EKS-CAF-00054

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00054

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	404.1	3.8E-121	667	928	262

Status

Unreviewed

Ensembl Protein

ENSCAFP00000014510

UniProt Accession

F1P721;

Protein Name

Protein Synonyms/Alias

Gene Name

KSR2

Gene Synonyms/Alias

KSR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000009865	ENSCAFP00000014510	ENSCAFT00000015680
ENSCAFG00000009865	ENSCAFP00000014505	ENSCAFT00000015673

Organism

Canis familiaris

Functional Description

Protein Length

949

Protein Sequence
(FASTA)

MDEENMTKSE EQQPLSLQKA LQQCELVQNM IDLSISNLEG LRTKCATSND LTQKEIRTLE 60

SKLVKYFSRQ LSCKKKVALQ ERNAELDGFP QLRHWFRIVD VRKEVLEEIT PGQLSLEDLL 120

EMTDEQVCET VEKYGANREE CARLNASLSC LRNVHMSGGN LSKQDWTIQW PTTETGKENN 180

PVCPPEPTPW IRTHLSQSPR VQTKCVQHYC HASPSPGAPV YTHMDRLTVD AYPGLCPPPP 240

LESGHRSLPP SPRQRHAVRT PPRTPNIVTT VTPPGTPPMR RKNKLKPPGT PPPSSRKLIH 300

LIPGFTALHR SKSHEFQLGH RVDEVHTPKA KKKSKPLNLK IHSSVGSCEN IPSQQRSPLL 360

SERSLRSFFV GHAPFLPSTP PVHTEANFSA NTLSVPRWSP QIPRRDLGNS IKHRFSTKYW 420

MSQTCTVCGK GMLFGLKCKN CKLKCHNKCT KEAPPCHLLI IHRGDPARLV RTESVPCDIN 480

NPLRKPPRYS DLHISQTLPK TNKISKDHIP VPYQPDSSSN PSSTTSSTPS SPAPPLPPSA 540

TPPSPLHPSP QCMRQQKNFN LPASHYYKYK QQFIFPDVVP VPETPTRAPQ VILHPVTSNP 600

ILEGNPLLQI EVEPTSENEE GHDEAEESED EFEEMNLSLL SARSFPRKAS QTSIFLQEWD 660

IPFEQLEIGE LIGKGRFGQV YHGRWHGEVA IRLIDIERDN EEQLKAFKRE VMAYRQTRHE 720

NVVLFMGACM SPPHLAIITS LCKGRTLYSV VRDAKIVLDV NKTRQIAQEI VKGMGYLHAK 780

GILHKDLKSK NVFYDNGKVV ITDFGLFSIS GVLQAGRRED KLRIQNGWLC HLAPEIIRQL 840

SPDTEEDKLP FSKHSDVFAL GTIWYELHAR EWPFKTQPAE AIIWQMGTGM KPNLSQIGMG 900

KEISDILLFC WAFEQEERPT FTKLMDMLEK LPKRNRRLSH PGHFWKSAE 949

Nucleotide Sequence
(FASTA)

