EKS-CAF-00255

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAF-00255

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	329.0	2.1E-98	98	348	251

Status

Unreviewed

Ensembl Protein

ENSCAFP00000014767

UniProt Accession

F1PEE7;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK2

Gene Synonyms/Alias

NUAK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSCAFG00000010038	ENSCAFP00000014767	ENSCAFT00000015965

Organism

Canis familiaris

Functional Description

Protein Length

671

Protein Sequence
(FASTA)

LDCGSCPSPG PGPGPGPIPI PITAPRAPRP APRSALLGPA MEPLAFPRRP GPAPAAASAL 60

AAELARPRAD GLIKSPKPQM KKQAVKRHHH KHNLRHRYEF LETLGKGTYG KVKKARESSG 120

RLVAIKSIRK DKIKDEQDLM HIRREIEIMS SLNHPHIIAI HEVFENSSKI VIVMEYASRG 180

DLYDYISERQ RLSEQDARHF FRQIVSAVRY CHQNGIVHRD LKLENILLDA NGNIKIADFG 240

LSNLYHQGKF LQTFCGSPLY ASPEIVNGKP YTGPEVDSWS LGVLLYILVH GTMPFDGQDH 300

KTLVRQISNG SYREPPKPSD ACGLIRWLLM VNPTRRATLE DVASHWWVNW GYATRVGEHE 360

APLEGGPPGS DSGRASVADW LRRSSRPLLE NGAKVCSFFK QHTPGASTGP GLERQHSLKK 420

SRKENDMAQS LQGDPADDPS VRPGRGNLKL PKSILKKKAP TVEGARGDPE PGPGPMDPGQ 480

AAPLLPKKGI LKKPRQRESG YYSSPEPSES GELLDAGDVF MSADSEEQKP PQVPGLPLHR 540

KGILKHNGKF SCTALELPTP STFGSLDELA SPHQLARASH PSGAMSEDSI LSSESFDQLD 600

LPQRLPEPVL RGCVSVDNLM GLEEPPAEGP GSRGLRRWWR ESLGDSCFSL TDCQEVTEAY 660

RQALGVSSKL S 671

Nucleotide Sequence
(FASTA)

