EKS-CAF-00316

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00316

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	349.3	1.7E-104	30	281	252

Status

Unreviewed

Ensembl Protein

ENSCAFP00000014145

UniProt Accession

F1PGB1;

Protein Name

Protein Synonyms/Alias

Gene Name

STK4

Gene Synonyms/Alias

STK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000009615	ENSCAFP00000014145	ENSCAFT00000015285

Organism

Canis familiaris

Functional Description

Protein Length

487

Protein Sequence
(FASTA)

METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ 60

VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT 120

LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK 180

RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP 240

PPTFRKPELW SDNFMDFVKQ CLVKSPEQRA TATQLLQHPF VKSAKGVSIL RDLINEAMDV 300

KLKRQEAQQR EVDQDDEENS EEDEMDSGTM VRAAGDEMGT VRVASTTSDG ASTMIEHGDT 360

LPSQLGTMVI NTEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQIHS FGQSVPGPLR 420

NSSDWKVPQD GDYEFLKSWT VEDLQKRLLA LDPMMEQEIE EIRQKYQSKR QPILDAIEAK 480

KRRQQNF 487

Nucleotide Sequence
(FASTA)

ATGGAGACGG TGCAGCTGAG GAACCCGCCG CGCCGGCAGC TGAAAAAGTT GGATGAAGAT 60

AGTTTAACTA AACAACCAGA AGAAGTATTT GATGTCTTAG AGAAACTTGG AGAAGGGTCC 120

TATGGCAGTG TGTACAAAGC TATTCACAAA GAGACTGGTC AGATTGTTGC AATTAAGCAA 180

GTTCCAGTGG AATCAGACCT ACAGGAGATA ATCAAAGAAA TCTCTATCAT GCAGCAATGT 240

GACAGCCCTC ACGTAGTCAA ATATTATGGC AGTTATTTTA AGAACACAGA CTTGTGGATT 300

GTTATGGAGT ACTGTGGGGC TGGTTCCGTG TCTGATATCA TTCGATTACG GAATAAAACG 360

TTAACAGAAG ATGAGATAGC TACAATATTA CAATCAACAC TTAAGGGACT GGAATACCTT 420

CATTTTATGA GAAAAATACA TCGGGATATC AAGGCAGGAA ATATTTTGCT AAATACAGAA 480

GGACATGCAA AACTTGCAGA TTTTGGGGTA GCAGGTCAAC TTACAGATAC CATGGCCAAA 540

CGGAATACAG TGATAGGGAC ACCATTTTGG ATGGCTCCAG AAGTGATTCA GGAAATTGGA 600

TACAACTGTG TGGCAGACAT CTGGTCATTG GGAATAACTG CCATAGAAAT GGCTGAGGGA 660

AAGCCCCCAT ATGCCGATAT CCATCCAATG AGGGCCATCT TTATGATTCC CACCAACCCT 720

CCCCCTACAT TTCGAAAGCC AGAACTATGG TCCGATAACT TCATGGATTT TGTGAAGCAA 780

TGCCTTGTAA AGAGCCCTGA GCAGAGAGCC ACAGCCACTC AACTCCTACA GCACCCGTTT 840

GTCAAAAGTG CCAAGGGAGT GTCAATACTG CGGGACTTAA TTAACGAGGC CATGGATGTG 900

AAGCTGAAAC GCCAGGAAGC CCAGCAGCGG GAGGTGGACC AGGATGATGA AGAGAACTCC 960

GAGGAGGATG AGATGGACTC TGGCACAATG GTTCGAGCAG CAGGTGATGA GATGGGCACC 1020

GTCCGGGTAG CCAGCACCAC AAGTGATGGG GCCAGCACTA TGATTGAGCA CGGGGACACA 1080

TTGCCATCAC AGCTGGGCAC CATGGTGATC AACACAGAGG ATGAGGAAGA GGAAGGGACC 1140

ATGAAAAGAA GGGATGAGAC CATGCAGCCT GCAAAACCAT CTTTCCTTGA ATATTTTGAA 1200

CAAAAAGAAA AAGAAAACCA GATCCACAGC TTTGGCCAGA GTGTCCCTGG CCCCCTGAGG 1260

AACTCCTCGG ATTGGAAAGT ACCGCAGGAT GGAGACTATG AGTTCCTTAA AAGTTGGACG 1320

GTGGAGGACC TTCAGAAGAG GCTCCTGGCC CTTGACCCCA TGATGGAGCA AGAGATTGAA 1380

GAGATCCGGC AAAAGTACCA GTCCAAGAGG CAGCCGATCC TGGACGCCAT CGAGGCTAAG 1440

AAGCGGCGGC AGCAGAACTT TTGA 1464

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +++le++g+G++g+vy+a +k+tg++vaik++ +e+  +l+e++keis+++++++p++v+

Q: 30    FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVK  87

         7899*******************************7..9*********************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s++k+++lw+vmey+ +Gs+sd+++  ++++l+E++ia+il+++lk+LeylH +++i

Q: 88    YYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLTEDEIATILQSTLKGLEYLHFMRKI  146

         ****************************.99*****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdika+niLl++eg+ kL+dfgva ql++t++kr+tv+gtp+wmAPEvi+  e gY++

Q: 147   HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ--EIGYNCV  204

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         aDiwslGItaie+aeg+pP++d++p++a+++i++n+pp++++++ +s++f +fv++cl k

Q: 205   ADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFMDFVKQCLVK  264

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         +pe+R++a++ll+h+F+

Q: 265   SPEQRATATQLLQHPFV  281

         ****************7

Domain Sequence
(FASTA)

FDVLEKLGEG SYGSVYKAIH KETGQIVAIK QVPVESDLQE IIKEISIMQQ CDSPHVVKYY 60

GSYFKNTDLW IVMEYCGAGS VSDIIRLRNK TLTEDEIATI LQSTLKGLEY LHFMRKIHRD 120

IKAGNILLNT EGHAKLADFG VAGQLTDTMA KRNTVIGTPF WMAPEVIQEI GYNCVADIWS 180

LGITAIEMAE GKPPYADIHP MRAIFMIPTN PPPTFRKPEL WSDNFMDFVK QCLVKSPEQR 240

ATATQLLQHP FV 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR011524	; SARAH.
IPR024205	; SARAH_domain.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF11629	; Mst1_SARAH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50951	; SARAH; 1.

Prints

Created Date

20-Feb-2013