EKS-CAF-00302

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00302

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IKK	434.0	3.0E-130	15	288	274

Status

Unreviewed

Ensembl Protein

ENSCAFP00000014093

UniProt Accession

E2RNA9;

Protein Name

Protein Synonyms/Alias

Gene Name

CHUK

Gene Synonyms/Alias

CHUK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000009588	ENSCAFP00000014093	ENSCAFT00000015231

Organism

Canis familiaris

Functional Description

Protein Length

745

Protein Sequence
(FASTA)

MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDVK IAIKSCRLEL STKNRERWCH 60

EIQIMKKLNH ANVVKACDVP EELNFLINDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ 120

ILSLLSDIGS GIRYLHENKI IHRDLKPENI VLQDVGGKIM HKIIDLGYAK DVDQGSLCTS 180

FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK 240

CIFACEEMTG EVRFSSHLPQ PNSLCSLIVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC 300

FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG SQELLSETGI 360

SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS RSLSDCVNYI VRDSKIQLPI 420

IQLRKVWAEA VHYVSGLKED YSRLFQGQRA AMLSLLRYNA NLTKMKNTLI SASQQLKAKL 480

EFFHKSIQLD LERYSEQMTY GISSEKMLKA WKEMEEKAIH YAEVGVIGYL EDQIMSLHTE 540

IMELQKSPYG RRQGDLMESL EQRAIDLYKQ LKHRPSDHSY SDSTEMVKII VHTVQSQDRV 600

LKELFGHLSK LLGCKQKIID LLPKVEMALS NIKEADNTVM FMQGKRQKEI WHLLKIACTQ 660

SSARSLVGSS LEGAVTPQAS AWLPPNSAER EHPLSCVVTP QDGETIVQMI EENLNCLGHL 720

STIIHEANEE QGSRMMNLDW SWLTE 745

Nucleotide Sequence
(FASTA)