ATGGATGAGG AAAACATGAC GAAAAGCGAG GAGCAGCAGC CTCTGAGTTT GCAAAAAGCC 60

TTACAGCAGT GCGAGTTGGT CCAAAACATG ATAGACCTGA GCATCTCCAA CCTGGAAGGG 120

CTTAGGACCA AATGTGCCAC CTCCAACGAC CTCACACAAA AAGAGATCCG GACCCTGGAG 180

AGCAAGCTGG TAAAGTACTT CAGCCGACAG CTGTCCTGCA AAAAGAAGGT GGCCCTGCAG 240

GAGCGCAACG CCGAGCTGGA TGGCTTCCCC CAGCTTCGAC ACTGGTTCCG GATCGTCGAT 300

GTGCGCAAGG AAGTCCTGGA GGAAATCACC CCCGGCCAGC TGAGTCTGGA GGACCTCTTG 360

GAGATGACAG ATGAGCAGGT GTGTGAGACC GTGGAGAAAT ACGGAGCCAA CCGGGAGGAG 420

TGTGCCCGTC TCAATGCCTC CCTGTCCTGT CTCCGGAACG TCCATATGTC AGGAGGCAAC 480

CTTTCCAAAC AAGACTGGAC CATCCAGTGG CCCACCACGG AAACGGGGAA GGAGAACAAC 540

CCTGTGTGCC CCCCGGAGCC CACCCCGTGG ATCCGCACCC ACCTCTCCCA GAGCCCCAGG 600

GTCCAGACCA AGTGTGTCCA GCACTACTGT CATGCCAGCC CCTCACCCGG GGCCCCCGTG 660

TACACTCACA TGGACAGGCT AACTGTGGAT GCCTACCCGG GTCTGTGCCC GCCACCACCA 720

CTGGAATCAG GCCACCGCTC CCTGCCCCCG TCGCCCCGGC AGCGGCACGC GGTCCGCACC 780

CCGCCACGCA CCCCCAATAT CGTCACCACC GTGACCCCAC CTGGCACACC ACCCATGAGG 840

AGGAAGAACA AGCTGAAGCC CCCAGGGACC CCACCGCCTT CCTCCCGGAA GCTGATCCAC 900

CTGATTCCAG GTTTCACTGC CCTGCATCGA AGCAAGTCTC ACGAATTCCA GCTGGGTCAC 960

CGTGTAGATG AGGTCCACAC TCCCAAAGCC AAGAAGAAAA GCAAACCATT GAACCTCAAG 1020

ATTCACAGCA GCGTGGGCAG CTGTGAGAAC ATTCCTTCTC AGCAGCGCTC CCCACTCCTG 1080

TCCGAGCGCT CCCTCCGCTC CTTCTTTGTG GGACATGCAC CTTTCCTGCC CTCCACCCCT 1140

CCTGTCCACA CCGAGGCCAA CTTCTCTGCA AACACACTGT CCGTGCCGCG CTGGTCCCCG 1200

CAGATCCCTC GCAGAGACCT CGGCAACTCC ATCAAGCACA GGTTTTCCAC CAAGTACTGG 1260

ATGTCTCAGA CATGCACAGT CTGTGGGAAA GGAATGCTTT TTGGCCTCAA GTGTAAAAAT 1320

TGCAAGTTAA AGTGCCACAA CAAATGCACC AAAGAAGCCC CTCCCTGTCA TCTCCTGATC 1380

ATCCACCGAG GAGATCCAGC AAGGTTAGTC CGAACAGAGT CTGTCCCATG TGACATCAAC 1440

AACCCTCTAC GAAAGCCACC CCGGTATTCG GACCTGCACA TCAGTCAGAC GCTCCCCAAA 1500

ACCAACAAAA TCAGCAAGGA CCACATCCCT GTCCCTTACC AGCCAGACTC TAGCAGCAAT 1560

CCCTCATCCA CCACGTCCTC CACACCCTCC TCGCCAGCAC CGCCGCTCCC TCCCAGCGCC 1620

ACACCGCCTT CTCCCCTGCA CCCTTCCCCG CAGTGCATGA GGCAGCAGAA GAACTTCAAC 1680

CTGCCAGCAT CCCACTACTA CAAATACAAG CAGCAGTTCA TCTTCCCAGA TGTTGTGCCG 1740

GTGCCAGAGA CGCCGACCCG GGCACCCCAG GTCATCCTGC ATCCAGTGAC CTCGAATCCA 1800

ATCTTGGAAG GAAATCCATT ACTTCAAATT GAAGTGGAGC CAACCTCAGA GAATGAAGAG 1860

GGCCACGATG AGGCCGAGGA GTCGGAGGAT GAATTTGAGG AGATGAACCT GTCCCTGCTC 1920

TCAGCCAGGA GCTTCCCACG CAAGGCCAGC CAGACCAGCA TCTTCCTGCA GGAGTGGGAC 1980

ATCCCTTTTG AGCAGCTGGA GATCGGCGAG CTCATTGGCA AGGGCCGCTT TGGGCAGGTA 2040

TACCATGGCC GCTGGCATGG CGAGGTGGCC ATCCGGCTGA TCGACATCGA GAGGGACAAC 2100

GAGGAACAGC TAAAGGCCTT CAAGCGAGAG GTGATGGCCT ACAGGCAGAC GCGGCATGAG 2160

AACGTGGTGC TCTTCATGGG CGCCTGCATG AGCCCACCTC ACCTGGCCAT CATCACCAGC 2220

