EPS-CAF-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAF-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	237.8	2.1E-70	94	344	251

Status

Unreviewed

Ensembl Protein

ENSCAFP00000014131

UniProt Accession

E2RJI1;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1K

Gene Synonyms/Alias

PPM1K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000009605	ENSCAFP00000014131	ENSCAFT00000015270

Organism

Canis familiaris

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MSTAALITLV RSGGSHVRRR VLLSSRLLQD DRRLTPTCHG STSEPRCSRF DPDGSGRPAT 60

WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASH IGKRKENEDR FDSAQLTDEV 120

LYFAVYDGHG GPAAADFCHT HMETCIMDLL PKEKNLETVL TLAFLEIDKA FARHAHLSAD 180

ATLLTSGTTA TVALVRDGIE LVVASVGDSR AILCRKGKPM KLTIDHTPER KDEKERIKKC 240

GGFVAWNSLG QPHVNGRLAM TRSLGDLDLK TSGVIAEPET KRIKLHHADD SFLVLTTDGI 300

NFMVNSQEIC NFVNQCHDPN EAAHAVIEQA IQYGSEDNST AVVVPFGAWG KYKNSEINFS 360

FSRSFASSGR WA 372

Nucleotide Sequence
(FASTA)

ATGTCAACAG CTGCCTTAAT TACTTTGGTT AGAAGTGGTG GGAGCCACGT GAGGAGGAGA 60

GTGCTGCTAA GCTCCCGCCT CCTGCAGGAC GACAGGCGGC TGACACCCAC CTGCCACGGC 120

TCCACTTCAG AGCCTCGGTG TTCGCGGTTT GACCCGGATG GTAGTGGGCG TCCAGCCACC 180

TGGGATAATT TCGGGATCTG GGATAACCGC ATCGACGAGC CCATTCTGCT GCCGCCCAGC 240

ATTAAGTACG GCAAGCCGAT CCCCAAAATC AGCCTGGAAA ACGTAGGCTG CGCCTCGCAT 300

ATTGGCAAAC GAAAGGAGAA CGAAGACCGG TTCGACAGCG CCCAGCTAAC AGATGAGGTC 360

CTGTACTTCG CGGTGTACGA CGGGCACGGC GGACCCGCAG CTGCTGATTT CTGTCACACC 420

CACATGGAGA CCTGCATCAT GGATTTGCTT CCTAAAGAGA AGAACTTGGA AACTGTGTTG 480

ACCTTGGCTT TTCTAGAAAT AGATAAAGCC TTTGCGAGGC ATGCCCACCT GTCTGCTGAT 540

GCAACCCTTC TGACCTCTGG GACTACTGCA ACAGTAGCCC TGGTGAGAGA TGGTATTGAA 600

CTGGTTGTAG CCAGTGTTGG GGATAGCCGG GCTATTTTGT GTAGAAAAGG AAAACCCATG 660

AAGCTGACCA TTGACCATAC TCCAGAAAGA AAAGATGAAA AAGAAAGGAT CAAGAAATGT 720

GGTGGTTTTG TAGCTTGGAA TAGTTTGGGA CAGCCTCATG TGAATGGCAG ACTTGCAATG 780

ACAAGGAGTC TTGGAGATTT GGATCTTAAA ACCAGTGGTG TGATAGCAGA ACCAGAAACA 840

AAGAGGATTA AGCTACATCA TGCCGATGAC AGCTTCCTGG TCCTCACCAC AGATGGAATT 900

AACTTCATGG TGAATAGTCA AGAGATTTGT AATTTCGTCA ACCAGTGCCA TGATCCCAAC 960

GAAGCAGCCC ATGCAGTGAT TGAACAGGCT ATACAGTATG GTAGTGAAGA TAACAGTACT 1020

GCAGTAGTAG TGCCTTTTGG TGCCTGGGGA AAATACAAGA ACTCTGAAAT CAACTTCTCA 1080

TTCAGCAGAA GCTTTGCCTC CAGTGGACGA TGGGCCTGA 1119

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         +vg++s  g+r+e ed+++s    +   + +d++ +f+vyDGhgg  +a+fc++++++++

Q: 94    NVGCASHIGKRKENEDRFDS----A---QLTDEVLYFAVYDGHGGPAAADFCHTHMETCI  146

         57999999*******99975....3...3445589*************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.k  116

            l     +e++++++l+ aFl++d+++    +++l+ d+    sG+ta+val++d  +

Q: 147   MDLLP----KEKNLETVLTLAFLEIDKAF--ARHAHLSADAtlltSGTTATVALVRDGiE  200

         ***87....********************..55555555556899*************9*

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLav  174

         l+va vGdSra+Lcr+gk+++l+ dH+p+r+dE+eRi++ gg v+ ++ g+ +v+G La+

Q: 201   LVVASVGDSRAILCRKGKPMKLTIDHTPERKDEKERIKKCGGFVAWNSlGQpHVNGRLAM  260

         ********************************************98889999********

S: 175   sRalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekk  232

         +R+lGdl+lk + v++ePe+  ++l++ d+ fl+L +DG+  +v+++e++++v+++++

Q: 261   TRSLGDLDLKtSGVIAEPETKRIKLHHADDsFLVLTTDGINFMVNSQEICNFVNQCHD--  318

         **********566************999999***************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           ++eaa+ ++++a+++gs+dn +a+vv

Q: 319   --PNEAAHAVIEQAIQYGSEDNSTAVVV  344

         ..***********************997

Domain Sequence
(FASTA)

NVGCASHIGK RKENEDRFDS AQLTDEVLYF AVYDGHGGPA AADFCHTHME TCIMDLLPKE 60

KNLETVLTLA FLEIDKAFAR HAHLSADATL LTSGTTATVA LVRDGIELVV ASVGDSRAIL 120

CRKGKPMKLT IDHTPERKDE KERIKKCGGF VAWNSLGQPH VNGRLAMTRS LGDLDLKTSG 180

VIAEPETKRI KLHHADDSFL VLTTDGINFM VNSQEICNFV NQCHDPNEAA HAVIEQAIQY 240

GSEDNSTAVV V 251

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013