ATGGAGCGGC CCCCGGGGCT GCGGCCGGGC GCGGGCGGGC CTTGGGAGAT GCGGGAGCGG 60

CTGGGCACTG GCGGCTTTGG GAACGTCTGT CTGTACCAGC ATCGGGAACT TGATGTTAAA 120

ATAGCAATTA AATCATGTCG CCTAGAACTA AGTACCAAAA ACAGAGAACG GTGGTGTCAT 180

GAAATCCAGA TCATGAAGAA GTTGAACCAC GCCAATGTTG TAAAGGCCTG TGATGTACCT 240

GAGGAATTGA ATTTTTTAAT TAATGATGTA CCTCTTCTAG CAATGGAATA CTGTTCTGGA 300

GGAGATCTCC GGAAGCTACT CAATAAACCA GAAAATTGCT GTGGACTTAA AGAAAGCCAG 360

ATACTTTCTT TACTGAGTGA TATAGGGTCT GGGATCCGAT ATTTGCATGA AAACAAAATA 420

ATACATCGTG ATCTAAAACC TGAAAACATA GTTCTTCAGG ATGTTGGTGG AAAGATTATG 480

CATAAAATAA TTGATCTAGG ATATGCCAAA GATGTTGATC AAGGAAGTCT GTGTACATCT 540

TTTGTGGGAA CACTGCAGTA TCTGGCCCCA GAGCTCTTTG AGAATAAGCC TTATACAGCC 600

ACTGTTGATT ATTGGAGCTT TGGGACCATG GTGTTTGAAT GTATTGCTGG ATATAGGCCT 660

TTTTTGCATC ATCTGCAGCC ATTTACTTGG CATGAGAAGA TTAAGAAGAA GGATCCAAAG 720

TGTATATTTG CATGTGAAGA AATGACAGGA GAAGTTCGGT TTAGTAGCCA TTTACCTCAA 780

CCAAATAGCC TTTGTAGTTT AATAGTAGAA CCCATGGAAA ACTGGCTTCA GTTGATGCTG 840

AATTGGGATC CTCAGCAAAG AGGAGGACCT GTTGATCTTA CTTTGAAGCA ACCAAGATGT 900

TTTGTATTAA TGGATCACAT TCTCAATTTG AAGATAGTAC ACATCCTAAA TATGACTTCT 960

GCAAAGATAA TTTCTTTTTT GTTACCACCT GATGAAAGTC TTCATTCACT ACAGTCTCGT 1020

ATTGAGCGTG AAACTGGAAT AAATACCGGT TCTCAAGAGC TTCTTTCAGA GACAGGAATT 1080

TCTCTGGATC CTCGGAAACC GGCCTCTCAA TGTGTTCTAG ATGGAGTAAG AGGCTGTGAT 1140

AGCTATATGG TGTATTTGTT TGATAAAAGT AAGACTGTAT ATGAAGGACC ATTTGCTTCC 1200

AGAAGTTTAT CTGACTGTGT AAATTATATT GTACGGGACA GCAAAATTCA GCTTCCAATT 1260

ATACAGCTGC GTAAAGTATG GGCTGAAGCA GTGCACTATG TGTCTGGGCT GAAAGAAGAC 1320

TATAGCAGGC TCTTTCAGGG ACAAAGAGCA GCAATGTTAA GTCTTCTTAG ATATAACGCT 1380

AACCTGACAA AAATGAAGAA CACTTTGATC TCAGCATCTC AGCAACTGAA AGCTAAATTG 1440

GAGTTTTTCC ACAAAAGCAT TCAGCTTGAC TTGGAAAGAT ACAGTGAGCA GATGACTTAT 1500

GGGATATCCT CAGAAAAAAT GTTAAAAGCA TGGAAGGAAA TGGAAGAAAA GGCTATCCAC 1560

TATGCCGAGG TGGGTGTCAT CGGTTACCTG GAGGATCAGA TCATGTCTCT GCACACTGAA 1620

ATCATGGAGC TGCAGAAGAG CCCTTATGGA AGACGTCAGG GAGACTTGAT GGAATCTCTG 1680

GAACAGCGTG CTATTGATCT GTATAAGCAG TTAAAGCACA GACCTTCAGA TCACTCCTAT 1740

AGCGACAGCA CGGAAATGGT GAAGATCATT GTGCATACTG TTCAGAGTCA GGACCGGGTT 1800

CTCAAGGAGC TGTTTGGTCA TCTGAGCAAG TTATTGGGCT GTAAGCAGAA GATTATTGAT 1860

CTACTGCCCA AGGTGGAAAT GGCCCTCAGT AACATCAAAG AAGCTGACAA TACTGTCATG 1920

TTTATGCAGG GAAAGAGACA GAAAGAAATA TGGCATCTCC TTAAAATTGC CTGTACACAG 1980

AGTTCTGCCC GGTCCCTCGT AGGATCCAGT CTAGAAGGTG CAGTAACCCC TCAGGCATCA 2040

GCATGGCTTC CTCCAAATTC AGCAGAACGT GAACATCCTC TGTCATGCGT GGTAACTCCT 2100

CAAGATGGGG AGACTATAGT ACAAATGATA GAAGAAAATT TGAACTGTCT TGGCCATTTA 2160

AGCACTATTA TTCATGAAGC AAATGAGGAA CAGGGCAGTA GAATGATGAA TCTTGATTGG 2220

AGTTGGTTAA CAGAATGA 2238

Domain Profile

S: 1     WelkelLGeGafgnvikarnkktgekiavkvikeesslrprevqvrelevlrklnhkniv  60

         We++e+LG+G+fgnv+ +++++ + kia+k+++ e+s+++re++++e+++++klnh+n+v

Q: 15    WEMRERLGTGGFGNVCLYQHRELDVKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV  74

         ************************************************************

S: 61    klvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvLsdvvaglry  120

         k++dv+eeln++ +++++l++eyCsgGdlrk+L++pen++GLkes++l++Lsd+ +g+ry

Q: 75    KACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY  134

         ************************************************************

S: 121   LrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGteeYlaPely  180

         L+enki+hRDlkPenivl+++ +gk ++k++DlG+a+++d++++++s+vGt++YlaPel+

Q: 135   LHENKIIHRDLKPENIVLQDV-GGKIMHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELF  193

         ********************9.**************************************

S: 181   eqkkytatvDlWsiGvllyeaitGslPflpfegprrlykkitkkpakaiagtekangeve  240

         e+k ytatvD+Ws+G++++e+i+G++Pfl++ +p+++++ki+kk++k+i+++e+++gev+

Q: 194   ENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMTGEVR  253

         ************************************************************

S: 241   fssslPlsaslssglqeklekllanllevdeekrw  275

         fss+lP+++sl+s+++e +e++l+++l++d+++r+

Q: 254   FSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRG  288

         ********************************986

Domain Sequence
(FASTA)

WEMRERLGTG GFGNVCLYQH RELDVKIAIK SCRLELSTKN RERWCHEIQI MKKLNHANVV 60

KACDVPEELN FLINDVPLLA MEYCSGGDLR KLLNKPENCC GLKESQILSL LSDIGSGIRY 120

LHENKIIHRD LKPENIVLQD VGGKIMHKII DLGYAKDVDQ GSLCTSFVGT LQYLAPELFE 180

NKPYTATVDY WSFGTMVFEC IAGYRPFLHH LQPFTWHEKI KKKDPKCIFA CEEMTGEVRF 240

SSHLPQPNSL CSLIVEPMEN WLQLMLNWDP QQRG 274

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0008384	; F:IkappaB kinase activity
GO:0007252	; P:I-kappaB phosphorylation
GO:0007595	; P:lactation
GO:0060749	; P:mammary gland alveolus development
GO:0033598	; P:mammary gland epithelial cell proliferation
GO:0002011	; P:morphogenesis of an epithelial sheet
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0030316	; P:osteoclast differentiation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade

KEGG

cfa:477796

;

InterPros

IPR022007	; IKKbetaNEMObind.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12179	; IKKbetaNEMObind; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013