CTCTGTAAGG GACGGACGCT CTATTCTGTG GTGAGGGATG CCAAAATCGT CTTGGATGTC 2280

AACAAAACGA GGCAGATTGC CCAAGAAATT GTGAAGGGCA TGGGCTACCT CCACGCAAAG 2340

GGGATCCTTC ACAAGGACCT CAAGTCAAAG AATGTCTTCT ATGACAATGG CAAAGTGGTG 2400

ATCACAGACT TCGGGCTCTT CAGCATTTCT GGGGTGCTGC AGGCTGGCAG GAGGGAGGAC 2460

AAGCTGCGCA TCCAGAATGG CTGGCTGTGC CACCTGGCAC CAGAGATCAT CCGCCAGCTG 2520

TCTCCTGACA CGGAAGAGGA CAAGCTCCCC TTCTCCAAGC ATTCAGATGT CTTTGCACTC 2580

GGCACAATTT GGTATGAACT CCATGCCAGG GAGTGGCCTT TCAAGACCCA ACCAGCAGAG 2640

GCAATAATCT GGCAAATGGG CACAGGCATG AAACCCAACC TCAGCCAGAT CGGCATGGGA 2700

AAAGAAATCT CGGACATTCT TCTCTTTTGC TGGGCCTTTG AACAAGAAGA AAGACCTACA 2760

TTCACTAAGC TCATGGACAT GCTGGAGAAA CTGCCAAAGC GAAACCGCCG CCTTTCTCAC 2820

CCTGGACATT TCTGGAAGTC TGCAGAG 2847

Domain Profile

S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61

         e++e iG+GrfG+vy+g+whG+va++l+++e+++eeql+aFk+ev+ay++tRhen+vLFm

Q: 667   EIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEEQLKAFKREVMAYRQTRHENVVLFM  726

         7899********************************************************

S: 62    G.yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120

         G ++s+p+lai+tslckg++Ly+++++++  ld++k+++ia++i++gm+YLhak+ilhkD

Q: 727   GaCMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKD  786

         ************************************************************

S: 121   lksknilleeglkvvitDFgllsvkrllsg.rrekqleipkgwilylapeviralsidle  179

         lkskn+++++g kvvitDFgl+s++ +l++ rre++l+i++gw+++lape+ir+ls+d+e

Q: 787   LKSKNVFYDNG-KVVITDFGLFSISGVLQAgRREDKLRIQNGWLCHLAPEIIRQLSPDTE  845

         ***********.***************9977*****************************

S: 180   qdelpfskesDvyafGivlyellarelpykeesadqilfavgrGlkpdlskvksklpkel  239

         +d+lpfsk+sDv+a+G+++yel+are+p+k+++a++i++++g+G+kp+ls++   ++ke+

Q: 846   EDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQI--GMGKEI  903

         ****************************************************..******

S: 240   kellleClkfekeeRPlftqilkkl  264

         +++ll C++fe+eeRP+ft+++++l

Q: 904   SDILLFCWAFEQEERPTFTKLMDML  928

         **********************986

Domain Sequence
(FASTA)

EIGELIGKGR FGQVYHGRWH GEVAIRLIDI ERDNEEQLKA FKREVMAYRQ TRHENVVLFM 60

GACMSPPHLA IITSLCKGRT LYSVVRDAKI VLDVNKTRQI AQEIVKGMGY LHAKGILHKD 120

LKSKNVFYDN GKVVITDFGL FSISGVLQAG RREDKLRIQN GWLCHLAPEI IRQLSPDTEE 180

DKLPFSKHSD VFALGTIWYE LHAREWPFKT QPAEAIIWQM GTGMKPNLSQ IGMGKEISDI 240

LLFCWAFEQE ERPTFTKLMD ML 262

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR025561	; KSR_SAM-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13543	; KSR1-SAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00109

; C1; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013