TTGGACTGCG GCTCCTGCCC CAGCCCCGGC CCCGGCCCCG GCCCCGGCCC CATCCCCATC 60

CCCATCACTG CGCCCCGCGC CCCGCGCCCC GCGCCCCGCT CCGCCCTCCT CGGCCCCGCC 120

ATGGAGCCGC TGGCTTTCCC CCGGCGCCCC GGCCCGGCTC CCGCCGCCGC CTCCGCGCTG 180

GCCGCCGAGC TTGCCCGGCC CCGGGCCGAC GGGCTCATCA AGTCGCCCAA GCCCCAGATG 240

AAGAAGCAGG CGGTCAAGCG GCACCACCAC AAGCACAACC TGCGCCACCG CTACGAGTTC 300

CTCGAGACCC TGGGCAAGGG CACCTACGGG AAGGTGAAGA AGGCGCGGGA GAGCTCGGGG 360

CGCCTGGTGG CCATAAAGTC AATCCGGAAA GACAAAATCA AAGATGAGCA AGACCTGATG 420

CACATCCGGC GAGAGATAGA GATCATGTCG TCACTCAACC ATCCCCACAT CATTGCCATC 480

CACGAAGTGT TTGAGAACAG CAGCAAGATT GTGATCGTCA TGGAGTACGC CAGCCGGGGT 540

GACCTGTATG ACTACATCAG CGAGCGGCAG CGGCTCAGTG AGCAGGACGC CCGCCATTTC 600

TTCCGCCAGA TCGTCTCTGC CGTGCGCTAC TGCCACCAGA ATGGGATTGT CCACCGAGAT 660

CTCAAGCTAG AGAACATCCT CTTAGATGCC AATGGAAATA TTAAGATCGC AGACTTCGGC 720

CTCTCCAACC TCTACCACCA GGGCAAGTTC CTGCAGACGT TCTGCGGGAG CCCCCTGTAC 780

GCCTCGCCGG AGATCGTCAA TGGGAAGCCC TACACGGGCC CAGAGGTGGA CAGCTGGTCC 840

TTGGGGGTCC TTCTGTACAT CCTGGTGCAT GGCACCATGC CCTTTGACGG GCAGGACCAT 900

AAGACACTGG TGAGACAGAT CAGCAATGGG TCCTACCGGG AGCCACCTAA ACCCTCTGAT 960

GCCTGTGGCC TGATCCGGTG GCTATTAATG GTGAACCCCA CCCGCCGGGC CACCCTGGAG 1020

GATGTGGCCA GCCACTGGTG GGTAAACTGG GGCTATGCCA CCCGTGTGGG GGAGCACGAG 1080

GCTCCGCTCG AGGGAGGACC CCCTGGCAGC GACTCCGGCC GGGCCTCCGT GGCCGACTGG 1140

CTCCGGCGGT CCTCCCGGCC TCTCCTGGAG AACGGGGCCA AGGTCTGCAG CTTCTTTAAG 1200

CAGCACACAC CCGGAGCGAG CACCGGCCCC GGCCTGGAGC GCCAGCATTC ACTGAAGAAG 1260

TCCCGCAAAG AGAACGACAT GGCCCAGTCT CTCCAGGGGG ACCCAGCTGA CGACCCCTCC 1320

GTTCGCCCTG GCAGGGGCAA CCTCAAGCTG CCGAAGAGCA TCCTCAAGAA GAAGGCACCA 1380

ACTGTGGAAG GGGCAAGGGG AGACCCTGAG CCCGGCCCAG GCCCCATGGA CCCAGGACAG 1440

GCTGCCCCCC TGCTCCCCAA GAAGGGCATC CTCAAGAAGC CTCGGCAGCG GGAATCTGGC 1500

TACTACTCCT CTCCTGAACC CAGTGAGTCT GGGGAGCTCC TGGACGCAGG AGATGTGTTC 1560

ATGAGTGCGG ACTCCGAGGA GCAGAAGCCC CCCCAAGTCC CGGGGCTGCC CCTCCATCGC 1620

AAAGGCATCC TCAAACACAA TGGCAAGTTC TCCTGCACAG CCCTGGAGCT CCCGACCCCC 1680

TCCACCTTCG GCTCCCTGGA TGAACTCGCC TCCCCTCACC AGCTGGCCCG GGCCAGCCAC 1740

CCCTCAGGAG CTATGAGTGA GGACAGCATC CTGTCTTCTG AGTCCTTCGA CCAGCTGGAC 1800

TTGCCCCAAC GGCTCCCTGA GCCTGTGCTG CGGGGCTGCG TGTCCGTGGA CAACCTTATG 1860

GGGCTCGAGG AGCCCCCGGC AGAGGGCCCT GGAAGCAGGG GCCTGAGGCG CTGGTGGAGG 1920

GAGTCCCTGG GGGATAGCTG CTTTTCCCTG ACAGACTGCC AGGAGGTGAC CGAAGCCTAC 1980

CGCCAAGCCC TGGGGGTCAG CTCAAAGCTC AGCTGA 2016

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y++l+tlG+g++gkVk+a+++  ++ va+K i+k+k+ +e+ l +i+rEiei+++l+hp+

Q: 98    YEFLETLGKGTYGKVKKARES-SGRLVAIKSIRKDKIkDEQDLMHIRREIEIMSSLNHPH  156

         99***************9986.799**********996778899****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii ++ev+e+++k+++v+eyas+g+L+dyi+e++rl+e++ar++f+q+vsav+Y+h++gi

Q: 157   IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQRLSEQDARHFFRQIVSAVRYCHQNGI  216

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld+++nikiaDFGl+nl+++gk l+tfcGsp Ya+Pe+++gk+Y+gp+v

Q: 217   VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV  276

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D WslGv+Ly+lv g++Pfd+++ k+l+++i++g+++ p k s ++  L+r lL+v+p++

Q: 277   DSWSLGVLLYILVHGTMPFDGQDHKTLVRQISNGSYREPPKPS-DACGLIRWLLMVNPTR  335

         ****************************************966.5668************

S: 240   Ratieeilkhewl  252

         Rat+e++ +h w+

Q: 336   RATLEDVASHWWV  348

         ************6

Domain Sequence
(FASTA)

YEFLETLGKG TYGKVKKARE SSGRLVAIKS IRKDKIKDEQ DLMHIRREIE IMSSLNHPHI 60

IAIHEVFENS SKIVIVMEYA SRGDLYDYIS ERQRLSEQDA RHFFRQIVSA VRYCHQNGIV 120

HRDLKLENIL LDANGNIKIA DFGLSNLYHQ GKFLQTFCGS PLYASPEIVN GKPYTGPEVD 180

SWSLGVLLYI LVHGTMPFDG QDHKTLVRQI SNGSYREPPK PSDACGLIRW LLMVNPTRRA 240

TLEDVASHWW V 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013