCAGGTCT ACGAGCAGGG GAAGATGACC 120

TGTAAGACCC CGCCATCACC TGGCCAAGCT GTGGAGTGCT GCCAAGGGGA CTGGTGTAAC 180

AGGAACATCA CGGCCCAGCT GCCCACTAAA GGGAAATCCT TTCCTGAAAC ACAGAATTTC 240

CACTTGGAGG TCGGCCTCAT TATTCTGTCC GTAGTATTTG CAGTATGCCT TCTAGCTTGC 300

CTACTGGGAG TCGCTCTCCG AAAATTTAAA AGGCGCAATC AAGAACGCCT CAATCCCAGA 360

GATGTGGAGT ACGGCACCAT CGAAGGGCTC ATCACCACCA ATGTTGGAGA CAGCACTCTA 420

GCAGATTTAT TGGATCATTC GTGTACATCA GGAAGTGGCT CTGGTCTCCC TTTTCTGGTA 480

CAAAGAACAG TGGCTCGTCA GATCACACTG TTGGAGTGTG TCGGGAAAGG CAGGTATGGT 540

GAGGTGTGGA GGGGCAGCTG GCAAGGGGAG AACGTTGCTG TGAAGATCTT CTCCTCCCGG 600

GATGAGAAGT CGTGGTTCAG GGAAACAGAA TTGTACAACA CTGTGATGCT GAGGCATGAA 660

AATATTTTAG GTTTTATTGC TTCAGACATG ACATCAAGAC ACTCCAGTAC CCAGTTGTGG 720

TTAATCACAC ATTATCATGA AATGGGATCG TTGTACGACT ATCTTCAGCT TACTACTCTG 780

GATACTGTTA GCTGCCTGCG AATAGTGCTG TCCATAGCTA GTGGTCTTGC ACATTTGCAC 840

ATAGAGATAT TTGGGACCCA AGGAAAGCCA GCCATTGCTC ATCGAGATTT AAAGAGCAAA 900

AACATCCTGG TTAAGAAGAA TGGACAGTGT TGCATAGCAG ATTTGGGCCT GGCAGTCATG 960

CATTCCCAGA GTACCAATCA GCTCGATGTG GGGAACAACC CCCGTGTGGG CACCAAACGC 1020

TACATGGCTC CTGAAGTTCT AGATGAAACC ATCCAGGTGG ACTGTTTCGA TTCTTACAAG 1080

AGAGTTGATA TTTGGGCCTT TGGTCTTGTC TTGTGGGAAG TGGCCAGGCG TATGGTAAGC 1140

AACGGTATTG TGGAGGATTA CAAGCCACCA TTTTACGATG TGGTCCCCAA TGACCCAAGT 1200

TTTGAAGATA TGAGAAAGGT GGTCTGTGTG GATCAACAGA GGCCAAACAT ACCCAATAGG 1260

TGGTTCTCAG ACCCGACATT AACCTCTCTG GCTAAGCTGA TGAAAGAATG CTGGTATCAG 1320

AATCCATCTG CAAGACTCAC AGCTCTGCGT ATCAAAAAGA CTTTGACCAA AATTGATAAT 1380

TCCCTAGACA AATTGAAAAC TGACTGTTGA 1410

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia

Q: 168   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  227

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 228   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  287

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 288   G--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  345

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 346   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  404

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 405   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  455

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKPAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

cfa:478757

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013